165
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Potential Application of Silicified Microcrystalline Cellulose in Direct-Fill Formulations for Automatic Capsule-Filling Machines

RESEARCH ARTICLE

&
Pages 47-59 | Received 25 Feb 2002, Accepted 11 May 2002, Published online: 20 Feb 2003

REFERENCES

  • , FMC Product Brochure (Microcrystalline Cellulose).
  • Sherwood B.E., Beck J.W. A new class of high-functionality excipients: silicified microcrystalline cellulose. Pharm. Technol. 1998; 22: 78–88
  • Guo M., Muller F.X., Augsburger L.L. Evaluation of the plug formation process of silicified microcrystalline cellulose. Int. J. Pharm. 2002; 233: 99–109
  • Etman M.A., Naggar V.F. Thermodynamics of paracetamol solubility in sugar-water cosolvent system. Int. J. Pharm. 1990; 58: 177–184
  • Swanepoel E., Liebenberg W., Villiers M.D., Dekker T.G. Dissolution properties of piroxicam powders and capsules as a function of particle size and the agglomeration of powders. Drug Dev. Ind. Pharm. 2000; 26(10)1067–1076
  • Hong-Guang W., Ru-Hua Z. Compaction behavior of paracetamol powders of different crystal shapes. Drug Dev. Ind. Pharm. 1995; 21(7)863–868
  • Small E., Augsburger L.L. Instrumentation of an automatic capsule-filling machine. J. Pharm. Sci. 1977; 66(4)504–509
  • Shah K.B., Augsburger L.L., Marshall K. An investigation of some factors influencing plug formation and fill weight in a dosing disk-type automatic capsule-filling machine. J. Pharm. Sci. 1986; 175(3)291–296
  • Jolliffe I.G., Newton J.M., Walters J.K. Theoretical considerations of the filling of pharmaceutical hard gelatin capsules. Powder Tech. 1980; 27: 189–195
  • Heda P.K. A comparative study of the formulation requirements of dosator and dosing disc encapsulators, simulation of plug formation and creation of rules for an expert system for formulation design. University of Maryland
  • Mehta A.M., Augsburger L.L. A preliminary study of the effect of slug hardness on drug dissolution from hard gelatin capsules filled on an automatic capsule-filling machine. Int. J. Pharm. 1981; 7: 327–334
  • Small L.E., Augsburger L.L. Aspects of the lubrication requirements for an automatic capsule filling machine. Drug Dev. Ind. Pharm. 1978; 4(4)345–372
  • Tattawasart A., Armstrong N.A. The formation of lactose plugs for hard shell capsule fills. Pharm. Dev. Tech. 1997; 2(4)335–343
  • , Penwest Product Brochure.
  • Shah K.B., Augsburger L.L., Marshall K.P. An investigation of some factors influencing plug formation and fill weight in a dosing disk-type automatic capsule-filling machine. J. Pharm. Sci. 1986; 75(3)291–296
  • Tan S.B., Newton J.M. Influence of compression setting ratio on capsule fill weight and weight variability. Int. J. Pharm. 1990; 66: 273–281
  • Patel R., Podczeck F. Investigation of the effect of type and source of microcrystalline cellulose on capsule filling. Int. J. Pharm. 1996; 128: 123–127
  • Buckton G., Yonemochi D., Yoon W.L., Moffat A.C. Water sorption and near IR spectroscopy to study the differences between microcrystalline cellulose and silicified microcrystalline cellulose before and after wet granulation. Int. J. Pharm. 1999; 181: 41–47
  • Tobyn M.J., McCarthy G.P., Staniforth J.N., Edge S. Physicochemical comparison between microcrystalline cellulose and silicified microcrystalline cellulose. Int. J. Pharm. 1998; 169: 183–194
  • Nakagwu H. Effects of particle size of rifampicin and addition of magnesium stearate in release of rifampicin from hard gelatin capsules. Yakugaku Zasshi 1980; 100: 1111–1117

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.