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Article

Transcription Factor Ets1, but Not the Closely Related Factor Ets2, Inhibits Antibody-Secreting Cell Differentiation

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Pages 522-532 | Received 21 May 2013, Accepted 13 Nov 2013, Published online: 20 Mar 2023

REFERENCES

  • Nutt SL, Fairfax KA, Kallies A. 2007. BLIMP1 guides the fate of effector B and T cells. Nat. Rev. Immunol. 7:923–927. http://dx.doi.org/10.1038/nri2204.
  • John SA, Garrett-Sinha LA. 2009. Blimp1: a conserved transcriptional repressor critical for differentiation of many tissues. Exp. Cell Res. 315:1077–1084. http://dx.doi.org/10.1016/j.yexcr.2008.11.015.
  • Iwakoshi NN, Lee AH, Glimcher LH. 2003. The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response. Immunol. Rev. 194:29–38. http://dx.doi.org/10.1034/j.1600-065X.2003.00057.x.
  • Lu R. 2008. Interferon regulatory factor 4 and 8 in B-cell development. Trends Immunol. 29:487–492. http://dx.doi.org/10.1016/j.it.2008.07.006.
  • Lin L, Gerth AJ, Peng SL. 2004. Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor. J. Exp. Med. 200:115–122. http://dx.doi.org/10.1084/jem.20040612.
  • Cobaleda C, Schebesta A, Delogu A, Busslinger M. 2007. Pax5: the guardian of B cell identity and function. Nat. Immunol. 8:463–470. http://dx.doi.org/10.1038/ni1454.
  • Igarashi K, Ochiai K, Muto A. 2007. Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation. J. Biochem. 141:783–789. http://dx.doi.org/10.1093/jb/mvm106.
  • John SA, Clements JL, Russell LM, Garrett-Sinha LA. 2008. Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1. J. Biol. Chem. 283:951–962. http://dx.doi.org/10.1074/jbc.M705262200.
  • Russell L, Garrett-Sinha LA. 2010. Transcription factor Ets-1 in cytokine and chemokine gene regulation. Cytokine 51:217–226. http://dx.doi.org/10.1016/j.cyto.2010.03.006.
  • Garrett-Sinha LA. 2013. Review of Ets1 structure, function, and roles in immunity. Cell. Mol. Life Sci. 70:3375–3390. http://dx.doi.org/10.1007/s00018-012-1243-7.
  • Woods DB, Ghysdael J, Owen MJ. 1992. Identification of nucleotide preferences in DNA sequences recognised specifically by c-Ets-1 protein. Nucleic Acids Res. 20:699–704. http://dx.doi.org/10.1093/nar/20.4.699.
  • Ascione R, Thompson DM, Thomas R, Panayiotakis A, Ramsay R, Tymms M, Seth A. 1992. Influence of nucleotides flanking the -GGAA- core sequence on ETS1 and ETS2 DNA-binding activity and the mechanism of ETS1 autoregulation. Int. J. Oncol. 1:631–637.
  • Wasylyk C, Bradford AP, Gutierrez-Hartmann A, Wasylyk B. 1997. Conserved mechanisms of Ras regulation of evolutionary related transcription factors, Ets1 and Pointed P2. Oncogene 14:899–913. http://dx.doi.org/10.1038/sj.onc.1200914.
  • Foulds CE, Nelson ML, Blaszczak AG, Graves BJ. 2004. Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment. Mol. Cell. Biol. 24:10954–10964. http://dx.doi.org/10.1128/MCB.24.24.10954-10964.2004.
  • Bhattacharya D, Cheah MT, Franco CB, Hosen N, Pin CL, Sha WC, Weissman IL. 2007. Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation. J. Immunol. 179:6808–6819. http://www.jimmunol.org/content/179/10/6808.long.
  • Kola I, Brookes S, Green AR, Garber R, Tymms M, Papas TS, Seth A. 1993. The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation. Proc. Natl. Acad. Sci. U. S. A. 90:7588–7592. http://dx.doi.org/10.1073/pnas.90.16.7588.
  • Naviaux RK, Costanzi E, Haas M, Verma IM. 1996. The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J. Virol. 70:5701–5705.
  • Muthusamy N, Barton K, Leiden JM. 1995. Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature 377:639–642. http://dx.doi.org/10.1038/377639a0.
  • Wang D, John SA, Clements JL, Percy DH, Barton KP, Garrett-Sinha LA. 2005. Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease. Int. Immunol. 17:1179–1191. http://dx.doi.org/10.1093/intimm/dxh295.
  • Wen F, Tynan JA, Cecena G, Williams R, Munera J, Mavrothalassitis G, Oshima RG. 2007. Ets2 is required for trophoblast stem cell self-renewal. Dev. Biol. 312:284–299. http://dx.doi.org/10.1016/j.ydbio.2007.09.024.
  • Carotta S, Nutt SL. 2008. Losing B cell identity. Bioessays 30:203–207. http://dx.doi.org/10.1002/bies.20725.
  • Hollenhorst PC, Jones DA, Graves BJ. 2004. Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors. Nucleic Acids Res. 32:5693–5702. http://dx.doi.org/10.1093/nar/gkh906.
  • Barton K, Muthusamy N, Fischer C, Ting CN, Walunas TL, Lanier LL, Leiden JM. 1998. The Ets-1 transcription factor is required for the development of natural killer cells in mice. Immunity 9:555–563. http://dx.doi.org/10.1016/S1074-7613(00)80638-X.
  • Bories JC, Willerford DM, Grevin D, Davidson L, Camus A, Martin P, Stehelin D, Alt FW. 1995. Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature 377:635–638. http://dx.doi.org/10.1038/377635a0.
  • Mouly E, Chemin K, Nguyen HV, Chopin M, Mesnard L, Leite-de-Moraes M, Burlen-Defranoux O, Bandeira A, Bories JC. 2010. The Ets-1 transcription factor controls the development and function of natural regulatory T cells. J. Exp. Med. 207:2113–2125. http://dx.doi.org/10.1084/jem.20092153.
  • Yamamoto H, Flannery ML, Kupriyanov S, Pearce J, McKercher SR, Henkel GW, Maki RA, Werb Z, Oshima RG. 1998. Defective trophoblast function in mice with a targeted mutation of Ets2. Genes Dev. 12:1315–1326. http://dx.doi.org/10.1101/gad.12.9.1315.
  • Werner MH, Clore GM, Fisher CL, Fisher RJ, Trinh L, Shiloach J, Gronenborn AM. 1997. Correction of the NMR structure of the ETS1/DNA complex. J. Biomol. NMR 10:317–328. http://dx.doi.org/10.1023/A:1018399711996.
  • Garvie CW, Hagman J, Wolberger C. 2001. Structural studies of Ets-1/Pax5 complex formation on DNA. Mol. Cell 8:1267–1276. http://dx.doi.org/10.1016/S1097-2765(01)00410-5.
  • Obika S, Reddy SY, Bruice TC. 2003. Sequence specific DNA binding of Ets-1 transcription factor: molecular dynamics study on the Ets domain-DNA complexes. J. Mol. Biol. 331:345–359. http://dx.doi.org/10.1016/S0022-2836(03)00726-5.
  • Seidel JJ, Graves BJ. 2002. An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors. Genes Dev. 16:127–137. http://dx.doi.org/10.1101/gad.950902.
  • Yang BS, Hauser CA, Henkel G, Colman MS, Van Beveren C, Stacey KJ, Hume DA, Maki RA, Ostrowski MC. 1996. Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Mol. Cell. Biol. 16:538–547.
  • Nelson ML, Kang HS, Lee GM, Blaszczak AG, Lau DK, McIntosh LP, Graves BJ. 2010. Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP. Proc. Natl. Acad. Sci. U. S. A. 107:10026–10031. http://dx.doi.org/10.1073/pnas.0915137107.
  • Ji Z, Degerny C, Vintonenko N, Deheuninck J, Foveau B, Leroy C, Coll J, Tulasne D, Baert JL, Fafeur V. 2007. Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation. Oncogene 26:395–406. http://dx.doi.org/10.1038/sj.onc.1209789.
  • Macauley MS, Errington WJ, Scharpf M, Mackereth CD, Blaszczak AG, Graves BJ, McIntosh LP. 2006. Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence. J. Biol. Chem. 281:4164–4172. http://dx.doi.org/10.1074/jbc.M510488200.
  • Nishida T, Terashima M, Fukami K. 2006. PIASy-mediated repression of the Ets-1 is independent of its sumoylation. Biochem. Biophys. Res. Commun. 345:1536–1546. http://dx.doi.org/10.1016/j.bbrc.2006.05.065.
  • Hollenhorst PC, Shah AA, Hopkins C, Graves BJ. 2007. Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev. 21:1882–1894. http://dx.doi.org/10.1101/gad.1561707.
  • Gallant S, Gilkeson G. 2006. ETS transcription factors and regulation of immunity. Arch. Immunol. Ther. Exp. (Warsz.) 54:149–163. http://dx.doi.org/10.1007/s00005-006-0017-z.
  • Hollenhorst PC, McIntosh LP, Graves BJ. 2011. Genomic and biochemical insights into the specificity of ETS transcription factors. Annu. Rev. Biochem. 80:437–471. http://dx.doi.org/10.1146/annurev.biochem.79.081507.103945.
  • Garrett-Sinha LA, Dahl R, Rao S, Barton KP, Simon MC. 2001. PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1. Blood 97:2908–2912. http://dx.doi.org/10.1182/blood.V97.9.2908.
  • Garrett-Sinha LA, Su GH, Rao S, Kabak S, Hao Z, Clark MR, Simon MC. 1999. PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction. Immunity 10:399–408. http://dx.doi.org/10.1016/S1074-7613(00)80040-0.
  • Wei G, Srinivasan R, Cantemir-Stone CZ, Sharma SM, Santhanam R, Weinstein M, Muthusamy N, Man AK, Oshima RG, Leone G, Ostrowski MC. 2009. Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood 114:1123–1130. http://dx.doi.org/10.1182/blood-2009-03-211391.
  • Maroulakou IG, Papas TS, Green JE. 1994. Differential expression of ets-1 and ets-2 proto-oncogenes during murine embryogenesis. Oncogene 9:1551–1565.
  • Kallies A, Hasbold J, Fairfax K, Pridans C, Emslie D, McKenzie BS, Lew AM, Corcoran LM, Hodgkin PD, Tarlinton DM, Nutt SL. 2007. Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1. Immunity 26:555–566. http://dx.doi.org/10.1016/j.immuni.2007.04.007.
  • Lin KI, Angelin-Duclos C, Kuo TC, Calame K. 2002. Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells. Mol. Cell. Biol. 22:4771–4780. http://dx.doi.org/10.1128/MCB.22.13.4771-4780.2002.
  • Slupsky CM, Gentile LN, Donaldson LW, Mackereth CD, Seidel JJ, Graves BJ, McIntosh LP. 1998. Structure of the Ets-1 pointed domain and mitogen-activated protein kinase phosphorylation site. Proc. Natl. Acad. Sci. U. S. A. 95:12129–12134. http://dx.doi.org/10.1073/pnas.95.21.12129.
  • Schmidlin H, Diehl SA, Nagasawa M, Scheeren FA, Schotte R, Uittenbogaart CH, Spits H, Blom B. 2008. Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression. Blood 112:1804–1812. http://dx.doi.org/10.1182/blood-2008-01-136440.

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