A review of the potential to restore vision with stem cells

REFERENCES

• Ahmad I, Dooley CM, Thoreson WB, Rogers JA, Afiat S. In vitro analysis of a mammalian retinal progenitor that gives rise to neurons and glia. Brain Res 1999; 831: 1–2.
   PubMed Web of Science ®Google Scholar
• Chacko DM, Rogers JA, Turner JE, Ahmad I. Survival and differentiation of cultured retinal progenitors transplanted in the subretinal space of the rat. Biochem Biophys Res Commun 2000; 268: 842–846.
   PubMed Web of Science ®Google Scholar
• Young MJ, Ray J, Whiteley SJO, Klassen H, Gage F. Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats. Mol Cell Neurosci 2000; 16: 197–205.
   PubMed Web of Science ®Google Scholar
• Snyder EY, Yoon C, Flax JD, Macklis JD. Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex. Proc Nat Acad Sci USA 1997; 94: 11663–11668.
   PubMed Web of Science ®Google Scholar
• Lanza R, Rosenthal N. The stem cell challenge. Sci Am 2004; 290: 93–99.
   Web of Science ®Google Scholar
• Thomson JA, Itskovitz‐eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282: 1145–1147.
   PubMed Web of Science ®Google Scholar
• Pederson R. Embryonic stem cells for medicine. Sci Am 1999; 280: 69–73.
   Web of Science ®Google Scholar
• Lee SH, Lumelsky N, Studer L, Auerback JM, Mckay RD. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol 2000; 18: 675–679.
   PubMed Web of Science ®Google Scholar
• Arnhold S. Klein H. Sembova I, Addicks K. Schraermeyer U. Neurally selected embryonic stem cells induce tumor formation after long‐term survival following engraftment into the subretinal space. Invest Ophthalmolol Vis Sci 2004; 45: 4251–4254.
   PubMed Web of Science ®Google Scholar
• Ahmad I, Tang L, Pham H. Identification of neural progenitors in the adult mammalian eye. Biochem Biophys Res Commun 2000; 270: 517–521.
   PubMed Web of Science ®Google Scholar
• Tropepe V, Coles BL, Chiasson BJ, Horsford DJ, Elia AJ, Mcinnes RR, Van der kooy D. Retinal stem cells in the adult mammalian eye. Science 2000; 287: 2032–2036.
   PubMed Web of Science ®Google Scholar
• Nishida A, Takahashi M, Tanihara H, Nakano I, Takahashi JB, Mizoguchi A, Ide C, Honda Y. Incorporation and differentiation of hippocampus‐derived neural stem cells transplanted in injured adult rat retina. Invest Ophthalmol Vis Sci 2000; 41: 4268–4274.
   PubMed Web of Science ®Google Scholar
• Kordower JH, Chen EY, Winkler C, Fricker R, Charles V, Messing A, Mufson EJ, Wong SC, Rosenstein JM, Bjorklund A, Emerich DF, Hammang J, Carpenter MK. Grafts of EGF‐responsive neural stem cells derived from GFAP‐hNGF transgenic mice: trophic and tropic effects in a rodent model of Huntington’s disease. J Comp Neurol 1997; 387: 96–113.
   Web of Science ®Google Scholar
• Cajal SR. Traumatic degeneration and regeneration of the optic nerve and retina. In: May R, ed. Degeneration and Regeneration of the Nervous System. Vol 2. New York: Hafner 1928; 583–596.
   Google Scholar
• Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 2001; 32: 1005–1011.
   PubMed Web of Science ®Google Scholar
• Thanos S, Thiel HJ. Mechanisms governing neuronal degeneration and axonal regeneration in the mature retinofugal system. J Cell Sci 1991; 15: 125–134.
   Google Scholar
• Richardson PM, Issa VMK, Shemie S. Regeneration and retrograde degeneration of axons in the rat optic nerve. J Neurocytol 1982; 11: 949–966.
   PubMedGoogle Scholar
• Di polo A, Aigner LJ, Dunn RJ, Bray GM, Aguayo AJ. Prolonged delivery of brain‐derived neurotrophic factor by adenovirus‐infected Müller cells temporarily rescues injured retinal ganglion cells. Proc Natl Acad Sci USA 1998; 95: 3978–3983.
   PubMed Web of Science ®Google Scholar
• Thanos S, Naskar R, Heiduschka P. Regenerating ganglion cell axons in the adult rat establish retinofugal topography and restore visual function. Exp Brain Res 1996; 114: 483–491.
   Web of Science ®Google Scholar
• Kim J, Wu HH, Lander AD, Lyons KM, Matzuk MM, Calof AL. GDF11 controls the timing of progenitor cell competence in developing retina. Science 2005; 308: 1927–1930.
   Web of Science ®Google Scholar
• Wiebel D, Cadelli D, Schwab ME. Regeneration of lesioned rat optic nerve fibers is improved after neutralization of myelin‐associated growth inhibitors. Brain Res 1994; 642: 259–266.
   Web of Science ®Google Scholar
• Takahashi M, Palmer T, Takahashi J, Gage F. Widespread integration and survival of adult‐derived neural progenitor cells in the developing optic retina. Mol Cell Neuro 1998; 12: 340–348.
   PubMed Web of Science ®Google Scholar
• Pressmar S, Ader M, Richard G, Schachner M. Bartsch U. The fate of heterotopically grafted neural precursor cells in the normal and dystrophic adult mouse retina. Invest Ophthalmol Vis Sci 2001; 42: 3311–3318.
   PubMed Web of Science ®Google Scholar
• Otteson DC, Hitchcock PF. Stem cells in the teleost retina: persistent neurogenesis and injury‐induced regeneration. Vision Res 2003; 43: 927–936.
   Web of Science ®Google Scholar
• Zhao X, Das AV, Thoreson WB, James J, Wattnem TE, Rodriguez‐sierra J, Ahmad I. Adult corneal limbal epithelium: a model for studying neural potential of non‐neural stem cells/progenitors. Dev Biol 2002; 250: 317–331.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Arner K, Ehinger B, Perez MTR. Limitation of anatomical integration between subretinal transplants and the host retina. Invest Ophthalmol Vis Sci 2003; 44: 324–331.
   PubMed Web of Science ®Google Scholar
• Mohand‐said S, Hicks D, Dreyfus H, Sahel JA. Selective transplantation of rods delays cone loss in a retinitis pigmentosa model. Arch Ophthalmol 2000; 118: 807–811.
   PubMedGoogle Scholar
• Meyer JS, Katz ML, Kirk MD. Stem cells for retinal degenerative disorders. Ann NY Acad Sci 2005; 1049: 135–145.
   Web of Science ®Google Scholar
• Klassen HJ, Ng TF, Kurimoto Y, Kirov I, Shatos M, Coffey P, Young MJ. Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light mediated behavior. Invest Ophthalmol Vis Sci 2004; 45: 4167–4172.
   PubMed Web of Science ®Google Scholar
• Wojciechowski AB, Englund U, Lundberg C, Warfvinge K. Long‐term survival and glial differentiation of the brain‐derived precursor cell line RN33B after subretinal transplantation to adult normal rats. Stem Cells 2002; 20: 163–173.
   PubMed Web of Science ®Google Scholar
• Wojciechowski AB, Englund U, Lundberg C, Wictorin K, Warfvinge K. Subretinal transplantation of brain‐derived precursor cells to young RCS rats promotes photoreceptor cell survival. Exp Eye Res 2002; 74: 23–37.
   Google Scholar
• Chen X, Katakowski M, Li Y, Lu D, Wang L, Zhang L, Chen J, Xu Y, Gautam S, Mahmood A, Chopp M. Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts; growth factor production. J Neurosci Res 2002; 69: 687–691.
   PubMed Web of Science ®Google Scholar
• Alvarez‐dolado M, Pardal R, Garcia‐verdugo JM, Fike JR, Lee HO, Pfeffer K, Lois C, Morrison SJ, Alvarez‐buylla A. Fusion of bone‐marrow‐derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 2003; 425: 928–973.
   Web of Science ®Google Scholar
• Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al‐dhalimy M. Cell fusion is the principal source of bone‐marrow‐derived hepatocytes. Nature 2003; 422: 897–901.
   PubMed Web of Science ®Google Scholar
• Warfvinge K, Kiilgaard JF, Lavik EB, Scherfig E, Langer R, Klassen HJ, Young MJ. Retinal progenitor cell xenografts to the pig retina. Arch Ophthalmol 2005; 123: 1385–1393.
   PubMed Web of Science ®Google Scholar
• Brummedorf T, Rathjen F. Cell Adhesion Molecules Immunoglobulin Superfamily. London: Academic Press, 1995.
   Google Scholar
• Holt CE. A single cell analysis of early retinal ganglion cell differentiation in xenopus from soma to axon tip. J Neurosci 1989; 9: 3123–3145.
   Web of Science ®Google Scholar
• Easter SSJ, Rusoff AC, Kish PE. The growth and organization of the optic nerve and tract in juvenile and adult goldfish. J Neurosci 1981; 1: 793–811.
   Web of Science ®Google Scholar
• Snow DM, Watanabe M, Letourneau PC, Silver J. A chondrotin sulfate proteoglycan may influence the direction of retinal ganglion cell outgrowth. Development 1991; 113: 1473–1485.
   Web of Science ®Google Scholar
• Stier H. Schlosshauer B. Axonal guidance in the chick retina. Development 1995; 121: 1443–1454.
   Web of Science ®Google Scholar
• Canning DR, Hoke A, Malemud CJ, Silver J. A potent inhibitor of nerve outgrowth that predominates in the extracellular matrix of reactive astrocytes. Int J Dev Neurosci 1996; 14: 153–175.
   PubMed Web of Science ®Google Scholar
• Snow DM, Lemmon V, Carrino DA, Caplan AI, Silver J. Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro. Exp Neurol 1990; 109:111–130.
   PubMed Web of Science ®Google Scholar
• Cheng H, Cao Y, Olson L. Spinal cord repair in adult paraplegic rats: partial restoration of hind limb function. Science 1996; 273: 510–513.
   PubMed Web of Science ®Google Scholar
• Carter DA, Bray GM, Aguayo AJ. Long‐term growth and remodeling of regeneration retino‐collicular connections in adult hamsters. J Neurosci 1994; 14: 590–598.
   Web of Science ®Google Scholar
• Carter DA, Bray GM, Aguayo AJ. Regenerated retinal ganglion cell axons can form well‐differentiated synapses in the superior colliculus of hamsters. J Neurosci 1989; 9: 4042–4050.
   Web of Science ®Google Scholar
• Keirstead SA, Rasminksky M, Fukuda Y, Darter DA, Aguayo AJ, Vidal‐sanz M. Electrophysiologic responses in hamster superior colliculus evoked by regeneration retinal axons. Science 1989; 246: 255–257.
   PubMed Web of Science ®Google Scholar
• Thanos S. Adult retinofugal axons regeneration through peripheral nerve grafts can restore the light‐induced pupilloconstriction reflex. Eur J Neurosci 1992; 4: 691–699.
   Web of Science ®Google Scholar
• Fricker RA, Carpenter MK, Winkler C, Greco C, Gates MA, Bjorklund A. Site‐specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain. J Neurosci 1999; 19: 5990–6005.
   PubMed Web of Science ®Google Scholar
• Aberg MA, Aberg ND, Hedbacker H, Oscarsson J, Eriksson PS. Peripheral infusion of IGF‐I selectively induces neurogenesis in the adult rat hippocampus. J Neurosci 2000; 20: 2896–2903.
   PubMed Web of Science ®Google Scholar
• Magavi SS, Leavitt BR, Macklis JD. Induction of neurogenesis in the neocortex of adult mice. Nature 2000; 405: 951–955.
   PubMed Web of Science ®Google Scholar
• Fricker‐gates RA, Shin JJ, Tai CC, Catapano LA, Macklis JD. Late‐stage immature neocortical neurons reconstruct interhemispheric connections and form synaptic contacts with increased efficiency in adult mouse cortex undergoing targeted neurodegeneration. J Neurosci 2002; 22: 4045–4056.
   Web of Science ®Google Scholar
• Gage FH, Kempermann G, Palmer TD, Peterson DA, Ray J. Multipotent progenitor cells in the adult dentate gyrus. J Neurobiol 1998; 36: 249–266.
   PubMedGoogle Scholar
• Nakatomi H, Kuriu T, Okabe S, Yamamoto S, Hatano O, Kawahara N, Tamura A, Kirino T, Nakafuku M. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 2002; 110: 429–441.
   PubMed Web of Science ®Google Scholar
• Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med 2002; 8: 963–970.
   PubMed Web of Science ®Google Scholar
• Englund U, Fricker‐gates RA, Lundberg C, Bjorklund A, Wictorin K. Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long‐distance axonal projections. Exp Neurol 2002; 173: 1–21.
   Web of Science ®Google Scholar
• Scharff C, Kiru JR, Grossman M, Macklis JD, Nottebohm F. Targeted neuronal death affects neuronal replacement and vocal behavior in adult songbirds. Neuron 2000; 25: 481–492.
   PubMed Web of Science ®Google Scholar
• Pellegrini G, Golisano O, Paterna P, Lambiase A, Bonini S, Rama P, De luca M. Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface. J Cell Biol 1999; 145: 769–782.
   PubMed Web of Science ®Google Scholar
• Kenyon KR, Tseng SC. Limbal autograft transplantation for ocular surface disorders. Ophthalmology 1989; 96: 709–722.
   PubMed Web of Science ®Google Scholar
• Dogru M, Tsubot K. Survival analysis of conjunctival limbal grafts and amnionic membrane transplantation in eyes with total limbal stem cell deficiency. Am J Ophthalmol 2005; 140: 305–306.
   Google Scholar
• Wallace VA. Stem cells: a source for neuron repair in retinal disease. Can J Ophthalmol 2007; 42: 442–446.
   Web of Science ®Google Scholar
• Sangwan VS, Matalia HP, Vemuganti GK, Fatima A, Ifthekar G, Singh S, Nutheti R, Rao GN. Clinical outcome of autologous cultivated limbal epithelium transplantation. Indian J Ophthalmol 2006; 54: 29–34.
   PubMedGoogle Scholar
• Ang LP, Sotozono C, Loizumi N, Suzuki T, Inatomi T, Kinoshita S. A comparison between cultivated and conventional limbal stem cell transplantation for Steven‐Johnson syndrome. Am J Ophthalmol 2007; 143: 178–180.
   PubMed Web of Science ®Google Scholar
• Kinoshita S, Koizumi N, Sotozono C, Yamada J, Nakamura T, Inatomi T. Concept and clinical application of cultivated epithelial transplantation for ocular surface disorders. Ocul Surf 2004; 2: 21–33.
   Google Scholar
• Tsubota K, Satake Y, Kaido M, Shinozaki N, Shimmura S, Bissen‐miyajima H, Shimazaki J. Treatment of severe ocular‐surface disorders with corneal epithelial stem‐cell transplantation. N Engl J Med 1999; 340: 1697–1703.
   PubMed Web of Science ®Google Scholar
• Binder S, Stolba U, Krebs I, Kellner L, Jahn C, Feichtinger H, Povelka M, Frohner U, Kruger A, Hilgers RD, Krugluger W. Transplantation of autologous retinal pigment epithelium in eyes with foveal neovascularization resulting from age‐related macular degeneration: a pilot study. Am J Ophthalmol 2002; 133: 215–225.
   PubMed Web of Science ®Google Scholar
• Blind World Magazine. Stem cell promise cure for vision loss. 2006 Apr 19 URL: http://www.home.earthlink.net/~blindworld2/MEDICAL/6‐04‐19‐01.htm. Accessed 22 May 2007.
   Google Scholar
• Blind World Magazine. Retinitis pigmentosa (RP) patient gets stem cell implant. 2006 May 5. URL: http://www.home.earthlink.net/~blindworld2/MEDICAL/6‐05‐05‐02.htm. Accessed 22 May 2007.
   Google Scholar
• Gage FH. Mammalian neural stem cells. Science 2000; 287: 1433–1438.
   PubMed Web of Science ®Google Scholar