Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 20
430
Views
10
CrossRef citations to date
0
Altmetric
Original Articles

New Synthesis of Thymidylate Synthase Inhibitor Raltitrexed

, &
Pages 3519-3526 | Received 28 Feb 2003, Published online: 15 Aug 2006

References

  • Jones , T.R. , Calvert , A.H. , Jackman , A.L. , Brown , S.T. , Jones , M. and Harrap , K.R. 1981 . A potent antitumor quinazoline inhibitor of thymidylate synthase: synthesis, biological properties, and therapeutic results in mice . Eur. J. Cancer , 17 : 11 – 19 .
  • Bavetsias , V. , Marriott , J.H. , Melin , C. , Kimbell , R. , Matusiak , Z.S. , Boyle , F.T. and Jackman , A.L. 2000 . Design and synthesis of cyclopenta[g] quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents . J. Med. Chem. , 43 : 1910 – 1926 .
  • Cunningham , D. , Zalcberg , J. , Maroun , J. , James , R. , Clarke , S. , Maughan , T.S. , Vincent , M. , Schulz , J. , Baron , M.G. and Facchini , T. 2002 . Efficacy, tolerability, and management of raltitrexed monotherapy in patients with advanced colorectal cancer—a review of phase II/III trials . Eur. J. Cancer , 38 : 478 – 486 .
  • Marsham , P.R. , Hughes , L.R. , Jackman , A.L. , Hayter , A.J. , Oldfield , J. , Wardleworth , J.M. , Bishop , J.A.M. , O'Connor , B.M. and Calvert , A.H. 1991 . Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications . J. Med. Chem. , 34 : 1594 – 1605 .
  • Shioiri , T. , Ninomiya , K. and Yamada , S. 1972 . Diphenylphosphoryl azide. A new convenient reagent for a modified curtius reaction and for the peptide synthesis . J. Am. Chem. Soc. , 94 : 6203 – 6205 .
  • Cao , S.L. , Feng , Y.P. and Wan , R. A facile method for the N-alkylation of Boc-protected aminothiophenes . Synth. Commun. , (submitted)

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.