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Article

The Ability of GAP1IP4BP To Function as a Rap1 GTPase-Activating Protein (GAP) Requires Its Ras GAP-Related Domain and an Arginine Finger Rather than an Asparagine Thumb

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Pages 3929-3940 | Received 02 Apr 2009, Accepted 29 Apr 2009, Published online: 21 Mar 2023

REFERENCES

  • Ahmadian, M. R., P. Stege, K. Scheffzek, and A. Wittinghofer. 1997. Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nat. Struct. Biol. 4:686–689.
  • Allen, M., S. Chu, S. Brill, C. Stotler, and A. Buckler. 1998. Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog. Gene 218:17–25.
  • Ballester, R., D. Marchuk, M. Boguski, A. Saulino, R. Letcher, M. Wigler, and F. Collins. 1990. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 63:851–859.
  • Bernards, A. 2003. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim. Biophys. Acta 1603:47–82.
  • Bernards, A., and J. Settleman. 2004. GAP control: regulating the regulators of small GTPases. Trends Cell Biol. 14:377–385.
  • Bos, J. L., B. Franke, L. M'Rabet, K. Reedquist, and F. Zwartkruis. 1997. In search of a function for the Ras-like GTPase Rap1. FEBS Lett. 410:59–62.
  • Bottomley, J. R., J. S. Reynolds, P. J. Lockyer, and P. J. Cullen. 1998. Structural and functional analysis of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m. Biochem. Biophys. Res. Commun. 250:143–149.
  • Brinkmann, T., O. Daumke, U. Herbrand, D. Kuhlmann, P. Stege, M. R. Ahmadian, and A. Wittinghofer. 2002. Rap-specific GTPase activating protein follows an alternative mechanism. J. Biol. Chem. 277:12525–12531.
  • Chakrabarti, P. P., Y. Suveyzdis, A. Wittinghofer, and K. Gerwert. 2004. Fourier transform infrared spectroscopy on the Rap·RapGAP reaction, GTPase activation without an arginine finger. J. Biol. Chem. 279:46226–46233.
  • Chen, H. J., M. Rojas-Soto, A. Oguni, and M. B. Kennedy. 1998. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron 20:895–904.
  • Cook, S. J., B. Rubinfeld, I. Albert, and F. McCormick. 1993. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J. 12:3475–3485.
  • Cozier, G. E., P. J. Lockyer, J. S. Reynolds, S. Kupzig, J. R. Bottomley, T. H. Millard, G. Banting, and P. J. Cullen. 2000. GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association. J. Biol. Chem. 275:28261–28268.
  • Cullen, P. J., J. J. Hsuan, O. Truong, A. J. Letcher, T. R. Jackson, A. P. Dawson, and R. F. Irvine. 1995. Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family. Nature 376:527–530.
  • Cullen, P. J., and P. J. Lockyer. 2002. Integration of calcium and Ras signalling. Nat. Rev. Mol. Cell Biol. 3:339–348.
  • Daumke, O., M. Weyand, P. P. Chakrabarti, I. R. Vetter, and A. Wittinghofer. 2004. The GTPase-activating protein Rap1GAP uses a catalytic asparagine. Nature 429:197–201.
  • Gao, Q., S. Srinivasan, S. N. Boyer, D. E. Wazer, and V. Band. 1999. The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation. Mol. Cell. Biol. 19:733–744.
  • Hattori, M., N. Tsukamoto, M. S. Nue-e-Kamal, B. Rubinfeld, K. Iwai, H. Kubota, H. Maruta, and N. Minato. 1995. Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. Mol. Cell. Biol. 15:552–560.
  • Kim, J. H., D. Liao, L. F. Lau, and R. L. Huganir. 1998. SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron 20:683–691.
  • Kitayama, H., Y. Sugimoto, T. Matsuzaki, Y. Ikawa, and M. Noda. 1989. A ras-related gene with transformation suppressor activity. Cell 56:77–84.
  • Kooistra, M. R. H., N. Dubé, and J. L. Bos. 2007. Rap1: a key regulator in cell-cell junction formation. J. Cell Sci. 120:17–22.
  • Krapivinsky, G., I. Medina, I. Krapivinsky, S. Gapon, and D. E. Clapham. 2004. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron 43:563–574.
  • Kupzig, S., D. Deaconescu, D. Bouyoucef, S. A. Walker, Q. Liu, C. L. Polte, O. Daumke, T. Ishizaki, P. J. Lockyer, A. Wittinghofer, and P. J. Cullen. 2006. GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins. J. Biol. Chem. 281:9891–9900.
  • Lockyer, P. J., S. Kupzig, and P. J. Cullen. 2001. CAPRI regulates Ca2+-dependent inactivation of the Ras-MAPK pathway. Curr. Biol. 11:981–986.
  • Lockyer, P. J., S. Wennstrom, S. Kupzig, K. Venkateswarlu, J. Downward, and P. J. Cullen. 1999. Identification of the ras GTPase-activating protein GAP1m as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo. Curr. Biol. 9:265–268.
  • Maekawa, M., S. A. Iwamatsu, T. Morishita, K. Yokota, Y. Imai, S. Kohsaka, S. Nakamura, and S. Hattori. 1994. A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions. Mol. Cell. Biol. 14:6879–6885.
  • Manning, B. D., and L. C. Cantley. 2003. Rheb fills a GAP between TSC and TOR. Trends Biochem. Sci. 28:573–576.
  • Martin, G. A., D. Viskochil, G. Bollag, P. C. McCabe, W. J. Crosier, H. Haubruck, L. Conroy, R. Clark, P. O'Connell, R. M. Cawthon, M. A. Innis, and F. McCormick. 1990. The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. Cell 63:843–849.
  • Mitin, N., K. L. Rossman, and C. J. Der. 2005. Signaling interplay in Ras superfamily function. Curr. Biol. 15:R563–R574.
  • Oinuma, I., Y. Ishikawa, H. Katoh, and M. Negishi. 2004. The semaphorin 4D receptor plexin-B1 is a GTPase activating protein for R-Ras. Science 305:862–865.
  • Pena, V., M. Hothorn, A. Eberth, N. Kaschau, A. Parret, L. Gremer, F. Bonneau, M. R. Ahmadian, and K. Scheffzek. 2008. The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction. EMBO Rep. 9:350–355.
  • Rajalingam, K., R. Schreck, U. R. Rapp, and S. Albert. 2007. Ras oncogenes and their downstream targets. Biochim. Biophys. Acta 1773:1177–1195.
  • Rubinfeld, B., S. Munemitsu, R. Clark, L. Conroy, K. Watt, W. J. Crosier, F. McCormick, and P. Polakis. 1991. Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1. Cell 65:1033–1042.
  • Scheffzek, K., M. R. Ahmadian, W. Kabsch, L. Wiesmuller, A. Lautwein, F. Schmitz, and A. Wittinghofer. 1997. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 277:333–338.
  • Scheffzek, K., A. Lautwein, W. Kabsch, M. R. Ahmadian, and A. Wittinghofer. 1996. Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras. Nature 384:591–596.
  • Schubbert, S., K. Shannon, and G. Bollag. 2007. Hyperactive Ras in developmental disorders and cancer. Nat. Rev. Cancer 7:295–308.
  • Scrima, A., C. Thomas, D. Deaconescu, and A. Wittinghofer. 2008. The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. EMBO J. 27:1145–1153.
  • Stork, P. J. 2003. Does Rap1 deserve a bad Rap? Trends Biochem. Sci. 28:267–275.
  • Vogel, U. S., R. A. Dixon, M. D. Schaber, R. E. Diehl, M. S. Marshall, E. M. Scolnick, I. S. Sigal, and J. B. Gibbs. 1988. Cloning of bovine GAP and its interaction with oncogenic ras p21. Nature 335:90–93.
  • Wang, Z., C. P. Tseng, R. C. Pong, H. Chen, J. D. McConnell, N. Navone, and J. T. Hsieh. 2002. The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. J. Biol. Chem. 277:12622–12631.
  • Xu, G. F., B. Lin, K. Tanaka, D. Dunn, D. Wood, R. Gesteland, R. White, R. Weiss, and F. Tamanoi. 1990. The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell 63:835–841.
  • Yarwood, S., D. Bouyoucef-Cherchalli, P. J. Cullen, and S. Kupzig. 2006. The GAP1 family of GTPase-activating proteins: spatial and temporal regulators of small GTPase signalling. Biochem. Soc. Trans. 34:846–850.

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