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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 10
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Original Articles

An Improved Synthesis of PET Dopamine D2 Receptors Radioligand [11C]Raclopride

Xiangshu Fei Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L‐3 Room 202, Indianapolis, Indiana, 46202‐2111, USA
,
Bruce H. Mock Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L‐3 Room 202, Indianapolis, Indiana, 46202‐2111, USA
,
Timothy R. DeGrado Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L‐3 Room 202, Indianapolis, Indiana, 46202‐2111, USA
,
Ji‐Quan Wang Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L‐3 Room 202, Indianapolis, Indiana, 46202‐2111, USA
,
Barbara E. Glick‐Wilson Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L‐3 Room 202, Indianapolis, Indiana, 46202‐2111, USA
,
Michael L. Sullivan Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L‐3 Room 202, Indianapolis, Indiana, 46202‐2111, USA
,
Gary D. Hutchins Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L‐3 Room 202, Indianapolis, Indiana, 46202‐2111, USA
&
Qi‐Huang Zheng Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L‐3 Room 202, Indianapolis, Indiana, 46202‐2111, USACorrespondence[email protected]
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Pages 1897-1907 | Received 06 Jan 2004, Published online: 20 Aug 2006

References

  • Brooks , D. J. 2003 . PET studies on the function of dopamine in health and Parkinson's disease . Ann. N. Y. Acad. Sci. , 991 : 22 – 35 . [PUBMED] [INFOTRIEVE] [CSA]
  • Langer , O. , Nagren , K. , Dolle , F. , Lundkvist , C. , Sandell , J. , Swahn , C.‐G. , Vaufrey , F. , Crouzel , C. , Maziere , B. and Halldin , C. 1999 . Precursor synthesis and radiolabelling of the dopamine D2 receptor ligand [11C]raclopride from [11C]methyl triflate . J. Labelled Cpd. Radiopharm. , 42 : 1183 – 1193 . [CROSSREF]
  • Iwata , R. , Pascali , C. , Bogni , A. , Miyake , Y. , Yanai , K. and Ido , T. 2001 . A simple loop method for the automated preparation of [11C]raclopride from [11C]methyl triflate . Appl. Radiat. Isot. , 55 : 17 – 22 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • Ishiwata , K. , Ishii , S. and Senda , M. 1999 . An alternative synthesis of [11C]raclopride for routine use . Ann. Nucl. Med. , 13 : 195 – 197 . [PUBMED] [INFOTRIEVE] [CSA]
  • Ehrin , E. , Gawell , L. , Hogberg , T. , de Paulis , T. and Strom , P. 1986 . Synthesis of [methoxy‐3H]‐ and [methoxy‐11C]‐labeled raclopride. Specific dopamine‐D2 receptor ligands . J. Labelled Cpd. Radiopharm. , 24 : 931 – 940 .
  • Jewett , D. M. 1992 . A simple synthesis of [11C]methyl triflate . Appl. Radiat. Isot. , 43 : 1383 – 1385 .
  • Mock , B. H. , Mulholland , G. K. and Vavrek , M. T. 1999 . Convenient gas phase bromination of [11C]methane and production of [11C]methyl triflate . Nucl. Med. Biol. , 26 : 467 – 471 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • Fei , X. , Zheng , Q.‐H. , Liu , X. , Wang , J.‐Q. , Sun , H. B. , Mock , B. H. , Stone , K. L. , Miller , K. D. , Sledge , G. W. and Hutchins , G. D. 2003 . Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents . Bioorg. Med. Chem. Lett. , 13 : 2217 – 2222 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • Zheng , Q.‐H. , Liu , X. , Fei , X. , Wang , J.‐Q. , Ohannesian , D. W. , Erickson , L. C. , Stone , K. L. and Hutchins , G. D. 2003 . Synthesis and preliminary biological evaluation of radiolabeled O6‐benzylguanine derivatives, new potential PET imaging agents for the DNA repair protein O6‐alkylguanine‐DNA alkyltransferase in breast cancer . Nucl. Med. Biol. , 30 : 405 – 415 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • Zheng , Q.‐H. , Fei , X. , DeGrado , T. R. , Wang , J.‐Q. , Stone , K. L. , Martinez , T. D. , Gay , D. J. , Baity , W. L. , Mock , B. H. , Glick‐Wilson , B. E. , Sullivan , M. L. , Miller , K. D. , Sledge , G. W. and Hutchins , G. D. 2003 . Synthesis, biodistribution and micro‐PET imaging of a potential cancer biomarker carbon‐11 labeled MMP inhibitor (2R)‐2‐[[4‐(6‐fluorohex‐1‐ynyl)phenyl]sulfonylamino]‐3‐methylbutyric acid [11C]methyl ester . Nucl. Med. Biol. , 30 : 753 – 760 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • Zheng , Q.‐H. and Mulholland , G. K. 1996 . Improved synthesis of β‐CIT and [11C]β‐CIT labeled at nitrogen or oxygen positions . Nucl. Med. Biol. , 23 : 981 – 986 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]

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