Actin-Induced Hyperactivation of the Ras Signaling Pathway Leads to Apoptosis in Saccharomyces cerevisiae

REFERENCES

• Ayscough, K. R., J. J. Eby, T. Lila, H. Dewar, K. G. Kozminski, and D. G. Drubin. 1999. Sla1p is a functionally modular component of the yeast cortical actin cytoskeleton required for correct localization of both Rho1p-GTPase and Sla2p, a protein with talin homology. Mol. Biol. Cell 10:1061–1075.
   PubMedGoogle Scholar
• Balaban, R. S., S. Nemoto, and T. Finkel. 2005. Mitochondria, oxidants, and aging. Cell 120:483–495.
   PubMed Web of Science ®Google Scholar
• Benedetti, H., S. Raths, F. Crausaz, and H. Riezman. 1994. The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast. Mol. Biol. Cell 5:1023–1037.
   PubMed Web of Science ®Google Scholar
• Chevtzoff, C., J. Vallortigara, N. Averet, M. Rigoulet, and A. Devin. 2005. The yeast cAMP protein kinase Tpk3p is involved in the regulation of mitochondrial enzymatic content during growth. Biochim. Biophys. Acta 1706:117–125.
   PubMedGoogle Scholar
• Choi, J., H. D. Rees, S. T. Weintraub, A. I. Levey, L. S. Chin, and L. Li. 2005. Oxidative modifications and aggregation of Cu, Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases. J. Biol. Chem. 280:11648–11655.
   PubMed Web of Science ®Google Scholar
• Colombo, S., D. Ronchetti, J. M. Thevelein, J. Winderickx, and E. Martegani. 2004. Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae. J. Biol. Chem. 279:46715–46722.
   PubMedGoogle Scholar
• Dejean, L., B. Beauvoit, A. P. Alonso, O. Bunoust, B. Guerin, and M. Rigoulet. 2002. cAMP-induced modulation of the growth yield of Saccharomyces cerevisiae during respiratory and respiro-fermentative metabolism. Biochim. Biophys. Acta 1554:159–169.
   PubMedGoogle Scholar
• Dejean, L., B. Beauvoit, O. Bunoust, B. Guerin, and M. Rigoulet. 2002. Activation of Ras cascade increases the mitochondrial enzyme content of respiratory competent yeast. Biochem. Biophys. Res. Commun. 293:1383–1388.
   PubMedGoogle Scholar
• Finkel, T. 2005. Opinion: radical medicine: treating aging to cure disease. Nat. Rev. Mol. Cell. Biol. 6:971–976.
   PubMed Web of Science ®Google Scholar
• Freeman, N. L., Z. Chen, J. Horenstein, A. Weber, and J. Field. 1995. An actin monomer binding activity localizes to the carboxyl-terminal half of the Saccharomyces cerevisiae cyclase-associated protein. J. Biol. Chem. 270:5680–5685.
   PubMedGoogle Scholar
• Freeman, N. L., T. Lila, K. A. Mintzer, Z. Chen, A. J. Pahk, R. Ren, D. G. Drubin, and J. Field. 1996. A conserved proline-rich region of the Saccharomyces cerevisiae cyclase-associated protein binds SH3 domains and modulates cytoskeletal localization. Mol. Cell. Biol. 16:548–556.
   PubMedGoogle Scholar
• Gerst, J. E., K. Ferguson, A. Vojtek, M. Wigler, and J. Field. 1991. CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex. Mol. Cell. Biol. 11:1248–1257.
   PubMed Web of Science ®Google Scholar
• Gourlay, C. W., and K. R. Ayscough. 2005. Identification of an upstream regulatory pathway controlling actin-mediated apoptosis in yeast. J. Cell Sci. 118:2119–2132.
   PubMedGoogle Scholar
• Gourlay, C. W., L. N. Carpp, P. Timpson, S. J. Winder, and K. R. Ayscough. 2004. A role for the actin cytoskeleton in cell death and aging in yeast. J. Cell Biol. 164:803–809.
   PubMed Web of Science ®Google Scholar
• Heeren, G., S. Jarolim, P. Laun, M. Rinnerthaler, K. Stolze, G. G. Perrone, S. D. Kohlwein, H. Nohl, I. W. Dawes, and M. Breitenbach. 2004. The role of respiration, reactive oxygen species and oxidative stress in mother cell-specific aging of yeast strains defective in the RAS signalling pathway. FEMS Yeast Res. 5:157–167.
   PubMedGoogle Scholar
• Herker, E., H. Jungwirth, K. A. Lehmann, C. Maldener, K. U. Frohlich, S. Wissing, S. Buttner, M. Fehr, S. Sigrist, and F. Madeo. 2004. Chronological aging leads to apoptosis in yeast. J. Cell Biol. 164:501–507.
   PubMed Web of Science ®Google Scholar
• Hlavata, L., H. Aguilaniu, A. Pichova, and T. Nystrom. 2003. The oncogenic RAS2(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS. EMBO J. 22:3337–3345.
   PubMedGoogle Scholar
• Laun, P., A. Pichova, F. Madeo, J. Fuchs, A. Ellinger, S. Kohlwein, I. Dawes, K. U. Frohlich, and M. Breitenbach. 2001. Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol. Microbiol. 39:1166–1173.
   PubMed Web of Science ®Google Scholar
• Longo, V. D. 2004. Ras: the other pro-aging pathway. Sci. Aging Knowledge Environ. 2004:pe36.
   PubMedGoogle Scholar
• Longo V. D., J. Mitteldorf, and V. P. Skulachev. 2005. Opinion: programmed and altruistic aging. Nat. Rev. Genet. 6:866–872.
   PubMedGoogle Scholar
• Longtine, M. S., A. McKenzie, D. J. Demarini, N. G. Shah, A. Wach, A. Brachat, P. Philippsen, and J. R. Pringle. 1998. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14:953–961.
   PubMed Web of Science ®Google Scholar
• Mason, D. A., N. Shulga, S. Undavai, E. Ferrando-May, M. F. Rexach, and D. S. Goldfarb. 2005. Increased nuclear envelope permeability and Pep4p-dependent degradation of nucleoporins during hydrogen peroxide-induced cell death. FEMS Yeast Res. 5:1237–1251.
   PubMed Web of Science ®Google Scholar
• Mattila, P. K., O. Quintero-Monzon, J. Kugler, J. B. Moseley, S. C. Almo, P. Lappalainen, and B. L. Goode. 2004. A high-affinity interaction with ADP-actin monomers underlies the mechanism and in vivo function of Srv2/cyclase-associated protein. Mol. Biol. Cell 15:5158–5171.
   PubMedGoogle Scholar
• Mitsuzawa, H. 1993. Responsiveness to exogenous cAMP of a Saccharomyces cerevisiae strain conferred by naturally occurring alleles of PDE1 and PDE2. Genetics 135:321–326.
   PubMedGoogle Scholar
• Phillips, A. J., J. D. Crowe, and M. Ramsdale. 2006. Ras pathway signaling accelerates programmed cell death in the pathogenic fungus Candida albicans. Proc. Natl. Acad. Sci. USA 103:726–731.
   PubMed Web of Science ®Google Scholar
• Rego, A. C., and C. R. Oliveira. 2003. Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases. Neurochem. Res. 28:1563–1574.
   PubMed Web of Science ®Google Scholar
• Robertson, L. S., H. C. Causton, R. A. Young, and G. R. Fink. 2000. The yeast A kinases differentially regulate iron uptake and respiratory function. Proc. Natl. Acad. Sci. USA 97:5984–5988.
   PubMedGoogle Scholar
• Rodal, A. A., A. L. Manning, B. L. Goode, and D. G. Drubin. 2003. Negative regulation of yeast WASp by two SH3 domain-containing proteins. Curr. Biol. 13:1000–1008.
   PubMedGoogle Scholar
• Serrano, M., A. W. Lin, M. E. McCurrach, D. Beach, and S. W. Lowe. 1997. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88:593–602.
   PubMed Web of Science ®Google Scholar
• Soulard, A., T. Lechler, V. Spiridonov, A. Shevchenko, R. Li, and B. Winsor. 2002. Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro. Mol. Cell. Biol. 22:7889–7906.
   PubMed Web of Science ®Google Scholar
• Tang, H. Y., J. Xu, and M. Cai. 2000. Pan1p, End3p, and S1a1p, three yeast proteins required for normal cortical actin cytoskeleton organization, associate with each other and play essential roles in cell wall morphogenesis. Mol. Cell. Biol. 20:12–25.
   PubMed Web of Science ®Google Scholar
• Thevelein, J. M. 1992. The RAS-adenylyl cyclase pathway and cell cycle control in Saccharomyces cerevisiae. Antonie Leeuwenhoek 62:109–130.
   PubMedGoogle Scholar
• Thevelein, J. M., and J. H. de Winde. 1999. Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol. Microbiol. 33:904–918.
   PubMed Web of Science ®Google Scholar
• Thevelein, J. M., R. Gelade, I. Holsbeeks, O. Lagatie, Y. Popova, F. Rolland, F. Stolz, S. Van de Velde, P. Van Dijck, P. Vandormael, A. Van Nuland, K. Van Roey, G. Van Zeebroeck, and B. Yan. 2005. Nutrient sensing systems for rapid activation of the protein kinase A pathway in yeast. Biochem. Soc. Trans. 33:253–256.
   PubMedGoogle Scholar
• Toda, T., I. Uno, T. Ishikawa, S. Powers, T. Kataoka, D. Broek, S. Cameron, J. Broach, K. Matsumoto, and M. Wigler. 1985. In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell 40:27–36.
   PubMed Web of Science ®Google Scholar