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Article

Inactivation of Uaf1 Causes Defective Homologous Recombination and Early Embryonic Lethality in Mice

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Pages 4360-4370 | Received 09 Jul 2013, Accepted 29 Aug 2013, Published online: 20 Mar 2023

REFERENCES

  • Symington LS, Gautier J. 2011. Double-strand break end resection and repair pathway choice. Annu. Rev. Genet. 45:247–271.
  • San Filippo J, Sung P, Klein H. 2008. Mechanism of eukaryotic homologous recombination. Annu. Rev. Biochem. 77:229–257.
  • O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW. 2010. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol. Cell 40:645–657.
  • Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ. 2012. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat. Cell Biol. 14:318–328.
  • Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ. 2007. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316:1160–1166.
  • Jackson SP, Durocher D. 2013. Regulation of DNA damage responses by ubiquitin and SUMO. Mol. Cell 49:795–807.
  • Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R. 2005. The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol. Cell 17:331–339.
  • Huang TT, Nijman SM, Mirchandani KD, Galardy PJ, Cohn MA, Haas W, Gygi SP, Ploegh HL, Bernards R, D'Andrea AD. 2006. Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat. Cell Biol. 8:339–347.
  • Oestergaard VH, Langevin F, Kuiken HJ, Pace P, Niedzwiedz W, Simpson LJ, Ohzeki M, Takata M, Sale JE, Patel KJ. 2007. Deubiquitination of FANCD2 is required for DNA crosslink repair. Mol. Cell 28:798–809.
  • Kim JM, Parmar K, Huang M, Weinstock DM, Ruit CA, Kutok JL, D'Andrea AD. 2009. Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev. Cell 16:314–320.
  • Cohn MA, Kowal P, Yang K, Haas W, Huang TT, Gygi SP, D'Andrea AD. 2007. A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Mol. Cell 28:786–797.
  • Yang K, Moldovan GL, Vinciguerra P, Murai J, Takeda S, D'Andrea AD. 2011. Regulation of the Fanconi anemia pathway by a SUMO-like delivery network. Genes Dev. 25:1847–1858.
  • Cohn MA, Kee Y, Haas W, Gygi SP, D'Andrea AD. 2009. UAF1 is a subunit of multiple deubiquitinating enzyme complexes. J. Biol. Chem. 284:5343–5351.
  • Murai J, Yang K, Dejsuphong D, Hirota K, Takeda S, D'Andrea AD. 2011. The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. Mol. Cell. Biol. 31:2462–2469.
  • Mortensen RM, Conner DA, Chao S, Geisterfer-Lowrance AA, Seidman JG. 1992. Production of homozygous mutant ES cells with a single targeting construct. Mol. Cell. Biol. 12:2391–2395.
  • Park E, Kim H, Kim JM, Primack B, Vidal-Cardenas S, Xu Y, Price BD, Mills AA, D'Andrea AD. 2013. FANCD2 activates transcription of TAp63 and suppresses tumorigenesis. Mol. Cell 50:908–918.
  • Pierce AJ, Hu P, Han M, Ellis N, Jasin M. 2001. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 15:3237–3242.
  • Weinstock DM, Nakanishi K, Helgadottir HR, Jasin M. 2006. Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase. Methods Enzymol. 409:524–540.
  • Williams SA, Maecker HL, French DM, Liu J, Gregg A, Silverstein LB, Cao TC, Carano RA, Dixit VM. 2011. USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma. Cell 146:918–930.
  • Auerbach AD. 2009. Fanconi anemia and its diagnosis. Mutat. Res. 668:4–10.
  • Moldovan GL, Dejsuphong D, Petalcorin MI, Hofmann K, Takeda S, Boulton SJ, D'Andrea AD. 2012. Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol. Cell 45:75–86.
  • Langevin F, Crossan GP, Rosado IV, Arends MJ, Patel KJ. 2011. Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice. Nature 475:53–58.
  • Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, Kannouche P, Wider G, Peter M, Lehmann AR, Hofmann K, Dikic I. 2005. Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science 310:1821–1824.
  • Nicassio F, Corrado N, Vissers JH, Areces LB, Bergink S, Marteijn JA, Geverts B, Houtsmuller AB, Vermeulen W, Di Fiore PP, Citterio E. 2007. Human USP3 is a chromatin modifier required for S phase progression and genome stability. Curr. Biol. 17:1972–1997.
  • Wiltshire TD, Lovejoy CA, Wang T, Xia F, O'Connor MJ, Cortez D. 2010. Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. J. Biol. Chem. 285:14565–14571.
  • Zhang D, Zaugg K, Mak TW, Elledge SJ. 2006. A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell 126:529–542.
  • Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T, Masuda M, Niwa M, Kameyama T, Kobayashi J, Iwaki Y, Imai S, Ishikawa Abe AK, Yoshimura T, Nabeshima T, Ebihara S. 2009. Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests. Nat. Genet. 41:688–695.
  • Imai S, Mamiya T, Tsukada A, Sakai Y, Mouri A, Nabeshima T, Ebihara S. 2012. Ubiquitin-specific peptidase 46 (Usp46) regulates mouse immobile behavior in the tail suspension test through the GABAergic system. PLoS One 7:e39084. doi:10.1371/journal.pone.0039084.
  • Joo HY, Jones A, Yang C, Zhai L, Smith AD, Zhang Z, Chandrasekharan MB, Sun ZW, Renfrow MB, Wang Y, Chang C, Wang H. 2011. Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. J. Biol. Chem. 286:7190–7201.
  • Sowa ME, Bennett EJ, Gygi SP, Harper JW. 2009. Defining the human deubiquitinating enzyme interaction landscape. Cell 138:389–403.

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