10
Views
22
CrossRef citations to date
0
Altmetric
Article

A Novel Role of the Mad Family Member Mad3 in Cerebellar Granule Neuron Precursor Proliferation

, , &
Pages 8178-8189 | Received 14 Apr 2006, Accepted 11 Sep 2007, Published online: 27 Mar 2023

REFERENCES

  • Amati, B., S. Dalton, M. W. Brooks, T. D. Littlewood, G. I. Evan, and H. Land. 1992. Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature 359:423–426.
  • Ayer, D. E., L. Kretzner, and R. N. Eisenman. 1993. Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 72:211–222.
  • Billin, A. N., A. L. Eilers, C. Queva, and D. E. Ayer. 1999. Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors. J. Biol. Chem. 274:36344–36350.
  • Ciemerych, M. A., A. M. Kenney, E. Sicinska, I. Kalaszczynska, R. T. Bronson, D. H. Rowitch, H. Gardner, and P. Sicinski. 2002. Development of mice expressing a single D-type cyclin. Genes Dev. 16:3277–3289.
  • Corrales, J. D., G. L. Rocco, S. Blaess, Q. Guo, and A. L. Joyner. 2004. Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development. Development 131:5581–5590.
  • Dahmane, N., and A. Ruiz-i-Altaba. 1999. Sonic hedgehog regulates the growth and patterning of the cerebellum. Development 126:3089–3100.
  • DeCamp, D. L., T. M. Thompson, F. J. de Sauvage, and M. R. Lerner. 2000. Smoothened activates Galphai-mediated signaling in frog melanophores. J. Biol. Chem. 275:26322–26327.
  • Diaz, E., Y. Ge, Y. H. Yang, K. C. Loh, T. A. Serafini, Y. Okazaki, Y. Hayashizaki, T. P. Speed, J. Ngai, and P. Scheiffele. 2002. Molecular analysis of gene expression in the developing pontocerebellar projection system. Neuron 36:417–434.
  • Dimova, D. K., and N. J. Dyson. 2005. The E2F transcriptional network: old acquaintances with new faces. Oncogene 24:2810–2826.
  • Eisen, M. B., P. T. Spellman, P. O. Brown, and D. Botstein. 1998. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95:14863–14868.
  • Foley, K. P., and R. N. Eisenman. 1999. Two MAD tails: what the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network. Biochim. Biophys. Acta 1423:M37–47.
  • Foley, K. P., G. A. McArthur, C. Queva, P. J. Hurlin, P. Soriano, and R. N. Eisenman. 1998. Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation. EMBO J. 17:774–785.
  • Fox, E. J., and S. C. Wright. 2001. S-phase-specific expression of the Mad3 gene in proliferating and differentiating cells. Biochem. J. 359:361–367.
  • Fox, E. J., and S. C. Wright. 2003. The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1. Biochem. J. 370:307–313.
  • Grandori, C., S. M. Cowley, L. P. James, and R. N. Eisenman. 2000. The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu. Rev. Cell Dev. Biol. 16:653–699.
  • Grinberg, A., C.-D. Hu, and T. K. Kerppola. 2004. Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells. Mol. Cell. Biol. 24:4294–4308.
  • Hatten, M. E., J. Alder, K. Zimmerman, and N. Heintz. 1997. Genes involved in cerebellar cell specification and differentiation. Curr. Opin. Neurobiol. 7:40–47.
  • Hatten, M. E., W. O. Gao, M. E. Morrison, and C. A. Mason. 1998. The cerebellum, p. 419–459. In G. Banker and K. Goslin (ed.), Culturing nerve cells, 2nd ed. MIT Press, Cambridge, MA.
  • Hooker, C. W., and P. J. Hurlin. 2006. Of Myc and Mnt. J. Cell Sci. 119:208–216.
  • Huard, J. M., C. C. Forster, M. L. Carter, P. Sicinski, and M. E. Ross. 1999. Cerebellar histogenesis is disturbed in mice lacking cyclin D2. Development 126:1927–1935.
  • Hurlin, P. J., K. P. Foley, D. E. Ayer, R. N. Eisenman, D. Hanahan, and J. M. Arbeit. 1995. Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis. Oncogene 11:2487–2501.
  • Hurlin, P. J., C. Queva, P. J. Koskinen, E. Steingrimsson, D. E. Ayer, N. G. Copeland, N. A. Jenkins, and R. N. Eisenman. 1995. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 14:5646–5659.
  • Ingham, P. W., and A. P. McMahon. 2001. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15:3059–3087.
  • Iritani, B. M., J. Delrow, C. Grandori, I. Gomez, M. Klacking, L. S. Carlos, and R. N. Eisenman. 2002. Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1. EMBO J. 21:4820–4830.
  • Kelly, K., B. H. Cochran, C. D. Stiles, and P. Leder. 1983. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 35:603–610.
  • Kenney, A. M., M. D. Cole, and D. H. Rowitch. 2003. Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development 130:15–28.
  • Klisch, T. J., J. Souopgui, K. Juergens, B. Rust, T. Pieler, and K. A. Henningfeld. 2006. Mxi1 is essential for neurogenesis in Xenopus and acts by bridging the pan-neural and proneural genes. Dev. Biol. 292:470–485.
  • Knoepfler, P. S., P. F. Cheng, and R. N. Eisenman. 2002. N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev. 16:2699–2712.
  • Knoepfler, P. S., X. Y. Zhang, P. F. Cheng, P. R. Gafken, S. B. McMahon, and R. N. Eisenman. 2006. Myc influences global chromatin structure. EMBO J. 25:2723–2734.
  • Kretzner, L., E. M. Blackwood, and R. N. Eisenman. 1992. Myc and Max proteins possess distinct transcriptional activities. Nature 359:426–429.
  • Lee, L. A., and C. V. Dang. 2006. Myc target transcriptomes. Curr. Top. Microbiol. Immunol. 302:145–167.
  • Manzini, M. C., M. S. Ward, Q. Zhang, M. D. Lieberman, and C. A. Mason. 2006. The stop signal revised: immature cerebellar granule neurons in the external germinal layer arrest pontine mossy fiber growth. J. Neurosci. 26:6040–6051.
  • McArthur, G. A., C. D. Laherty, C. Queva, P. J. Hurlin, L. Loo, L. James, C. Grandori, P. Gallant, Y. Shiio, W. C. Hokanson, A. C. Bush, P. F. Cheng, Q. A. Lawrence, B. Pulverer, P. J. Koskinen, K. P. Foley, D. E. Ayer, and R. N. Eisenman. 1998. The Mad protein family links transcriptional repression to cell differentiation. Cold Spring Harb. Symp. Quant. Biol. 63:423–433.
  • Meroni, G., S. Cairo, G. Merla, S. Messali, R. Brent, A. Ballabio, and A. Reymond. 2000. Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? Oncogene 19:3266–3277.
  • Meyer, N., S. S. Kim, and L. Z. Penn. 2006. The Oscar-worthy role of Myc in apoptosis. Semin. Cancer Biol. 16:275–287.
  • Migheli, A., R. Piva, S. Casolino, C. Atzori, S. R. Dlouhy, and B. Ghetti. 1999. A cell cycle alteration precedes apoptosis of granule cell precursors in the weaver mouse cerebellum. Am. J. Pathol. 155:365–373.
  • Nilsson, J. A., and J. L. Cleveland. 2003. Myc pathways provoking cell suicide and cancer. Oncogene 22:9007–9021.
  • Oliver, T. G., L. L. Grasfeder, A. L. Carroll, C. Kaiser, C. L. Gillingham, S. M. Lin, R. Wickramasinghe, M. P. Scott, and R. J. Wechsler-Reya. 2003. Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. Proc. Natl. Acad. Sci. USA 100:7331–7336.
  • Oliver, T. G., T. A. Read, J. D. Kessler, A. Mehmeti, J. F. Wells, T. T. Huynh, S. M. Lin, and R. J. Wechsler-Reya. 2005. Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma. Development 132:2425–2439.
  • Pelengaris, S., M. Khan, and G. Evan. 2002. c-MYC: more than just a matter of life and death. Nat. Rev. Cancer 2:764–776.
  • Pulverer, B., A. Sommer, G. A. McArthur, R. N. Eisenman, and B. Luscher. 2000. Analysis of Myc/Max/Mad network members in adipogenesis: inhibition of the proliferative burst and differentiation by ectopically expressed Mad1. J. Cell Physiol. 183:399–410.
  • Queva, C., P. J. Hurlin, K. P. Foley, and R. N. Eisenman. 1998. Sequential expression of the MAD family of transcriptional repressors during differentiation and development. Oncogene 16:967–977.
  • Queva, C., G. A. McArthur, B. M. Iritani, and R. N. Eisenman. 2001. Targeted deletion of the S-phase-specific Myc antagonist Mad3 sensitizes neuronal and lymphoid cells to radiation-induced apoptosis. Mol. Cell. Biol. 21:703–712.
  • Rabbitts, P. H., J. V. Watson, A. Lamond, A. Forster, M. A. Stinson, G. Evan, W. Fischer, E. Atherton, R. Sheppard, and T. H. Rabbitts. 1985. Metabolism of c-myc gene products: c-myc mRNA and protein expression in the cell cycle. EMBO J. 4:2009–2015.
  • Ross, M. E., M. L. Carter, and J. H. Lee. 1996. MN20, a D2 cyclin, is transiently expressed in selected neural populations during embryogenesis. J. Neurosci. 16:210–219.
  • Rottmann, S., and B. Luscher. 2006. The Mad side of the Max network: antagonizing the function of Myc and more. Curr. Top. Microbiol. Immunol. 302:63–122.
  • Rudolph, B., A. O. Hueber, and G. I. Evan. 2001. Expression of Mad1 in T cells leads to reduced thymic cellularity and impaired mitogen-induced proliferation. Oncogene 20:1164–1175.
  • Schreiber-Agus, N., Y. Meng, T. Hoang, H. Hou, Jr., K. Chen, R. Greenberg, C. Cordon-Cardo, H. W. Lee, and R. A. DePinho. 1998. Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. Nature 393:483–487.
  • Seoane, J., C. Pouponnot, P. Staller, M. Schader, M. Eilers, and J. Massague. 2001. TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat. Cell Biol. 3:400–408.
  • Taipale, J., J. K. Chen, M. K. Cooper, B. Wang, R. K. Mann, L. Milenkovic, M. P. Scott, and P. A. Beachy. 2000. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406:1005–1009.
  • van den Heuvel, M., and P. W. Ingham. 1996. smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 382:547–551.
  • Vastrik, I., A. Kaipainen, T. L. Penttila, A. Lymboussakis, R. Alitalo, M. Parvinen, and K. Alitalo. 1995. Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro. J. Cell Biol. 128:1197–1208.
  • Wechsler-Reya, R., and M. P. Scott. 2001. The developmental biology of brain tumors. Annu. Rev. Neurosci. 24:385–428.
  • Wechsler-Reya, R. J., and M. P. Scott. 1999. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22:103–114.
  • Wernecke, H., J. Lindner, and M. Schachner. 1985. Cell type specificity and developmental expression of the L2/HNK-1 epitopes in mouse cerebellum. J. Neuroimmunol. 9:115–130.
  • Wu, S., C. Cetinkaya, M. J. Munoz-Alonso, N. von der Lehr, F. Bahram, V. Beuger, M. Eilers, J. Leon, and L. G. Larsson. 2003. Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene 22:351–360.
  • Zhou, Z. Q., and P. J. Hurlin. 2001. The interplay between Mad and Myc in proliferation and differentiation. Trends Cell Biol. 11:S10–S14.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.