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Article

Drosophila FoxO Regulates Organism Size and Stress Resistance through an Adenylate Cyclase

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Pages 5357-5365 | Received 08 Mar 2009, Accepted 20 Jul 2009, Published online: 21 Mar 2023

REFERENCES

  • Arden, K. C. 2008. FOXO animal models reveal a variety of diverse roles for FOXO transcription factors. Oncogene 27:2345–2350.
  • Belgacem, Y. H., and J. R. Martin. 2007. Hmgcr in the corpus allatum controls sexual dimorphism of locomotor activity and body size via the insulin pathway in Drosophila. PLoS ONE 2:e187.
  • Biggs, W. H., III, J. Meisenhelder, T. Hunter, W. K. Cavenee, and K. C. Arden. 1999. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl. Acad. Sci. USA 96:7421–7426.
  • Broughton, S. J., M. D. Piper, T. Ikeya, T. M. Bass, J. Jacobson, Y. Driege, P. Martinez, E. Hafen, D. J. Withers, S. J. Leevers, and L. Partridge. 2005. Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc. Natl. Acad. Sci. USA 102:3105–3110.
  • Brunet, A., A. Bonni, M. J. Zigmond, M. Z. Lin, P. Juo, L. S. Hu, M. J. Anderson, K. C. Arden, J. Blenis, and M. E. Greenberg. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857–868.
  • Buch, S., C. Melcher, M. Bauer, J. Katzenberger, and M. J. Pankratz. 2008. Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling. Cell Metab. 7:321–332.
  • Cann, M. J., E. Chung, and L. R. Levin. 2000. A new family of adenylyl cyclase genes in the male germline of Drosophila melanogaster. Dev. Genes Evol. 210:200–206.
  • Cann, M. J., and L. R. Levin. 2000. Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster. Dev. Genes Evol. 210:34–40.
  • Coleman, R. A., and B. F. Pugh. 1997. Slow dimer dissociation of the TATA binding protein dictates the kinetics of DNA binding. Proc. Natl. Acad. Sci. USA 94:7221–7226.
  • Dai, M., P. Wang, A. D. Boyd, G. Kostov, B. Athey, E. G. Jones, W. E. Bunney, R. M. Myers, T. P. Speed, H. Akil, S. J. Watson, and F. Meng. 2005. Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res. 33:e175.
  • Dentin, R., Y. Liu, S. H. Koo, S. Hedrick, T. Vargas, J. Heredia, J. Yates, III, and M. Montminy. 2007. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449:366–369.
  • Gershman, B., O. Puig, L. Hang, R. M. Peitzsch, M. Tatar, and R. S. Garofalo. 2007. High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO. Physiol. Genomics 29:24–34.
  • Giannakou, M. E., M. Goss, M. A. Junger, E. Hafen, S. J. Leevers, and L. Partridge. 2004. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305:361.
  • Han, P. L., L. R. Levin, R. R. Reed, and R. L. Davis. 1992. Preferential expression of the Drosophila rutabaga gene in mushroom bodies, neural centers for learning in insects. Neuron 9:619–627.
  • Herzig, S., F. Long, U. S. Jhala, S. Hedrick, R. Quinn, A. Bauer, D. Rudolph, G. Schutz, C. Yoon, P. Puigserver, B. Spiegelman, and M. Montminy. 2001. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413:179–183.
  • Hurley, J. H. 1999. Structure, mechanism, and regulation of mammalian adenylyl cyclase. J. Biol. Chem. 274:7599–7602.
  • Hwangbo, D. S., B. Gershman, M. P. Tu, M. Palmer, and M. Tatar. 2004. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429:562–566.
  • Jones, D., and G. Jones. 2007. Farnesoid secretions of dipteran ring glands: what we do know and what we can know. Insect Biochem. Mol. Biol. 37:771–798.
  • Jowett, T. 1999. Analysis of protein and gene expression. Methods Cell Biol. 59:63–85.
  • Junger, M. A., F. Rintelen, H. Stocker, J. D. Wasserman, M. Vegh, T. Radimerski, M. E. Greenberg, and E. Hafen. 2003. The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J. Biol. 2:20.
  • Koo, S. H., L. Flechner, L. Qi, X. Zhang, R. A. Screaton, S. Jeffries, S. Hedrick, W. Xu, F. Boussouar, P. Brindle, H. Takemori, and M. Montminy. 2005. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437:1109–1111.
  • Kops, G. J., T. B. Dansen, P. E. Polderman, I. Saarloos, K. W. Wirtz, P. J. Coffer, T. T. Huang, J. L. Bos, R. H. Medema, and B. M. Burgering. 2002. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419:316–321.
  • Kops, G. J., N. D. de Ruiter, A. M. Vries-Smits, D. R. Powell, J. L. Bos, and B. M. Burgering. 1999. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398:630–634.
  • Kramer, J. M., J. D. Slade, and B. E. Staveley. 2008. foxo is required for resistance to amino acid starvation in Drosophila. Genome 51:668–672.
  • Mattila, J., J. Kallijarvi, and O. Puig. 2008. RNAi screening for kinases and phosphatases identifies FoxO regulators. Proc. Natl. Acad. Sci. USA 105:14873–14878.
  • Medema, R. H., G. J. Kops, J. L. Bos, and B. M. Burgering. 2000. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404:782–787.
  • Puig, O., M. T. Marr, M. L. Ruhf, and R. Tjian. 2003. Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 17:2006–2020.
  • Richard, D. S., S. W. Applebaum, and L. I. Gilbert. 1990. Allatostatic regulation of juvenile hormone production in vitro by the ring gland of Drosophila melanogaster. Mol. Cell Endocrinol. 68:153–161.
  • Seamon, K. B., W. Padgett, and J. W. Daly. 1981. Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc. Natl. Acad. Sci. USA 78:3363–3367.
  • Seoane, J., H. V. Le, L. Shen, S. A. Anderson, and J. Massague. 2004. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117:211–223.
  • Skoulakis, E. M., and S. Grammenoudi. 2006. Dunces and da Vincis: the genetics of learning and memory in Drosophila. Cell Mol. Life Sci. 63:975–988.
  • Tang, E. D., G. Nunez, F. G. Barr, and K. L. Guan. 1999. Negative regulation of the forkhead transcription factor FKHR by Akt. J. Biol. Chem. 274:16741–16746.
  • Tatar, M., A. Kopelman, D. Epstein, M. P. Tu, C. M. Yin, and R. S. Garofalo. 2001. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292:107–110.
  • Tettweiler, G., M. Miron, M. Jenkins, N. Sonenberg, and P. F. Lasko. 2005. Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes Dev. 19:1840–1843.
  • Tong, J. J., S. E. Schriner, D. McCleary, B. J. Day, and D. C. Wallace. 2007. Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. Nat. Genet. 39:476–485.
  • Wang, B., J. Goode, J. Best, J. Meltzer, P. E. Schilman, J. Chen, D. Garza, J. B. Thomas, and M. Montminy. 2008. The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. Cell Metab. 7:434–444.
  • Wang, M. C., D. Bohmann, and H. Jasper. 2005. JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121:115–125.
  • Zhang, W., S. Patil, B. Chauhan, S. Guo, D. R. Powell, J. Le, A. Klotsas, R. Matika, X. Xiao, R. Franks, K. A. Heidenreich, M. P. Sajan, R. V. Farese, D. B. Stolz, P. Tso, S. H. Koo, M. Montminy, and T. G. Unterman. 2006. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J. Biol. Chem. 281:10105–10117.

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