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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 13
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Original Articles

The Synthesis of Novel cis-α-Substituted-β-aminotetralins

Mark A. Youngman Johnson & Johnson Pharmaceutical Research and Development, LLC, Spring House, Pennsylvania, USA
,
Nicole M. Willard Johnson & Johnson Pharmaceutical Research and Development, LLC, Spring House, Pennsylvania, USA
,
Scott L. Dax Johnson & Johnson Pharmaceutical Research and Development, LLC, Spring House, Pennsylvania, USA
&
James J. McNally Johnson & Johnson Pharmaceutical Research and Development, LLC, Spring House, Pennsylvania, USACorrespondence[email protected]
Pages 2215-2227 | Received 08 Nov 2002, Published online: 17 Aug 2006

References

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  • Johansson , A.M. , Grol , C.J. , Karlen , A. and Hacksell , U. 1994 . Dopamine D2 receptor agonists: an analysis of indirect models . Drug Design and Discovery , 11 : 159
  • Babaoglu , M.O. , Aydos , T.R. , Orer , H.S. and Ilhan , M. 1999 . Antinicotinic activity of some 2-aminotetralin derivatives. A structure-activity relationship study . Arzneim-Forsch. , 49 : 566
  • Youngman , M.A. , McNally , J.J. , Lovenberg , T.W. , Reitz , A.B. , Willard , N.M. , Nepomuceno , D. , Wilson , S. , Crooke , J. , Rosenthal , D. , Vaidya , A.H. and Dax , S.L. 2000 . α-Substituted N-(sulfonamido)alkyl-β-aminotetralins: potent and selective neuropeptide Y Y5 receptor antagonists . Journal of Medicinal Chemistry , 43 : 346
  • McNally , J.J. , Youngman , M.A. , Lovenberg , T.W. , Nepomuceno , D. , Wilson , S. and Dax , S.L. 2000 . N-(Sulfonamido)alkyl[tetrahydro-1H-benzo [e] indol-2-yl]amines: potent antagonists of the human neuropeptide Y Y5 receptor . Bioorganic and Medicinal Chemistry Letters , 10 : 213
  • McNally , J.J. , Youngman , M.A. , Lovenberg , T.W. , Nepomuceno , D. , Wilson , S. and Dax , S.L. 2000 . N-Acylated N-acylated α-(3-Pyridylmethyl)-β-aminotetralin antagonists of the human neuropeptide Y Y5 receptor . Bioorganic and Medicinal Chemistry Letters , 10 : 1641
  • Stjernlof , P. , Ennis , M.D. , Hansson , L.O. , Hoffman , R.L. , Ghazal , N.B. , Sundell , S. , Smith , M.W. , Svensson , K. , Carlsson , A. and Wikstrom , H. 1995 . Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes . J. Med. Chem. , 38 : 2202 3,4-Dihydro-6-fluoro-2(1H)-naphthalenone was prepared using a modified procedure of

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