miR-130 Suppresses Adipogenesis by Inhibiting Peroxisome Proliferator-Activated Receptor γ Expression

REFERENCES

• Abdelmohsen, K., S. Srikantan, Y. Kuwano, and M. Gorospe. 2008. miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. Proc. Natl. Acad. Sci. U. S. A. 105:20297–20302.
   PubMed Web of Science ®Google Scholar
• Baltimore, D., M. P. Boldin, R. M. O'Connell, D. S. Rao, and K. D. Taganov. 2008. MicroRNAs: new regulators of immune cell development and function. Nat. Immunol. 9:839–845.
   PubMed Web of Science ®Google Scholar
• Bartel, D. P. 2009. MicroRNAs: target recognition and regulatory functions. Cell 136:215–233.
   PubMed Web of Science ®Google Scholar
• Cowherd, R. M., R. E. Lyle, and R. E. McGehee, Jr. 1999. Molecular regulation of adipocyte differentiation. Cell Dev. Biol. 10:3–10.
   Google Scholar
• Danforth, E., Jr. 2000. Failure of adipocyte differentiation causes type II diabetes mellitus? Nat. Genet. 26:13.
   PubMed Web of Science ®Google Scholar
• Duursma, A. M., M. Kedde, M. Schrier, C. le Sage, and R. Agami. 2008. miR-148 targets human DNMT3b protein coding region. RNA 14:872–877.
   PubMed Web of Science ®Google Scholar
• Eulalio, A., E. Huntzinger, and E. Izaurralde. 2008. Getting to the root of miRNA-mediated gene silencing. Cell 132:9–14.
   PubMed Web of Science ®Google Scholar
• Fajas, L., et al. 1999. Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol. Cell. Biol. 19:5495–5503.
   PubMed Web of Science ®Google Scholar
• Fajas, L., et al. 2002. The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev. Cell 3:903–910.
   PubMed Web of Science ®Google Scholar
• Farmer, S. R. 2006. Transcriptional control of adipocyte formation. Cell Metab. 4:263–273.
   PubMed Web of Science ®Google Scholar
• Flier, J. S. 2004. Obesity wars: molecular progress confronts an expanding epidemic. Cell 116:337–350.
   PubMed Web of Science ®Google Scholar
• Fried, S. K., C. D. Russell, N. L. Grauso, and R. E. Brolin. 1993. Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men. J. Clin. Invest. 92:2191–2198.
   Google Scholar
• Gantt, K., J. Cherry, R. Tenney, V. Karschner, and P. H. Pekala. 2005. An early event in adipogenesis, the nuclear selection of the CCAAT enhancer-binding protein β (C/EBPβ) mRNA by HuR and its translocation to the cytosol. J. Biol. Chem. 280:24768–24774.
   PubMed Web of Science ®Google Scholar
• Hauner, H., T. Skurk, and M. Wabitsch. 2001. Cultures of human adipose precursor cells. Methods Mol. Biol. 155:239–247.
   PubMedGoogle Scholar
• Isakson, P., A. Hammarstedt, B. Gustafson, and U. Smith. 2009. Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-α, and inflammation. Diabetes 58:1550–1557.
   PubMed Web of Science ®Google Scholar
• Kajimoto, K., H. Naraba, and N. Iwai. 2006. MicroRNA and 3T3-L1 preadipocyte differentiation. RNA 12:1626–1632.
   PubMed Web of Science ®Google Scholar
• Karagiannides, I., et al. 2006. Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging. J. Biol. Chem. 281:23025–23033.
   PubMedGoogle Scholar
• Karbiener, M., et al. 2009. microRNA miR-27b impairs human adipocyte differentiation and targets PPARgamma. Biochem. Biophys. Res. Commun. 390:247–251.
   PubMed Web of Science ®Google Scholar
• Kennell, J. A., I. Gerin, O. A. MacDougald, and K. M. Cadigan. 2008. The microRNA miR-8 is a conserved negative regulator of Wnt signaling. Proc. Natl. Acad. Sci. U. S. A. 105:15417–15422.
   PubMed Web of Science ®Google Scholar
• Kim, S. Y., et al. 2010. miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARγ expression. Biochem. Biophys. Res. Commun. 392:323–328.
   PubMed Web of Science ®Google Scholar
• Kloosterman, W. P., and R. H. Plasterk. 2006. The diverse functions of microRNAs in animal development and disease. Dev. Cell 11:441–450.
   PubMed Web of Science ®Google Scholar
• Kudo, M., A. Sugawara, A. Uruno, K. Takeuchi, and S. Ito. 2004. Transcription suppression of peroxisome proliferator-activated receptor gamma2 gene expression by tumor necrosis factor alpha via an inhibition of CCAAT/ enhancer-binding protein delta during the early stage of adipocyte differentiation. Endocrinology 145:4948–4956.
   PubMed Web of Science ®Google Scholar
• Lal, A., et al. 2008. p16INK4a translation suppressed by miR-24. PLoS One 3:e1864.
   PubMed Web of Science ®Google Scholar
• Lee, E. K., and M. Gorospe. Coding region: the neglected post-transcriptional code. RNA Biol., in press.
   Google Scholar
• Lin, Q., Z. Gao, R. M. Alarcon, J. Ye, and Z. Yun. 2009. A role of miR-27 in the regulation of adipogenesis. FEBS J. 276:2348–2358.
   PubMed Web of Science ®Google Scholar
• MacDougald, O. A., and M. D. Lane. 1995. Transcriptional regulation of gene expression during adipocyte differentiation. Annu. Rev. Biochem. 64:345–373.
   PubMed Web of Science ®Google Scholar
• Mikkelsen, T. S., et al. 2010. Comparative epigenomic analysis of murine and human adipogenesis. Cell 143:156–169.
   PubMed Web of Science ®Google Scholar
• Mori, T., et al. 2005. Role of Krüppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J. Biol. Chem. 280:12867–12875.
   PubMed Web of Science ®Google Scholar
• Oishi, Y., et al. 2005. Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab. 1:27–39.
   PubMed Web of Science ®Google Scholar
• Pettersson, A. T., et al. 13 October 2010, posting date. Twist1 in human white adipose tissue and obesity. J. Clin. Endocrinol. Metab . [Epub ahead of print].
   Google Scholar
• Ruan, H., H. J. Pownall, and H. F. Lodish. 2003. Troglitazone antagonizes tumor necrosis factor-alpha-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kappaB. J. Biol. Chem. 278:28181–28192.
   PubMed Web of Science ®Google Scholar
• Stefani, G., and F. J. Slack. 2008. Small non-coding RNAs in animal development. Nat. Rev. Mol. Cell Biol. 9:219–230.
   PubMed Web of Science ®Google Scholar
• Sun, F., et al. 2009. Characterization of function and regulation of miR-24-1 and miR-31. Biochem. Biophys. Res. Commun. 380:660–665.
   PubMed Web of Science ®Google Scholar
• Tchkonia, T., et al. 2005. Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots. Am. J. Physiol. Endocrinol. Metab. 288:E267–277.
   PubMed Web of Science ®Google Scholar
• Tchkonia, T., et al. 2007. Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. Am. J. Physiol. Endocrinol. Metab. 292:E298–307.
   PubMed Web of Science ®Google Scholar
• Tiller, G., et al. 2009. Effects of TWEAK (TNF superfamily member 12) on differentiation, metabolism, and secretory function of human primary preadipocytes and adipocytes. Endocrinology 150:5373–5383.
   PubMedGoogle Scholar
• Vidal-Puig, A. J., et al. 1997. Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J. Clin. Invest. 99:2416–2422.
   Google Scholar
• Wang, Q., et al. 2008. miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc. Natl. Acad. Sci. U. S. A. 105:2889–2894.
   PubMed Web of Science ®Google Scholar
• Wu, Z., N. L. R. Bucher, and S. R. Farmer. 1996. Induction of peroxisome proliferator activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ, C/EBPδ, and glucocorticoids. Mol. Cell. Biol. 16:4128–4136.
   PubMed Web of Science ®Google Scholar
• Wu, Z., Y. Xie, N. L. R. Bucher, and S. R. Farmer. 1995. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Genes Dev. 9:2350–2363.
   PubMed Web of Science ®Google Scholar