Mammalian SWI/SNF-A Subunit BAF250/ARID1 Is an E3 Ubiquitin Ligase That Targets Histone H2B

REFERENCES

• Bailey, T. L., and M. Gribskov. 1998. Combining evidence using p-values: application to sequence homology searches. Bioinformatics 14:48–54.
   PubMed Web of Science ®Google Scholar
• Blanchette, P., C. Y. Cheng, Q. Yan, G. Ketner, D. A. Ornelles, T. Dobner, R. C. Conaway, J. W. Conaway, and P. E. Branton. 2004. Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53. Mol. Cell. Biol. 24:9619–9629.
   PubMedGoogle Scholar
• Boyer, L. A., T. I. Lee, M. F. Cole, S. E. Johnstone, S. S. Levine, J. P. Zucker, M. G. Guenther, R. M. Kumar, H. L. Murray, R. G. Jenner, D. K. Gifford, D. A. Melton, R. Jaenisch, and R. A. Young. 2005. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122:947–956.
   PubMed Web of Science ®Google Scholar
• Cairns, B. R. 2007. Chromatin remodeling: insights and intrigue from single-molecule studies. Nat. Struct. Mol. Biol. 14:989–996.
   PubMed Web of Science ®Google Scholar
• Cao, R., Y. Tsukada, and Y. Zhang. 2005. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol. Cell 20:845–854.
   PubMed Web of Science ®Google Scholar
• Collins, R. T., T. Furukawa, N. Tanese, and J. E. Treisman. 1999. Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genes. EMBO J. 18:7029–7040.
   PubMedGoogle Scholar
• Collins, R. T., and J. E. Treisman. 2000. Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes. Genes Dev. 14:3140–3152.
   PubMed Web of Science ®Google Scholar
• Davie, J. R., and L. C. Murphy. 1994. Inhibition of transcription selectively reduces the level of ubiquitinated histone H2B in chromatin. Biochem. Biophys. Res. Commun. 203:344–350.
   PubMedGoogle Scholar
• Deato, M. D., and R. Tjian. 2007. Switching of the core transcription machinery during myogenesis. Genes Dev. 21:2137–2149.
   PubMed Web of Science ®Google Scholar
• Gao, X., P. Tate, P. Hu, R. Tjian, W. C. Skarnes, and Z. Wang. 2008. ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc. Natl. Acad. Sci. U. S. A. 105:6656–6661.
   PubMed Web of Science ®Google Scholar
• Hwang, W. W., S. Venkatasubrahmanyam, A. G. Ianculescu, A. Tong, C. Boone, and H. D. Madhani. 2003. A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol. Cell 11:261–266.
   PubMed Web of Science ®Google Scholar
• Inoue, H., T. Furukawa, S. Giannakopoulos, S. Zhou, D. S. King, and N. Tanese. 2002. Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors. J. Biol. Chem. 277:41674–41685.
   PubMedGoogle Scholar
• Kamura, T., C. S. Brower, R. C. Conaway, and J. W. Conaway. 2002. A molecular basis for stabilization of the von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase. J. Biol. Chem. 277:30388–30393.
   PubMedGoogle Scholar
• Kamura, T., K. Maenaka, S. Kotoshiba, M. Matsumoto, D. Kohda, R. C. Conaway, J. W. Conaway, and K. I. Nakayama. 2004. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev. 18:3055–3065.
   PubMed Web of Science ®Google Scholar
• Kennison, J. A., and J. W. Tamkun. 1988. Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 85:8136–8140.
   PubMed Web of Science ®Google Scholar
• Kim, J., M. Guermah, R. K. McGinty, J. S. Lee, Z. Tang, T. A. Milne, A. Shilatifard, T. W. Muir, and R. G. Roeder. 2009. RAD6-mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell 137:459–471.
   PubMedGoogle Scholar
• Lemon, B., C. Inouye, D. S. King, and R. Tjian. 2001. Selectivity of chromatin-remodelling cofactors for ligand-activated transcription. Nature 414:924–928.
   PubMed Web of Science ®Google Scholar
• Lessard, J., J. I. Wu, J. A. Ranish, M. Wan, M. M. Winslow, B. T. Staahl, H. Wu, R. Aebersold, I. A. Graef, and G. R. Crabtree. 2007. An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron 55:201–215.
   PubMed Web of Science ®Google Scholar
• Luo, B., H. W. Cheung, A. Subramanian, T. Sharifnia, M. Okamoto, X. Yang, G. Hinkle, J. S. Boehm, R. Beroukhim, B. A. Weir, C. Mermel, D. A. Barbie, T. Awad, X. Zhou, T. Nguyen, B. Piqani, C. Li, T. R. Golub, M. Meyerson, N. Hacohen, W. C. Hahn, E. S. Lander, D. M. Sabatini, and D. E. Root. 2008. Highly parallel identification of essential genes in cancer cells. Proc. Natl. Acad. Sci. U. S. A. 105:20380–20385.
   PubMed Web of Science ®Google Scholar
• Minsky, N., E. Shema, Y. Field, M. Schuster, E. Segal, and M. Oren. 2008. Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells. Nat. Cell Biol. 10:483–488.
   PubMed Web of Science ®Google Scholar
• Nagl, N. G., Jr., X. Wang, A. Patsialou, M. Van Scoy, and E. Moran. 2007. Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control. EMBO J. 26:752–763.
   PubMed Web of Science ®Google Scholar
• Narlikar, G. J., M. L. Phelan, and R. E. Kingston. 2001. Generation and interconversion of multiple distinct nucleosomal states as a mechanism for catalyzing chromatin fluidity. Mol. Cell 8:1219–1230.
   PubMedGoogle Scholar
• Ng, M., F. J. Diaz-Benjumea, J. P. Vincent, J. Wu, and S. M. Cohen. 1996. Specification of the wing by localized expression of wingless protein. Nature 381:316–318.
   PubMedGoogle Scholar
• Nie, Z., Y. Xue, D. Yang, S. Zhou, B. J. Deroo, T. K. Archer, and W. Wang. 2000. A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex. Mol. Cell. Biol. 20:8879–8888.
   PubMed Web of Science ®Google Scholar
• Nolo, R., L. A. Abbott, and H. J. Bellen. 2000. Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell 102:349–362.
   PubMed Web of Science ®Google Scholar
• Pavri, R., B. Zhu, G. Li, P. Trojer, S. Mandal, A. Shilatifard, and D. Reinberg. 2006. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell 125:703–717.
   PubMed Web of Science ®Google Scholar
• Phelan, M. L., S. Sif, G. J. Narlikar, and R. E. Kingston. 1999. Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. Mol. Cell 3:247–253.
   PubMed Web of Science ®Google Scholar
• Schoenfeld, A. R., E. J. Davidowitz, and R. D. Burk. 2000. Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products. Proc. Natl. Acad. Sci. U. S. A. 97:8507–8512.
   PubMed Web of Science ®Google Scholar
• Schuettengruber, B., D. Chourrout, M. Vervoort, B. Leblanc, and G. Cavalli. 2007. Genome regulation by polycomb and trithorax proteins. Cell 128:735–745.
   PubMed Web of Science ®Google Scholar
• Shahbazian, M. D., K. Zhang, and M. Grunstein. 2005. Histone H2B ubiquitylation controls processive methylation but not monomethylation by Dot1 and Set1. Mol. Cell 19:271–277.
   PubMed Web of Science ®Google Scholar
• Shema, E., I. Tirosh, Y. Aylon, J. Huang, C. Ye, N. Moskovits, N. Raver-Shapira, N. Minsky, J. Pirngruber, G. Tarcic, P. Hublarova, L. Moyal, M. Gana-Weisz, Y. Shiloh, Y. Yarden, S. A. Johnsen, B. Vojtesek, S. L. Berger, and M. Oren. 2008. The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes Dev. 22:2664–2676.
   PubMed Web of Science ®Google Scholar
• Stebbins, C. E., W. G. Kaelin, Jr., and N. P. Pavletich. 1999. Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. Science 284:455–461.
   PubMed Web of Science ®Google Scholar
• Sun, Z. W., and C. D. Allis. 2002. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 418:104–108.
   PubMed Web of Science ®Google Scholar
• Trotter, K. W., H. Y. Fan, M. L. Ivey, R. E. Kingston, and T. K. Archer. 2008. The HSA domain of BRG1 mediates critical interactions required for glucocorticoid receptor-dependent transcriptional activation in vivo. Mol. Cell. Biol. 28:1413–1426.
   PubMedGoogle Scholar
• Vodermaier, H. C. 2004. APC/C and SCF: controlling each other and the cell cycle. Curr. Biol. 14:R787–R796.
   PubMed Web of Science ®Google Scholar
• Wang, X., N. G. Nagl, D. Wilsker, M. Van Scoy, S. Pacchione, P. Yaciuk, P. B. Dallas, and E. Moran. 2004. Two related ARID family proteins are alternative subunits of human SWI/SNF complexes. Biochem. J. 383:319–325.
   PubMedGoogle Scholar
• Wang, X., D. M. Truckses, S. Takada, T. Matsumura, N. Tanese, and R. H. Jacobson. 2007. Conserved region I of human coactivator TAF4 binds to a short hydrophobic motif present in transcriptional regulators. Proc. Natl. Acad. Sci. U. S. A. 104:7839–7844.
   PubMedGoogle Scholar
• Wilsker, D., A. Patsialou, S. D. Zumbrun, S. Kim, Y. Chen, P. B. Dallas, and E. Moran. 2004. The DNA-binding properties of the ARID-containing subunits of yeast and mammalian SWI/SNF complexes. Nucleic Acids Res. 32:1345–1353.
   PubMed Web of Science ®Google Scholar
• Wu, J. I., J. Lessard, and G. R. Crabtree. 2009. Understanding the words of chromatin regulation. Cell 136:200–206.
   PubMed Web of Science ®Google Scholar
• Xi, Q., W. He, X. Zhang, H. Le, and J. Massague. 2008. Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor transcriptional program. J. Biol. Chem. 283:1146–1155.
   PubMed Web of Science ®Google Scholar
• Yan, Z., Z. Wang, L. Sharova, A. Sharov, C. Ling, Y. Piao, K. Aiba, R. Matoba, W. Wang, and M. Ko. 2008. BAF250B-associated SWI/SNF chromatin-remodeling complex is required to maintain undifferentiated mouse embryonic stem cells. Stem Cells 26:1155–1165.
   PubMedGoogle Scholar
• Zheng, N., B. A. Schulman, L. Song, J. J. Miller, P. D. Jeffrey, P. Wang, C. Chu, D. M. Koepp, S. J. Elledge, M. Pagano, R. C. Conaway, J. W. Conaway, J. W. Harper, and N. P. Pavletich. 2002. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature 416:703–709.
   PubMed Web of Science ®Google Scholar
• Zhu, B., Y. Zheng, A. D. Pham, S. S. Mandal, H. Erdjument-Bromage, P. Tempst, and D. Reinberg. 2005. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol. Cell 20:601–611.
   PubMed Web of Science ®Google Scholar