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Research Article

Modifying the Release of Gentamicin from Microparticles Using a PLGA Blend

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Pages 235-248 | Received 20 Mar 2001, Accepted 29 Aug 2001, Published online: 29 May 2002

REFERENCES

  • Taylor E.W. Surgical Infection: Current Concerns. Eur. J. Surg. 1997; 163(Suppl. 578)5–9
  • Wahlig H. Gentamicin–PMMA: a Drug Delivered System in Treatment of Chronic Bone Soft Tissue Infections. J. Antimicrob. Chemother. 1982; 10: 463–465
  • Bailey I.S., Bundred N.J., Pearson H.J., Bell P.R.F. Successful Treatment of an Infected Vascular Graft with Gentamicin Beads. Eur. J. Vasc. Surg. 1987; 1: 143–144
  • Hedstrøm S.Å., Lidgren L., Tørholm S., Önnerfält R. Antibiotic Containing Bone Cement Beads in the Treatment of Deep Muscle and Skeletal Infections. Acta Orthop. Scand. 1980; 51: 863–869
  • Stemberger A., Grimm H., Bader F., Rahn H.D., Ascherl R. Local Treatment of Bone and Soft Tissue Infections with the Collagen–Gentamicin Sponge. Eur. J. Surg. 1997; 163(Suppl. 578)17–26
  • Grimm H. A. Stemberger, R. Ascherl, F. Lechner, G. BlümelBakteriologische und Pharmakokinetische Aspekte der Topischen Antibiotikaanwendung. Kollagen als Wirkstoffträger-Einsatzmöglichkeiten in der Chirurg ie, . Schattauer, StuttgartGermany 1989; 33–37
  • Walenkamp G.H.I.M. Gentamicin PMMA beads. A Clinical, Pharmacokinetic and Toxicological Study. University of Nijmegen, Netherlands
  • Stemberger A., Sorg K.H., Machka C., Blümel G. A. Stemberger, R. Ascherl, F. Lechner, G. BlümelTechnologische und Biochemische Aspekte von Kollagen-Implantaten. Kollagen als Wirkstoffträger-Einsatzmöglichkeiten in der Chirurg ie, . Schattauer, StuttgartGermany 1989; 17–29
  • Friess W. Drug Delivery Systems Based on Collagen. Shaker Verlag, AachenGermany 2000
  • Firsov A.A., Nazarov A.D., Fomina I.P. Biodegradable Implants Containing Gentamicin: Drug Release and Pharmacokinetics. Drug Dev. Ind. Pharm. 1987; 13: 1651–1674
  • Jørgensen L.G., Sandberg Sørensen T., Lorentzen J.E. Clinical and Pharmacokinetic Evaluation of Gentamycin Containing Collagen in Groin Wound Infections After Vascular Reconstruction. Eur. J. Vasc. Surg. 1991; 5: 87–91
  • v. Hasselbach C. Clinical Aspects and Pharmacokinetics of Collagen–Gentamicin as Adjuvant Local Therapy of Osseous Infections. Unfallchirurgie 1989; 92: 459–470
  • , Gericke, R.; Wahlig, H.; Dingeldein, E. Flavanone derivatives. US Patent 4,937,257, June 26, 1990.
  • Stemberger A., Unkauf M., Arnold D.E., Blümel G. C.G. Gebelein, T. Cheng, V.C. YangDrug Carrier Systems Based on Resorbable Polyester Collagen and/or Biomaterial Combinations. Cosmetic and Pharmaceutical Applications of Polymers, . Plenum Press, New York 1990; 263–268
  • Stephens D., Li L., Robinson D., Chen S., Chang H.-C., Liu R.M., Tian Y., Ginsburg E.J., Gao X., Stultz T. Investigation of the In Vitro Release of Gentamicin from a Polyanhydride Matrix. J. Control. Release 2000; 63: 305–317
  • Lee K.B., Kang S.B., Kwon I.C., Kim Y.H., Choi K., Jeong S.Y. Controlled Release and In Vitro Antimicrobial Activity of Gentamicin from the Poly-Alpha-Hydroxy Acid Films. Proc. Int. Symp. Control. Release Bioact. Mater. 1997; 24: 571–572
  • Sampath S.S., Garvin K., Robinson D.H. Preparation and Characterization of Biodegradable Poly(l-Lactic Acid) Gentamicin Delivery Systems. Int. J. Pharm. 1992; 78: 165–174
  • Schmidt C., Wenz R., Nies B., Moll F. Antibiotic In Vivo/In Vitro Release, Histocompatibility and Biodegradation of Gentamicin Implants Based on Lactic Acid Polymers and Copolymers. J. Control. Release 1995; 37: 83–94
  • Webber W.L., Lago F., Thanos C., Mathiowitz E. Characterization of Soluble Salt-Loaded, Degradable PLGA Films and Their Release of Tetracycline. J. Biomed. Mater. Res. 1998; 41: 18–29
  • Mauduit J., Bukh N., Vert M. Gentamycin/Poly(Lactic Acid) Blends Aimed at Sustained Release Local Antibiotic Therapy Administered Per-operatively. I. The Case of Gentamycin Base and Gentamycin Sulfate in Poly(dl-Lactic Acid) Oligomers. J. Control. Release 1993; 23: 209–220
  • Mauduit J., Bukh N., Vert M. Gentamycin/Poly(Lactic Acid) Blends Aimed at Sustained Release Local Antibiotic Therapy Administered Per-operatively. II. The Case of Gentamycin Sulfate in High Molecular Weight Poly(dl-Lactic Acid) and Poly(l-Lactic Acid). J. Control. Release 1993; 23: 221–230
  • , Fleckenstein, P.; Wahlig, H.; Dingeldein, E. Wirkstoff-Depot. Offenlegungsschrift DE3429038, January 2, 1986.
  • Ipsen T., Jørgensen P.S., Damholt V., Tørholm C. Gentamicin–Collagen Sponge for Local Applications. Acta Orthop. Scand. 1991; 62: 592–594
  • Wachol-Drewek Z., Pfeiffer M., Scholl E. Comparative Investigation of Drug Delivery of Collagen Implants Saturated in Antibiotic Solutions and a Sponge Containing Gentamicin. Biomaterials 1966; 17: 1733–1738
  • Sampath S.S., Robinson D.H. Comparison of New and Existing Spectrophotometric Methods for the Analysis of Tobramycin and Other Aminoglycosides. J. Pharm. Sci. 1990; 79: 428–431
  • Boss J.H. D.L. WiseBiocompatibility: Review of the Concept and Its Relevance to Clinical Practice. Biomaterials and Bioengineering Handbook, . Marcel Dekker Inc., New York 2000; 1–94
  • Alex R., Bodmeier R. Encapsulation of Water-Soluble Drugs by a Modified Solvent Evaporation Method. I. Effect of Process and Formulation Variables on Drug Entrapment. J. Microencapsul. 1990; 7: 347–355
  • Cheng Y.-H., Illum L., Davis S.S. A Poly(d,l-Lactide-co-glycolide) Microsphere Depot System for Delivery of Haloperidol. J. Control. Release 1998; 55: 203–212
  • Cruaud O., Benita S., Benoit J.P. The Characterization and Release Kinetics Evaluation of Baclofen Microspheres Designed for Intrathecal Injection. Int. J. Pharm. 1999; 177: 247–257
  • Rosenkrantz B.E., Greco J.R., Hoogerheide J.G., Oden E.M. K. FloreyGentamicin. Analytical Profiles of Drug Substances, . Academic Press, Orlando 1980; Vol. 9: 295–340
  • Asano A., Fukuzaki H., Yoshida M., Kumakura M., Mashimo T., Yuasa H., Imai K., Yamanaka H. In Vivo Characteristics of Low Molecular Weight Copoly(d,l-Lactic Acid) Formulations with Controlled Release of LH–RH. Biomaterials 1989; 10: 569–573
  • Lewis D.H. M. Chasin, R. LangerControlled Release of Bioactive Agents from Lactide/Glycolide Polymers. Biodegradable Polymers as Drug Delivery Systems, . Marcel Dekker Inc., New York 1990; 1–41
  • Calvör A. Herstellung bioabbaubarer Mikropartikel mittels Hochdruckhomogenisation. University of Kiel, Germany
  • Ogawa Y., Yamamoto M., Okada H., Yashiki T., Shimamoto T. A New Technique to Efficiently Entrap Leuprolide Acetate Into Microcapsules of Polylactic Acid or Copoly(Lactic/Glycolic) Acid. Chem. Pharm. Bull. 1988; 36: 1095–1103
  • Jeffery H., Davis S.S., O'Hagan D.T. The Preparation and Characterization of Poly(Lactide-co-glycolide) Microparticles. II. The Entrapment of a Model Protein Using a (Water-in-Oil)-in-Water Emulsion Solvent Evaporation Technique. Pharm. Res. 1993; 10: 362–368
  • Cleland J.L., Lim A., Barrón L., Duenas E.T., Powell M.F. Development of a Single-Shot Subunit Vaccine for HIV-1: Part 4. Optimizing Microencapsulation and Pulsatile Release of MN rgp 120 from Biodegradable Microspheres. J. Control. Release 1997; 47: 135–150
  • Ciftci K., Kas H.S., Hincal A.A., Ercan T.M., Güven O., Ruacan S. In Vitro and In Vivo Evaluation of PLAGA (50/50) Microspheres Containing 5-Fluorouracil Prepared by a Solvent Evaporation Method. Int. J. Pharm. 1996; 131: 73–82
  • Bodmeier R., McGinity J.W. Polylactic Acid Microspheres Containing Quinidine Base and Quinidine Sulphate Prepared by the Solvent Evaporation. J. Microencapsul. 1988; 5: 325–330
  • Fukuzaki H., Yoshida M., Asano M., Kumakura M., Mashimo T., Yuasa H., Imai K., Yamanaka H. In Vivo Characteristics of High Molecular Weight Copoly(l-Lactide/Glycolide) with S-Type Degradation Pattern for Application in Drug Delivery Systems. Biomaterials 1991; 12: 433–437
  • Göpferich A., Alonso M.J., Langer R. Development and Characterization of Microencapsulated Microspheres. Pharm. Res. 1994; 11: 1568–1574
  • Pekarek K.J., Dyrud M.J., Ferrer K., Jong Y.S., Mathiowitz E. In Vitro and In Vivo Degradation of Double-Walled Polymer Microspheres. J. Control. Release 1996; 40: 169–178
  • Cohn D., Younes H. Compositional and Structural Analysis of PELA Biodegradable Block Copolymers Degrading Under In Vitro Conditions. Biomaterials 1989; 10: 466–474
  • Kissel T., Brich Z., Bantle S., Lancranjan I., Nimmerfall F., Vit P. Parenteral Depot-Systems on the Basis of Biodegradable Polyesters. J. Control. Release 1991; 16: 27–42
  • Mauduit J., Pérouse E., Vert M. Hydrolytic Degradation of Films Prepared from Blends of High and Low Molecular Weight Poly(dl-Lactic Acid)s. J. Biomed. Mater. Res. 1996; 30: 201–207
  • Pettit D.K., Lawter J.R., Huang W.J., Pankey S.C., Nightlinger N.S., Lynch D.H., Schuh J.A.C.L., Morrissey P.J., Gombotz W.R. Characterization of Poly(Glycolide-co-d,l-lactide)/Poly (d,l-Lactide) Microspheres for Controlled Release of GM–CSF. Pharm. Res. 1997; 14: 1422–1430
  • Ravivarapu H.B., Burton K., DeLuca P.P. Polymer and Microsphere Blending to Alter the Release of a Peptide from PLGA Microspheres. Eur. J. Pharm. Biopharm. 2000; 50: 263–270
  • Bodmeier R., Chen H.G. Evaluation of Biodegradable Poly(Lactide) Pellets Prepared by Direct Compression. J. Pharm. Sci. 1989; 10: 819–822
  • Herrlinger M. In vitro Polymerabbau und Wirkstofffreigabe von Poly-dl-Laktid-Formlingen. University of Heidelberg, Germany
  • Park T.G., Lu W., Crotts G. Importance of In Vitro Experimental Conditions on Protein Release Kinetics, Stability and Polymer Degradation in Protein Encapsulated Poly(d,l-Lactic Acid-co-glycolic acid) Microspheres. J. Control. Release 1995; 33: 211–222
  • Blanco-Prieto M.J., Besseghir K., Orsolini P., Heimgartner F., Deuschel C., Merkle H.P., Nam-Tran H., Gander B. Importance of the Test Medium for the Release Kinetics of a Somatostatin Analogue from Poly(d,l-Lactide-co-Glycolide) Microspheres. Int. J. Pharm. 1999; 184: 243–250
  • Takano M., Ohishi Y., Okuda M., Yasuhara M., Hori R. Transport of Gentamicin and Fluid-Phase Endocytosis Markers in the LLC-PK1 Kidney Epithelial Cell Line. J. Pharmacol. Exp. Ther. 1994; 268: 669–674
  • Laurent G., Carlier M.B., Rollman B., van Hoof F., Tulkens P. Mechanism of Aminoglycoside-Induced Lysosomal Phospholipidosis: In Vitro and In Vivo Studies with Gentamicin and Amikacin. Biochem. Pharmacol. 1982; 31: 3861–3870
  • Bodmer D., Kissel T., Traechslin E. Factors Influencing the Release of Peptides and Proteins from Biodegradable Depot Systems. J. Control. Release 1992; 21: 129–138
  • 5.4 Residual Solvents. 3rd Ed., Council of Europe, Strasbourg, France 1999; 295–302, Suppl. 2000
  • Falk R.F., Randolph T.W. Process Variable Implications for Residual Solvent Removal and Polymer Morphology in the Formation of Gentamycin Loaded Poly(l-Lactide) Microparticles. Pharm. Res. 1998; 15: 1233–1237
  • Bitz C., Doelker E. Influence of the Preparation Method on Residual Solvents in Biodegradable Microspheres. Int. J. Pharm. 1996; 131: 171–181
  • Giunchedi P., Alpar H.O., Conte U. PDLLA Microspheres Containing Steroids: Spray-Drying, o/w and w/o/w Emulsifications as Preparation Methods. J. Microencapsul. 1998; 15: 185–195
  • Wang J., Schwendeman S.P. Mechanisms of Solvent Evaporation Encapsulation Processes: Predicting Solvent Evaporation Rate. Proc. Int. Symp. Control. Release Bioact. Mater. 1998; 25: 246–247
  • Lill N., Sandow J. Two Poly(d,l-Lactide-co-glycolide) 50:50 Types: Same Polymer but Different Properties?. Proc. Int. Symp. Control. Release Bioact. Mater. 1996; 23: 329–330
  • Friess W., Schlapp M. Release Mechanisms from Gentamicin Loaded Microparticles. J. Pharm. Sci. 2002; 91: 845–855
  • Tracy M.A., Firouzabadian L., Zhang Y. Effects of PLGA End Groups on Degradation. Proc. Int. Symp. Control. Release Bioact. Mater. 1995; 22: 786–787
  • Kissel T., Koneberg R., Hilbert A.K., Hungerer K.-D. Microencapsulation of Antigens Using Biodegradable Polyesters: Facts and Phantasies. Behring Inst. Mitt. 1997; 98: 172–183
  • Pitt C.G., Gratzl M.M., Kimmel G.L., Surles J., Schindler A. Aliphatic Polyesters II. The Degradation of Poly(dl-Lactide), Poly(Epsilon-Caprolactone), and Their Copolymers In Vivo. Biomaterials 1981; 2: 215–220
  • Tsuji H., Ikada Y. Blends of Crystalline and Amorphous Polylactide. III. Hydrolysis of Solution-Cast Blend Films. J. Appl. Polym. Sci. 1997; 63: 855–863
  • Li S.M., Garreau H., Vert M. Structure–Property Relationships in the Case of the Degradation of Massive Poly(α-Hydroxy Acids) in Aqueous Media. II. Degradation of Lactide-Glycolide Copolymers: PLA37.5GA25 and PLA75GA25. J. Mater. Sci. Mat. Med. 1990; 1: 131–139
  • Kenley R.A., Lee M.O., Mahoney T.R., Sanders L.M. Poly(Lactide-co-glycolide) Decomposition Kinetics In Vivo and In Vitro. Macromolecules 1987; 20: 2398–2403
  • Göpferich A. Erosion-Controlled Drug Release. University of Erlangen, Germany

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