1,123
Views
26
CrossRef citations to date
0
Altmetric
Research Article

Identifying the Stable Polymorph Early in the Drug Discovery–Development Process

, , , &
Pages 291-297 | Received 20 Sep 2004, Accepted 13 Dec 2004, Published online: 07 Oct 2008

References

  • Bernstein, J. Polymorphism in Molecular Crystals; Oxford University Press: Oxford, 2002.
  • Threlfall, T.L. Analysis of organic polymorphs. A review.Analyst 1995, 120, 2435–2460.
  • Grant, D.J.W. Brittain, H.GTheory and origin of polymorphism. In Polymorphism in Pharmaceutical Solids; ., Ed.; Marcel Dekker: New York, 1999; 1–33.
  • Chemburkar, S.R.; Bauer, J.; Deming, K.; Spiwek, H.; Patel, K.; Morris, J.; Henry, R.; Spanton, S.; Dziki, W.; Porter, W.; Quick, J.; Bauer, P.; Donaubauer, J.; Narayanan, B.A.; Soldani, M.; Riley, D.; McFarland, K. Dealing with the impact of ritonavir polymorphs on the late stages of bulk drug process development.Org. Process Res. Dev. 2000, 4, 413–417., [CROSSREF]
  • Guillory, J.K. Brittain, H.GGeneration of polymorphs, hydrates, solvates, and amorphous solids. In Polymorphism in Pharmaceutical Solids; ., Ed.; Marcel Dekker: New York, 1999; 183–226.
  • Mullin, J.W. Crystallization, 3rd Ed.; Butterworth-Heineman: Oxford, 1993.
  • Ostwald, W. Studien Uber Die Bildung und Umwandlung Fester Korper.Z. Physik. Chem. 1897, 22, 289–302.
  • Rodriguez-Hornedo, N.; Murphy, D. Significance of controlling crystallization mechanisms and kinetics in pharmaceutical systems.J. Pharm. Sci. 1999, 88, 651–660., [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Gu, C.; Young, V., Jr.; Grant, D.J.W. Polymorph screening: influence of solvents on the rate of solvent-mediated polymorphic transformation.J. Pharm. Sci. 2001, 90, 1878–1890., [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Morissette, S.L.; Soukasene, S.; Levinson, D.; Cima, M.J.; Almarsson, O. Elucidation of crystal form diversity of the HIV protease inhibitor ritonavir by high-throughput crystallization.Proc. Natl. Acad. Sci. 2003, 100, 2180–2184., [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Bauer, J.; Spanton, S.; Henry, R.; Quick, J.; Dziki, W.; Porter, W.; Morris, J. Ritonavir: an extraordinary example of conformational polymorphism.Pharm. Res. 2001, 18, 859–866., [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Gu, C.; Chatterjee, K.; Young, V., Jr.; Grant, D.J.W. Stabilization of a metastable polymorph of sulfamerazine by structurally related additives.J. Cryst. Growth 2002, 235, 471–481., [CROSSREF]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.