Phosphorylation of Trask by Src Kinases Inhibits Integrin Clustering and Functions in Exclusion with Focal Adhesion Signaling

REFERENCES

• Arias-Salgado, E. G., et al. 2003. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc. Natl. Acad. Sci. U. S. A. 100:13298–13302.
   PubMed Web of Science ®Google Scholar
• Arnaout, M. A., B. Mahalingam, and J. P. Xiong. 2005. Integrin structure, allostery, and bidirectional signaling. Annu. Rev. Cell Dev. Biol. 21:381–410.
   PubMed Web of Science ®Google Scholar
• Awakura, Y., et al. 2008. Microarray-based identification of CUB-domain containing protein 1 as a potential prognostic marker in conventional renal cell carcinoma. J. Cancer Res. Clin. Oncol. 134:1363–1369.
   PubMedGoogle Scholar
• Bellis, S. L., J. T. Miller, and C. E. Turner. 1995. Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. J. Biol. Chem. 270:17437–17441.
   PubMed Web of Science ®Google Scholar
• Bhatt, A. S., H. Erdjument-Bromage, P. Tempst, C. S. Craik, and M. M. Moasser. 2005. Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene 24:5333–5343.
   PubMed Web of Science ®Google Scholar
• Blaschke, F., et al. 2002. Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 296:890–896.
   PubMed Web of Science ®Google Scholar
• Bockholt, S. M., and K. Burridge. 1995. An examination of focal adhesion formation and tyrosine phosphorylation in fibroblasts isolated from src-, fyn-, and yes- mice. Cell Adhes. Commun. 3:91–100.
   PubMed Web of Science ®Google Scholar
• Brown, T. A., et al. 2004. Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia. J. Biol. Chem. 279:14772–14783.
   PubMed Web of Science ®Google Scholar
• Calderwood, D. A., et al. 2002. The phosphotyrosine binding-like domain of talin activates integrins. J. Biol. Chem. 277:21749–21758.
   PubMed Web of Science ®Google Scholar
• Chodniewicz, D., and R. L. Klemke. 2004. Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. Biochim. Biophys. Acta 1692:63–76.
   PubMedGoogle Scholar
• David-Pfeuty, T., and S. J. Singer. 1980. Altered distributions of the cytoskeletal proteins vinculin and alpha-actinin in cultured fibroblasts transformed by Rous sarcoma virus. Proc. Natl. Acad. Sci. U. S. A. 77:6687–6691.
   PubMed Web of Science ®Google Scholar
• Deryugina, E. I., et al. 2009. Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination. Mol. Cancer Res. 7:1197–1211.
   PubMedGoogle Scholar
• Dittel, B. N., J. B. McCarthy, E. A. Wayner, and T. W. LeBien. 1993. Regulation of human B-cell precursor adhesion to bone marrow stromal cells by cytokines that exert opposing effects on the expression of vascular cell adhesion molecule-1 (VCAM-1). Blood 81:2272–2282.
   PubMed Web of Science ®Google Scholar
• Engen, J. R., et al. 2008. Structure and dynamic regulation of Src-family kinases. Cell. Mol. Life Sci. 65:3058–3073.
   PubMed Web of Science ®Google Scholar
• Fincham, V. J., and M. C. Frame. 1998. The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J. 17:81–92.
   PubMed Web of Science ®Google Scholar
• Fincham, V. J., et al. 1996. Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins. J. Cell Biol. 135:1551–1564.
   PubMedGoogle Scholar
• Frame, M. C. 2004. Newest findings on the oldest oncogene; how activated src does it. J. Cell Sci. 117:989–998.
   PubMedGoogle Scholar
• Frame, M. C., V. J. Fincham, N. O. Carragher, and J. A. Wyke. 2002. v-Src's hold over actin and cell adhesions. Nat. Rev. Mol. Cell Biol. 3:233–245.
   PubMed Web of Science ®Google Scholar
• Fukuchi, K., et al. 2010. Inhibition of tumor metastasis: functional immune modulation of the CUB domain containing protein 1. Mol. Pharm. 7:245–253.
   PubMedGoogle Scholar
• Glenney, J. R., Jr., and L. Zokas. 1989. Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton. J. Cell Biol. 108:2401–2408.
   PubMed Web of Science ®Google Scholar
• Harte, M. T., J. D. Hildebrand, M. R. Burnham, A. H. Bouton, and J. T. Parsons. 1996. p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase. J. Biol. Chem. 271:13649–13655.
   PubMed Web of Science ®Google Scholar
• Hooper, J. D., et al. 2003. Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Oncogene 22:1783–1794.
   PubMed Web of Science ®Google Scholar
• Huveneers, S., and E. H. Danen. 2009. Adhesion signaling—crosstalk between integrins, Src and Rho. J. Cell Sci. 122:1059–1069.
   PubMed Web of Science ®Google Scholar
• Ikeda, J., et al. 2009. Expression of CUB domain containing protein (CDCP1) is correlated with prognosis and survival of patients with adenocarcinoma of lung. Cancer Sci. 100:429–433.
   PubMed Web of Science ®Google Scholar
• Kaplan, K. B., et al. 1994. Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. EMBO J. 13:4745–4756.
   PubMed Web of Science ®Google Scholar
• Kaplan, K. B., J. R. Swedlow, D. O. Morgan, and H. E. Varmus. 1995. c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes Dev. 9:1505–1517.
   PubMed Web of Science ®Google Scholar
• Klinghoffer, R. A., C. Sachsenmaier, J. A. Cooper, and P. Soriano. 1999. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18:2459–2471.
   PubMed Web of Science ®Google Scholar
• Mamat, S., et al. 2010. Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma. Oncol. Rep. 23:1221–1227.
   PubMedGoogle Scholar
• McCleverty, C. J., D. C. Lin, and R. C. Liddington. 2007. Structure of the PTB domain of tensin1 and a model for its recruitment to fibrillar adhesions. Protein Sci. 16:1223–1229.
   PubMedGoogle Scholar
• Mitra, S. K., and D. D. Schlaepfer. 2006. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 18:516–523.
   PubMed Web of Science ®Google Scholar
• Miyazawa, Y., et al. 2010. CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation. Cancer Res. 70:5136–5146.
   PubMedGoogle Scholar
• Moser, M., K. R. Legate, R. Zent, and R. Fassler. 2009. The tail of integrins, talin, and kindlins. Science 324:895–899.
   PubMed Web of Science ®Google Scholar
• Nigg, E. A., B. M. Sefton, T. Hunter, G. Walter, and S. J. Singer. 1982. Immunofluorescent localization of the transforming protein of Rous sarcoma virus with antibodies against a synthetic src peptide. Proc. Natl. Acad. Sci. U. S. A. 79:5322–5326.
   PubMed Web of Science ®Google Scholar
• Parsons, S. J., and J. T. Parsons. 2004. Src family kinases, key regulators of signal transduction. Oncogene 23:7906–7909.
   PubMed Web of Science ®Google Scholar
• Playford, M. P., and M. D. Schaller. 2004. The interplay between Src and integrins in normal and tumor biology. Oncogene 23:7928–7946.
   PubMed Web of Science ®Google Scholar
• Sakai, T., R. Jove, R. Fassler, and D. F. Mosher. 2001. Role of the cytoplasmic tyrosines of beta 1A integrins in transformation by v-src. Proc. Natl. Acad. Sci. U. S. A. 98:3808–3813.
   PubMedGoogle Scholar
• Schaller, M. D., et al. 1994. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol. Cell. Biol. 14:1680–1688.
   PubMed Web of Science ®Google Scholar
• Schaller, M. D., and J. T. Parsons. 1995. pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk. Mol. Cell. Biol. 15:2635–2645.
   PubMed Web of Science ®Google Scholar
• Scherl-Mostageer, M., et al. 2001. Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene 20:4402–4408.
   PubMed Web of Science ®Google Scholar
• Shattil, S. J. 2005. Integrins and Src: dynamic duo of adhesion signaling. Trends Cell Biol. 15:399–403.
   PubMed Web of Science ®Google Scholar
• Siva, A. C., et al. 2008. Targeting CUB domain-containing protein 1 with a monoclonal antibody inhibits metastasis in a prostate cancer model. Cancer Res. 68:3759–3766.
   PubMed Web of Science ®Google Scholar
• Spassov, D. S., F. L. Baehner, C. H. Wong, S. McDonough, and M. M. Moasser. 2009. The transmembrane src substrate Trask is an epithelial protein that signals during anchorage deprivation. Am. J. Pathol. 174:1756–1765.
   PubMed Web of Science ®Google Scholar
• Timpson, P., G. E. Jones, M. C. Frame, and V. G. Brunton. 2001. Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity. Curr. Biol. 11:1836–1846.
   PubMed Web of Science ®Google Scholar
• Turner, C. E. 2000. Paxillin and focal adhesion signalling. Nat. Cell Biol. 2:E231–E236.
   PubMed Web of Science ®Google Scholar
• Uekita, T., et al. 2007. CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma. Mol. Cell. Biol. 27:7649–7660.
   PubMedGoogle Scholar
• Uekita, T., et al. 2008. CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma. Am. J. Pathol. 172:1729–1739.
   PubMedGoogle Scholar
• Volberg, T., L. Romer, E. Zamir, and B. Geiger. 2001. pp60(c-src) and related tyrosine kinases: a role in the assembly and reorganization of matrix adhesions. J. Cell Sci. 114:2279–2289.
   PubMed Web of Science ®Google Scholar
• Vuori, K. 1998. Integrin signaling: tyrosine phosphorylation events in focal adhesions. J. Membr. Biol. 165:191–199.
   PubMed Web of Science ®Google Scholar
• Wegener, K. L., et al. 2007. Structural basis of integrin activation by talin. Cell 128:171–182.
   PubMed Web of Science ®Google Scholar
• Wong, C. H., et al. 2009. Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers. Clin. Cancer Res. 15:2311–2322.
   PubMed Web of Science ®Google Scholar
• Yamana, N., et al. 2006. The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol. Cell. Biol. 26:6844–6858.
   PubMed Web of Science ®Google Scholar
• Yokosaki, Y., et al. 1994. The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin. J. Biol. Chem. 269:26691–26696.
   PubMed Web of Science ®Google Scholar