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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 31, 2001 - Issue 17
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Original Articles

EFFICIENT FLUORESCEIN SPIROLACTAM AND BIS-SPIROLACTAM SYNTHESIS

Maciej Adamczyk Department of Chemistry (D9NM), AP-20, Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL, 60064-6016, U.S.A.
&
Jonathan Grote Department of Chemistry (D9NM), AP-20, Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL, 60064-6016, U.S.A.
Pages 2681-2690 | Received 27 Nov 2000, Published online: 09 Nov 2006

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  • Product previously noted in reference 4 without full experimental detail
  • The hydrazone co-crystallized with a molecule of acetone as shown in the Figure 1
  • Spirolactams were examined for fluorescence at 100 nM using an ISS PC1 spectrofluorometer as noted in the general experimental
  • Spirolactam 2m showed a λexcit at 490 nm, a λemis at 525 nm and ε = 62,000, essentially the same as 6-aminomethyl fluorescein

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