TPC1 Knockout Knocks Out TPC1

REFERENCES

• Rahman T, Cai X, Brailoiu GC, Abood ME, Brailoiu E, Patel S. 2014. Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels. Sci Signal 7:ra109. http://dx.doi.org/10.1126/scisignal.2005450.
   PubMed Web of Science ®Google Scholar
• Patel S, Docampo R. 2010. Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling. Trends Cell Biol 20:277–286. http://dx.doi.org/10.1016/j.tcb.2010.02.003.
   PubMed Web of Science ®Google Scholar
• Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans MA, Galione A, Zhu MX. 2009. NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459:596–600. http://dx.doi.org/10.1038/nature08030.
   PubMed Web of Science ®Google Scholar
• Brailoiu E, Churamani D, Cai X, Schrlau MG, Brailoiu GC, Gao X, Hooper R, Boulware MJ, Dun NJ, Marchant JS, Patel S. 2009. Essential requirement for two pore channel 1 in NAADP-mediated calcium signalling. J Cell Biol 186:201–209. http://dx.doi.org/10.1083/jcb.200904073.
   PubMed Web of Science ®Google Scholar
• Zong X, Schieder M, Cuny H, Fenske S, Gruner C, Rötzer K, Griesbeck O, Harz H, Biel M, Wahl-Schott C. 2009. The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores. Pflugers Arch 458:891–899. http://dx.doi.org/10.1007/s00424-009-0690-y.
   PubMed Web of Science ®Google Scholar
• Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. 2012. TPC proteins are phosphoinositide-activated sodium-selective ion channels in endosomes and lysosomes. Cell 151:372–383. http://dx.doi.org/10.1016/j.cell.2012.08.036.
   PubMed Web of Science ®Google Scholar
• Jha A, Ahuja M, Patel S, Brailoiu E, Muallem S. 2014. Convergent regulation of the lysosomal two-pore channel-2 by Mg2+, NAADP, PI(3,5)P2 and multiple protein kinases. EMBO J 33:501–511. http://dx.doi.org/10.1002/embj.201387035.
   PubMedGoogle Scholar
• Lin-Moshier Y, Keebler MV, Hooper R, Boulware MJ, Liu X, Churamani D, Abood ME, Walseth TF, Brailoiu E, Patel S, Marchant JS. 2014. The two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation. Proc Natl Acad Sci U S A 111:13087–13092. http://dx.doi.org/10.1073/pnas.1407004111.
   PubMed Web of Science ®Google Scholar
• Marchant JS, Patel S. 2013. Questioning regulation of two-pore channels by NAADP. Messenger 2:113–119. http://dx.doi.org/10.1166/msr.2013.1027.
   Google Scholar
• Morgan AJ, Galione A. February 2013. Two-pore channels (TPCs): current controversies. Bioessays http://dx.doi.org/10.1002/bies.201300118.
   Google Scholar
• Lin-Moshier Y, Walseth TF, Churamani D, Davidson SM, Slama JT, Hooper R, Brailoiu E, Patel S, Marchant JS. 2012. Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells. J Biol Chem 287:2296–2307. http://dx.doi.org/10.1074/jbc.M111.305813.
   PubMedGoogle Scholar
• Walseth TF, Lin-Moshier Y, Jain P, Ruas M, Parrington J, Galione A, Marchant JS, Slama JT. 2012. Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg. J Biol Chem 287:2308–2315. http://dx.doi.org/10.1074/jbc.M111.306563.
   PubMedGoogle Scholar
• Walseth TF, Lin-Moshier Y, Weber K, Marchant JS, Slama JT, Guse AH. 2012. Nicotinic acid adenine dinucleotide 2′-phosphate binding proteins in T lymphocytes. Messenger 1:86–94. http://dx.doi.org/10.1166/msr.2012.1008.
   Google Scholar
• Marchant JS, Lin-Moshier Y, Walseth T, Patel S. 2012. The molecular basis for Ca2+ signalling by NAADP: two-pore channels in a complex? Messenger 1:63–76. http://dx.doi.org/10.1166/msr.2012.1003.
   Google Scholar
• Ruas M, Chuang KT, Davis LC, Al-Douri A, Tynan PW, Tunn R, Teboul L, Galione A, Parrington J. 2014. TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2. Mol Cell Biol 34:3981–3992. http://dx.doi.org/10.1128/MCB.00113-14.
   PubMed Web of Science ®Google Scholar
• Churamani D, Hooper R, Rahman T, Brailoiu E, Patel S. 2013. The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP. Biochem J 453:147–151. http://dx.doi.org/10.1042/BJ20130474.
   PubMedGoogle Scholar
• Hooper R, Churamani D, Brailoiu E, Taylor CW, Patel S. 2011. Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation. J Biol Chem 286:9141–9149. http://dx.doi.org/10.1074/jbc.M110.189985.
   PubMed Web of Science ®Google Scholar
• Hockey L, Kilpatrick BS, Eden ER, Lin-Moshier Y, Brailoiu GC, Brailoiu E, Futter CE, Schapira AH, Marchant JS, Patel S. 2015. Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition. J Cell Sci 128:232–238. http://dx.doi.org/10.1242/jcs.164152.
   PubMed Web of Science ®Google Scholar