Highly Specific Alternative Splicing of Transcripts Encoding BK Channels in the Chicken's Cochlea Is a Minor Determinant of the Tonotopic Gradient

REFERENCES

• Art, J. J., and R. Fettiplace. 1987. Variation of membrane properties in hair cells isolated from the turtle cochlea. J. Physiol. 385:207–242.
   PubMed Web of Science ®Google Scholar
• Art, J. J., Y. C. Wu, and R. Fettiplace. 1995. The calcium-activated potassium channels of turtle hair cells. J. Gen. Physiol. 105:49–72.
   PubMedGoogle Scholar
• Beisel, K. W., S. M. Rocha-Sanchez, S. J. Ziegenbein, K. A. Morris, C. Kai, J. Kawai, P. Carninci, Y. Hayashizaki, and R. L. Davis. 2007. Diversity of Ca2+-activated K+ channel transcripts in inner ear hair cells. Gene 386:11–23.
   PubMedGoogle Scholar
• Brandle, U., S. Frohnmayer, T. Krieger, H. P. Zenner, J. P. Ruppersberg, and M. M. Maassen. 2001. Expression of Ca2+-activated K+ channel subunits and splice variants in the rat cochlea. Hear Res. 161:23–28.
   PubMedGoogle Scholar
• Brownstein, M. J., J. D. Carpten, and J. R. Smith. 1996. Modulation of non-templated nucleotide addition by Taq DNA polymerase: primer modifications that facilitate genotyping. Biotechniques 20:1004–1010.
   PubMed Web of Science ®Google Scholar
• Duncan, R. K., and P. A. Fuchs. 2003. Variation in large-conductance, calcium-activated potassium channels from hair cells along the chicken basilar papilla. J. Physiol. 547:357–371.
   PubMedGoogle Scholar
• Enright, A. J., B. John, U. Gaul, T. Tuschl, C. Sander, and D. S. Marks. 2003. MicroRNA targets in Drosophila. Genome Biol. 5:R1.
   PubMed Web of Science ®Google Scholar
• Fettiplace, R., and P. A. Fuchs. 1999. Mechanisms of hair cell tuning. Annu. Rev. Physiol. 61:809–834.
   PubMedGoogle Scholar
• Gao, T., A. J. Chien, and M. M. Hosey. 1999. Complexes of the α1C and β subunits generate the necessary signal for membrane targeting of class C L-type calcium channels. J. Biol. Chem. 274:2137–2144.
   PubMed Web of Science ®Google Scholar
• Hoffmann, R., and A. Valencia. 2004. A gene network for navigating the literature. Nat. Genet. 36:664.
   PubMed Web of Science ®Google Scholar
• Hudspeth, A. J. 1997. How hearing happens. Neuron 19:947–950.
   PubMed Web of Science ®Google Scholar
• Hudspeth, A. J., and R. S. Lewis. 1988. A model for electrical resonance and frequency tuning in saccular hair cells of the bull-frog, Rana catesbeiana. J. Physiol. 400:275–297.
   PubMedGoogle Scholar
• Jespersen, T., M. Grunnet, K. Angelo, D. A. Klaerke, and S. P. Olesen. 2002. Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes. Biotechniques 32:536–540.
   PubMed Web of Science ®Google Scholar
• Jiang, G. J., M. Zidanic, R. L. Michaels, T. H. Michael, C. Griguer, and P. A. Fuchs. 1997. cSlo encodes calcium-activated potassium channels in the chick's cochlea. Proc. Biol. Sci. 264:731–737.
   PubMedGoogle Scholar
• Jones, E. M., M. Gray-Keller, J. J. Art, and R. Fettiplace. 1999. The functional role of alternative splicing of Ca2+-activated K+ channels in auditory hair cells. Ann. N. Y. Acad. Sci. 868:379–385.
   PubMedGoogle Scholar
• Jones, E. M., M. Gray-Keller, and R. Fettiplace. 1999. The role of Ca2+-activated K+ channel spliced variants in the tonotopic organization of the turtle cochlea. J. Physiol. 518 (Pt. 3):653–665.
   PubMed Web of Science ®Google Scholar
• Jones, E. M., C. Laus, and R. Fettiplace. 1998. Identification of Ca2+-activated K+ channel splice variants and their distribution in the turtle cochlea. Proc. Biol. Sci. 265:685–692.
   PubMedGoogle Scholar
• Kim, E. Y., L. D. Ridgway, S. Zou, Y. H. Chiu, and S. E. Dryer. 2007. Alternatively spliced C-terminal domains regulate the surface expression of large conductance calcium-activated potassium channels. Neuroscience 146:1652–1661.
   PubMed Web of Science ®Google Scholar
• Kim, E. Y., S. Zou, L. D. Ridgway, and S. E. Dryer. 2007. Beta1-subunits increase surface expression of a large-conductance Ca2+-activated K+ channel isoform. J. Neurophysiol. 97:3508–3516.
   PubMedGoogle Scholar
• Konig, H., N. Matter, R. Bader, W. Thiele, and F. Muller. 2007. Splicing segregation: the minor spliceosome acts outside the nucleus and controls cell proliferation. Cell 131:718–729.
   PubMed Web of Science ®Google Scholar
• Kutzleb, C., G. Sanders, R. Yamamoto, X. Wang, B. Lichte, E. Petrasch-Parwez, and M. W. Kilimann. 1998. Paralemmin, a prenyl-palmitoyl-anchored phosphoprotein abundant in neurons and implicated in plasma membrane dynamics and cell process formation. J. Cell Biol. 143:795–813.
   PubMedGoogle Scholar
• Kwon, S. H., and W. B. Guggino. 2004. Multiple sequences in the C terminus of MaxiK channels are involved in expression, movement to the cell surface, and apical localization. Proc. Natl. Acad. Sci. U. S. A. 101:15237–15242.
   PubMedGoogle Scholar
• Langer, P., S. Grunder, and A. Rusch. 2003. Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea. J. Comp. Neurol. 455:198–209.
   PubMed Web of Science ®Google Scholar
• Lewis, B. P., R. E. Green, and S. E. Brenner. 2003. Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc. Natl. Acad. Sci. U. S. A. 100:189–192.
   PubMed Web of Science ®Google Scholar
• Lewis, R. S., and A. J. Hudspeth. 1983. Voltage- and ion-dependent conductances in solitary vertebrate hair cells. Nature 304:538–541.
   PubMed Web of Science ®Google Scholar
• Lu, R., A. Alioua, Y. Kumar, M. Eghbali, E. Stefani, and L. Toro. 2006. MaxiK channel partners: physiological impact. J. Physiol. 570:65–72.
   PubMed Web of Science ®Google Scholar
• Ma, D., T. Nakata, G. Zhang, T. Hoshi, M. Li, and S. Shikano. 2007. Differential trafficking of carboxyl isoforms of Ca2+-gated (Slo1) potassium channels. FEBS Lett. 581:1000–1008.
   PubMed Web of Science ®Google Scholar
• Marciniak, S. J., and D. Ron. 2006. Endoplasmic reticulum stress signaling in disease. Physiol. Rev. 86:1133–1149.
   PubMed Web of Science ®Google Scholar
• Morrow, J. P., S. I. Zakharov, G. Liu, L. Yang, A. J. Sok, and S. O. Marx. 2006. Defining the BK channel domains required for beta1-subunit modulation. Proc. Natl. Acad. Sci. U. S. A. 103:5096–5101.
   PubMedGoogle Scholar
• Navaratnam, D. S., T. J. Bell, T. D. Tu, E. L. Cohen, and J. C. Oberholtzer. 1997. Differential distribution of Ca2+-activated K+ channel splice variants among hair cells along the tonotopic axis of the chick cochlea. Neuron 19:1077–1085.
   PubMedGoogle Scholar
• Orio, P., P. Rojas, G. Ferreira, and R. Latorre. 2002. New disguises for an old channel: MaxiK channel beta-subunits. News Physiol. Sci. 17:156–161.
   PubMedGoogle Scholar
• Pietrzykowski, A. Z., R. M. Friesen, G. E. Martin, S. I. Puig, C. L. Nowak, P. M. Wynne, H. T. Siegelmann, and S. N. Treistman. 2008. Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol. Neuron 59:274–287.
   PubMed Web of Science ®Google Scholar
• Qian, X., C. M. Nimigean, X. Niu, B. L. Moss, and K. L. Magleby. 2002. Slo1 tail domains, but not the Ca2+ bowl, are required for the beta 1 subunit to increase the apparent Ca2+ sensitivity of BK channels. J. Gen. Physiol. 120:829–843.
   PubMedGoogle Scholar
• Ramanathan, K., and P. A. Fuchs. 2002. Modeling hair cell tuning by expression gradients of potassium channel beta subunits. Biophys. J. 82:64–75.
   PubMedGoogle Scholar
• Ramanathan, K., T. H. Michael, and P. A. Fuchs. 2000. beta subunits modulate alternatively spliced, large conductance, calcium-activated potassium channels of avian hair cells. J. Neurosci. 20:1675–1684.
   PubMedGoogle Scholar
• Ramanathan, K., T. H. Michael, G. J. Jiang, H. Hiel, and P. A. Fuchs. 1999. A molecular mechanism for electrical tuning of cochlear hair cells. Science 283:215–217.
   PubMedGoogle Scholar
• Rosenblatt, K. P., Z. P. Sun, S. Heller, and A. J. Hudspeth. 1997. Distribution of Ca2+-activated K+ channel isoforms along the tonotopic gradient of the chicken's cochlea. Neuron 19:1061–1075.
   PubMedGoogle Scholar
• Salkoff, L., A. Butler, G. Ferreira, C. Santi, and A. Wei. 2006. High-conductance potassium channels of the SLO family. Nat. Rev. Neurosci. 7:921–931.
   PubMed Web of Science ®Google Scholar
• Soom, M., G. Gessner, H. Heuer, T. Hoshi, and S. H. Heinemann. 2008. A mutually exclusive alternative exon of slo1 codes for a neuronal BK channel with altered function. Channels 2:278–282.
   PubMed Web of Science ®Google Scholar
• Toro, B., N. Cox, R. J. Wilson, E. Garrido-Sanabria, E. Stefani, L. Toro, and M. M. Zarei. 2006. KCNMB1 regulates surface expression of a voltage and Ca2+-activated K+ channel via endocytic trafficking signals. Neuroscience 142:661–669.
   PubMed Web of Science ®Google Scholar
• Valencia-Sanchez, M. A., J. Liu, G. J. Hannon, and R. Parker. 2006. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20:515–524.
   PubMed Web of Science ®Google Scholar
• Weston, M. D., M. L. Pierce, S. Rocha-Sanchez, K. W. Beisel, and G. A. Soukup. 2006. MicroRNA gene expression in the mouse inner ear. Brain Res. 1111:95–104.
   PubMedGoogle Scholar
• Wu, Y. C., J. J. Art, M. B. Goodman, and R. Fettiplace. 1995. A kinetic description of the calcium-activated potassium channel and its application to electrical tuning of hair cells. Prog. Biophys. Mol. Biol. 63:131–158.
   PubMed Web of Science ®Google Scholar
• Zarei, M. M., N. Zhu, A. Alioua, M. Eghbali, E. Stefani, and L. Toro. 2001. A novel MaxiK splice variant exhibits dominant-negative properties for surface expression. J. Biol. Chem. 276:16232–16239.
   PubMed Web of Science ®Google Scholar