MicroRNA 22 Regulates Cell Cycle Length in Cerebellar Granular Neuron Precursors

REFERENCES

• Dahmane N, Ruiz i Altaba A. 1999. Sonic hedgehog regulates the growth and patterning of the cerebellum. Development 126:3089–3100.
   PubMed Web of Science ®Google Scholar
• Wechsler-Reya RJ, Scott MP. 1999. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22:103–114.
   PubMed Web of Science ®Google Scholar
• Altman J, Bayer SA. 2008. Development of the cerebellar system: in relation to its evolution, structure, and functions. CRC Press, Boca Raton, FL.
   Google Scholar
• Kenney AM, Cole MD, Rowitch DH. 2003. Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development 130:15–28.
   PubMed Web of Science ®Google Scholar
• Hatton BA, Knoepfler PS, Kenney AM, Rowitch DH, de Alboran IM, Olson JM, Eisenman RN. 2006. N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res. 66:8655–8661.
   PubMed Web of Science ®Google Scholar
• Oliver TG, Grasfeder LL, Carroll AL, Kaiser C, Gillingham CL, Lin SM, Wickramasinghe R, Scott MP, Wechsler-Reya RJ. 2003. Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc. Natl. Acad. Sci. U. S. A. 100:7331–7336.
   PubMed Web of Science ®Google Scholar
• Meyer N, Penn LZ. 2008. Reflecting on 25 years with MYC. Nat. Rev. Cancer 8:976–990.
   PubMed Web of Science ®Google Scholar
• Malynn BA, de Alboran IM, O'Hagan RC, Bronson R, Davidson L, DePinho RA, Alt FW. 2000. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev. 14:1390–1399.
   PubMed Web of Science ®Google Scholar
• Kawauchi D, Robinson G, Uziel T, Gibson P, Rehg J, Gao C, Finkelstein D, Qu C, Pounds S, Ellison DW, Gilbertson RJ, Roussel MF. 2012. A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell 21:168–180.
   PubMed Web of Science ®Google Scholar
• Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN, Weintraub H. 1990. Sequence-specific DNA binding by the c-Myc protein. Science 250:1149–1151.
   PubMed Web of Science ®Google Scholar
• Blackwood EM, Eisenman RN. 1991. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251:1211–1217.
   PubMed Web of Science ®Google Scholar
• Bouchard C, Dittrich O, Kiermaier A, Dohmann K, Menkel A, Eilers M, Luscher B. 2001. Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter. Genes Dev. 15:2042–2047.
   PubMed Web of Science ®Google Scholar
• Rios I, Alvarez-Rodriguez R, Marti E, Pons S. 2004. Bmp2 antagonizes sonic hedgehog-mediated proliferation of cerebellar granule neurones through Smad5 signalling. Development 131:3159–3168.
   PubMedGoogle Scholar
• Alvarez-Rodriguez R, Barzi M, Berenguer J, Pons S. 2007. Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc. J. Biol. Chem. 282:37170–37180.
   PubMedGoogle Scholar
• Alvarez-Rodriguez R, Pons S. 2009. Expression of the proneural gene encoding Mash1 suppresses MYCN mitotic activity. J. Cell Sci. 122:595–599.
   PubMedGoogle Scholar
• Zhao H, Ayrault O, Zindy F, Kim JH, Roussel MF. 2008. Posttranscriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development. Genes Dev. 22:722–727.
   PubMedGoogle Scholar
• Flora A, Klisch TJ, Schuster G, Zoghbi HY. 2009. Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma. Science 326:1424–1427.
   PubMed Web of Science ®Google Scholar
• Grimmer MR, Weiss WA. 2008. BMPs oppose Math1 in cerebellar development and in medulloblastoma. Genes Dev. 22:693–699.
   PubMedGoogle Scholar
• Bartel DP. 2009. MicroRNAs: target recognition and regulatory functions. Cell 136:215–233.
   PubMed Web of Science ®Google Scholar
• Ghildiyal M, Zamore PD. 2009. Small silencing RNAs: an expanding universe. Nat. Rev. Genet. 10:94–108.
   PubMed Web of Science ®Google Scholar
• Fabian MR, Sonenberg N, Filipowicz W. 2010. Regulation of mRNA translation and stability by microRNAs. Annu. Rev. Biochem. 79:351–379.
   PubMed Web of Science ®Google Scholar
• Gentner B, Schira G, Giustacchini A, Amendola M, Brown BD, Ponzoni M, Naldini L. 2009. Stable knockdown of microRNA in vivo by lentiviral vectors. Nat. Methods 6:63–66.
   PubMed Web of Science ®Google Scholar
• Wang B, Fallon JF, Beachy PA. 2000. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100:423–434.
   PubMed Web of Science ®Google Scholar
• Nowakowski RS, Lewin SB, Miller MW. 1989. Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population. J. Neurocytol. 18:311–318.
   PubMedGoogle Scholar
• Arai Y, Pulvers JN, Haffner C, Schilling B, Nusslein I, Calegari F, Huttner WB. 2011. Neural stem and progenitor cells shorten S-phase on commitment to neuron production. Nat. Commun. 2:154. doi:10.1038/ncomms1155.
   PubMedGoogle Scholar
• Grandori C, Cowley SM, James LP, Eisenman RN. 2000. The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu. Rev. Cell Dev. Biol. 16:653–699.
   PubMed Web of Science ®Google Scholar
• Queva C, Hurlin PJ, Foley KP, Eisenman RN. 1998. Sequential expression of the MAD family of transcriptional repressors during differentiation and development. Oncogene 16:967–977.
   PubMed Web of Science ®Google Scholar
• Rottmann S, Luscher B. 2006. The Mad side of the Max network: antagonizing the function of Myc and more. Curr. Top. Microbiol. Immunol. 302:63–122.
   PubMed Web of Science ®Google Scholar
• Marzi MJ, Puggioni EM, Dall'Olio V, Bucci G, Bernard L, Bianchi F, Crescenzi M, Di Fiore PP, Nicassio F. 2012. Differentiation-associated microRNAs antagonize the Rb-E2F pathway to restrict proliferation. J. Cell Biol. 199:77–95.
   PubMed Web of Science ®Google Scholar
• Ting Y, Medina DJ, Strair RK, Schaar DG. 2010. Differentiation-associated miR-22 represses Max expression and inhibits cell cycle progression. Biochem. Biophys. Res. Commun. 394:606–611.
   PubMedGoogle Scholar
• Xiong J, Du Q, Liang Z. 2010. Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein. Oncogene 29:4980–4988.
   PubMed Web of Science ®Google Scholar
• Xu D, Takeshita F, Hino Y, Fukunaga S, Kudo Y, Tamaki A, Matsunaga J, Takahashi RU, Takata T, Shimamoto A, Ochiya T, Tahara H. 2011. miR-22 represses cancer progression by inducing cellular senescence. J. Cell Biol. 193:409–424.
   PubMed Web of Science ®Google Scholar
• Walton JD, Kattan DR, Thomas SK, Spengler BA, Guo HF, Biedler JL, Cheung NK, Ross RA. 2004. Characteristics of stem cells from human neuroblastoma cell lines and in tumors. Neoplasia 6:838–845.
   PubMed Web of Science ®Google Scholar
• Siu IM, Lal A, Blankenship JR, Aldosari N, Riggins GJ. 2003. c-Myc promoter activation in medulloblastoma. Cancer Res. 63:4773–4776.
   PubMed Web of Science ®Google Scholar
• Takwi AA, Li Y, Becker Buscaglia LE, Zhang J, Choudhury S, Park AK, Liu M, Young KH, Park WY, Martin RC. 2012. A statin-regulated microRNA represses human c-Myc expression and function. EMBO Mol. Med. 4:896–909.
   PubMedGoogle Scholar
• He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ, Hammond SM. 2005. A microRNA polycistron as a potential human oncogene. Nature 435:828–833.
   PubMed Web of Science ®Google Scholar
• Uziel T, Karginov FV, Xie S, Parker JS, Wang YD, Gajjar A, He L, Ellison D, Gilbertson RJ, Hannon G, Roussel MF. 2009. The miR-17∼92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma. Proc. Natl. Acad. Sci. U. S. A. 106:2812–2817.
   PubMed Web of Science ®Google Scholar
• O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. 2005. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435:839–843.
   PubMed Web of Science ®Google Scholar
• Northcott PA, Jones DT, Kool M, Robinson GW, Gilbertson RJ, Cho YJ, Pomeroy SL, Korshunov A, Lichter P, Taylor MD, Pfister SM. 2012. Medulloblastomics: the end of the beginning. Nat. Rev. Cancer 12:818–834.
   PubMed Web of Science ®Google Scholar
• Kenney AM, Widlund HR, Rowitch DH. 2004. Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development 131:217–228.
   PubMed Web of Science ®Google Scholar
• Esquela-Kerscher A, Slack FJ. 2006. Oncomirs—microRNAs with a role in cancer. Nat. Rev. Cancer 6:259–269.
   PubMed Web of Science ®Google Scholar
• Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O'Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J. 2009. miR-24 inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to “seedless” 3′UTR microRNA recognition elements. Mol. Cell 35:610–625.
   PubMed Web of Science ®Google Scholar
• Choong ML, Yang HH, McNiece I. 2007. MicroRNA expression profiling during human cord blood-derived CD34 cell erythropoiesis. Exp. Hematol. 35:551–564.
   PubMed Web of Science ®Google Scholar
• Van Dang C, McMahon SB. 2010. Emerging concepts in the analysis of transcriptional targets of the MYC oncoprotein: are the targets targetable? Genes Cancer 1:560–567.
   PubMedGoogle Scholar
• Bui TV, Mendell JT. 2010. Myc: maestro of microRNAs. Genes Cancer 1:568–575.
   PubMedGoogle Scholar
• Dews M, Homayouni A, Yu D, Murphy D, Sevignani C, Wentzel E, Furth EE, Lee WM, Enders GH, Mendell JT, Thomas-Tikhonenko A. 2006. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat. Genet. 38:1060–1065.
   PubMed Web of Science ®Google Scholar
• Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT. 2008. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat. Genet. 40:43–50.
   PubMed Web of Science ®Google Scholar
• Northcott PA, Korshunov A, Pfister SM, Taylor MD. 2012. The clinical implications of medulloblastoma subgroups. Nat. Rev. Neurol. 8:340–351.
   PubMed Web of Science ®Google Scholar
• Pan E, Pellarin M, Holmes E, Smirnov I, Misra A, Eberhart CG, Burger PC, Biegel JA, Feuerstein BG. 2005. Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients. Clin. Cancer Res. 11:4733–4740.
   PubMed Web of Science ®Google Scholar
• Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, Eberhart CG, Parsons DW, Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM. 2012. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 123:465–472.
   PubMed Web of Science ®Google Scholar
• Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, Cho YJ, Koster J, Schouten-van Meeteren A, van Vuurden D, Clifford SC, Pietsch T, von Bueren AO, Rutkowski S, McCabe M, Collins VP, Backlund ML, Haberler C, Bourdeaut F, Delattre O, Doz F, Ellison DW, Gilbertson RJ, Pomeroy SL, Taylor MD, Lichter P, Pfister SM. 2012. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 123:473–484.
   PubMed Web of Science ®Google Scholar
• Cogen PH, Daneshvar L, Metzger AK, Duyk G, Edwards MS, Sheffield VC. 1992. Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis. Am. J. Hum. Genet. 50:584–589.
   PubMed Web of Science ®Google Scholar
• Jung HL, Wang KC, Kim SK, Sung KW, Koo HH, Shin HY, Ahn HS, Shin HJ, Cho BK. 2004. Loss of heterozygosity analysis of chromosome 17p13.1-13.3 and its correlation with clinical outcome in medulloblastomas. J. Neurooncol. 67:41–46.
   PubMedGoogle Scholar
• McDonald JD, Daneshvar L, Willert JR, Matsumura K, Waldman F, Cogen PH. 1994. Physical mapping of chromosome 17p13.3 in the region of a putative tumor suppressor gene important in medulloblastoma. Genomics 23:229–232.
   PubMed Web of Science ®Google Scholar
• Ferretti E, De Smaele E, Di Marcotullio L, Screpanti I, Gulino A. 2005. Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm. Trends Mol. Med. 11:537–545.
   PubMed Web of Science ®Google Scholar