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Research Article

Properties of Chimeric Prostacyclin/Prostaglandin D2 Receptors: Site‐Directed Mutagenesis Reveals the Significance of the Isoleucine Residue at Position 323

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Pages 83-97 | Published online: 28 Feb 2003

References

  • Coleman R. A., Smith W. L., Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution and structure of the receptors and their subtypes. Pharmacol Rev 1994; 46: 205–229
  • Kobayashi T., Ushikubi F., Narumiya S. Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. J Biol Chem 2000; 275: 24294–24303
  • Kobayashi T., Kiriyama M., Hirata T., Hirata M., Ushikubi F., Narumiya S. Identification of domains conferring ligand binding specificity to the prostanoid receptor. J Biol Chem 1997; 272: 15154–15160
  • Wise H. Characterization of chimeric prostacyclin/prostaglandin D2 receptors. Eur J Pharmacol 1999; 386: 89–96
  • Narumiya S., Sugimoto Y., Ushikubi F. Prostanoid receptors: structure, properties and functions. Physiol Rev 1999; 79: 1193–1226
  • Namba T., Oida H., Sugimoto Y., Kakizuka A., Negishi M., Ichikawa A., Narumiya S. cDNA cloning of a mouse prostacyclin receptor. J Biol Chem 1994; 269: 9986–9992
  • Kam Y. W., Chow K. B.S., Wise H. Factors affecting prostacyclin receptor agonist efficacy in different cell types. Cell Signal 2001; 13: 841–847
  • Chow K. B.S., Wong Y. H., Wise H. Prostacyclin receptor‐independent inhibition of phospholipase C activity by non‐prostanoid prostacyclin mimetics. Br J Pharmacol 2001; 134: 1375–1384
  • Barber R., Ray K. P., Butcher R. W. Turnover of adenosine 3″,5″‐monophosphate in WI‐38 cultured fibroblasts. Biochemistry 1980; 19: 2560–2567
  • Conklin B. R., Chabre O., Wong Y. H., Federman A. D., Bourne H. R. Recombinant Gqα. J Biol Chem 1992; 267: 31–34
  • Megson A. C., Dickenson J. M., Townsend‐Nicholson A., Hill S. J. Synergy between the inositol phosphate responses to transfected human adenosine A1‐receptors and constitutive P2‐purinoceptors in CHO‐K1 cells. Br J Pharmacol 1995; 115: 1415–1424
  • Wise H., Jones R. L. Focus on prostacyclin and its novel mimetics. Trends Pharmacol Sci 1996; 17: 17–21
  • Smith J. A.M., Amagasu S. M., Eglen R. M., Hunter J. C., Bley K. R. Characterization of prostanoid receptor‐evoked responses in rat sensory neurones. Br J Pharmacol 1998; 124: 513–523
  • Parkinson P. A., Parfenova H., Leffler C. W. Phospholipase C activation by prostacyclin receptor agonist in cerebral microvascular smooth muscle cells. Proc Soc Exp Biol Med 2000; 223: 53–58
  • Jones R. L., Qian Y. M., Wise H., Wong H. N.C., Chan H. W., Lam W. L., Ho J. K.S., Yim A. P.C. Relaxant actions of prostanoid and non‐prostanoid IP‐receptor agonists on the human pulmonary artery. Br J Pharmacol 1996; 119: 193P
  • Lawler O. A., Miggin S. M., Kinsella B. T. Protein kinase A‐mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to Gs‐, to Gi‐, and to Gq‐coupled effector signaling. J Biol Chem 2001; 276: 33596–33607
  • Wise H., Chow K. B.S. Multiple G‐protein coupling of chimeric prostacyclin/ prostaglandin D2 receptors. Advances in Prostaglandin and Leukotriene Research, B. Samuelsson, R. Paoletti, G. C. Folco, E. Granström, S. Nicosia. Kluwer Academic Publishers, The Netherlands 2001; 121–123
  • Smyth E. M., Hong Li W., Fitzgerald G. A. Phosphorylation of the prostacyclin receptor during homologous desensitization. J Biol Chem 1998; 273: 23358–23266
  • Hayes J. S., Lawler O. A., Walsh M. T., Kinsella B. T. The prostacyclin receptor is isoprenylated. J Biol Chem 1999; 274: 23707–23718
  • Blom N., Gammeltoft S., Brunak S. Sequence‐ and structure‐based prediction of eukaryotic protein phosphorylation sites. J Mol Biol 1999; 294: 1351–1362
  • Ushikubi F., Hirata M., Narumiya S. Molecular biology of prostanoid receptors; an overview. J Lipid Mediators Cell Signal 1995; 12: 343–359

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