Histone Deacetylase 3 Interacts with and Deacetylates Myocyte Enhancer Factor 2

REFERENCES

• Baek, S. H., K. A. Ohgi, D. W. Rose, E. H. Koo, C. K. Glass, and M. G. Rosenfeld. 2002. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell 110:55–67.
   PubMed Web of Science ®Google Scholar
• Bereshchenko, O. R., W. Gu, and R. Dalla-Favera. 2002. Acetylation inactivates the transcriptional repressor BCL6. Nat. Genet. 32:606–613.
   PubMed Web of Science ®Google Scholar
• Black, J. C., J. E. Choi, S. R. Lombardo, and M. Carey. 2006. A mechanism for coordinating chromatin modification and preinitiation complex assembly. Mol. Cell 23:809–818.
   PubMed Web of Science ®Google Scholar
• Blander, G., and L. Guarente. 2004. The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 73:417–435.
   PubMed Web of Science ®Google Scholar
• Bouras, T., M. Fu, A. A. Sauve, F. Wang, A. A. Quong, N. D. Perkins, R. T. Hay, W. Gu, and R. G. Pestell. 2005. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J. Biol. Chem. 280:10264–10276.
   PubMed Web of Science ®Google Scholar
• Chen, J. D., and R. M. Evans. 1995. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454–457.
   PubMed Web of Science ®Google Scholar
• Cho, Y., A. Griswold, C. Campbell, and K. T. Min. 2005. Individual histone deacetylases in Drosophila modulate transcription of distinct genes. Genomics 86:606–617.
   PubMedGoogle Scholar
• Chuang, H. C., C. W. Chang, G. D. Chang, T. P. Yao, and H. Chen. 2006. Histone deacetylase 3 binds to and regulates the GCMa transcription factor. Nucleic Acids Res. 34:1459–1469.
   PubMed Web of Science ®Google Scholar
• Codina, A., J. D. Love, Y. Li, M. A. Lazar, D. Neuhaus, and J. W. Schwabe. 2005. Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors. Proc. Natl. Acad. Sci. USA 102:6009–6014.
   PubMedGoogle Scholar
• Cohen, T., and T. P. Yao. 2004. AcK-knowledge reversible acetylation. Sci. STKE 2004:pe42.
   PubMedGoogle Scholar
• Dequiedt, F., J. Van Lint, E. Lecomte, V. Van Duppen, T. Seufferlein, J. R. Vandenheede, R. Wattiez, and R. Kettmann. 2005. Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis. J. Exp. Med. 201:793–804.
   PubMed Web of Science ®Google Scholar
• Emiliani, S., W. Fischle, C. Van Lint, Y. Al-Abed, and E. Verdin. 1998. Characterization of a human RPD3 ortholog, HDAC3. Proc. Natl. Acad. Sci. USA 95:2795–2800.
   PubMed Web of Science ®Google Scholar
• Flavell, S. W., C. W. Cowan, T. K. Kim, P. L. Greer, Y. Lin, S. Paradis, E. C. Griffith, L. S. Hu, C. Chen, and M. E. Greenberg. 2006. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science 311:1008–1012.
   PubMed Web of Science ®Google Scholar
• Foglietti, C., G. Filocamo, E. Cundari, E. De Rinaldis, A. Lahm, R. Cortese, and C. Steinkuhler. 2006. Dissecting the biological functions of Drosophila histone deacetylases by RNA interference and transcriptional profiling. J. Biol. Chem. 281:17968–17976.
   PubMed Web of Science ®Google Scholar
• Fulco, M., R. L. Schiltz, S. Iezzi, M. T. King, P. Zhao, Y. Kashiwaya, E. Hoffman, R. L. Veech, and V. Sartorelli. 2003. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell 12:51–62.
   PubMed Web of Science ®Google Scholar
• Girdwood, D., D. Bumpass, O. A. Vaughan, A. Thain, L. A. Anderson, A. W. Snowden, E. Garcia-Wilson, N. D. Perkins, and R. T. Hay. 2003. p300 transcriptional repression is mediated by SUMO modification. Mol. Cell 11:1043–1054.
   PubMedGoogle Scholar
• Gong, X., X. Tang, M. Wiedmann, X. Wang, J. Peng, D. Zheng, L. A. Blair, J. Marshall, and Z. Mao. 2003. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron 38:33–46.
   PubMed Web of Science ®Google Scholar
• Gonzalez, P., M. Garcia-Castro, J. R. Reguero, A. Batalla, A. G. Ordonez, R. L. Palop, I. Lozano, M. Montes, V. Alvarez, and E. Coto. 2006. The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction. J. Med. Genet. 43:167–169.
   PubMed Web of Science ®Google Scholar
• Grégoire, S., A. M. Tremblay, L. Xiao, Q. Yang, K. Ma, J. Nie, Z. Mao, Z. Wu, V. Giguere, and X. J. Yang. 2006. Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation. J. Biol. Chem. 281:4423–4433.
   PubMed Web of Science ®Google Scholar
• Grégoire, S., and X. J. Yang. 2005. Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. Mol. Cell. Biol. 25:2273–2282.
   PubMed Web of Science ®Google Scholar
• Gregoretti, I. V., Y. M. Lee, and H. V. Goodson. 2004. Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J. Mol. Biol. 338:17–31.
   PubMed Web of Science ®Google Scholar
• Grozinger, C. M., and S. L. Schreiber. 2002. Deacetylase enzymes: biological functions and the use of small-molecule inhibitors. Chem. Biol. 9:3–16.
   PubMed Web of Science ®Google Scholar
• Guenther, M. G., O. Barak, and M. A. Lazar. 2001. The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Mol. Cell. Biol. 21:6091–6101.
   PubMed Web of Science ®Google Scholar
• Guenther, M. G., W. S. Lane, W. Fischle, E. Verdin, M. A. Lazar, and R. Shiekhattar. 2000. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes Dev. 14:1048–1057.
   PubMed Web of Science ®Google Scholar
• Han, A., J. He, Y. Wu, J. O. Liu, and L. Chen. 2005. Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2. J. Mol. Biol. 345:91–102.
   PubMed Web of Science ®Google Scholar
• Han, J., Y. Jiang, Z. Li, V. V. Kravchenko, and R. J. Ulevitch. 1997. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature 386:296–299.
   PubMed Web of Science ®Google Scholar
• Han, J., and J. D. Molkentin. 2000. Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology. Trends Cardiovasc. Med. 10:19–22.
   PubMedGoogle Scholar
• Han, T.-H., and R. Prywes. 1995. Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol. Cell. Biol. 15:2907–2915.
   PubMedGoogle Scholar
• Hietakangas, V., J. Anckar, H. A. Blomster, M. Fujimoto, J. J. Palvimo, A. Nakai, and L. Sistonen. 2006. PDSM, a motif for phosphorylation-dependent SUMO modification. Proc. Natl. Acad. Sci. USA 103:45–50.
   PubMed Web of Science ®Google Scholar
• Hoberg, J. E., F. Yeung, and M. W. Mayo. 2004. SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival. Mol. Cell 16:245–255.
   PubMed Web of Science ®Google Scholar
• Huang, E. Y., J. Zhang, E. A. Miska, M. G. Guenther, T. Kouzarides, and M. A. Lazar. 2000. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. Genes Dev. 14:45–54.
   PubMedGoogle Scholar
• Hubbert, C., A. Guardiola, R. Shao, Y. Kawaguchi, A. Ito, A. Nixon, M. Yoshida, X. F. Wang, and T. P. Yao. 2002. HDAC6 is a microtubule-associated deacetylase. Nature 417:455–458.
   PubMed Web of Science ®Google Scholar
• Jin, Y. H., E. J. Jeon, Q. L. Li, Y. H. Lee, J. K. Choi, W. J. Kim, K. Y. Lee, and S. C. Bae. 2004. Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. J. Biol. Chem. 279:29409–29417.
   PubMed Web of Science ®Google Scholar
• Jonas, B. A., and M. L. Privalsky. 2004. SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways. J. Biol. Chem. 279:54676–54686.
   PubMedGoogle Scholar
• Kang, J., C. B. Gocke, and H. Yu. 2006. Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity. BMC Biochem. 7:5.
   PubMedGoogle Scholar
• Kao, H. Y., M. Downes, P. Ordentlich, and R. M. Evans. 2000. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 14:55–66.
   PubMed Web of Science ®Google Scholar
• Kasler, H. G., J. Victoria, O. Duramad, and A. Winoto. 2000. ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domain. Mol. Cell. Biol. 20:8382–8389.
   PubMed Web of Science ®Google Scholar
• Kato, Y., M. Zhao, A. Morikawa, T. Sugiyama, D. Chakravortty, N. Koide, T. Yoshida, R. I. Tapping, Y. Yang, T. Yokochi, et al. 2000. Big mitogen-activated kinase regulates multiple members of the MEF2 protein family. J. Biol. Chem. 275:18534–18540.
   PubMedGoogle Scholar
• Khochbin, S., A. Verdel, C. Lemercier, and D. Seigneurin-Berny. 2001. Functional significance of histone deacetylase diversity. Curr. Opin. Genet. Dev. 11:162–166.
   PubMed Web of Science ®Google Scholar
• Kim, S. C., R. Sprung, Y. Chen, Y. Xu, H. Ball, J. Pei, T. Cheng, Y. Kho, H. Xiao, L. Xiao, et al. 2006. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol. Cell 23:607–618.
   PubMed Web of Science ®Google Scholar
• Kouzarides, T. 2000. Acetylation: a regulatory modification to rival phosphorylation? EMBO J. 19:1176–1179.
   PubMed Web of Science ®Google Scholar
• Laganiere, J., G. Deblois, C. Lefebvre, A. R. Bataille, F. Robert, and V. Giguere. 2005. Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response. Proc. Natl. Acad. Sci. USA 102:11651–11656.
   PubMed Web of Science ®Google Scholar
• Lee, H., N. Rezai-Zadeh, and E. Seto. 2004. Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A. Mol. Cell. Biol. 24:765–773.
   PubMed Web of Science ®Google Scholar
• Li, J., J. Wang, Z. Nawaz, J. M. Liu, J. Qin, and J. Wong. 2000. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. EMBO J. 19:4342–4350.
   PubMed Web of Science ®Google Scholar
• Liu, S., P. Liu, A. Borras, T. Chatila, and S. H. Speck. 1997. Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member. EMBO J. 16:143–153.
   PubMedGoogle Scholar
• Luo, J., A. Y. Nikolaev, S. Imai, D. Chen, F. Su, A. Shiloh, L. Guarente, and W. Gu. 2001. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107:137–148.
   PubMed Web of Science ®Google Scholar
• Luo, J., F. Su, D. Chen, A. Shiloh, and W. Gu. 2000. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408:377–381.
   PubMed Web of Science ®Google Scholar
• Ma, K., J. K. Chan, G. Zhu, and Z. Wu. 2005. Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation. Mol. Cell. Biol. 25:3575–3582.
   PubMed Web of Science ®Google Scholar
• McKinsey, T. A., C. L. Zhang, and E. N. Olson. 2002. MEF2: a calcium-dependent regulator of cell division, differentiation and death. Trends Biochem. Sci. 27:40–47.
   PubMed Web of Science ®Google Scholar
• North, B. J., B. L. Marshall, M. T. Borra, J. M. Denu, and E. Verdin. 2003. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol. Cell 11:437–444.
   PubMed Web of Science ®Google Scholar
• Ogryzko, V. V., R. L. Schiltz, V. Russanova, B. H. Howard, and Y. Nakatani. 1996. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87:953–959.
   PubMed Web of Science ®Google Scholar
• Pan, F., A. R. Means, and J. O. Liu. 2005. Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. EMBO J. 24:2104–2113.
   PubMed Web of Science ®Google Scholar
• Parra, M., H. Kasler, T. A. McKinsey, E. N. Olson, and E. Verdin. 2005. Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after TCR activation. J. Biol. Chem. 280:13762–13770.
   PubMed Web of Science ®Google Scholar
• Pelletier, N., N. Champagne, H. Lim, and X. J. Yang. 2003. Expression, purification, and analysis of MOZ and MORF histone acetyltransferases. Methods 31:24–32.
   PubMed Web of Science ®Google Scholar
• Puri, P. L., V. Sartorelli, X. J. Yang, Y. Hamamori, L. Kedes, A. Graessmann, Y. Nakatani, and M. Levrero. 1997. Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol. Cell 1:35–45.
   PubMed Web of Science ®Google Scholar
• Robyr, D., Y. Suka, I. Xenarios, S. K. Kurdistani, A. Wang, N. Suka, and M. Grunstein. 2002. Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109:437–446.
   PubMed Web of Science ®Google Scholar
• Santos-Rosa, H., E. Valls, T. Kouzarides, and M. Martinez-Balbas. 2003. Mechanisms of P/CAF auto-acetylation. Nucleic Acids Res. 31:4285–4292.
   PubMed Web of Science ®Google Scholar
• Sartorelli, V., J. Huang, Y. Hamamori, and L. Kedes. 1997. Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol. Cell. Biol. 17:1010–1026.
   PubMed Web of Science ®Google Scholar
• Schroeder, T. M., R. A. Kahler, X. Li, and J. J. Westendorf. 2004. Histone deacetylase 3 interacts with Runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. J. Biol. Chem. 279:41998–42007.
   PubMed Web of Science ®Google Scholar
• Shalizi, A., B. Gaudilliere, Z. Yuan, J. Stegmuller, T. Shirogane, Q. Ge, Y. Tan, B. Schulman, J. W. Harper, and A. Bonni. 2006. A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science 311:1012–1017.
   PubMed Web of Science ®Google Scholar
• Sterner, D. E., and S. L. Berger. 2000. Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev. 64:435–459.
   PubMed Web of Science ®Google Scholar
• Thompson, P. R., D. Wang, L. Wang, M. Fulco, N. Pediconi, D. Zhang, W. An, Q. Ge, R. G. Roeder, J. Wong, et al. 2004. Regulation of the p300 HAT domain via a novel activation loop. Nat. Struct. Mol. Biol. 11:308–315.
   PubMed Web of Science ®Google Scholar
• Vaziri, H., S. K. Dessain, E. Ng Eaton, S. I. Imai, R. A. Frye, T. K. Pandita, L. Guarente, and R. A. Weinberg. 2001. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107:149–159.
   PubMed Web of Science ®Google Scholar
• Vega, R. B., B. C. Harrison, E. Meadows, C. R. Roberts, P. J. Papst, E. N. Olson, and T. A. McKinsey. 2004. Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol. Cell. Biol. 24:8374–8385.
   PubMed Web of Science ®Google Scholar
• Vega, R. B., K. Matsuda, J. Oh, A. C. Barbosa, X. Yang, E. Meadows, J. McAnally, C. Pomajzl, J. M. Shelton, J. A. Richardson, et al. 2004. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 119:555–566.
   PubMed Web of Science ®Google Scholar
• Verdin, E., F. Dequiedt, and H. G. Kasler. 2003. Class II histone deacetylases: versatile regulators. Trends Genet. 19:286–293.
   PubMed Web of Science ®Google Scholar
• Wang, A. H., N. R. Bertos, M. Vezmar, N. Pelletier, M. Crosato, H. H. Heng, J. Th'ng, J. Han, and X. J. Yang. 1999. HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. Mol. Cell. Biol. 19:7816–7827.
   PubMed Web of Science ®Google Scholar
• Wen, Y. D., V. Perissi, L. M. Staszewski, W. M. Yang, A. Krones, C. K. Glass, M. G. Rosenfeld, and E. Seto. 2000. The histone deacetylase-3 complex contains nuclear receptor corepressors. Proc. Natl. Acad. Sci. USA 97:7202–7207.
   PubMed Web of Science ®Google Scholar
• Westendorf, J. J., S. K. Zaidi, J. E. Cascino, R. Kahler, A. J. van Wijnen, J. B. Lian, M. Yoshida, G. S. Stein, and X. Li. 2002. Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21CIP1/WAF1 promoter. Mol. Cell. Biol. 22:7982–7992.
   PubMed Web of Science ®Google Scholar
• Wiren, M., R. A. Silverstein, I. Sinha, J. Walfridsson, H. M. Lee, P. Laurenson, L. Pillus, D. Robyr, M. Grunstein, and K. Ekwall. 2005. Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast. EMBO J. 24:2906–2918.
   PubMedGoogle Scholar
• Wu, X., H. Li, E. J. Park, and J. D. Chen. 2001. SMRTe inhibits MEF2C transcriptional activation by targeting HDAC4 and 5 to nuclear domains. J. Biol. Chem. 276:24177–24185.
   PubMed Web of Science ®Google Scholar
• Xu, Q., L. Yu, L. Liu, C. F. Cheung, X. Li, S. K. Yee, X.-J. Yang, and Z. Wu. 2002. The p38 MAPK, CaMK and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expression. Mol. Biol. Cell 13:1940–1952.
   PubMedGoogle Scholar
• Yamagoe, S., T. Kanno, Y. Kanno, S. Sasaki, R. M. Siegel, M. J. Lenardo, G. Humphrey, Y. Wang, Y. Nakatani, B. H. Howard, et al. 2003. Interaction of histone acetylases and deacetylases in vivo. Mol. Cell. Biol. 23:1025–1033.
   PubMed Web of Science ®Google Scholar
• Yang, C. C., O. I. Ornatsky, J. C. McDermott, T. F. Cruz, and C. A. Prody. 1998. Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1. Nucleic Acids Res. 26:4771–4777.
   PubMedGoogle Scholar
• Yang, W. M., S. C. Tsai, Y. D. Wen, G. Fejer, and E. Seto. 2002. Functional domains of histone deacetylase-3. J. Biol. Chem. 277:9447–9454.
   PubMed Web of Science ®Google Scholar
• Yang, W. M., Y. L. Yao, J. M. Sun, J. R. Davie, and E. Seto. 1997. Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J. Biol. Chem. 272:28001–28007.
   PubMed Web of Science ®Google Scholar
• Yang, X. J. 2004. Lysine acetylation and the bromodomain: a new partnership for signaling. BioEssays 26:1076–1087.
   PubMed Web of Science ®Google Scholar
• Yang, X. J., and S. Grégoire. 2005. Class II histone deacetylases: from sequence to function, regulation and clinical implication. Mol. Cell. Biol. 25:2873–2884.
   PubMed Web of Science ®Google Scholar
• Yang, X. J., and S. Grégoire. 2006. A recurrent phospho-sumoyl switch in transcriptional repression and beyond. Mol. Cell 23:779–786.
   PubMedGoogle Scholar
• Yang, X. J., V. V. Ogryzko, J. Nishikawa, B. H. Howard, and Y. Nakatani. 1996. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382:319–324.
   PubMed Web of Science ®Google Scholar
• Yuan, Z. L., Y. J. Guan, D. Chatterjee, and Y. E. Chin. 2005. Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science 307:269–273.
   PubMed Web of Science ®Google Scholar
• Yuki, Y., I. Imoto, M. Imaizumi, S. Hibi, Y. Kaneko, T. Amagasa, and J. Inazawa. 2004. Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13). Cancer Sci. 95:503–507.
   PubMed Web of Science ®Google Scholar
• Zhang, X., Y. Ozawa, H. Lee, Y. D. Wen, T. H. Tan, B. E. Wadzinski, and E. Seto. 2005. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Genes Dev. 19:827–839.
   PubMed Web of Science ®Google Scholar
• Zhao, M., L. New, V. V. Kravchenko, Y. Kato, H. Gram, F. D. Padova, E. N. Olson, R. J. Ulevitch, and J. Han. 1999. Regulation of the MEF2 family of transcription factors by p38. Mol. Cell. Biol. 19:21–30.
   PubMedGoogle Scholar
• Zhao, X., T. Sternsdorf, T. A. Bolger, R. M. Evans, and T. P. Yao. 2005. Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol. Cell. Biol. 25:8456–8464.
   PubMed Web of Science ®Google Scholar
• Zhu, B., and T. Gulick. 2004. Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activity. Mol. Cell. Biol. 24:8264–8275.
   PubMedGoogle Scholar