Deficient repair regulatory response to injury in keratoconic stromal cells

References

• Rabinowitz Y. Keratoconus. Surv Ophthalmol 1998; 42: 297–319.
   PubMed Web of Science ®Google Scholar
• Sherwin T, Brookes NH. Morphological changes in keratoconus: pathology or pathogenesis? Clin Experiment Ophthalmol 2004; 32: 211–217.
   PubMed Web of Science ®Google Scholar
• Ambekar R, Toussaint KC Jr, Wagoner johnson A. The effect of keratoconus on the structural, mechanical, and optical properties of the cornea. J Mech Behav Biomed Mater 2011; 4: 223–236.
   PubMed Web of Science ®Google Scholar
• Colin J, Velou S. Current surgical options for keratoconus. J Cataract Refract Surg 2003; 29: 379–386.
   Web of Science ®Google Scholar
• Al‐yousuf N, Mavrikakis I, Mavrikakis E, Daya S. Penetrating keratoplasty: indications over a 10 year period. Br J Ophthalmol 2004; 88: 998–1001.
   PubMed Web of Science ®Google Scholar
• Cunningham WJ, Brookes NH, Twohill HC, Moffatt SL, Pendergrast DGC, Stewart JM, Mcghee CN. Trends in the distribution of donor corneal tissue and indications for corneal transplantation: the New Zealand National Eye Bank Study 2000–2009. Clin Experiment Ophthalmol 2012; 40: 141–147.
   PubMed Web of Science ®Google Scholar
• Cheung I, Mcghee CNJ, Sherwin T. A new perspective on the pathobiology of keratoconus: interplay of stromal wound healing and reactive species associated processes. Clin Exp Optom 2013; 96: 188–196.
   PubMed Web of Science ®Google Scholar
• Kim WJ, Rabinowitz YS, Meisler DM, Wilson SE. Keratocyte apoptosis associated with keratoconus. Exp Eye Res 1999; 69: 475–481.
   PubMed Web of Science ®Google Scholar
• Kaldawy RM, Wagner J, Ching S, Seigel GM. Evidence of apoptotic cell death in keratoconus. Cornea 2002; 21: 206–209.
   PubMed Web of Science ®Google Scholar
• Rabinowitz YS, Dong L, Wistow G. Gene expression profile studies of human keratoconus cornea for NEIBank: a novel cornea‐expressed gene and the absence of transcripts for aquaporin 5. Invest Ophthalmol Vis Sci 2005; 46: 1239–1246.
   PubMed Web of Science ®Google Scholar
• Ha NT, Nakayasu K, Murakami A, Ishidoh K, Kanai A. Microarray analysis identified differentially expressed genes in keratocytes from keratoconus patients. Curr Eye Res 2004; 28: 373–379.
   PubMed Web of Science ®Google Scholar
• Lee JE, Oum BS, Choi HY, Lee SU, Lee JS. Evaluation of differentially expressed genes identified in keratoconus. Mol Vis 2009; 15: 2480–2487.
   PubMed Web of Science ®Google Scholar
• Wilson SE, Mohan RR, Mohan RR, Ambrósio Jr R, Hong JW, Lee JS. The corneal wound healing response: cytokine‐mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res 2001; 20: 625–637.
   PubMed Web of Science ®Google Scholar
• Wilson SE, Liu JJ, Mohan RR. Stromal‐epithelial interactions in the cornea. Prog Retin Eye Res 1999; 18: 293–309.
   PubMed Web of Science ®Google Scholar
• Becker J, Salla S, Dohmen U, Redbrake C, Reim M. Explorative study of interleukin levels in the human cornea. Graefes Arch Clin Exp Ophthalmol 1995; 233: 766–771.
   PubMed Web of Science ®Google Scholar
• Zhou L, Yue B, Twining S, Sugar J, Feder R. Expression of wound healing and stress‐related proteins in keratoconus corneas. Curr Eye Res 1996; 15: 1124–1131.
   PubMed Web of Science ®Google Scholar
• Fabre EJ, Bureau J, Pouliquen Y, Lorans G. Binding sites for human interleukin 1 alpha, gamma interferon and tumor necrosis factor on cultured fibroblasts of normal cornea and keratoconus. Curr Eye Res 1991; 10: 585–592.
   PubMed Web of Science ®Google Scholar
• Kim SH, Mok JW, Kim HS, Joo CK. Association of −31T > C and −511 C > T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Mol Vis 2008; 14: 2109–2116.
   PubMed Web of Science ®Google Scholar
• Mikami T, Meguro A, Teshigawara T, Takeuchi M, Uemoto R, Kawagoe T, Nomura E et al. Interleukin 1 beta promoter polymorphism is associated with keratoconus in a Japanese population. Mol Vis 2013; 19: 845–851.
   PubMed Web of Science ®Google Scholar
• Nowak DM, Karolak JA, Kubiak J, Gut M, Pitarque JA, Molinari A, Bejjani BA et al. Substitution at IL1RN and deletion at SLC4A11 segregating with phenotype in familial keratoconus. Invest Ophthalmol Vis Sci 2013; 54: 2207–2215.
   PubMed Web of Science ®Google Scholar
• Balasubramanian SA, Mohan S, Pye DC, Willcox MDP. Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus. Acta Ophthalmol 2012; 90: e303–e309.
   PubMed Web of Science ®Google Scholar
• Duran JA, Lema I. Inflammatory markers in keratoconus. Invest Ophthalmol Vis Sci 2003; 44: E‐abstract 1314.
   Web of Science ®Google Scholar
• Lema I, Sobrino T, Durán JA, Brea D, Díez‐feijoo E. Subclinical keratoconus and inflammatory molecules from tears. Br J Ophthalmol 2009; 93: 820–824.
   PubMed Web of Science ®Google Scholar
• Lema I, Durán JA. Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology 2005; 112: 654–659.
   PubMed Web of Science ®Google Scholar
• Engler C, Chakravarti S, Doyle J, Eberhart CG, Meng H, Stark WJ, Kelliher C et al. Transforming growth factor‐β signaling pathway activation in keratoconus. Am J Ophthalmol 2011; 151: 752–759.
   PubMed Web of Science ®Google Scholar
• Lee JE, Oum BS, Choi HY, Lee SU, Lee JS. Evaluation of differentially expressed genes identified in keratoconus. Mol Vis 2009; 15: 2480–2487.
   PubMed Web of Science ®Google Scholar
• Jun AS, Cope L, Speck C, Feng X, Lee S, Meng H, Hamad A, Chakravarti S. Subnormal cytokine profile in the tear fluid of keratoconus patients. PLoS ONE 2011; 6: e16437.
   PubMed Web of Science ®Google Scholar
• Sherwin T, Green CR. Stromal wound healing. In: Brightbill FS, Mcdonnell PJ, Mcghee CNJ, Farjo AA, Serdarevic ON, eds. Corneal Surgery: Theory, Technique and Tissue, 4th ed. Missouri: Mosby Elsevier, 2009. p 45–56.
   Google Scholar
• Fini M. Keratocyte and fibroblast phenotypes in the repairing cornea. Prog Retin Eye Res 1999; 18: 529–551.
   PubMed Web of Science ®Google Scholar
• Efron N, Hollingsworth JG. New perspectives on keratoconus as revealed by corneal confocal microscopy. Clin Exp Optom 2008; 91: 34–55.
   PubMed Web of Science ®Google Scholar
• Arnal E, Peris‐martínez C, Menezo JL, Johnsen‐soriano S, Romero FJ. Oxidative stress in keratoconus? Invest Ophthalmol Vis Sci 2011; 52: 8592–8597.
   PubMed Web of Science ®Google Scholar
• Kenney MC, Chwa M, Opbroek AJ, Brown DJ. Increased gelatinolytic activity in keratoconus keratocyte cultures: a correlation to an altered matrix metalloproteinase‐2/tissue inhibitor of metalloproteinase ratio. Cornea 1994; 13: 114–124.
   PubMed Web of Science ®Google Scholar
• Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M, Vasiliou V et al. Increased levels of catalase and cathepsin V/L2 but decreased TIMP‐1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder. Invest Ophthalmol Vis Sci 2005; 46: 823–832.
   PubMed Web of Science ®Google Scholar
• Kao WWY, Vergnes JP, Ebert J, Sundar‐raj CV, Brown SI. Increased collagenase and gelatinase activities in keratoconus. Biochem Biophys Res Commun 1982; 107: 929–936.
   PubMed Web of Science ®Google Scholar
• Nelidova D, Sherwin T. Keratoconus layer by layer—pathology and matrix metalloproteinases [monograph on the Internet]. InTech; 2012 Mar. Available from: http://www.intechopen.com/books/advances‐in‐ophthalmology/the‐matrix‐metalloproteinasehypothesis‐of‐keratoconus‐layer‐by‐layer. [Accessed July 2012].
   Google Scholar
• Yue BYJT, Sugar J, Benveniste K. Heterogeneity in keratoconus: possible biochemical basis. Proc Soc Exp Biol Med 1984; 175: 336–341.
   PubMed Web of Science ®Google Scholar
• Kenney MC, Chwa M, Escobar M, Brown D. Altered gelatinolytic activity by keratoconus corneal cells. Biochem Biophys Res Commun 1989; 161: 353–357.
   PubMed Web of Science ®Google Scholar
• Maatta M, Vaisanen T, Vaisanen MR, Pihlajaniemi T, Tervo T. Altered expression of type XIII collagen in keratoconus and scarred human cornea: increased expression in scarred cornea is associated with myofibroblast transformation. Cornea 2006; 25: 448–453.
   PubMed Web of Science ®Google Scholar
• Maatta MP, Heljasvaara RP, Sormunen RP, Pihlajaniemi TP, Autio‐harmainen HP, Tervo TP. Differential expression of collagen types XVIII/endostatin and XV in normal, keratoconus and scarred human corneas. Cornea 2006; 25: 341–349.
   PubMed Web of Science ®Google Scholar
• Li X, Bykhovskaya Y, Canedo ALC, Haritunians T, Siscovick D, Aldave AJ, Szczotka‐flynn L et al. Genetic association of COL5A1 variants in keratoconus patients suggests a complex connection between corneal thinning and keratoconus. Invest Ophthalmol Vis Sci 2013; 54: 2696–2704.
   PubMed Web of Science ®Google Scholar
• Tuori A, Virtanen I, Aine E, Uusitalo H. The expression of tenascin and fibronectin in keratoconus, scarred and normal human cornea. Graefes Arch Clin Exp Ophthalmol 1997; 235: 222–229.
   PubMed Web of Science ®Google Scholar
• Sawaguchi S, Yue BY, Chang I, Sugar J, Robin J. Proteoglycan molecules in keratoconus corneas. Invest Ophthalmol Vis Sci 1991; 32: 1846–1853.
   PubMed Web of Science ®Google Scholar
• Lambiase A, Merlo D, Mollinari C, Bonini P, Rinaldi AM, Amato MD, Micera A et al. Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3. Proc Natl Acad Sci USA 2005; 102: 16795–16800.
   PubMed Web of Science ®Google Scholar
• Zhou H, Kimura K, Orita T, Nishida T, Sonoda KH. Inhibition by medroxyprogesterone acetate of interleukin‐1 induced collagen degradation by corneal fibroblasts. Invest Ophthalmol Vis Sci 2012; 53: 4213–4219.
   PubMed Web of Science ®Google Scholar
• Nagano T, Nakamura M, Nishida T. Differential regulation of collagen degradation by rabbit keratocytesand polymorphonuclear leukocytes. Curr Eye Res 2002; 24: 240–243.
   PubMed Web of Science ®Google Scholar
• Elner VM, Strieter RM, Pavilack MA, Elner SG, Remick DG, Danforth JM, Kunkel SL. Human corneal interleukin‐8. IL‐1 and TNF‐induced gene expression and secretion. Am J Pathol 1991; 139: 977–988.
   PubMed Web of Science ®Google Scholar
• Tran MT, Tellaetxe‐isusi M, Elner V, Strieter RM, Lausch RN, Oakes JE. Proinflammatory cytokines induce RANTES and MCP‐1 synthesis in human corneal keratocytes but not in corneal epithelial cells: beta‐chemokine synthesis in corneal cells. Invest Ophthalmol Vis Sci 1996; 37: 987–996.
   PubMed Web of Science ®Google Scholar
• Kaur H, Chaurasia SS, Agrawal V, Suto C, Wilson SE. Corneal myofibroblast viability: opposing effects of IL‐1 and TGF. Exp Eye Res 2009; 89: 152–158.
   PubMed Web of Science ®Google Scholar
• Kurosaka H, Kurosaka D, Kato K, Mashima Y, Tanaka Y. Transforming growth factor‐beta 1 promotes contraction of collagen gel by bovine corneal fibroblasts through differentiation of myofibroblasts. Invest Ophthalmol Vis Sci 1998; 39: 699–704.
   PubMed Web of Science ®Google Scholar
• He J, Bazan HEP. Epidermal growth factor synergism with TGF via PI‐3 kinase activity in corneal keratocyte differentiation. Invest Ophthalmol Vis Sci 2008; 49: 2936–2945.
   Web of Science ®Google Scholar
• Garrett Q, Khaw PT, Blalock TD, Schultz GS, Grotendorst GR, Daniels JT. Involvement of CTGF in TGF stimulation of myofibroblast differentiation and collagen matrix contraction in the presence of mechanical stress. Invest Ophthalmol Vis Sci 2004; 45: 1109–1116.
   PubMed Web of Science ®Google Scholar
• Karamichos D, Hutcheon AEK, Zieske JD. Transforming growth factor‐β3 regulates assembly of a non‐fibrotic matrix in a 3D corneal model. J Regen Med Tissue Eng 2011; 5: e228–e238.
   Google Scholar
• Karamichos D, Guo XQ, Hutcheon AEK, Zieske JD. Human corneal fibrosis: an in vitro model. Invest Ophthalmol Vis Sci 2010; 51: 1382–1388.
   PubMed Web of Science ®Google Scholar
• Izumi K, Kurosaka D, Iwata T, Oguchi Y, Tanaka Y, Mashima Y, Tsubota K. Involvement of insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 in corneal fibroblasts during corneal wound healing. Invest Ophthalmol Vis Sci 2006; 47: 591–598.
   Web of Science ®Google Scholar
• Borderie VM, Mourra N, Laroche L. Influence of fetal calf serum, fibroblast growth factors, and hepatocyte growth factor on three‐dimensional cultures of human keratocytes in collagen gel matrix. Graefes Arch Clin Exp Ophthalmol 1999; 237: 861–869.
   Web of Science ®Google Scholar
• Burdon KP, Macgregor S, Bykhovskaya Y, Javadiyan S, Li X, Laurie KJ, Muszynska D et al. Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus. Invest Ophthalmol Vis Sci 2011; 52: 8514–8519.
   PubMed Web of Science ®Google Scholar
• Saghizadeh M, Chwa M, Aoki A, Lin B, Pirouzmanesh A, Brown DJ, Ljubimov AV, Kenney MC. Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas. Exp Eye Res 2001; 73: 179–189.
   PubMed Web of Science ®Google Scholar
• Etheredge L, Kane BP, Hassell JR. The effect of growth factor signaling on keratocytes in vitro and its relationship to the phases of stromal wound repair. Invest Ophthalmol Vis Sci 2009; 50: 3128–3136.
   Web of Science ®Google Scholar
• Grant MB, Khaw PT, Schultz GS, Adams JL, Shimizu RW. Effects of epidermal growth factor, fibroblast growth factor, and transforming growth factor‐beta on corneal cell chemotaxis. Invest Ophthalmol Vis Sci 1992; 33: 3292–3301.
   PubMed Web of Science ®Google Scholar
• Maltseva O, Folger P, Zekaria D, Petridou S, Masur SK. Fibroblast growth factor reversal of the corneal myofibroblast phenotype. Invest Ophthalmol Vis Sci 2001; 42: 2490–2495.
   PubMed Web of Science ®Google Scholar
• Chen J, Guerriero E, Sado Y, Sundar‐raj N. Rho‐mediated regulation of TGF‐beta1‐ and FGF‐2‐induced activation of corneal stromal keratocytes. Invest Ophthalmol Vis Sci 2009; 50: 3662–3670.
   Web of Science ®Google Scholar
• Awata T, Nishida T, Nakagawa S, Manabe R. Differential regulation of fibronectin synthesis in three different types of corneal cells. Jpn J Ophthalmol 1989; 33: 132–143.
   PubMed Web of Science ®Google Scholar
• Assouline M, Chew SJ, Thompson HW, Beuerman R. Effect of growth factors on collagen lattice contraction by human keratocytes. Invest Ophthalmol Vis Sci 1992; 33: 1742–1755.
   PubMed Web of Science ®Google Scholar
• Kim A, Lakshman N, Karamichos D, Petroll WM. Growth factor regulation of corneal keratocyte differentiation and migration in compressed collagen matrices. Invest Ophthalmol Vis Sci 2010; 51: 864–875.
   Web of Science ®Google Scholar
• Kaur H, Chaurasia SS, de Medeiros FW, Agrawal V, Salomao MQ, Singh N, Ambati BK et al. Corneal stroma PDGF blockade and myofibroblast development. Exp Eye Res 2009; 88: 960–965.
   Web of Science ®Google Scholar
• Jester JV, Ho‐chang J. Modulation of cultured corneal keratocyte phenotype by growth factors/cytokines control in vitro contractility and extracellular matrix contraction. Exp Eye Res 2003; 77: 581–592.
   PubMed Web of Science ®Google Scholar
• Chen J, Wong‐chong J, Sundar‐raj N. FGF‐2‐ and TGF‐β1‐induced downregulation of lumican and keratocan in activated corneal keratocytes by JNK signaling pathway. Invest Ophthalmol Vis Sci 2011; 52: 8957–8964.
   Web of Science ®Google Scholar
• Nakazawa K, Morita A, Nakano H, Mano C, Tozawa N. Keratan sulfate synthesis by corneal stromal cells within three‐dimensional collagen gel cultures. J Biochem 1996; 120: 117–125.
   Web of Science ®Google Scholar
• Kenney CM, Brown DJ. The cascade hypothesis of keratoconus. Cont Lens Anterior Eye 2003; 26: 139–146.
   PubMedGoogle Scholar
• Mcmonnies CW. Abnormal rubbing and keratectasia. Eye Cont Lens 2007; 33: 265–271.
   PubMedGoogle Scholar
• Gasset AR, Houde WL, Garcia‐bengochea M. Hard contact lens wear as an environmental risk in keratoconus. Am J Ophthalmol 1978; 85: 339–341.
   PubMed Web of Science ®Google Scholar