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Review

Animal models in myopia research

, PhD & , PhD
Pages 507-517 | Received 21 Oct 2014, Accepted 26 Apr 2015, Published online: 15 Apr 2021

REFERENCES

  • Sorsby A. The control of school myopia. Br Med J 1933; 2: 730–733.
  • Cohn H. Hygiene of the Eye. London: De Vries, 1886.
  • Wiesel TN, Raviola E. Myopia and eye enlargement after neonatal lid fusion in monkeys. Nature 1977; 266: 66–68.
  • Sherman SM, Norton TT, Casagrande VA. Myopia in the lid‐sutured tree shrew (Tupaia glis). Brain Res 1977; 124: 154–157.
  • Wallman J, Turkel J, Trachtman J. Extreme myopia produced by modest change in early visual experience. Science 1978; 201: 1249–1251.
  • Schaeffel F, Howland HC. Corneal accommodation in chick and pigeon. J Comp Physiol A 1987; 160: 375–384.
  • Glasser A, Howland HC. In vitro changes in back vertex distance of chick and pigeon lenses: species differences and the effects of aging. Vision Res 1995; 35: 1813–1824.
  • Glasser A, Murphy CJ, Troilo D, Howland HC. The mechanism of lenticular accommodation in chicks. Vision Res 1995; 35: 1525–1540.
  • Sivak JG. Accommodation in vertebrates: a contemporary survey. Curr Top Eye Res 1980; 3: 281–330.
  • Mcbrien NA, Moghaddam HO, Reeder AP. Atropine reduces experimental myopia and eye enlargement via a nonaccommodative mechanism. Invest Ophthalmol Vis Sci 1993; 34: 205–215.
  • Schaeffel F, Glasser A, Howland HC. Accommodation, refractive error and eye growth in chickens. Vision Res 1988; 28: 639–657.
  • Troilo D, Gottlieb MD, Wallman J. Visual deprivation causes myopia in chicks with optic nerve section. Curr Eye Res 1987; 6: 993–999.
  • Wildsoet CF, Pettigrew JD. Kainic acid‐induced eye enlargement in chickens: differential effects on anterior and posterior segments. Invest Ophthalmol Vis Sci 1988; 29: 311–319.
  • Wallman J, Gottlieb MD, Rajaram V, Fugate wentzek LA. Local retinal regions control local eye growth and myopia. Science 1987; 237: 73‐77.
  • Wallman J, Adams JI, Trachtman JN. The eyes of young chickens grow toward emmetropia. Invest Ophthalmol Vis Sci 1981; 20: 557–561.
  • Schaeffel F, Troilo D, Wallman J, Howland HC. Developing eyes that lack accommodation grow to compensate for imposed defocus. Vis Neurosci 1990; 4: 177–183.
  • Schmid KL, Wildsoet CF. Effects on the compensatory responses to positive and negative lenses of intermittent lens wear and ciliary nerve section in chicks. Vision Res 1996; 36: 1023–1036.
  • Wallman J, Wildsoet C, Xu A, Gottlieb MD, Nickla DL, Marran L, Krebs W et al. Moving the retina: choroidal modulation of refractive state. Vision Res 1995; 35: 37–50.
  • Diether S, Schaeffel F. Long‐term changes in retinal contrast sensitivity in chicks from frosted occluders and drugs: relations to myopia? Vision Res 1999; 39: 2499–2510.
  • Wallman J, Winawer J. Homeostasis of eye growth and the question of myopia. Neuron 2004; 43: 447–468.
  • Zhu X, Park TW, Winawer J, Wallman J. In a matter of minutes, the eye can know which way to grow. Invest Ophthalmol Vis Sci 2005; 46: 2238–2241.
  • Seidemann A, Schaeffel F. Effects of longitudinal chromatic aberration on accommodation and emmetropization. Vision Res 2002; 42: 2409–2417.
  • Schaeffel F, Howland HC. Properties of the feedback loops controlling eye growth and refractive state in the chicken. Vision Res 1991; 31: 717–734.
  • Wildsoet CF, Howland HC, Falconer S, Dick K. Chromatic aberration and accommodation: their role in emmetropization in the chick. Vision Res 1993; 33: 1593–1603.
  • Rucker FJ, Wallman J. Cone signals for spectacle‐lens compensation: differential responses to short and long wavelengths. Vision Res 2008; 48: 1980–1991.
  • Fischer AJ, Mcguire JJ, Schaeffel F, Stell WK. Light‐ and focus‐dependent expression of the transcription factor ZENK in the chick retina. Nat Neurosci 1999; 2: 706–712.
  • Bitzer M, Schaeffel F. Defocus‐induced changes in ZENK expression in the chicken retina. Invest Ophthalmol Vis Sci 2002; 43: 246–252.
  • Buck C, Schaeffel F, Simon P, Feldkaemper M. Effects of positive and negative lens treatment on retinal and choroidal glucagon and glucagon receptor mRNA levels in the chicken. Invest Ophthalmol Vis Sci 2004; 45: 402–409.
  • Feldkaemper MP, Schaeffel F. Evidence for a potential role of glucagon during eye growth regulation in chicks. Vis Neurosci 2002; 19: 755–766.
  • Vessey KA, Lencses KA, Rushforth DA, Hruby VJ, Stell WK. Glucagon receptor agonists and antagonists affect the growth of the chick eye: a role for glucagonergic regulation of emmetropization? Invest Ophthalmol Vis Sci 2005; 46: 3922–3931.
  • Stone RA, Lin T, Laties AM, Iuvone PM. Retinal dopamine and form‐deprivation myopia. Proc Natl Acad Sci USA 1989; 86: 704–706.
  • Feldkaemper M, Diether S, Kleine G, Schaeffel F. Interactions of spatial and luminance information in the retina of chickens during myopia development. Exp Eye Res 1999; 68: 105–115.
  • Feldkaemper M, Schaeffel F. An updated view on the role of dopamine in myopia. Exp Eye Res 2013; 114: 106–119.
  • Ashby R, Ohlendorf A, Schaeffel F. The effect of ambient illuminance on the development of deprivation myopia in chicks. Invest Ophthalmol Vis Sci 2009; 50: 5348–5354.
  • Ashby RS, Schaeffel F. The effect of bright light on lens compensation in chicks. Invest Ophthalmol Vis Sci 2010; 51: 5247–5253.
  • Cohen Y, Peleg E, Belkin M, Polat U, Solomon AS. Ambient illuminance, retinal dopamine release and refractive development in chicks. Exp Eye Res 2012; 103: 33–40.
  • Stone RA, Lin T, Laties AM. Muscarinic antagonist effects on experimental chick myopia. Exp Eye Res 1991; 52: 755–758.
  • Stone RA, Sugimoto R, Gill AS, Liu J, Capehart C, Lindstrom JM. Effects of nicotinic antagonists on ocular growth and experimental myopia. Invest Ophthalmol Vis Sci 2001; 42: 557–565.
  • Diether S, Schaeffel F, Lambrou GN, Fritsch C, Trendelenburg AU. Effects of intravitreally and intraperitonally injected atropine on two types of experimental myopia in chicken. Exp Eye Res 2007; 84: 266–274.
  • Mcbrien NA, Moghaddam HO, Cottriall CL, Leech EM, Cornell LM. The effects of blockade of retinal cell action potentials on ocular growth, emmetropization and form deprivation myopia in young chicks. Vision Res 1995; 35: 1141–1152.
  • Mertz JR, Wallman J. Choroidal retinoic acid synthesis: A possible mediator between refractive error and compensatory eye growth. Exp Eye Res 2000; 70: 519–527.
  • Nickla DL, Wildsoet CF. The effect of the non‐specific nitric oxide synthase inhibitor NG‐nitro‐L‐arginine methyl ester on the choroidal compensatory response to myopic defocus in chickens. Optom Vis Sci 2004; 81: 111–118.
  • Rohrer B, Stell WK. Basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF‐beta) act as stop and go signals to modulate postnatal ocular growth in the chick. Exp Eye Res 1994; 58: 553–561.
  • Seltner RL, Stell WK. The effect of vasoactive intestinal peptide on development of form deprivation myopia in the chick: a pharmacological and immunocytochemical study. Vision Res 1995; 35: 1265–1270.
  • Gottlieb MD, Joshi HB, Nickla DL. Scleral changes in chicks with form‐deprivation myopia. Curr Eye Res 1990; 9: 1157–1165.
  • Rada JA, Thoft RA, Hassell JR. Increased aggrecan (cartilage proteoglycan) production in the sclera of myopic chicks. Dev Biol 1991; 147: 303–312.
  • Winawer J, Wallman J. Temporal constraints on lens compensation in chicks. Vision Res 2002; 42: 2651–2668.
  • Schmid KL, Wildsoet CF. Natural and imposed astigmatism and their relation to emmetropization in the chick. Exp Eye Res 1997; 64: 837–847.
  • Thomas S, Schaeffel F. Developmental compensation of imposed astigmatism is not initiated by astigmatic accommodation in chickens. Vision Res 2000; 40: 3553–3558.
  • Mcbrien NA, Norton TT. The development of experimental myopia and ocular component dimensions in monocularly lid‐sutured tree shrews (Tupaia belangeri). Vision Res 1992; 32: 843–852.
  • Norton TT, Essinger JA, Mcbrien NA. Lid‐suture myopia in tree shrews with retinal ganglion cell blockade. Vis Neurosci 1994; 11: 143–153.
  • Norton TT, JT S. Local myopia produced by partial visualfield deprivation in tree shrew. Soc Neurosci Abstr 1991; 17: 558.
  • Siegwart JT, Ward AH, Norton TT. Moderately elevated fluorescent light levels slow form deprivation and minus lens‐induced myopia development in tree shrews. ARVO Abstracts 2012; 53: 3457.
  • Norton TT, Siegwart JT Jr. Light levels, refractive development and myopia‐a speculative review. Exp Eye Res 2013; 114: 48–57.
  • Frost MR, Norton TT. Differential protein expression in tree shrew sclera during development of lens‐induced myopia and recovery. Mol Vis 2007; 13: 1580–1588.
  • Frost MR, Norton TT. Alterations in protein expression in tree shrew sclera during development of lens‐induced myopia and recovery. Invest Ophthalmol Vis Sci 2012; 53: 322–336.
  • Guo L, Frost MR, He L, Siegwart JT Jr, Norton TT. Gene expression signatures in tree shrew sclera in response to three myopiagenic conditions. Invest Ophthalmol Vis Sci 2013; 54: 6806–6819.
  • He L, Frost MR, Siegwart JT Jr, Norton TT. Gene expression signatures in tree shrew choroid during lens‐induced myopia and recovery. Exp Eye Res 2014; 123: 56–71.
  • Mcbrien NA, Gentle A. Role of the sclera in the development and pathological complications of myopia. Prog Retin Eye Res 2003; 22: 307–338.
  • Mcbrien NA, Jobling AI, Gentle A. Biomechanics of the sclera in myopia: extracellular and cellular factors. OptomVis Sci 2009; 86: 23–30.
  • Beuerman RW, Saw S‐M, Tan DTH, Wong T‐Y. Animal Models to Clinical Trials. Singapore: World Scientific Publishing, 2010.
  • Troilo D, Judge SJ. Ocular development and visual deprivation myopia in the common marmoset (Callithrix jacchus). Vision Res 1993; 33: 1311–1324.
  • Graham B, Judge SJ. Normal development of refractive state and ocular component dimensions in the marmoset (Callithrix jacchus). Vision Res 1999; 39: 177–187.
  • Graham B, Judge SJ. The effects of spectacle wear in infancy on eye growth and refractive error in the marmoset (Callithrix jacchus). Vision Res 1999; 39: 189–206.
  • Troilo D, Nickla DL, Wildsoet CF. Choroidal thickness changes during altered eye growth and refractive state in a primate. Invest Ophthalmol Vis Sci 2000; 41: 1249–1258.
  • Troilo D, Nickla DL, Wildsoet CF. Form deprivation myopia in mature common marmosets (Callithrix jacchus). Invest Ophthalmol Vis Sci 2000; 41: 2043–2049.
  • Whatham AR, Judge SJ. Compensatory changes in eye growth and refraction induced by daily wear of soft contact lenses in young marmosets. Vision Res 2001; 41: 267–273.
  • Troilo D, Nickla DL, Mertz JR, Summers rada JA. Change in the synthesis rates of ocular retinoic acid and scleral glycosaminoglycan during experimentally altered eye growth in marmosets. Invest Ophthalmol Vis Sci 2006; 47: 1768–1777.
  • Troilo D, Quinn N, Baker K. Accommodation and induced myopia in marmosets. Vision Res 2007; 47: 1228–1244.
  • Benavente–perez A, Nour A, Troilo D. Axial eye growth and refractive error development can be modified by exposing the peripheral retina to relative myopic or hyperopic defocus. Invest Ophthalmol Vis Sci 2014; 55: 6765–6773.
  • Benavente‐perez A, Nour A, Troilo D. The effect of simultaneous negative and positive defocus on eye growth and development of refractive state in marmosets. Invest Ophthalmol Vis Sci 2012; 53: 6479–6487.
  • Raviola E, Wiesel TN. Effect of dark‐rearing on experimental myopia in monkeys. Invest Ophthalmol Vis Sci 1978; 17: 485–488.
  • Stone RA, Laties AM, Raviola E, Wiesel TN. Increase in retinal vasoactive intestinal polypeptide after eyelid fusion in primates. Proc Natl Acad Sci USA 1988; 85: 257–260.
  • Iuvone PM, Tigges M, Stone RA, Lambert S, Laties AM. Effects of apomorphine, a dopamine receptor agonist, on ocular refraction and axial elongation in a primate model of myopia. Invest Ophthalmol Vis Sci 1991; 32: 1674–1677.
  • Hung LF, Crawford ML, Smith EL. Spectacle lenses alter eye growth and the refractive status of young monkeys. Nat Med 1995; 1: 761–765.
  • Hung LF, Wallman J, Smith EL, III. Vision‐dependent changes in the choroidal thickness of macaque monkeys. Invest Ophthalmol Vis Sci 2000; 41: 1259–1269.
  • Smith EL, III, Bradley DV, Fernandes A, Boothe RG. Form deprivation myopia in adolescent monkeys. Optom Vis Sci 1999; 76: 428–432.
  • Smith EL 3rd, Hung LF. Form‐deprivation myopia in monkeys is a graded phenomenon. Vision Res 2000; 40: 371–381.
  • Smith EL 3rd, Ramamirtham R, Qiao‐grider Y, Hung LF, Huang J, Kee CS, Coats D et al. Effects of foveal ablation on emmetropization and form‐deprivation myopia. Invest Ophthalmol Vis Sci 2007; 48: 3914–3922.
  • Smith EL 3rd, Hung LF, Huang J. Relative peripheral hyperopic defocus alters central refractive development in infant monkeys. Vision Res 2009; 49: 2386–2392.
  • Smith EL 3rd, Huang J, Hung LF, Blasdel TL, Humbird TL, Bockhorst KH. Hemiretinal form deprivation: evidence for local control of eye growth and refractive development in infant monkeys. Invest Ophthalmol Vis Sci 2009; 50: 5057–5069.
  • Kee CS, Hung LF, Qiao Y, Smith EL 3rd. Astigmatism in infant monkeys reared with cylindrical lenses. Vision Res 2003; 43: 2721–2739.
  • Smith EL 3rd, Hung LF, Arumugam B, Huang J. Negative lens‐induced myopia in infant monkeys: effects of high ambient lighting. Invest Ophthalmol Vis Sci 2013; 54: 2959–2969.
  • Smith EL 3rd, Hung LF, Huang J. Protective effects of high ambient lighting on the development of form‐deprivation myopia in rhesus monkeys. Invest Ophthalmol Vis Sci 2012; 53: 421–428.
  • Mcfadden SW, Wallman J. Guinea‐pig eye growth compensate for spectacle lenses. Invest Ophthalmol Vis Sci 1995; 36: S758.
  • Howlett MH, Mcfadden SA. Spectacle lens compensation in the pigmented guinea pig. Vision Res 2009; 49: 219–227.
  • Jiang LQ, Zhang S, Mo DP, Ye LY, Qu J, Zhou XT. [Measurement of grating acuity in guinea pigs by a customized automated optomotor device]. [Zhonghua yan ke za zhi] Chinese J Ophthalmol 2010; 46: 725–730.
  • Ostrin LA, Garcia MB, Choh V, Wildsoet CF. Pharmacologically stimulated pupil and accommodative changes in Guinea pigs. Invest Ophthalmol Vis Sci 2014; 55: 5456–5465.
  • Mcfadden S. Partial occlusion produces local form deprivation myopia in the guinea pig eye. Invest Ophthalmol Vis Sci 2002; 43: E‐Abstract 189.
  • Bagnoli P, Porciatti V, Francesconi W, Barsellotti R. Pigeon pattern electroretinogram: a response unaffected by chronic section of the optic nerve. Exp Brain Res 1984; 55: 253–262.
  • Jiang L, Schaeffel F, Zhou X, Zhang S, Jin X, Pan M, Ye L et al. Spontaneous axial myopia and emmetropization in a strain of wild‐type guinea pig (Cavia porcellus). Invest Ophthalmol Vis Sci 2009; 50: 1013–1019.
  • Jiang L, Long K, Schaeffel F, Zhang S, Zhou X, Lu F, Qu J. Disruption of emmetropization and high susceptibility to deprivation myopia in albino guinea pigs. Invest Ophthalmol Vis Sci 2011; 52: 6124–6132.
  • Li W, Lan W, Yang S, Liao Y, Xu Q, Lin L, Yang Z. The effect of spectral property and intensity of light on natural refractive development and compensation to negative lenses in Guinea pigs. Invest Ophthalmol Vis Sci 2014; 55: 6324–6332.
  • Jiang L, Long K, Schaeffel F, Zhou X, Zheng Y, Ying H, Lu F et al. Effects of dopaminergic agents on progression of naturally occurring myopia in albino guinea pigs (Cavia porcellus). Invest Ophthalmol Vis Sci 2014; 55: 7508–7519.
  • Mcfadden SA, Howlett MH, Mertz JR. Retinoic acid signals the direction of ocular elongation in the guinea pig eye. Vision Res 2004; 44: 643–653.
  • Schmucker C, Schaeffel F. In vivo biometry in the mouse eye with low coherence interferometry. Vision Res 2004; 44: 2445–2456.
  • Tkatchenko TV, Shen Y, Tkatchenko AV. Analysis of postnatal eye development in the mouse with high‐resolution small animal magnetic resonance imaging. Invest Ophthalmol Vis Sci 2010; 51: 21–27.
  • Park Hn, Tan CC, Chow RL, Iuvone PM, Pardue MT. Role of Vsx1 in refractive development. ARVO Abstracts 2012; 53: 4658.
  • Schaeffel F, Burkhardt E, Howland HC, Williams RW. Measurement of refractive state and deprivation myopia in two strains of mice. Optom Vis Sci 2004; 81: 99–110.
  • Schaeffel FB, E. Measurement of refractive state and deprivation myopia in a black wildtype mouse. Invest Ophthalmol Vis Sci 2002; 43: U33–U33.
  • Faulkner AE, Kim MK, Iuvone PM, Pardue MT. Head‐mounted goggles for murine form deprivation myopia. J Neurosci Meth 2007; 161: 96–100.
  • Barathi VA, Boopathi VG, Yap EP, Beuerman RW. Two models of experimental myopia in the mouse. Vision Res 2008; 48: 904–916.
  • Tkatchenko TV, Shen Y, Tkatchenko AV. Mouse experimental myopia has features of primate myopia. Invest Ophthalmol Vis Sci 2010; 51: 1297–1303.
  • Tejedor J, De LV. Refractive changes induced by form deprivation in the mouse eye. Invest Ophthalmol Vis Sci 2003; 44: 32–36.
  • Tkatchenko TV, Shen Y, Braun RD, Bawa G, Kumar P, Avrutsky I, Tkatchenko AV. Photopic visual input is necessary for emmetropization in mice. Exp Eye Res 2013; 115: 87–95.
  • Robbers Y, Koster EA, Krijbolder DI, Ruijs A, van Berloo S, Meijer JH. Temporal behaviour profiles of Mus musculus in nature are affected by population activity. Physiol Behav 2014; 139: 351–360.
  • de la Cera EG, Rodriguez G, Llorente L, Schaeffel F, Marcos S. Optical aberrations in the mouse eye. Vision Res 2006; 46: 2546–2553.
  • Geng Y, Schery LA, Sharma R, Dubra A, Ahmad K, Libby RT, Williams DR. Optical properties of the mouse eye. Biomed Opt Express 2011; 2: 717–738.
  • Pardue MT, Faulkner AE, Fernandes A, Yin H, Schaeffel F, Williams RW, Pozdeyev N et al. High susceptibility to experimental myopia in a mouse model with a retinal on pathway defect. Invest Ophthalmol Vis Sci 2008; 49: 706–712.
  • Crewther SG, Crewther DP. Inhibition of retinal ON/OFF systems differentially affects refractive compensation to defocus. Neuroreport 2003; 14: 1233–1237.
  • Mathis U, Schaeffel F. Glucagon‐related peptides in the mouse retina and the effects of deprivation of form vision. Graefes Arch Clin Exp Ophthalmol 2007; 245: 267–275.
  • Schippert R, Burkhardt E, Feldkaemper M, Schaeffel F. Relative axial myopia in Egr‐1 (ZENK) knockout mice. Invest Ophthalmol Vis Sci 2007; 48: 11–17.
  • Brand C, Schaeffel F, Feldkaemper MP. A microarray analysis of retinal transcripts that are controlled by image contrast in mice. Mol Vis 2007; 13: 920–932.
  • Liu H, Xiang N, Zhang H. Influence of high level TGF‐beta1 on scleral thickness. J Huazhong Univ Sci Technolog Med Sci 2007; 27: 601–604.
  • Barathi VA, Weon SR, Beuerman RW. Expression of muscarinic receptors in human and mouse sclera and their role in the regulation of scleral fibroblasts proliferation. Mol Vis 2009; 15: 1277–1293.
  • Zhou XT, Huang QZ, An JH, Lu RX, Qin XY, Jiang LQ, Li YA et al. Genetic deletion of the adenosine A(2A) receptor confers postnatal development of relative myopia in mice. Invest Ophthalmol Vis Sci 2010; 51: 4362–4370.
  • Gottlieb MD, Wallman J. Retinal activity modulates eye growth: evidence from rearing in stroboscopic illumination. Soc Neurosci Abstr 1987; 13: 1297.
  • Li S, Wu J, Ding H, Liao A, He H, Stell WK, Zhong X. Flicker downregulates the content of crystallin proteins in form‐deprived C57BL/6 mouse retina. Exp Eye Res 2012; 101: 1–8.
  • Park H, Tan CC, Faulkner A, Jabbar SB, Schmid G, Abey J, Iuvone PM et al. Retinal degeneration increases susceptibility to myopia in mice. Mol Vis 2013; 19: 2068–2079.
  • Park HN, Jabbar SB, Tan CC, Sidhu CS, Abey J, Aseem F, Schmid G et al. Visually‐driven ocular growth in mice requires functional rod photoreceptors. Invest Ophthalmol Vis Sci 2014; 55: 6272–6279.
  • Huang J, Hung LF, Smith EL 3rd. Effects of foveal ablation on the pattern of peripheral refractive errors in normal and form‐deprived infant rhesus monkeys (Macaca mulatta). Invest Ophthalmol Vis Sci 2011; 52: 6428–6434.
  • Pardue MT, Stone RA, Iuvone PM. Investigating mechanisms of myopia in mice. Exp Eye Res 2013; 114: 96–105.
  • Kroger RH, Wagner HJ. The eye of the blue acara (Aequidens pulcher, Cichlidae) grows to compensate for defocus due to chromatic aberration. J Comp Physiol A 1996; 179: 837–842.
  • Shen W, Vijayan M, Sivak JG. Inducing form‐deprivation myopia in fish. Invest Ophthalmol Vis Sci 2005; 46: 1797‐1803.
  • Sivak JG. The role of the lens in refractive development of the eye: animal models of ametropia. Exp Eye Res 2008; 87: 3–8.
  • Shen W, Sivak JG. Eyes of a lower vertebrate are susceptible to the visual environment. Invest Ophthalmol Vis Sci 2007; 48: 4829–4837.
  • Yeh LK, Liu CY, Kao WW, Huang CJ, Hu FR, Chien CL, Wang IJ. Knockdown of zebrafish lumican gene (ZLUM) causes scleral thinning and increased size of scleral coats. J Biol Chem 2010; 285: 28141–28155.
  • Andison ME, Sivak JG, Bird DM. The refractive development of the eye of the American kestrel (Falco sparverius): a new avian model. J Comp Physiol A 1992; 170: 565–574.
  • Schaeffel F, Wagner H. Emmetropization and optical development of the eye of the barn owl (Tyto alba). J Comp Physiol 1996; 178: 491‐498.
  • Tokoro T. Experimental myopia in rabbits. Invest Ophthalmol 1970; 9: 926–934.
  • Verolino M, Nastri G, Sellitti L, Costagliola C. Axial length increase in lid‐sutured rabbits. Surv Ophthalmol 1999; 44 (Suppl 1): S103–S108.
  • Gao Q, Liu Q, Ma P, Zhong X, Wu J, Ge J. Effects of direct intravitreal dopamine injections on the development of lid‐suture induced myopia in rabbits. Graefe's Arch Clin Exp Ophthalmol 2006; 244: 1329–1335.
  • Lin Z, Chen X, Ge J, Cui D, Wu J, Tang F, Tan J et al. Effects of direct intravitreal dopamine injection on sclera and retina in form‐deprived myopic rabbits. J Ocul Pharmacol Ther 2008; 24: 543–550.
  • Nie HH, Huo LJ, Yang X, Gao ZY, Zeng JW, Trier K, Cui DM. Effects of 7‐methylxanthine on form‐deprivation myopia in pigmented rabbits. Int J Ophthalmol 2012; 5: 133–137.
  • Gwiazda J, Hyman L, Hussein M, Everett D, Norton TT, Kurtz D, Leske MC et al. A randomized clinical trial of progressive addition lenses versus single vision lenses on the progression of myopia in children. Invest Ophthalmol Vis Sci 2003; 44: 1492–1500.
  • Berntsen DA, Sinnott LT, Mutti DO, Zadnik K. A randomized trial using progressive addition lenses to evaluate theories of myopia progression in children with a high lag of accommodation. Invest Ophthalmol Vis Sci 2012; 53: 640–649.
  • Cheng D, Schmid KL, Woo GC, Drobe B. Randomized trial of effect of bifocal and prismatic bifocal spectacles on myopic progression two‐year results. Arch Ophthalmol 2010; 128: 12–19.
  • Smith EL 3rd, Campbell MC, Irving E. Does peripheral retinal input explain the promising myopia control effects of corneal reshaping therapy (CRT or ortho‐K) & multifocal soft contact lenses? Ophthalmic Physiol Opt 2013; 33: 379–384.
  • Chung K, Mohidin N, O'leary DJ. Undercorrection of myopia enhances rather than inhibits myopia progression. Vision Res 2002; 42: 2555–2559.
  • Li L, Sankaridurg P, Naduvilath T, Chen X, Lin Z, Holden B, Brien Holden Vision Institute. What is the 'real' baseline for the rate of progress of myopia for a child? The rate of progress of myopia with and without spectacle vision correction. Invest Ophthalmol Vis Sci 2013; 54: 5718 (ARVO abstract).
  • Cheng D, Woo GC, Drobe B, Schmid KL. Effect of bifocal and prismatic bifocal spectacles on myopia progression in children: three‐year results of a randomized clinical trial. JAMA Ophthalmol 2014; 132: 258–264.
  • Phillips JR. Monovision slows juvenile myopia progression unilaterally. Br J Ophthalmol 2005; 89: 1196–1200.
  • Adler D, Millodot M. The possible effect of undercorrection on myopic progression in children. Clin Exp Optom 2006; 89: 315–321.
  • Diether S, Gekeler F, Schaeffel F. Changes in contrast sensitivity induced by defocus and their possible relations to emmetropization in the chicken. Invest Ophthalmol Vis Sci 2001; 42: 3072–3079.
  • Schaeffel F, Hagel G, Eikermann J, Collett T. Lower‐field myopia and astigmatism in amphibians and chickens. J Opt Soc Am A 1994; 11: 487–495.
  • Rabin J, Van sluyters RC, Malach R. Emmetropization: a vision‐dependent phenomenon. Invest Ophthalmol Vis Sci 1981; 20: 561–564.
  • O'leary DJ, Millodot M. Eyelid closure causes myopia in humans. Experientia 1979; 35: 1478–1479.
  • Meyer C, Muller M. [Form deprivation myopia caused by keratitis scrophulosa]. Ophthalmologe 1996; 93: 361–366.
  • von Noorden GK, Lewis RA. Ocular axial length in unilateral congenital cataracts and blepharoptosis. Invest Ophthalmol Vis Sci 1987; 28: 750–752.
  • Schmidt D, Meyer JH, Brandi DJ. Wide‐spread myelinated nerve fibers of the optic disc: do they influence the development of myopia? Int Ophthalmol 1996; 20: 263–268.
  • Atkinson J, Anker S, Bobier W, Braddick O, Durden K, Nardini M, Watson P. Normal emmetropization in infants with spectacle correction for hyperopia. Invest Ophthalmol Vis Sci 2000; 41: 3726–3731.
  • Mutti DO. To emmetropize or not to emmetropize? The question for hyperopic development. Optom Vis Sci 2007; 84: 97–102.
  • Read SA, Collins MJ, Sander BP. Human optical axial length and defocus. Invest Ophthalmol Vis Sci 2010; 51: 6262–6269.
  • Benard Y, Schaeffel F, Esser G, Seidemann A, Wildenmann U. Effects of short term full field or peripheral positive defocus on human axial length and choroidal thickness. Invest Ophthalmol Vis Sci 2014; 55: 2134.
  • Chakraborty R, Read SA, Collins MJ. Monocular myopic defocus and daily changes in axial length and choroidal thickness of human eyes. Exp Eye Res 2012; 103: 47–54.
  • Chakraborty R, Read SA, Collins MJ. Hyperopic defocus and diurnal changes in human choroid and axial length. Optom Vis Sci 2013; 90: 1187–1198.
  • Weiss S, Schaeffel F. Diurnal growth rhythms in the chicken eye: relation to myopia development and retinal dopamine levels. J Comp Physiol A 1993; 172: 263–270.
  • Rose KA, Morgan IG, Ip J, Kifley A, Huynh S, Smith W, Mitchell P. Outdoor activity reduces the prevalence of myopia in children. Ophthalmology 2008; 115: 1279–1285.
  • Jones LA, Sinnott LT, Mutti DO, Mitchell GL, Moeschberger ML, Zadnik K. Parental history of myopia, sports and outdoor activities, and future myopia. Invest Ophthalmol Vis Sci 2007; 48: 3524–3532.
  • Read SA, Collins MJ, Vincent SJ. Light exposure and physical activity in myopic and emmetropic children. Optom Vis Sci 2014; 91: 330‐341.
  • Lan W, Feldkaemper M, Schaeffel F. Intermittent episodes of bright light suppress myopia in the chicken more than continuous bright light. Plos One 2014; 9: e110906.
  • Karouta C, Ashby RS. Correlation between light levels and the development of deprivation myopia. Invest Ophthalmol Vis Sci 2015; 56: 299‐309.
  • Bedrossian RH. The effect of atropine on myopia. Ann Ophthalmol 1971; 3: 891–897.
  • Shih YF, Hsiao CK, Chen CJ, Chang CW, Hung PT, Lin LL. An intervention trial on efficacy of atropine and multi‐focal glasses in controlling myopic progression. Acta Ophthalmol Scand 2001; 79: 233–236.
  • Shih YF, Chen CH, Chou AC, Ho TC, Lin LL, Hung PT. Effects of different concentrations of atropine on controlling myopia in myopic children. J Ocul Pharmacol Ther 1999; 15: 85–90.
  • Chia A, Chua W‐H, Wen L, Fong A, Goon YY, Tan D. Atropine for the treatment of childhood myopia: changes after stopping atropine 0.01%, 0.1% and 0.5%. Am J Ophthalmol 2014; 157: 451–457.e451.
  • Schwahn HN, Kaymak H, Schaeffel F. Effects of atropine on refractive development, dopamine release, and slow retinal potentials in the chick. Vis Neurosci 2000; 17: 165–176.
  • Sander BP, Collins MJ, Read SA. The effect of topical adrenergic and anticholinergic agents on the choroidal thickness of young healthy adults. Exp Eye Res 2014; 128: 181–189.
  • Shaikh AW, Siegwart JT Jr, Norton TT. Effect of interrupted lens wear on compensation for a minus lens in tree shrews. Optom Vis Sci 1999; 76: 308–315.
  • Norton TT, Siegwart JT Jr, Amedo AO. Effectiveness of hyperopic defocus, minimal defocus, or myopic defocus in competition with a myopiagenic stimulus in tree shrew eyes. Invest Ophthalmol Vis Sci 2006; 47: 4687–4699.
  • Metlapally S, Mcbrien NA. The effect of positive lens defocus on ocular growth and emmetropization in the tree shrew. J Vision 2008; 8: 1–12.
  • Troilo D, Totonelly K, Harb E. Imposed anisometropia, accommodation, and regulation of refractive state. Optom Vis Sci 2009; 86: E31–39.
  • Norton TT. Animal models of myopia: learning how vision controls the size of the eye. ILAR J 1999; 40: 59–77.
  • Qian YF, Dai JH, Liu R, Chen MJ, Zhou XT, Chu RY. Effects of the chromatic defocus caused by interchange of two monochromatic lights on refraction and ocular dimension in guinea pigs. Plos One 2013; 8: e63229.
  • Nickla DL, Zhu X, Wallman J. Effects of muscarinic agents on chick choroids in intact eyes and eyecups: evidence for a muscarinic mechanism in choroidal thinning. Ophthalmic Physiol Opt 2013; 33: 245–256.
  • Mcbrien NA, Cornell LM, Gentle A. Structural and ultrastructural changes to the sclera in a mammalian model of high myopia. Invest Ophthalmol Vis Sci 2001; 42: 2179–2187.
  • He L, Frost MR, Norton TT. Differential gene expression in tree shrew retina compared with retinal pigment epithelium (RPE) in response to six hours of minus‐lens wear. Invest Ophthalmol Vis Sci 2014; 55: 3037.
  • Arumugam B, Mcbrien NA. Muscarinic antagonist control of myopia: evidence for m4 and m1 receptor‐based pathways in the inhibition of experimentally‐induced axial myopia in the tree shrew. Invest Ophthalmol Vis Sci 2012; 53: 5827–5837.
  • Norton TT, Rada JA. Reduced extracellular matrix in mammalian sclera with induced myopia. Vision Res 1995; 35: 1271–1281.
  • Norton TT, Rada JA. Reduced extracellular matrix in mammalian sclera with induced myopia. Vision Res 1995; 35: 1271–1281
  • Siegwart JT Jr, Strang CE. Selective modulation of scleral proteoglycan mRNA levels during minus lens compensation and recovery. Mol Vis 2007; 13: 1878–1886.
  • Mao JF, Liu. Mechanism of the DL‐alpha‐aminoadipic acid inhibitory effect on form‐deprived myopia in guinea pig. SZ Int J Ophthalmol 2013; 6:19–22
  • Le QH, Cheng NN, Wu W, Chu RY. Effect of pirenzepine ophthalmic solution on form‐deprivation myopia in the guinea pigs. Chin Med J 2005; 118: 561–566.
  • Wu J, Liu Q, Yang X, Yang H, Wang XM, Zeng JW. Time‐course of changes to nitric oxide signaling pathways in form‐deprivation myopia in guinea pigs. Brain Res 2007; 1186: 155–163.
  • Xiao H, Fan ZY, Tian XD, Xu YC. Comparison of form‐deprived myopia and lens‐induced myopia in guinea pigs. Int J Ophthalmol 2014; 7: 245–250.
  • Cui DM, Trier K, Zeng JW, Wu KL, Yu MB, Hu JM, Chen X et al. Effects of 7‐methylxanthine on the sclera in form deprivation myopia in guinea pigs. Acta Ophthalmol 2011; 89: 328–334.
  • Rada JA, Nickla DL, Troilo D. Decreased proteoglycan synthesis associated with form deprivation myopia in mature primate eyes. Invest Ophthalmol Vis Sci 2000; 41: 2050–2058.
  • Zhong X, Ge J, Smith EL 3rd, Stell WK. Image defocus modulates activity of bipolar and amacrine cells in macaque retina. Invest Ophthalmol Vis Sci 2004; 45: 2065–2074.
  • Tigges M, Iuvone PM, Fernandes A, Sugrue MF, Mallorga PJ, Laties AM, Stone RA. Effects of muscarinic cholinergic receptor antagonists on postnatal eye growth of rhesus monkeys. Optom Vis Sci 1999; 76: 397–407.
  • Funata M, Tokoro T. Scleral change in experimentally myopic monkeys. Graefe's Arch Clin Exp Ophthalmol 1990; 228: 174–179.

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