Advanced search
Publication Cover
Nucleosides, Nucleotides & Nucleic Acids Volume 24, 2005 - Issue 8
Submit an article Journal homepage
102
Views
2
CrossRef citations to date
0
Altmetric
Original Articles

N4-Hydroxycytosine Dioxolane Nucleosides and Their Activity Against Hepatitis B Virus

Jinfa Du Pharmasset, Inc., Tucker, Georgia, USA
,
Laurent Hollecker Pharmasset, Inc., Tucker, Georgia, USA
,
Junxing Shi Pharmasset, Inc., Tucker, Georgia, USA
,
Byoung-Kwon Chun Pharmasset, Inc., Tucker, Georgia, USA
,
Kyoichi A. Watanabe Pharmasset, Inc., Tucker, Georgia, USA
,
Raymond F. Schinazi Veterans Affairs Medical Center, Decatur, Georgia, USA; Emory University, Atlanta, Georgia, USA
,
Tammy Y. Nachman Pharmasset, Inc., Tucker, Georgia, USA
,
Stefania Lostia Pharmasset, Inc., Tucker, Georgia, USA
,
Lieven J. Stuyver Pharmasset, Inc., Tucker, Georgia, USA
&
Michael J. Otto Pharmasset, Inc., Tucker, Georgia, USA
 show all
Pages 1209-1214 | Received 01 Dec 2004, Accepted 22 Mar 2005, Published online: 31 Aug 2006

References

  • Kumar , R .; Nath , M .; Tyrrell , D . J . Design and synthesis of novel 5-substituted acyclic pyrimidine nucleosides as potent and selective inhibitors of hepatitis B virus . J. Med. Chem . 2002 , 45 , 2032 – 2040 . [PUBMED] [INFOTRIEVE] [CSA]
  • Angus , P .; Vaughan , R .; Xiong , S .; Yang , H .; Delaney , W .; Gibbs , C .; Brosgart , C .; Colledge , D .; Edwards , R .; Ayres , A .; Bartholomeusz , A .; Locarnini , S . Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase . Gastroenterology 2003 , 125 , 292 – 297 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Schinazi , R . F . Unpublished results . [CSA]
  • Popowska , E .; Janion , C . N 4-hydroxycytidine—a new mutagen of a base analogue type . Biochem. Biophys. Res. Commun . 1974 , 56 , 459 – 466 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Popowska , E .; Janion , C . The metabolism of N 4-hydroxycytidine—a mutagen for Salmonella typhimurium . Nucleic Acids Res . 1975 , 2 , 1143 – 1151 . [PUBMED] [INFOTRIEVE] [CSA]
  • Storer , R . Method for the Treatment of Flaviviridea Viral Infection Using Nucleoside Analogues . U.S. Patent 6,566,365 , 20 May 2003 .
  • Luo , M.-Z .; Liu , M.-C .; Mozdziesz , D . E .; Lin , T.-S .; Dutschman , G . E .; Gullen , E . A .; Cheng , Y.-C .; Sartorelli , A . C . Synthesis and biological evaluation of l- and d-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides . Bioorg. Med. Chem. Lett . 2000 , 10 , 2145 – 2148 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Ladner , S . K .; Otto , M . J .; Barker , C . S .; Zaifert , K .; Wang , G . H .; Guo , J . T .; Seeger , C .; King , R . W . Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication . Antimicrob. Agents Chemother . 1997 , 41 , 1715 – 1720. [PUBMED] [INFOTRIEVE] [CSA]
  • Ladner , S . K .; Miller , T . J .; King , R . W . The M539V polymerase variant of human hepatitis B virus demonstrates resistance to 2′-deoxy-3′-thiacytidine and a reduced ability to synthesize viral DNA . Antimicrob. Agents Chemother . 1998 , 42 , 2128 – 2131 . [PUBMED] [INFOTRIEVE] [CSA]
  • Stuyver , L . J .; Lostia , S .; Adams , M .; Mathew , J . S .; Pai , B . S .; Grier , J .; Tharnish , P . M .; Choi , Y .; Chong , Y .; Choo , H .; Chu , C . K .; Otto , M . J .; Schinazi , R . F . Antiviral activities and cellular toxicities of modified 2′,3′-dideoxy-2′,3′-didehydrocytidine analogues . Antimicrob. Agents Chemother . 2002 , 46 , 3854 – 3860 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
  • Lee , M .; Chu , C . K .; Pai , S . B .; Zhu , Y.-L .; Cheng , Y.-C .; Chun , M . W .; Chung , W . K . Dioxolane cytosine nucleosides as anti-hepatitis B agents . Bioorg. Med. Chem. Lett . 1995 , 5 , 2011 – 2014 . [CSA] [CROSSREF]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.