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Hypertension in Pregnancy Volume 21, 2002 - Issue 1
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THE LEVELS OF CIRCULATORY FETAL DNA IN MATERNAL PLASMA ARE ELEVATED PRIOR TO THE ONSET OF PREECLAMPSIA

Xiao Yan Zhong Department of Obstetrics and Gynaecology, University of Basel, Schanzenstrasse 46, Basel, CH-4031, Switzerland
,
Wolfgang Holzgreve Department of Obstetrics and Gynaecology, University of Basel, Schanzenstrasse 46, Basel, CH-4031, Switzerland
&
Sinuhe Hahn Department of Obstetrics and Gynaecology, University of Basel, Schanzenstrasse 46, Basel, CH-4031, Switzerland
Pages 77-83 | Published online: 07 Jul 2009

REFERENCES

  • Roberts J. M., Redman C. W. Pre-eclampsia: More than Pregnancy-Induced Hypertension. Lancet 1993; 341(8858)1447–1451
  • Roberts J. M., Cooper D. W. Pathogenesis and Genetics of Pre-eclampsia. Lancet 2001; 357(9249)53–56
  • Holzgreve W., Ghezzi F., Di Naro E., Ganshirt D., Maymon E., Hahn S. Disturbed Feto-Maternal Cell Traffic in Preeclampsia. Obstet. Gynecol. 1998; 91(5 Pt. 1)669–672
  • Ganshirt D., Smeets F. W., Dohr A., Walde C., Steen I., Lapucci C., Falcinelli C., Sant R., Velasco M., Garritsen H. S., Holzgreve W. Enrichment of Fetal Nucleated Red Blood Cells from the Maternal Circulation for Prenatal Diagnosis: Experiences with Triple Density Gradient and MACS Based on More than 600 Cases. Fetal Diagn. Ther. 1998; 13(5)276–286
  • Lo Y. M., Leung T. N., Tein M. S., Sargent I. L., Zhang J., Lau T. K., Haines C. J., Redman C. W. Quantitative Abnormalities of Fetal DNA in Maternal Serum in Preeclampsia. Clin. Chem. 1999; 45(2)184–188
  • Zhong X. Y., Laivuori H., Livingston J. C., Ylikorkala O., Sibai B. M., Holzgreve W., Hahn S. Elevation of Both Maternal and Fetal Extracellular Circulating Deoxyribonucleic Acid Concentrations in the Plasma of Pregnant Women with Preeclampsia. Am. J. Obstet. Gynecol. 2001; 184(3)414–419
  • Knight M., Redman C. W., Linton E. A., Sargent I. L. Shedding of Syncytiotrophoblast Microvilli into the Maternal Circulation in Pre-eclamptic Pregnancies. Br. J. Obstet. Gynaecol. 1998; 105(6)632–640
  • Brosens I. A., Robertson W. B., Dixon H. G. The Role of the Spinal Arteries in the Pathogenesis of Pre-eclampsia. J. Pathol. 1970; 101(4)vi
  • Redman C. W. Cytotrophoblasts: Masters of Disguise. Nat. Med. 1997; 3(6)610–611
  • Holzgreve W., Hahn S. Novel Molecular Biological Approaches for the Diagnosis of Preeclampsia. Clin. Chem. 1999; 45(4)451–452
  •  
  •  
  •  
  •  
  •  
  •  
  •  
  •  
  •  
  •  
  • Zhong X. Y., Holzgreve W., Hahn S. Risk Free Simultaneous Prenatal Identification of Fetal Rhesus D Status and Sex by Multiplex Real-Time PCR Using Cell Free Fetal DNA in Maternal Plasma. Swiss Med. Wkly. 2001; 131(5–6)70–74
  • Zhong X. Y., Holzgreve W., Li J. C., Aydinli K., Hahn S. High Levels of Fetal Erythroblasts and Fetal Extracellular DNA in the Peripheral Blood of a Pregnant Woman with Idiopathic Polyhydramnios: Case Report. Prenatal Diagn. 2000; 20(10)838–841
  • Zhong X. Y., Burk M. R., Troeger C., Jackson L. R., Holzgreve W., Hahn S. Fetal DNA in Maternal Plasma is Elevated in Pregnancies with Aneuploid Fetuses. Prenatal Diagn. 2000; 20(10)795–798
  • Stroun M., Maurice P., Vasioukhin V., Lyautey J., Lederrey C., Lefort F., Rossier A., Chen X. Q., Anker P. The Origin and Mechanism of Circulating DNA. Ann. N. Y. Acad. Sci. 2000; 906: 161–168
  • Bret L., Lule J., Alary C., Appolinaire-Pilipenko S., Pourrat J. P., Fournie G. J. Quantitation of Blood Plasma DNA as an Index of In Vivo Cytotoxicity. Toxicology 1990; 61(3)283–292
  • Giacona M. B., Ruben G. C., Iczkowski K. A., Roos T. B., Porter D. M., Sorenson G. D. Cell-Free DNA in Human Blood Plasma: Length Measurements in Patients with Pancreatic Cancer and Healthy Controls. Pancreas 1998; 17(1)89–97
  • DiFederico E., Genbacev O., Fisher S. J. Preeclampsia is Associated with Widespread Apoptosis of Placental Cytotrophoblasts Within the Uterine Wall. Am. J. Pathol. 1999; 155(1)293–301
  • Cockell A. P., Learmont J. G., Smarason A. K., Redman C. W., Sargent I. L., Poston L. Human Placental Syncytiotrophoblast Microvillous Membranes Impair Maternal Vascular Endothelial Function. Br. J. Obstet. Gynaecol. 1997; 104(2)235–240
  • Redman C. W., Sacks G. P., Sargent I. L. Preeclampsia: An Excessive Maternal Inflammatory Response to Pregnancy. Am. J. Obstet. Gynecol. 1999; 180(2 Pt. 1)499–506
  • Roberts J. M., Taylor R. N., Goldfien A. Clinical and Biochemical Evidence of Endothelial Cell Dysfunction in the Pregnancy Syndrome Preeclampsia. Am. J. Hypertens. 1991; 4(8)700–708

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