Transactivation of Atg4b by C/EBPβ Promotes Autophagy To Facilitate Adipogenesis

REFERENCES

• Rajala MW, Scherer PE. 2003. The adipocyte—at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144:3765–3773.
   PubMed Web of Science ®Google Scholar
• Rosen ED, Spiegelman BM. 2006. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444:847–853.
   PubMed Web of Science ®Google Scholar
• Schaffler A, Muller-Ladner U, Scholmerich J, Buchler C. 2006. Role of adipose tissue as an inflammatory organ in human diseases. Endocr. Rev. 27:449–467.
   PubMed Web of Science ®Google Scholar
• Calle EE, Kaaks R. 2004. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat. Rev. Cancer 4:579–591.
   PubMed Web of Science ®Google Scholar
• Haslam DW, James WP. 2005. Obesity. Lancet 366:1197–1209.
   PubMed Web of Science ®Google Scholar
• Kopelman PG. 2000. Obesity as a medical problem. Nature 404:635–643.
   PubMed Web of Science ®Google Scholar
• Green H, Kehinde O. 1975. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 5:19–27.
   PubMed Web of Science ®Google Scholar
• Tang QQ, Lane MD. 1999. Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation. Genes Dev. 13:2231–2241.
   PubMed Web of Science ®Google Scholar
• Guo L, Li X, Huang JX, Huang HY, Zhang YY, Qian SW, Zhu H, Zhang YD, Liu Y, Wang KK, Tang QQ. 2012. Histone demethylase Kdm4b functions as a co-factor of C/EBPbeta to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes. Cell Death Differ. 19:1917–1927.
   PubMed Web of Science ®Google Scholar
• Tang QQ, Otto TC, Lane MD. 2003. CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis. Proc. Natl. Acad. Sci. U. S. A. 100:850–855.
   PubMed Web of Science ®Google Scholar
• Zhang YY, Li X, Qian SW, Guo L, Huang HY, He Q, Liu Y, Ma CG, Tang QQ. 2011. Transcriptional activation of histone H4 by C/EBPβ during the mitotic clonal expansion of 3T3-L1 adipocyte differentiation. Mol. Biol. Cell 22:2165–2174.
   PubMedGoogle Scholar
• Banerjee SS, Feinberg MW, Watanabe M, Gray S, Haspel RL, Denkinger DJ, Kawahara R, Hauner H, Jain MK. 2003. The Kruppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis. J. Biol. Chem. 278:2581–2584.
   PubMed Web of Science ®Google Scholar
• Bezy O, Vernochet C, Gesta S, Farmer SR, Kahn CR. 2007. TRB3 blocks adipocyte differentiation through the inhibition of C/EBPβ transcriptional activity. Mol. Cell. Biol. 27:6818–6831.
   PubMed Web of Science ®Google Scholar
• Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL, MacDougald OA. 2000. Inhibition of adipogenesis by Wnt signaling. Science 289:950–953.
   PubMed Web of Science ®Google Scholar
• Sue N, Jack BH, Eaton SA, Pearson RC, Funnell AP, Turner J, Czolij R, Denyer G, Bao S, Molero-Navajas JC, Perkins A, Fujiwara Y, Orkin SH, Bell-Anderson K, Crossley M. 2008. Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis. Mol. Cell. Biol. 28:3967–3978.
   PubMed Web of Science ®Google Scholar
• Sul HS. 2009. Pref-1: role in adipogenesis and mesenchymal cell fate. Mol. Endocrinol. 23:1717–1725.
   PubMedGoogle Scholar
• Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS. 2000. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science 290:134–138.
   PubMed Web of Science ®Google Scholar
• Cecconi F, Levine B. 2008. The role of autophagy in mammalian development: cell makeover rather than cell death. Dev. Cell 15:344–357.
   PubMed Web of Science ®Google Scholar
• Mizushima N. 2007. Autophagy: process and function. Genes Dev. 21:2861–2873.
   PubMed Web of Science ®Google Scholar
• Baerga R, Zhang Y, Chen PH, Goldman S, Jin S. 2009. Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice. Autophagy 5:1118–1130.
   PubMed Web of Science ®Google Scholar
• Singh R, Xiang Y, Wang Y, Baikati K, Cuervo AM, Luu YK, Tang Y, Pessin JE, Schwartz GJ, Czaja MJ. 2009. Autophagy regulates adipose mass and differentiation in mice. J. Clin. Invest. 119:3329–3339.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Goldman S, Baerga R, Zhao Y, Komatsu M, Jin S. 2009. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc. Natl. Acad. Sci. U. S. A. 106:19860–19865.
   PubMed Web of Science ®Google Scholar
• Goldman S, Zhang Y, Jin S. 2010. Autophagy and adipogenesis: implications in obesity and type II diabetes. Autophagy 6:179–181.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zeng X, Jin S. 2012. Autophagy in adipose tissue biology. Pharmacol. Res. 66:505–512.
   PubMed Web of Science ®Google Scholar
• Wang Z, Cao L, Kang R, Yang M, Liu L, Zhao Y, Yu Y, Xie M, Yin X, Livesey KM, Tang D. 2011. Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARalpha oncoprotein. Autophagy 7:401–411.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Yoshimori T, Levine B. 2010. Methods in mammalian autophagy research. Cell 140:313–326.
   PubMed Web of Science ®Google Scholar
• Fujita N, Hayashi-Nishino M, Fukumoto H, Omori H, Yamamoto A, Noda T, Yoshimori T. 2008. An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure. Mol. Biol. Cell 19:4651–4659.
   PubMed Web of Science ®Google Scholar
• Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19:5720–5728.
   PubMed Web of Science ®Google Scholar
• Zhou L, Zhang J, Fang Q, Liu M, Liu X, Jia W, Dong LQ, Liu F. 2009. Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance. Mol. Pharmacol. 76:596–603.
   PubMedGoogle Scholar
• Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T. 2007. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282:24131–24145.
   PubMed Web of Science ®Google Scholar
• Lee SJ, Pfluger PT, Kim JY, Nogueiras R, Duran A, Pages G, Pouyssegur J, Tschop MH, Diaz-Meco MT, Moscat J. 2010. A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis. EMBO Rep. 11:226–232.
   PubMedGoogle Scholar
• Rodriguez A, Duran A, Selloum M, Champy MF, Diez-Guerra FJ, Flores JM, Serrano M, Auwerx J, Diaz-Meco MT, Moscat J. 2006. Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab. 3:211–222.
   PubMed Web of Science ®Google Scholar
• Elefanty AG, Stanley EG. 2012. Efficient generation of adipocytes in a dish. Nat. Cell Biol. 14:126–127.
   PubMedGoogle Scholar
• Rahman SM, Janssen RC, Choudhury M, Baquero KC, Aikens RM, de la Houssaye BA, Friedman JE. 2012. CCAAT/enhancer-binding protein beta (C/EBPbeta) expression regulates dietary-induced inflammation in macrophages and adipose tissue in mice. J. Biol. Chem. 287:34349–34360.
   PubMed Web of Science ®Google Scholar
• Kraft C, Peter M, Hofmann K. 2010. Selective autophagy: ubiquitin-mediated recognition and beyond. Nat. Cell Biol. 12:836–841.
   PubMed Web of Science ®Google Scholar
• Moscat J, Diaz-Meco MT. 2011. Feedback on fat: p62-mTORC1-autophagy connections. Cell 147:724–727.
   PubMed Web of Science ®Google Scholar
• Prusty D, Park BH, Davis KE, Farmer SR. 2002. Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARgamma) and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes. J. Biol. Chem. 277:46226–46232.
   PubMed Web of Science ®Google Scholar
• Font de Mora J, Porras A, Ahn N, Santos E. 1997. Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation. Mol. Cell. Biol. 17:6068–6075.
   PubMedGoogle Scholar
• Gao C, Cao W, Bao L, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG. 2010. Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat. Cell Biol. 12:781–790.
   PubMed Web of Science ®Google Scholar
• Marino G, Salvador-Montoliu N, Fueyo A, Knecht E, Mizushima N, Lopez-Otin C. 2007. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J. Biol. Chem. 282:18573–18583.
   PubMed Web of Science ®Google Scholar
• Marino G, Fernandez AF, Cabrera S, Lundberg YW, Cabanillas R, Rodriguez F, Salvador-Montoliu N, Vega JA, Germana A, Fueyo A, Freije JM, Lopez-Otin C. 2010. Autophagy is essential for mouse sense of balance. J. Clin. Invest. 120:2331–2344.
   PubMed Web of Science ®Google Scholar