134
Views
9
CrossRef citations to date
0
Altmetric
Research Article

THE α1b-ADRENERGIC RECEPTOR SUBTYPE: MOLECULAR PROPERTIES AND PHYSIOLOGICAL IMPLICATIONS

, , , , &
Pages 1-16 | Published online: 11 Nov 2002

REFERENCES

  • Wess J. G. Protein-Coupled Receptors: Molecular Mechanisms Involved in Receptor Activation and Selectivity of G Protein Recognition. FASEB J. 1997; 11: 346–354
  • Schwinn D. A., Johnston G. I., Page S. O., Mosley M. J., Wilson K. H., Worman N. P., Campbell S., Fidock M. D., Furness L. M., Parry-Smith D. J., Beate P., Bailey D. S. Cloning and Pharmacological Characterization of Human Alpha-1 Adrenergic Receptors: Sequence Corrections and Direct Comparison with Other Species Homologues. J. Pharmacol. Exp. Ther. 1995; 272: 134–142
  • Graham R. M., Perez D. M., Hwa J., Piascik M. T. Alpha1-Adrenergic Receptor Subtypes: Molecular Structure, Function and Signaling. Circ. Res. 1996; 78: 737–749
  • Chen S., Lin F., Iismaa S., Lee K. N., Birckbichler P. J., Graham R. M. Alpha1-Adrenergic Receptor Signaling via Gh is Subtype Specific and Independent of Its Transglutaminase Activity. J. Biol. Chem. 1996; 271: 32385–32391
  • Cotecchia S., Schwinn D. A., Randall R. R., Lefkowitz R. J., Caron M. G., Kobilka B. K. Molecular Cloning and Expression of the cDNA for the Hamster Alpha1B-Adrenergic Receptor. Proc. Natl. Acad. Sci. USA 1988; 85: 7159–7163
  • Sawutz D. G., Lanier S. M., Warren C. D., Graham R. M. Glycosylation of the Mammalian Alpha1B-Adrenergic Receptor by Complex-Type N-Linked Oligosaccharides. Mol. Pharmacol. 1987; 32: 565–571
  • Stevens P. A., Pediani J., Carrillo J. J., Milligan G. Coordinated Agonist Regulation of Receptor and G Protein Palmitoylation and Functional Rescue of Palmitoylation. J. Biol. Chem. 2001; 276: 35883–35890
  • Diviani D., Lattion A. L., Cotecchia S. Characterization of the Phosphorylation Sites Involved in G Protein-Coupled Receptor Kinase- and Protein Kinase C-Mediated Desensitization of the Alpha1B-Adrenergic Receptor. J. Biol. Chem. 1997; 272: 28712–28719
  • Cavalli A., Fanelli F., Taddei C., De Benedetti P. G., Cotecchia S. Amino Acids of the Alpha1B-Adrenergic Receptor Involved in Agonist Binding: Differences in Docking Catecholamines to Receptor Subtypes. FEBS Lett. 1996; 399: 9–13
  • Chen S., Xu M., Lin F., Lee D., Riek P., Graham R. M. Phe310 in Transmembrane VI of the α1B-Adrenergic Receptor is a Key Switch Residue Involved in Activation and Catecholamine Ring Aromatic Bonding. J. Biol. Chem. 1999; 274: 16320–16330
  • Hwa J., Graham R. M., Perez D. M. Identification of Critical Determinants of Alpha1-Adrenergic Receptor Subtype Selective Agonist Binding. J. Biol. Chem. 1995; 270: 23189–23195
  • Zhao M. M., Hwa J., Perez D. M. Identification of Critical Extracellular Loop Residues Involved in Alpha 1-Adrenergic Receptor Subtype-Selective Antagonist Binding. Mol. Pharmacol. 1996; 50: 1118–1126
  • De Benedetti P. G., Fanelli F., Menziani M. C., Cocchi M., Testa R., Leonardi A. Alpha1-Adrenoceptor Subtype Selectivity: Molecular Modelling and Theoretical Quantitative Structure-Affinity Relationships. Bioorg. Med. Chem. 1997; 5: 809–816
  • Fanelli F., Menziani C., Scheer A., Cotecchia S., De Benedetti P. G. Ab initio Modeling and Molecular Dynamics Simulation of the Alpha1b-Adrenergic Receptor Activation. Methods 1998; 14: 302–317
  • Baldwin J. M., Schertler G. F., Unger V. M. An Alpha-Carbon Template for the Transmembrane Helices in the Rhodopsin Family of G Protein-Coupled Receptors. J. Mol. Biol. 1997; 272: 144–164
  • Unger V. M., Hargrave P. A., Baldwin J. M., Schertler G. F. Arrangement of Rhodopsin Transmembrane Alpha-Helices. Nature 1997; 389: 203–206
  • Scheer A., Fanelli F., Costa T., De Benedetti P. G., Cotecchia S. Constitutively Active Mutants of the α1b-Adrenergic Receptor: Role of Highly Conserved Polar Amino Acids in Receptor Activation. Embo J. 1996; 15: 3566–3578
  • Greasley P. J., Fanelli F., Scheer A., Abuin L., Nenniger-Tosato M., De Benedetti P. G., Cotecchia S. Mutational and Computational Analysis of the α1b-Adrenergic Receptor: Involvement of Basic and Hydrophobic Residues in Receptor Activation and G Protein Coupling. J. Biol. Chem. 2001; 276: 46485–46494
  • Palczewski K., Kumasaka T., Hori T., Behnke C. A., Motoshima H., Fox B. A., LeTrong I., Teller D. C., Okada T., Stenkamp R. E., Yamamoto M., Miyano M. Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor (see comments). Science 2000; 289: 739–745
  • Fanelli F., Menziani C., Scheer A., Cotecchia S., De Benedetti P. G. Theoretical Study on the Electrostatically Driven Step of Receptor–G Protein Recognition. Proteins: Structure. Function and Genetics 1999; 37: 145–156
  • Gether U. Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors. Endocr. Rev. 2000; 21: 90–113
  • Kjelsberg M. A., Cotecchia S., Ostrowski J., Caron M. G., Lefkowitz R. J. Constitutive Activation of the α1B-Adrenergic Receptor by All Amino Acid Substitutions at a Single Site. J. Biol. Chem. 1992; 267: 1430–1433
  • Scheer A., Costa T., Fanelli F., De Benedetti P. G., Mhaouty-Kodja S., Abuin L., Nenniger-Tosato M., Cotecchia S. Mutational Analysis of the Highly Conserved Arginine Within the Glu/Asp-Arg-Tyr Motif of the Alpha(lb)-Adrenergic Receptor: Effects on Receptor Isomerization and Activation. Mol. Pharmacol. 2000; 57: 219–231
  • Cotecchia S., Ostrowski J., Kjelsberg M. A., Caron M. G., Lefkowitz R. J. Discrete Amino Acid Sequences of the α1-Adrenergic Receptor Determine the Selectivity of Coupling to Phosphatidylinositol Hydrolysis. J. Biol. Chem. 1992; 267: 1633–1639
  • Cavalli A., Lattion A. L., Hummler E., Nenniger M., Pedrazzini T., Aubert J. F., Michel M., Yang M., Lembo G., Vecchione C., Mostardini M., Schmidt A., Beermann F., Cotecchia S. Decreased Blood Pressure Response in Mice Deficient of the α1b-Adrenergic Receptor. Proc. Natl. Acad. Sci. USA 1997; 94: 11589–11594
  • Milano C. A., Dolber P. C., Rockman H. A., Bond R., Venable M. E., Allen L. F., Lefkowitz R. J. Myocardial Expression of a Constitutively Active α1B-Adrenergic Receptor in Transgenic Mice Induces Cardiac Hypertrophy. Proc. Natl. Acad. Sci. USA. 1994; 91: 10109–10113
  • Zuscik M. J., Chalothorn D., Hellard D., Deighan C., McGee A., Daly C. J., Waugh D.J. J., Ross S. A., Gaivin R. J., Morehead A. J., Thomas J. D., Plow E. F., McGrath J. C., Piascik M. T., Perez D. M. Hypotension, Autonomic Failure, and Cardiac Hypertrophy in Transgenic Mice Overexpressing the α1B-Adrenergic Receptor. J. Biol. Chem. 2001; 276: 13738–13743
  • Spreng M., Cotecchia S., Schenck F. A Behavioral Study of the Alpha1b-Adrenergic Receptor Knock Out Mice: Increased Reaction to Novelty and Selectively Reduced Learning Capacities. Neurobiology of Learning and Memory 2001; 75: 214–229
  • Björklöf K., Lundström K., Abuin L., Greasley P., Cotecchia S. Co- and Posttranslational Modification of the Alpha1B-Adrenergic Receptor: Effects on Receptor Expression and Function. Biochemistry 2002; 41: 4281–4291
  • Drouin C., Darracq L., Trovero F., Blanc G., Glowinski J., Cotecchia S., Tassin J. -P. Alpha 1b-Adrenergic Receptors Control Locomotor and Rewarding Effects of Psychostimulants and Opiates. J. Neuroscience 2002; 22: 2873–2884

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.