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Original

METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISMS IN PREECLAMPSIA AND THE HELLP SYNDROME

, M.D., , M.D., Ph.D., , Ph.D., , Ph.D., , B.Sc., , M.D., Ph.D. & show all
Pages 299-307 | Published online: 03 Aug 2009

REFERENCES

  • Cooper D W, Brennecke S P, Wilton A N. Genetics of preeclampsia. Hypertens Pregn 1993; 12: 1–23
  • Higgins J R, Brennecke S P. Preeclampsia—still a disease of theories?. Curr Opin Obstet Gynecol 1998; 10: 129–33
  • Dekker G A, Sibai B M. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 1998; 179: 1359–75
  • Roberts J M, Redman C W. Pre-eclampsia: more than pregnancy induced hypertension. Lancet 1993; 341: 1447–51
  • Refsum H, Ueland P M, Nygård O, Vollset S E. Homocysteine and cardiovascular disease. Annu Rev Med 1998; 49: 31–62
  • Goddijn-Wessel T AW, Wouters M, Molen van der E F, Spuijbroek M DEH, Steegers-Theunissen R PM, Blom H J. Hyperhomocysteinemia: a risk factor for placental abruption or infarction. Eur J Obstet Gynecol Reprod Biol 1996; 66: 23–9
  • Wouters M GAJ, Boers G HJ, Blom H J, Trijbels F JM, Thomas C MG, Borm G F. Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil Steril 1993; 60: 820–5
  • Steegers-Theunissen R PM, Boers G HJ, Trijbels J MF, Finkelstein J D, Blom H J, Thomas C MG. Maternal hyperhomocysteinemia: a risk factor for neural-tube defects?. Metabolism 1994; 43: 1475–80
  • Dekker G A, De Vries J I, Doelitzsch PM, Huijens P C, Von Blomberg B M, Jakobs C. Underlying disorders associated with severe early-onset preeclampsia. Am J Obstet Gynecol 1995; 173: 1042–8
  • Powers R W, Evans R W, Majors A K, Ojimba J I, Ness R B, Crombleholme W R. Plasma homocysteine concentration is increased in preeclampsia and is associated with evidence of endothelial activation. Am J Obstet Gynecol 1998; 179: 1605–11
  • Frosst P, Blom H J, Milos R, Goyette P, Sheppard C A, Matthews R G. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111–3
  • Kluijtmans L AJ, Kastelein J JP, Lindemans J, Boers G HJ, Heil S G, Bruschke A VG. Thermolabile methylenetetrahydrofolate reductase in coronary artery disease. Circulation 1997; 96: 2573–7
  • Van der Put N MJ, Gabreëls F, Stevens E MB, Smeitink J AM, Trijbels F JM, Eskes T KAB. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. Am J Hum Genet 1998; 62: 1044–51
  • Grandone E, Margaglione M, Colaizzo D, Cappucci G, Paladini D, Martinell P. Factor V Leiden, C > T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thromb Haemost 1997; 77: 1052–4
  • Sohda S, Arinami T, Hamada H, Yamada N, Hamaguchi H, Kubo T. Methylenetetrahydrofolate reductase polymorphism and preeclampsia. J Med Genet 1997; 34: 525–6
  • Kupferminc M J, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 1999; 340: 9–13
  • Powers R W, Minich L A, Lykins D L, Ness R B, Crombleholme W R, Roberts J M. Methylenetetrahydrofolate reductase polymorphism, folate, and susceptibility to preeclampsia. J Soc Gynecol Invest 1999; 6: 74–9
  • Visser W, Wallenburg H CS. Temporising management of severe preeclampsia with and without the HELLP syndrome. Br J Obstet Gynaecol 1995; 102: 111–7
  • Malinow M R. Hyperhomocyste(i)nemia: a common and easily reversible risk factor for occlusive atherosclerose. Circulation 1990; 81: 2004–6
  • Rajkovic A, Catalano P M, Malinow W HR. Elevated homocyst(e)ine levels with preeclampsia. Obstet Gynecol 1997; 90: 168–71
  • Van der Put N M, Eskes T AB, Blom H J. Is the common 677 C → T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects?. Quart J Med 1997; 90: 111–5
  • Nelen W LDM, Steegers E AP, Eskes T KAB, Blom H J. Genetic risk factor for unexplained recurrent early pregnancy loss. Lancet 1997; 350: 861
  • Jaques P F, Bostom A G, Williams R R, Curtis Ellison R, Eckfeldt J H, Rosenberg I H. Relation between folate status, a common polymorphism in methylene-tetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996; 93: 7–9
  • Guttormsen A B, Ueland P M, Nesthus I, Nygard O, Scheede J, Vollset S E. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥ 40 μmol/l). The Hordaland Homocysteine Study. J Clin Invest 1996; 98: 2174–83
  • Blom H J. Mutated 5,10-methylenetetrahydrofolate reductase and moderate hyperhomocysteinaemia. Eur J Pediatr 1998; 157((Suppl. 2))S131–4
  • Nelen W LDM, Blom H J, Thomas C MG, Steegers E AP, Boers G HJ, Eskes T KAB. Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages. J Nutr 1998; 128: 1336–41

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