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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 12
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Original Articles

Use of a Modified Leimgruber–Batcho Reaction to Prepare 6‐Chloro‐5‐fluoroindole

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Pages 2295-2301 | Received 03 Mar 2004, Published online: 17 Aug 2006

References

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  • Peroutka , S. J. and Howell , T. A. 1997 . 5‐Hydroxytryptamine receptors . Princ. Med. Biol. , 8A : 59 – 72 .
  • Bos , M. , Jenck , F. , Martin , J. R. , Moreau , J‐L. , Sleight , A. J. , Wichmann , J. and Widmer , U. J. 1997 . Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2‐(indol‐1‐yl)‐1‐methylethylamines and 2‐(indeno[1,2‐b]pyrrol‐1‐yl)‐1‐methylethylamines. Improved therapeutics for obsessive compulsive disorder . J. Med. Chem. , 40 : 2762 – 2769 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
  • Batcho , A. D. and Leimgruber , W. Intermediates for Indoles . US Patent 3,976,639 . 31 March, 1976 .
  • Adams , D. R. , Duncton , M. A.J. , Roffey , J. R.A. and Spencer , J. 2002 . Preparation of 6‐chloro‐5‐fluoroindole via the use of palladium and copper‐mediated heterocyclisations . Tet. Lett. , 43 : 7581 – 7583 . [CROSSREF]
  • Bentley , J. M. , Dawson , C. E. , George , A. R. , Hamlyn , R. J. , Pratt , R. M. , Gaur , S. , Adams , D. R. , Bebbington , D. and Duncton , M. A.J. Preparation of Indolinealkylamine Derivatives as 5‐HT2B and/or 5‐HT2C Receptor Ligands . European Patent 1,109,784 . 1 September 1999 .

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