821
Views
80
CrossRef citations to date
0
Altmetric
Research Article

Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors

, , , , , , & ORCID Icon show all
Article: e00479-16 | Received 25 Aug 2016, Accepted 17 Feb 2017, Published online: 17 Mar 2023

REFERENCES

  • Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon S-O, Cantley LC, Blenis J. 2010. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol Cell 38:487–499. https://doi.org/10.1016/j.molcel.2010.05.007.
  • DeBerardinis RJ, Sayed N, Ditsworth D, Thompson CB. 2008. Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev 18:54–61. https://doi.org/10.1016/j.gde.2008.02.003.
  • Iurlaro R, León-Annicchiarico CL, Munoz-Pinedo C. 2014. Regulation of cancer metabolism by oncogenes and tumor suppressors. Methods Enzymol 542:59–80. https://doi.org/10.1016/B978-0-12-416618-9.00003-0.
  • El Mjiyad N, Caro-Maldonado A, Ramirez-Peinado S, Munoz-Pinedo C. 2011. Sugar-free approaches to cancer cell killing. Oncogene 30:253–264. https://doi.org/10.1038/onc.2010.466.
  • Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gélinas C, Fan Y, Nelson DA, Jin S, White E. 2006. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10:51–64. https://doi.org/10.1016/j.ccr.2006.06.001.
  • Leon-Annicchiarico CL, Ramirez-Peinado S, Dominguez-Villanueva D, Gonsberg A, Lampidis TJ, Munoz-Pinedo C. 2015. ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2-deoxyglucose in the same cells. FEBS J 282:3647–3658. https://doi.org/10.1111/febs.13369.
  • Caro-Maldonado A, Munoz-Pinedo C. 2011. Dying for something to eat: how cells respond to starvation. Open Cell Signal J 3:42–51. https://doi.org/10.2174/1876390101103010042.
  • Lowman XH, McDonnell MA, Kosloske A, Odumade OA, Jenness C, Karim CB, Jemmerson R, Kelekar A. 2010. The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose. Mol Cell 40:823–833. https://doi.org/10.1016/j.molcel.2010.11.035.
  • Zhao Y, Coloff JL, Ferguson EC, Jacobs SR, Cui K, Rathmell JC. 2008. Glucose metabolism attenuates p53 and puma-dependent cell death upon growth factor deprivation. J Biol Chem 283:36344–36353. https://doi.org/10.1074/jbc.M803580200.
  • Caro-Maldonado A, Tait SWG, Ramirez-Peinado S, Ricci JE, Fabregat I, Green DR, Munoz-Pinedo C. 2010. Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells. Cell Death Differ 17:1335–1344. https://doi.org/10.1038/cdd.2010.21.
  • Qing G, Li B, Vu A, Skuli N, Walton ZE, Liu X, Mayes PA, Wise DR, Thompson CB, Maris JM, Hogarty MD, Simon MC. 2012. ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer Cell 22:631–644. https://doi.org/10.1016/j.ccr.2012.09.021.
  • Ramírez-Peinado S, Alcázar-Limones F, Lagares-Tena L, El Mjiyad N, Caro-Maldonado A, Tirado OM, Muñoz-Pinedo C. 2011. 2-Deoxyglucose induces noxa-dependent apoptosis in alveolar rhabdomyosarcoma. Cancer Res 71:6796–6806. https://doi.org/10.1158/0008-5472.CAN-11-0759.
  • Shin S, Buel GR, Wolgamott L, Plas DR, Asara JM, Blenis J, Yoon SO. 2015. ERK2 mediates metabolic stress response to regulate cell fate. Mol Cell 59:382–398. https://doi.org/10.1016/j.molcel.2015.06.020.
  • Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR. 2011. A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell 44:517–531. https://doi.org/10.1016/j.molcel.2011.10.001.
  • He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X. 2009. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 137:1100–1111. https://doi.org/10.1016/j.cell.2009.05.021.
  • Vandenabeele P, Grootjans S, Callewaert N, Takahashi N. 2013. Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models. Cell Death Differ 20:185–187. https://doi.org/10.1038/cdd.2012.151.
  • Zhang J, Fan J, Venneti S, Cross JR, Takagi T, Bhinder B, Djaballah H, Kanai M, Cheng EH, Judkins AR, Pawel B, Baggs J, Cherry S, Rabinowitz JD, Thompson CB. 2014. Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Mol Cell 56:205–218. https://doi.org/10.1016/j.molcel.2014.08.018.
  • Palorini R, Cammarata FP, Balestrieri C, Monestiroli A, Vasso M, Gelfi C, Alberghina L, Chiaradonna F. 2013. Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response. Cell Death Dis 4:e732. https://doi.org/10.1038/cddis.2013.257.
  • Muaddi H, Majumder M, Peidis P, Papadakis AI, Holcik M, Scheuner D, Kaufman RJ, Hatzoglou M, Koromilas AE. 2010. Phosphorylation of eIF2alpha at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Mol Biol Cell 21:3220–3231. https://doi.org/10.1091/mbc.E10-01-0023.
  • Martin-Perez R, Niwa M, Lopez-Rivas A. 2012. ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2. Apoptosis 17:349–363. https://doi.org/10.1007/s10495-011-0673-2.
  • Iurlaro R, Munoz-Pinedo C. 2016. Cell death induced by endoplasmic reticulum stress. FEBS J 283:2640–2652. https://doi.org/10.1111/febs.13598.
  • Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, Mendez AS, Paton AW, Paton JC, Walter P, Ashkenazi A. 2014. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science 345:98–101. https://doi.org/10.1126/science.1254312.
  • Martin-Perez R, Palacios C, Yerbes R, Cano-Gonzalez A, Iglesias-Serret D, Gil J, Reginato MJ, Lopez-Rivas A. 2014. Activated ERBB2/HER2 licenses sensitivity to apoptosis upon endoplasmic reticulum stress through a PERK-dependent pathway. Cancer Res 74:1766–1777. https://doi.org/10.1158/0008-5472.CAN-13-1747.
  • Yamaguchi H, Wang HG. 2004. CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem 279:45495–45502. https://doi.org/10.1074/jbc.M406933200.
  • Jiang CC, Chen LH, Gillespie S, Kiejda KA, Mhaidat N, Wang YF, Thorne R, Zhang XD, Hersey P. 2007. Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response. Cancer Res 67:5880–5888. https://doi.org/10.1158/0008-5472.CAN-07-0213.
  • Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M, Cain K, MacFarlane M, Hacker G, Leverkus M. 2011. cIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 43:449–463. https://doi.org/10.1016/j.molcel.2011.06.011.
  • Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K, Meier P. 2011. The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell 43:432–448. https://doi.org/10.1016/j.molcel.2011.06.006.
  • Jin Z, Li Y, Pitti R, Lawrence D, Pham VC, Lill JR, Ashkenazi A. 2009. Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 137:721–735. https://doi.org/10.1016/j.cell.2009.03.015.
  • Pan JA, Ullman E, Dou Z, Zong WX. 2011. Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes. Mol Cell Biol 31:3158–3170. https://doi.org/10.1128/MCB.05460-11.
  • Ramírez-Peinado S, León-Annicchiarico CL, Galindo-Moreno J, Iurlaro R, Caro-Maldonado A, Prehn JHM, Ryan KM, Muñoz-Pinedo C. 2013. Glucose starved cells do not engage in pro-survival autophagy. J Biol Chem 288:30387–30398. https://doi.org/10.1074/jbc.M113.490581.
  • Li T, Su L, Lei Y, Liu X, Zhang Y, Liu X. 2015. DDIT3 and KAT2A proteins regulate TNFRSF10A and TNFRSF10B expression in endoplasmic reticulum stress-mediated apoptosis in human lung cancer cells. J Biol Chem 290:11108–11118. https://doi.org/10.1074/jbc.M115.645333.
  • Ye J, Kumanova M, Hart LS, Sloane K, Zhang H, De Panis DN, Bobrovnikova-Marjon E, Diehl JA, Ron D, Koumenis C. 2010. The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J 29:2082–2096. https://doi.org/10.1038/emboj.2010.81.
  • Zagorodna O, Martin SM, Rutkowski DT, Kuwana T, Spitz DR, Knudson CM. 2012. 2-Deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines. Oncogene 31:2738–2749. https://doi.org/10.1038/onc.2011.454.
  • Munoz-Pinedo C, Ruiz-Ruiz C, Ruiz de Almodovar C, Palacios C, Lopez-Rivas A. 2003. Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing. J Biol Chem 278:12759–12768. https://doi.org/10.1074/jbc.M212392200.
  • Nam SY, Amoscato AA, Lee YJ. 2002. Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway. Oncogene 21:337–346. https://doi.org/10.1038/sj.onc.1205068.
  • Chan FK, Chun HJ, Zheng L, Siegel RM, Bui KL, Lenardo MJ. 2000. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science 288:2351–2354. https://doi.org/10.1126/science.288.5475.2351.
  • Wei MC, Zong W-X, Cheng EHY, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ. 2001. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292:727–730. https://doi.org/10.1126/science.1059108.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.