669
Views
24
CrossRef citations to date
0
Altmetric
Papers

How meaningful are risk determinations in the absence of a complete dataset? Making the case for publishing standardized test guideline and ‘no effect’ studies for evaluating the safety of nanoparticulates versus spurious ‘high effect’ results from single investigative studies

&
Article: 034603 | Received 25 Feb 2015, Accepted 19 Mar 2015, Published online: 05 May 2015

References

  • KrugH 2014 Nanosafety research—are we on the right track? Angew. Chem. 53 12304 12319 12304–19 10.1002/anie.201403367
  • DonaldsonKPolandC A 2013 Nanotoxicity: challenging the myth of nano-specific toxicity Curr. Opin. Biotechnol. 24 724 734 724–34 10.1016/j.copbio.2013.05.003
  • OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring—Number 1 OECD Principles on Good Laboratory Practice (as revised in 1997) Paris OECD
  • TassinariR 2014 Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen Nanotoxicology 8 654 662 654–62 10.3109/17435390.2013.822114
  • DuPont—Subchronic Toxicity 90 Day-Gavage Study in Rats with Pigment-Grade Titanium Dioxide (OECD Guideline for the Testing of Chemicals; Section 4: Health Effects Number 408 1998) (Unpublished data 2011)
  • OECD Guideline for the Testing of Chemicals—Repeated Dose 90-Day Oral Toxicity Study in Rodents—OECD 408, Adopted 21st September 1998
  • ChoW SKangB CLeeJ KJeongJCheJ HSeokS H 2013 Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration Part. Fibre Toxicol. 10 9 10.1186/1743-8977-10-9
  • GeraetsLOomenA GKrystekPJacobsenN RWallinHLaurentieMVerharenH WBrandonE F Ade JongW H 2014 Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticle in rats Part. Fibre Toxicol. 11 30 10.1186/1743-8977-11-30
  • HimmelsteinM WRamseyJ BBoatmanR JWarheitD B 2015 Pharmacokinetic comparison of 2 titanium dioxide (1 pigment and 1 nanostructured) materials demonstrate absence of systemic exposure in orally exposed rats Toxicologist 144 450 451 450–1
  • MacNicollAKellyMAksoyHKramerEBouwmeesterHChaudhryQ 2015 A study of the uptake and biodistribution of nano-titanium dioxide using in vitro and in vivo models of oral intake J. Nanopart. Res. 17 66 10.1007/s11051-015-2862-3
  • JonesKMortonJSmithIJurkschatKHardingA HEvansG 2015 Human in vivo and in vitro studies on gastrointestinal absorption of titanium dioxide nanoparticles Toxicol. Lett. 233 95 101 95–101 10.1016/j.toxlet.2014.12.005
  • DuPont—Repeated-dose oral Toxicity 28-Day Gavage Study in Rats with Pigment-Grade Titanium Dioxide (OECD Guideline for the Testing of Chemicals; Section 4: Health Effects Number 407 1995) (Unpublished data 2006)