Brain-Specific Homeobox Factor as a Target Selector for Glucocorticoid Receptor in Energy Balance

REFERENCES

• Fehm HL, Born J, Peters A. 2004. Glucocorticoids and melanocortins in the regulation of body weight in humans. Horm. Metab. Res. 36:360–364.
   PubMedGoogle Scholar
• Coppola A, Diano S. 2007. Hormonal regulation of the arcuate nucleus melanocortin system. Front. Biosci. 12:3519–3530.
   PubMed Web of Science ®Google Scholar
• Jeanrenaud B, Rohner-Jeanrenaud F. 2000. CNS-periphery relationships and body weight homeostasis: influence of the glucocorticoid status. Int. J. Obes. Relat. Metab. Disord. 24(Suppl. 2):S74–S76.
   PubMedGoogle Scholar
• Makimura H, Mizuno TM, Isoda F, Beasley J, Silverstein JH, Mobbs CV. 2003. Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression. BMC Physiol. 3:5. doi:10.1186/1472-6793-3-5.
   PubMedGoogle Scholar
• Savontaus E, Conwell IM, Wardlaw SL. 2002. Effects of adrenalectomy on AGRP, POMC, NPY and CART gene expression in the basal hypothalamus of fed and fasted rats. Brain Res. 958:130–138.
   PubMed Web of Science ®Google Scholar
• Dhillo WS, Small CJ, Gardiner JV, Bewick GA, Whitworth EJ, Jethwa PH, Seal LJ, Ghatei MA, Hinson JP, Bloom SR. 2003. Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland. Biochem. Biophys. Res. Commun. 301:102–107.
   PubMedGoogle Scholar
• Shimizu H, Arima H, Watanabe M, Goto M, Banno R, Sato I, Ozaki N, Nagasaki H, Oiso Y. 2008. Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats. Endocrinology 149:4544–4553.
   PubMed Web of Science ®Google Scholar
• Stahn C, Löwenberg M, Hommes DW, Buttgereit F. 2007. Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists. Mol. Cell. Endocrinol. 275:71–78.
   PubMed Web of Science ®Google Scholar
• Adcock IM, Caramori G. 2001. Cross-talk between pro-inflammatory transcription factors and glucocorticoids. Immunol. Cell Biol. 79:376–384.
   PubMed Web of Science ®Google Scholar
• Cremona M, Colombo E, Andreazzoli M, Cossu G, Broccoli V. 2004. Bsx, an evolutionary conserved brain specific homeobox gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus. Gene Expr. Patterns 4:47–51.
   PubMedGoogle Scholar
• McArthur T, Ohtoshi A. 2007. A brain-specific homeobox gene, Bsx, is essential for proper postnatal growth and nursing. Mol. Cell. Biol. 27:5120–5127.
   PubMedGoogle Scholar
• Sakkou M, Wiedmer P, Anlag K, Hamm A, Seuntjens E, Ettwiller L, Tschöp MH, Treier M. 2007. A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior. Cell Metab. 5:450–463.
   PubMed Web of Science ®Google Scholar
• Nogueiras R, López M, Lage R, Perez-Tilve D, Pfluger P, Mendieta-Zerón H, Sakkou M, Wiedmer P, Benoit SC, Datta R, Dong JZ, Culler M, Sleeman M, Vidal-Puig A, Horvath T, Treier M, Diéguez C, Tschöp MH. 2008. Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability. Endocrinology 149:3009–3015.
   PubMedGoogle Scholar
• Ceccatelli S, Cintra A, Hökfelt T, Fuxe K, Wikström AC, Gustafsson JA. 1989. Coexistence of glucocorticoid receptor-like immunoreactivity with neuropeptides in the hypothalamic paraventricular nucleus. Exp. Brain Res. 78:33–42.
   PubMed Web of Science ®Google Scholar
• Cone RD, Cowley MA, Butler AA, Fan W, Marks DL, Low MJ. 2001. The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int. J. Obes. Relat. Metab. Disord. 25(Suppl. 5):S63–S67.
   PubMed Web of Science ®Google Scholar
• Baulieu EE. 1988. RU486 (an anti-steroid hormone) receptor structure and heat shock protein mol. wt 90,000 (hsp 90). Hum. Reprod. 3:541–547.
   PubMedGoogle Scholar
• Brewer JA. 2003. T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat. Med. 9:1318–1322.
   PubMedGoogle Scholar
• Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, Orban PC, Bock R, Klein R, Schutz G. 1999. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat. Genet. 23:99–103.
   PubMed Web of Science ®Google Scholar
• Tong Q, Ye C-P, Jones JE, Elmquist JK, Lowell BB. 2008. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat. Neurosci. 11:998–1000.
   PubMed Web of Science ®Google Scholar
• Kitamura T, Feng Y, Kitamura YI, Chua SCJr, Xu AW, Barsh GS, Rossetti L, Accili D. 2006. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat. Med. 12:534–540.
   PubMed Web of Science ®Google Scholar
• Kim MS, Pak YK, Jang PG, Namkoong C, Choi YS, Won JC, Kim KS, Kim SW, Kim HS, Park JY, Kim YB, Lee KU. 2006. Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nat. Neurosci. 9:901–906.
   PubMed Web of Science ®Google Scholar
• Muraoka O, Xu B, Tsurumaki T, Akira S, Yamaguchi T, Higuchi H. 2003. Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines. Neurochem. Int. 42:591–601.
   PubMedGoogle Scholar
• Zhang K, Rao F, Pablo Miramontes-Gonzalez J, Hightower CM, Vaught B, Chen Y, Greenwood TA, Schork AJ, Wang L, Mahata M, Stridsberg M, Khandrika S, Biswas N, Fung MM, Waalen J, Middelberg RP, Heath AC, Montgomery GW, Martin NG, Whitfield JB, Baker DG, Schork NJ, Nievergelt CM, O'Connor DT. 2012. Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses. J. Am. Coll. Cardiol. 60:1678–1689.
   PubMed Web of Science ®Google Scholar
• Reichardt HM, Kaestner KH, Tuckermann J, Kretz O, Wessely O, Bock R, Gass P, Schmid W, Herrlich P, Angel P, Schütz G. 1998. DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93:531–541.
   PubMed Web of Science ®Google Scholar
• So AY, Bernal TU, Pillsbury ML, Yamamoto KR, Feldman BJ. 2009. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proc. Natl. Acad. Sci. U. S. A. 106:17582–17587.
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Nakahata Y, Tanaka M, Yoshida M, Soma H, Shinohara K, Yasuda A, Mamine T, Takumi T. 2005. Acute physical stress elevates mouse period1 mRNA expression in mouse peripheral tissues via a glucocorticoid-responsive element. J. Biol. Chem. 280:42036–42043.
   PubMed Web of Science ®Google Scholar
• Matsui D, Takekida S, Okamura H. 2005. Molecular oscillation of Per1 and Per2 genes in the rodent brain: an in situ hybridization and molecular biological study. Kobe J. Med. Sci. 51:85–93.
   PubMedGoogle Scholar
• Feillet CA, Mendoza J, Albrecht U, Pévet P, Challet E. 2008. Forebrain oscillators ticking with different clock hands. Mol. Cell Neurosci. 37:209–221.
   PubMed Web of Science ®Google Scholar
• Minana-Solis MC, Angeles-Castellanos M, Feillet C, Pevet P, Challet E, Escobar C. 2009. Differential effects of a restricted feeding schedule on clock-gene expression in the hypothalamus of the rat. Chronobiol. Int. 26:808–820.
   PubMed Web of Science ®Google Scholar
• Shieh KR, Yang SC, Lu XY, Akil H, Watson SJ. 2005. Diurnal rhythmic expression of the rhythm-related genes, rPeriod1, rPeriod2, and rClock, in the rat brain. J. Biomed. Sci. 12:209–217.
   PubMed Web of Science ®Google Scholar
• Li JY, Kuick R, Thompson RC, Misek DE, Lai YM, Liu YQ, Chai BX, Hanash SM, Gantz I. 2005. Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuits. J. Neuroendocrinol. 17:394–404.
   PubMedGoogle Scholar
• Hechler D, Nitsch R, Hendrix S. 2006. Green-fluorescent-protein-expressing mice as models for the study of axonal growth and regeneration in vitro. Brain Res. Rev. 52:160–169.
   PubMedGoogle Scholar
• Reddi PP, Urekar CJ, Abhyankar MM, Ranpura SA. 2007. Role of an insulator in testis-specific gene transcription. Ann. N. Y. Acad. Sci. 1120:95–103.
   PubMed Web of Science ®Google Scholar
• Sahar S, Sassone-Corsi P. 2012. Regulation of metabolism: the circadian clock dictates the time. Trends Endocrinol. Metab. 23:1–8.
   PubMed Web of Science ®Google Scholar
• Li JY, Chai B, Zhang W, Wu X, Zhang C, Fritze D, Xia Z, Patterson C, Mulholland MW. 2011. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation. BMC Neurosci. 12:95. doi:10.1186/1471-2202-12-95.
   PubMedGoogle Scholar
• Jovanovic Z, Tung YC, Lam BY, O'Rahilly S, Yeo GS. 2010. Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin. J. Neuroendocrinol. 22:915–925.
   PubMedGoogle Scholar