Pseudomonas Exotoxin A-Mediated Apoptosis Is Bak Dependent and Preceded by the Degradation of Mcl-1

REFERENCES

• Adams, J. M., and S. Cory. 2007. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26:1324–1327.
   PubMed Web of Science ®Google Scholar
• Adams, K. W., and G. M. Cooper. 2007. Rapid turnover of mcl-1 couples translation to cell survival and apoptosis. J. Biol. Chem. 282:6192–6200.
   PubMed Web of Science ®Google Scholar
• Andersson, Y., S. Juell, and Ø. Fodstad. 2004. Downregulation of the antiapoptotic MCL-1 protein and apoptosis in MA-11 breast cancer cells induced by an anti-epidermal growth factor receptor-Pseudomonas exotoxin A immunotoxin. Int. J. Cancer 112:475–483.
   PubMed Web of Science ®Google Scholar
• Antignani, A., and R. J. Youle. 2006. How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane? Curr. Opin. Cell Biol. 18:685–689.
   PubMed Web of Science ®Google Scholar
• Chen, L., S. N. Willis, A. Wei, B. J. Smith, J. I. Fletcher, M. G. Hinds, P. M. Colman, C. L. Day, J. M. Adams, and D. C. Huang. 2005. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol. Cell 17:393–403.
   PubMed Web of Science ®Google Scholar
• Chipuk, J. E., and D. R. Green. 2008. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol. 18:157–164.
   PubMed Web of Science ®Google Scholar
• Cuconati, A., C. Mukherjee, D. Perez, and E. White. 2003. DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells. Genes Dev. 17:2922–2932.
   PubMed Web of Science ®Google Scholar
• Galluzzi, L., N. Zamzami, T. de La Motte Rouge, C. Lemaire, C. Brenner, and G. Kroemer. 2007. Methods for the assessment of mitochondrial membrane permeabilization in apoptosis. Apoptosis 12:803–813.
   PubMed Web of Science ®Google Scholar
• Gillissen, B., F. Essmann, V. Graupner, L. Stärck, S. Radetzki, B. Dörken, K. Schulze-Osthoff, and P. T. Daniel. 2003. Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. EMBO J. 22:3580–3590.
   PubMed Web of Science ®Google Scholar
• Gillissen, B., F. Essmann, P. G. Hemmati, A. Richter, A. Richter, I. Oztop, G. Chinnadurai, B. Dörken, and P. T. Daniel. 2007. Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis. J. Cell Biol. 179:701–715.
   PubMed Web of Science ®Google Scholar
• Han, J., L. A. Goldstein, B. R. Gastman, and H. Rabinowich. 2006. Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis. J. Biol. Chem. 281:10153–10163.
   PubMed Web of Science ®Google Scholar
• Hsu, Y. T., and R. J. Youle. 1998. Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations. J. Biol. Chem. 273:10777–10783.
   PubMed Web of Science ®Google Scholar
• Jenkins, C. E., A. Swiatoniowski, A. C. Issekutz, and T. J. Lin. 2004. Pseudomonas aeruginosa exotoxin A induces human mast cell apoptosis by a caspase-8 and -3-dependent mechanism. J. Biol. Chem. 279:37201–37207.
   PubMed Web of Science ®Google Scholar
• Johnstone, R. W., A. A. Ruefli, and S. W. Lowe. 2002. Apoptosis: a link between cancer genetics and chemotherapy. Cell 108:153–164.
   PubMed Web of Science ®Google Scholar
• Kepp, O., K. Rajalingam, S. Kimmig, and T. Rudel. 2007. Bak and Bax are non-redundant during infection and DNA damage-induced apoptosis. EMBO J. 26:825–834.
   PubMed Web of Science ®Google Scholar
• Keppler-Hafkemeyer, A., U. Brinkmann, and I. Pastan. 1998. Role of caspases in immunotoxin-induced apoptosis of cancer cells. Biochemistry 37:16934–16942.
   PubMed Web of Science ®Google Scholar
• Keppler-Hafkemeyer, A., R. J. Kreitman, and I. Pastan. 2000. Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies. Int. J. Cancer 87:86–94.
   PubMed Web of Science ®Google Scholar
• Kreitman, R. J., D. R. Squires, M. Stetler-Stevenson, P. Noel, D. J. FitzGerald, W. H. Wilson, and I. Pastan. 2005. Phase I trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with B-cell malignancies. J. Clin. Oncol. 23:6719–6729.
   PubMed Web of Science ®Google Scholar
• Kreitman, R. J., W. H. Wilson, K. Bergeron, M. Raffio, M. Stetler-Stevenson, D. J. FitzGerald, and I. Pastan. 2001. Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia. N. Engl. J. Med. 345:241–247.
   PubMed Web of Science ®Google Scholar
• Kroemer, G., and J. Pouyssegur. 2008. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 13:472–482.
   PubMed Web of Science ®Google Scholar
• Letai, A. G. 2008. Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nat. Rev. Cancer. 8:121–132.
   PubMed Web of Science ®Google Scholar
• Lindenboim, L., S. Kringel, T. Braun, C. Borner, and R. Stein. 2005. Bak but not Bax is essential for Bcl-xS-induced apoptosis. Cell Death Differ. 12:713–723.
   PubMedGoogle Scholar
• MacCallum, D. E., J. Melville, S. Frame, K. Watt, S. Anderson, A. Gianella-Borradori, D. P. Lane, and S. R. Green. 2005. Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1. Cancer Res. 65:5399–5407.
   PubMed Web of Science ®Google Scholar
• Melet, A., K. Song, O. Bucur, Z. Jagani, A. R. Grassian, and R. Khosravi-Far. 2008. Apoptotic pathways in tumor progression and therapy. Adv. Exp. Med. Biol. 615:47–79.
   PubMed Web of Science ®Google Scholar
• Nijhawan, D., M. Fang, E. Traer, Q. Zhong, W. Gao, F. Du, and X. Wang. 2003. Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev. 17:1475–1486.
   PubMed Web of Science ®Google Scholar
• Olsen, E., M. Duvic, A. Frankel, Y. Kim, A. Martin, E. Vonderheid, B. Jegasothy, G. Wood, M. Gordon, P. Heald, A. Oseroff, L. Pintner-Brown, G. Bowen, T. Kuzel, D. Fivenson, F. Foss, M. Glode, A. Molina, E. Knobler, S. Stewart, K. Cooper, S. Stevens, F. Craig, J. Reuben, P. Bacha, and J. Nichols. 2001. Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma. J. Clin. Oncol. 19:376–388.
   PubMed Web of Science ®Google Scholar
• Pardo, J., C. Urban, E. M. Galvez, P. G. Ekert, U. Müller, J. Kwon-Chung, M. Lobigs, A. Müllbacher, R. Wallich, C. Borner, and M. M. Simon. 2006. The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. J. Cell Biol. 174:509–519.
   PubMed Web of Science ®Google Scholar
• Pastan, I., R. Hassan, D. J. Fitzgerald, and R. J. Kreitman. 2006. Immunotoxin therapy of cancer. Nat. Rev. Cancer. 6:559–565.
   PubMed Web of Science ®Google Scholar
• Pastan, I., R. Hassan, D. J. FitzGerald, and R. J. Kreitman. 2007. Immunotoxin treatment of cancer. Annu. Rev. Med. 58:221–237.
   PubMed Web of Science ®Google Scholar
• Perentesis, J. P., K. G. Waddick, A. E. Bendel, Y. Shao, B. E. Warman, M. Chandan-Langlie, and F. M. Uckun. 1997. Induction of apoptosis in multidrug-resistant and radiation-resistant acute myeloid leukemia cells by a recombinant fusion toxin directed against the human granulocyte macrophage colony-stimulating factor receptor. Clin. Cancer Res. 3:347–355.
   PubMed Web of Science ®Google Scholar
• Shimazu, T., K. Degenhardt, A. Nur-E-Kamal, J. Zhang, T. Yoshida, Y. Zhang, R. Mathew, E. White, and M. Inouye. 2007. NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition. Genes Dev. 21:929–941.
   PubMedGoogle Scholar
• Thorburn, A., J. Thorburn, and A. E. Frankel. 2004. Induction of apoptosis by tumor cell-targeted toxins. Apoptosis 9:19–25.
   PubMedGoogle Scholar
• Thorburn, J., A. E. Frankel, and A. Thorburn. 2003. Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein. Clin. Cancer Res. 9:861–865.
   PubMed Web of Science ®Google Scholar
• Upreti, M., R. Chu, E. Galitovskaya, S. K. Smart, and T. C. Chambers. 2008. Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine. Mol. Cancer Ther. 7:2224–2232.
   PubMed Web of Science ®Google Scholar
• Urban, C., C. Rhême, S. Maerz, B. Berg, R. Pick, R. Nitschke, and C. Borner. 2008. Apoptosis induced by Semliki Forest virus is RNA replication dependent and mediated via Bak. Cell Death Differ. 15:1396–1407.
   PubMed Web of Science ®Google Scholar
• Von Haefen, C., B. Gillissen, P. G. Hemmati, J. Wendt, D. Güner, A. Mrozek, C. Belka, B. Dörke, and P. T. Daniel. 2004. Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway. Oncogene 23:8320–8332.
   PubMed Web of Science ®Google Scholar
• Wei, M. C., W. X. Zong, E. H. Cheng, T. Lindsten, V. Panoutsakopoulou, A. J. Ross, K. A. Roth, G. R. MacGregor, C. B. Thompson, and S. J. Korsmeyer. 2001. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292:727–730.
   PubMed Web of Science ®Google Scholar
• Wendt, J., C. von Haefen, P. Hemmati, C. Belka, B. Dörken, and P. T. Daniel. 2005. TRAIL sensitizes for ionizing irradiation-induced apoptosis through an entirely Bax-dependent mitochondrial cell death pathway. Oncogene 24:4052–4064.
   PubMed Web of Science ®Google Scholar
• Willis, S. N., L. Chen, G. Dewson, A. Wei, E. Naik, J. I. Fletcher, J. M. Adams, and D. C. Huang. 2005. Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 19:1294–1305.
   PubMed Web of Science ®Google Scholar
• Willis, S. N., J. I. Fletcher, T. Kaufmann, M. F. van Delft, L. Chen, P. E. Czabotar, H. Ierino, E. F. Lee, W. D. Fairlie, P. Bouillet, A. Strasser, R. M. Kluck, J. M. Adams, and D. C. S. Huang. 2007. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315:856–859.
   PubMed Web of Science ®Google Scholar
• Zhang, B., I. Gojo, and R. G. Fenton. 2002. Myeloid cell factor-1 is a critical survival factor for multiple myeloma. Blood 99:1885–1893.
   PubMed Web of Science ®Google Scholar
• Zhang, L., J. Yu, B. H. Park, K. W. Kinzler, and B. Vogelstein. 2000. Role of BAX in the apoptotic response to anticancer agents. Science 290:989–992.
   PubMed Web of Science ®Google Scholar
• Zong, W. X., T. Lindsten, A. J. Ross, G. R. MacGregor, and C. B. Thompson. 2001. BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev. 15:1481–1486.
   PubMed Web of Science ®Google Scholar