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Article

Serum Response Factor Utilizes Distinct Promoter- and Enhancer-Based Mechanisms To Regulate Cytoskeletal Gene Expression in Macrophages

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Pages 861-875 | Received 20 Jul 2010, Accepted 26 Nov 2010, Published online: 20 Mar 2023

REFERENCES

  • Aftab, S., L. Semenec, J. S. Chu, and N. Chen. 2008. Identification and characterization of novel human tissue-specific RFX transcription factors. BMC Evol. Biol. 8:226.
  • Alberti, S., et al. 2005. Neuronal migration in the murine rostral migratory stream requires serum response factor. Proc. Natl. Acad. Sci. U. S. A. 102:6148–6153.
  • Arsenian, S., B. Weinhold, M. Oelgeschlager, U. Ruther, and A. Nordheim. 1998. Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J. 17:6289–6299.
  • Bailey, T. L., and C. Elkan. 1994. Fitting a mixture model by expectation maximization to discover motifs in biopolymers. Proc. Int. Conf. Intell. Syst. Mol. Biol. 2:28–36.
  • Blackshear, P. J., et al. 2003. Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4. Development 130:4539–4552.
  • Cen, B., et al. 2003. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Mol. Cell. Biol. 23:6597–6608.
  • Delanote, V., J. Vandekerckhove, and J. Gettemans. 2005. Plastins: versatile modulators of actin organization in (patho)physiological cellular processes. Acta Pharmacol. Sin. 26:769–779.
  • Dennis, G., Jr., et al. 2003. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4:P3.
  • Ernst, W. H., R. Janknecht, M. A. Cahill, and A. Nordheim. 1995. Transcriptional repression mediated by the serum response factor. FEBS Lett. 357:45–49.
  • Ferrari, G., H. Langen, M. Naito, and J. Pieters. 1999. A coat protein on phagosomes involved in the intracellular survival of mycobacteria. Cell 97:435–447.
  • Ghisletti, S., et al. 2010. Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. Immunity 32:317–328.
  • Han, Z., X. Li, J. Wu, and E. N. Olson. 2004. A myocardin-related transcription factor regulates activity of serum response factor in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 101:12567–12572.
  • Heintzman, N. D., et al. 2009. Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 459:108–112.
  • Heintzman, N. D., et al. 2007. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat. Genet. 39:311–318.
  • Heinz, S., et al. 2010. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38:576–589.
  • Huang, Q. Q., et al. 2008. Role of H2-calponin in regulating macrophage motility and phagocytosis. J. Biol. Chem. 283:25887–25899.
  • Johansen, F. E., and R. Prywes. 1995. Serum response factor: transcriptional regulation of genes induced by growth factors and differentiation. Biochim. Biophys. Acta 1242:1–10.
  • Jongstra-Bilen, J., and J. Jongstra. 2006. Leukocyte-specific protein 1 (LSP1): a regulator of leukocyte emigration in inflammation. Immunol. Res. 35:65–74.
  • Kent, W. J., et al. 2002. The human genome browser at UCSC. Genome Res. 12:996–1006.
  • Kim, T. K., et al. 2010. Widespread transcription at neuronal activity-regulated enhancers. Nature 465:182–187.
  • Kuhn, R., F. Schwenk, M. Aguet, and K. Rajewsky. 1995. Inducible gene targeting in mice. Science 269:1427–1429.
  • Laslo, P., et al. 2006. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell 126:755–766.
  • Lattin, J. E., et al. 2008. Expression analysis of G protein-coupled receptors in mouse macrophages. Immunome Res. 4:5.
  • L'honore, A., et al. 2003. MyoD distal regulatory region contains an SRF binding CArG element required for MyoD expression in skeletal myoblasts and during muscle regeneration. Mol. Biol. Cell 14:2151–2162.
  • Li, L., Z. Liu, B. Mercer, P. Overbeek, and E. N. Olson. 1997. Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells. Dev. Biol. 187:311–321.
  • Li, S., et al. 2005. Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice. Proc. Natl. Acad. Sci. U. S. A. 102:1082–1087.
  • Lin, C. S., T. Park, Z. P. Chen, and J. Leavitt. 1993. Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. J. Biol. Chem. 268:2781–2792.
  • Ma, K., S. Zheng, and Z. Zuo. 2006. The transcription factor regulatory factor X1 increases the expression of neuronal glutamate transporter type 3. J. Biol. Chem. 281:21250–21255.
  • McLean, C. Y., et al. 2010. GREAT improves functional interpretation of cis-regulatory regions. Nat. Biotechnol. 28:495–501.
  • Mellor, J., P. Dudek, and D. Clynes. 2008. A glimpse into the epigenetic landscape of gene regulation. Curr. Opin. Genet. Dev. 18:116–122.
  • Miano, J. M. 2003. Serum response factor: toggling between disparate programs of gene expression. J. Mol. Cell. Cardiol. 35:577–593.
  • Miano, J. M., X. Long, and K. Fujiwara. 2007. Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. Am. J. Physiol. Cell Physiol. 292:C70–C81.
  • Miano, J. M., et al. 2004. Restricted inactivation of serum response factor to the cardiovascular system. Proc. Natl. Acad. Sci. U. S. A. 101:17132–17137.
  • Miralles, F., G. Posern, A. I. Zaromytidou, and R. Treisman. 2003. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113:329–342.
  • Mosser, D. M., and J. P. Edwards. 2008. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8:958–969.
  • Niu, Z., et al. 2005. Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J. Biol. Chem. 280:32531–32538.
  • Parlakian, A., et al. 2004. Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality. Mol. Cell. Biol. 24:5281–5289.
  • Pollard, J. W. 2009. Trophic macrophages in development and disease. Nat. Rev. Immunol. 9:259–270.
  • Ragu, C., et al. 2010. The transcription factor SRF regulates hematopoietic stem cell adhesion. Blood 116:4464–4473.
  • Ramanan, N., et al. 2005. SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat. Neurosci. 8:759–767.
  • Robertson, G., et al. 2007. Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nat. Methods 4:651–657.
  • Sasazuki, T., et al. 2002. Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. J. Biol. Chem. 277:28853–28860.
  • Schratt, G., et al. 2002. Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells. J. Cell Biol. 156:737–750.
  • Schratt, G., et al. 2001. Serum response factor is required for immediate-early gene activation yet is dispensable for proliferation of embryonic stem cells. Mol. Cell. Biol. 21:2933–2943.
  • Selvaraj, A., and R. Prywes. 2003. Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation. J. Biol. Chem. 278:41977–41987.
  • Shen, X., et al. 2009. The correlations of the function and positional distribution of the cis-elements CArG around the TSS in the genes of Mus musculus. Genome 52:217–221.
  • Shore, P., and A. D. Sharrocks. 1995. The MADS-box family of transcription factors. Eur. J. Biochem. 229:1–13.
  • Shore, P., and A. D. Sharrocks. 1994. The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1. Mol. Cell. Biol. 14:3283–3291.
  • Spencer, J. A., and R. P. Misra. 1996. Expression of the serum response factor gene is regulated by serum response factor binding sites. J. Biol. Chem. 271:16535–16543.
  • Sun, Q., et al. 2006. Defining the mammalian CArGome. Genome Res. 16:197–207.
  • Treisman, R. 1986. Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors. Cell 46:567–574.
  • Treisman, R., R. Marais, and J. Wynne. 1992. Spatial flexibility in ternary complexes between SRF and its accessory proteins. EMBO J. 11:4631–4640.
  • Valledor, A. F., et al. 2004. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc. Natl. Acad. Sci. U. S. A. 101:17813–17818.
  • Walsh, J. C., et al. 2002. Cooperative and antagonistic interplay between PU. 1 and GATA-2 in the specification of myeloid cell fates. Immunity 17:665–676.
  • Wang, D., et al. 2001. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell 105:851–862.
  • Wang, D. Z., et al. 2002. Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc. Natl. Acad. Sci. U. S. A. 99:14855–14860.
  • Wang, Z., et al. 2004. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature 428:185–189.
  • Watson, D. K., et al. 1997. FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements. Oncogene 14:213–221.
  • Wei, G. H., et al. 2010. Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 29:2147–2160.
  • Weinhold, B., et al. 2000. Srf(−/−) ES cells display non-cell-autonomous impairment in mesodermal differentiation. EMBO J. 19:5835–5844.
  • Wickramasinghe, S. R., et al. 2008. Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron 58:532–545.
  • Wu, C., et al. 2009. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol. 10:R130.
  • Xie, X., et al. 2005. Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals. Nature 434:338–345.

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