The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development

REFERENCES

• Moore MJ, Proudfoot NJ. 2009. Pre-mRNA processing reaches back to transcription and ahead to translation. Cell 136:688–700. http://dx.doi.org/10.1016/j.cell.2009.02.001.
   PubMed Web of Science ®Google Scholar
• Keene JD. 2010. Minireview: global regulation and dynamics of ribonucleic Acid. Endocrinology 151:1391–1397. http://dx.doi.org/10.1210/en.2009-1250.
   PubMed Web of Science ®Google Scholar
• Tian Q, Nakayama T, Dixon MP, Christian JL. 1999. Post-transcriptional regulation of Xwnt-8 expression is required for normal myogenesis during vertebrate embryonic development. Development 126:3371–3380.
   PubMedGoogle Scholar
• Blech-Hermoni Y, Ladd AN. 2013. RNA binding proteins in the regulation of heart development. Int J Biochem Cell Biol 45:2467–2478. http://dx.doi.org/10.1016/j.biocel.2013.08.008.
   PubMedGoogle Scholar
• Kim B-M, Buchner G, Miletich I, Sharpe PT, Shivdasani RA. 2005. The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev Cell 8:611–622. http://dx.doi.org/10.1016/j.devcel.2005.01.015.
   PubMed Web of Science ®Google Scholar
• Gorgoni B, Richardson WA, Burgess HM, Anderson RC, Wilkie GS, Gautier P, Martins JPS, Brook M, Sheets MD, Gray NK. 2011. Poly(A)-binding proteins are functionally distinct and have essential roles during vertebrate development. Proc Natl Acad Sci U S A 108:7844–7849. http://dx.doi.org/10.1073/pnas.1017664108.
   PubMed Web of Science ®Google Scholar
• Yang J, Chan CY, Jiang B, Yu X, Zhu G-Z, Chen Y, Barnard J, Mei W. 2009. hnRNP I inhibits Notch signaling and regulates intestinal epithelial homeostasis in the zebrafish. PLoS Genet 5:e1000363. http://dx.doi.org/10.1371/journal.pgen.1000363.
   PubMedGoogle Scholar
• Takahashi T, Suzuki H, Imai T, Shibata S, Tabuchi Y, Tsuchimoto K, Okano H, Hibi T. 2013. Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain-containing m-Numb protein expression in regenerating gastric mucosa. PLoS One 8:e53540. http://dx.doi.org/10.1371/journal.pone.0053540.
   PubMedGoogle Scholar
• Guallar D, Wang J. 2014. RNA-binding proteins in pluripotency, differentiation, and reprogramming. Front Biol (Beijing) 9:389–409. http://dx.doi.org/10.1007/s11515-014-1326-y.
   PubMedGoogle Scholar
• Mueller AA, Cheung TH, Rando TA. 2013. All's well that ends well: alternative polyadenylation and its implications for stem cell biology. Curr Opin Cell Biol 25:222–232. http://dx.doi.org/10.1016/j.ceb.2012.12.008.
   PubMedGoogle Scholar
• Kini HK, Kong J, Liebhaber SA. 2014. Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation. Mol Cell Biol 34:1300–1309. http://dx.doi.org/10.1128/MCB.01683-13.
   PubMedGoogle Scholar
• Ostareck DH, Ostareck-Lederer A, Wilm M, Thiele BJ, Mann M, Hentze MW. 1997. mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3′ end. Cell 89:597–606. http://dx.doi.org/10.1016/S0092-8674(00)80241-X.
   PubMed Web of Science ®Google Scholar
• Williamson AJK, Smith DL, Blinco D, Unwin RD, Pearson S, Wilson C, Miller C, Lancashire L, Lacaud G, Kouskoff V, Whetton AD. 2008. Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis. Mol Cell Proteomics 7:459–472.
   PubMed Web of Science ®Google Scholar
• Ostareck-Lederer A, Ostareck DH. 2004. Control of mRNA translation and stability in haematopoietic cells: the function of hnRNPs K and E1/E2. Biol Cell 96:407–411. http://dx.doi.org/10.1016/j.biolcel.2004.03.010.
   PubMed Web of Science ®Google Scholar
• Makeyev AV, Liebhaber SA. 2002. The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms. RNA 8:265–278. http://dx.doi.org/10.1017/S1355838202024627.
   PubMed Web of Science ®Google Scholar
• Makeyev AV, Chkheidze AN, Liebhaber SA. 1999. A set of highly conserved RNA-binding proteins, alphaCP-1 and alphaCP-2, implicated in mRNA stabilization, are coexpressed from an intronless gene and its intron-containing paralog. J Biol Chem 274:24849–24857. http://dx.doi.org/10.1074/jbc.274.35.24849.
   PubMed Web of Science ®Google Scholar
• Aasheim HC, Loukianova T, Deggerdal A, Smeland EB. 1994. Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K. Nucleic Acids Res 22:959–964. http://dx.doi.org/10.1093/nar/22.6.959.
   PubMedGoogle Scholar
• Leffers H, Dejgaard K, Celis JE. 1995. Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains. Eur J Biochem 230:447–453. http://dx.doi.org/10.1111/j.1432-1033.1995.tb20581.x.
   PubMedGoogle Scholar
• Chaudhury A, Chander P, Howe PH. 2010. Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles. RNA 16:1449–1462. http://dx.doi.org/10.1261/rna.2254110.
   PubMed Web of Science ®Google Scholar
• Waggoner SA, Liebhaber SA. 2003. Identification of mRNAs associated with αCP2-containing RNP complexes. Mol Cell Biol 23:7055–7067. http://dx.doi.org/10.1128/MCB.23.19.7055-7067.2003.
   PubMed Web of Science ®Google Scholar
• Flynn RA, Martin L, Spitale RC, Do BT, Sagan SM, Zarnegar B, Qu K, Khavari PA, Quake SR, Sarnow P, Chang HY. 2015. Dissecting noncoding and pathogen RNA-protein interactomes. RNA 21:135–143. http://dx.doi.org/10.1261/rna.047803.114.
   PubMedGoogle Scholar
• Ji X, Kong J, Liebhaber SA. 2011. An RNA-protein complex links enhanced nuclear 3′ processing with cytoplasmic mRNA stabilization. EMBO J 30:2622–2633. http://dx.doi.org/10.1038/emboj.2011.171.
   PubMed Web of Science ®Google Scholar
• Ji X, Kong J, Carstens RP, Liebhaber SA. 2007. The 3′ untranslated region complex involved in stabilization of human alpha-globin mRNA assembles in the nucleus and serves an independent role as a splice enhancer. Mol Cell Biol 27:3290–3302. http://dx.doi.org/10.1128/MCB.02289-05.
   PubMed Web of Science ®Google Scholar
• Thisted T, Lyakhov DL, Liebhaber SA. 2001. Optimized RNA targets of two closely related triple KH domain proteins, heterogeneous nuclear ribonucleoprotein K and αCP-2KL, suggest distinct modes of RNA recognition. J Biol Chem 276:17484–17496. http://dx.doi.org/10.1074/jbc.M010594200.
   PubMed Web of Science ®Google Scholar
• Makeyev AV, Eastmond DL, Liebhaber SA. 2002. Targeting a KH-domain protein with RNA decoys. RNA 8:1160–1173. http://dx.doi.org/10.1017/S135583820202808X.
   PubMed Web of Science ®Google Scholar
• Ji X, Wan J, Vishnu M, Xing Y, Liebhaber SA. 2013. αCP poly(C) binding proteins act as global regulators of alternative polyadenylation. Mol Cell Biol 33:2560–2573. http://dx.doi.org/10.1128/MCB.01380-12.
   PubMed Web of Science ®Google Scholar
• Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, Hodge CL, Haase J, Janes J, Huss JW, Su AI. 2009. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol 10:R130. http://dx.doi.org/10.1186/gb-2009-10-11-r130.
   PubMed Web of Science ®Google Scholar
• Geng C, Macdonald PM. 2007. Identification of genes that influence gurken expression. Fly 1:259–267. http://dx.doi.org/10.4161/fly.5246.
   PubMed Web of Science ®Google Scholar
• Charroux B, Angelats C, Fasano L, Kerridge S, Vola C. 1999. The levels of the bancal product, a Drosophila homologue of vertebrate hnRNP K protein, affect cell proliferation and apoptosis in imaginal disc cells. Mol Cell Biol 19:7846–7856. http://dx.doi.org/10.1128/MCB.19.11.7846.
   PubMed Web of Science ®Google Scholar
• Colaiácovo MP, Stanfield GM, Reddy KC, Reinke V, Kim SK, Villeneuve AM. 2002. A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline. Genetics 162:113–128.
   PubMed Web of Science ®Google Scholar
• Roshon MJ, Ruley HE. 2005. Hypomorphic mutation in hnRNP U results in post-implantation lethality. Transgenic Res 14:179–192. http://dx.doi.org/10.1007/s11248-004-8147-8.
   PubMed Web of Science ®Google Scholar
• Williamson DJ, Banik-Maiti S, DeGregori J, Ruley HE. 2000. hnRNP C is required for postimplantation mouse development but Is dispensable for cell viability. Mol Cell Biol 20:4094–4105. http://dx.doi.org/10.1128/MCB.20.11.4094-4105.2000.
   PubMedGoogle Scholar
• Katsanou V, Milatos S, Yiakouvaki A, Sgantzis N, Kotsoni A, Alexiou M, Harokopos V, Aidinis V, Hemberger M, Kontoyiannis DL. 2009. The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol 29:2762–2776. http://dx.doi.org/10.1128/MCB.01393-08.
   PubMed Web of Science ®Google Scholar
• Shibayama M, Ohno S, Osaka T, Sakamoto R, Tokunaga A, Nakatake Y, Sato M, Yoshida N. 2009. Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation. FEBS J 276:6658–6668. http://dx.doi.org/10.1111/j.1742-4658.2009.07380.x.
   PubMedGoogle Scholar
• Waggoner SA, Johannes GJ, Liebhaber SA. 2009. Depletion of the poly(C)-binding proteins αCP1 and αCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. J Biol Chem 284:9039–9049. http://dx.doi.org/10.1074/jbc.M806986200.
   PubMed Web of Science ®Google Scholar
• Gamarnik AV, Andino R. 1997. Two functional complexes formed by KH domain containing proteins with the 5′ noncoding region of poliovirus RNA. RNA 3:882–892.
   PubMed Web of Science ®Google Scholar
• Tang Y-S, Khan RA, Zhang Y, Xiao S, Wang M, Hansen DK, Jayaram HN, Antony AC. 2011. Incrimination of heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) as a candidate sensor of physiological folate deficiency. J Biol Chem 286:39100–39115. http://dx.doi.org/10.1074/jbc.M111.230938.
   PubMed Web of Science ®Google Scholar
• Shi H, Bencze KZ, Stemmler TL, Philpott CC. 2008. A cytosolic iron chaperone that delivers iron to ferritin. Science 320:1207–1210. http://dx.doi.org/10.1126/science.1157643.
   PubMed Web of Science ®Google Scholar
• Blyn LB, Towner JS, Semler BL, Ehrenfeld E. 1997. Requirement of poly(rC) binding protein 2 for translation of poliovirus RNA. J Virol 71:6243–6246.
   PubMed Web of Science ®Google Scholar
• Perrotti D, Calabretta B. 2002. Post-transcriptional mechanisms in BCR/ABL leukemogenesis: role of shuttling RNA-binding proteins. Oncogene 21:8577–8583. http://dx.doi.org/10.1038/sj.onc.1206085.
   PubMed Web of Science ®Google Scholar
• Woolaway K, Asai K, Emili A, Cochrane A. 2007. hnRNP E1 and E2 have distinct roles in modulating HIV-1 gene expression. Retrovirology 4:28. http://dx.doi.org/10.1186/1742-4690-4-28.
   PubMed Web of Science ®Google Scholar
• Chaudhury A, Hussey GS, Ray PS, Jin G, Fox PL, Howe PH. 2010. TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nat Cell Biol 12:286–293. http://dx.doi.org/10.1038/ncb2029.
   PubMed Web of Science ®Google Scholar
• Hussey GS, Chaudhury A, Dawson AE, Lindner DJ, Knudsen CR, Wilce MCJ, Merrick WC, Howe PH. 2011. Identification of an mRNP complex regulating tumorigenesis at the translational elongation step. Mol Cell 41:419–431. http://dx.doi.org/10.1016/j.molcel.2011.02.003.
   PubMed Web of Science ®Google Scholar
• Ghanem LR, Chatterji P, Liebhaber SA. 2014. Specific enrichment of the RNA-binding proteins PCBP1 and PCBP2 in chief cells of the murine gastric mucosa. Gene Expr Patterns 14:78–87. http://dx.doi.org/10.1016/j.gep.2014.01.004.
   PubMed Web of Science ®Google Scholar
• Ye J, Coulouris G, Zaretskaya I, Cutcutache I, Rozen S, Madden TL. 2012. Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction. BMC Bioinformatics 13:134. http://dx.doi.org/10.1186/1471-2105-13-134.
   PubMed Web of Science ®Google Scholar
• Rotmistrovsky K, Jang W, Schuler GD. 2004. A web server for performing electronic PCR. Nucleic Acids Res 32:W108–W112. http://dx.doi.org/10.1093/nar/gkh450.
   PubMedGoogle Scholar
• Miller JC, Tan S, Qiao G, Barlow KA, Wang J, Xia DF, Meng X, Paschon DE, Leung E, Hinkley SJ, Dulay GP, Hua KL, Ankoudinova I, Cost GJ, Urnov FD, Zhang HS, Holmes MC, Zhang L, Gregory PD, Rebar EJ. 2011. A TALE nuclease architecture for efficient genome editing. Nat Biotechnol 29:143–148. http://dx.doi.org/10.1038/nbt.1755.
   PubMed Web of Science ®Google Scholar
• Liu P, Jenkins NA, Copeland NG. 2003. A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res 13:476–484. http://dx.doi.org/10.1101/gr.749203.
   PubMed Web of Science ®Google Scholar
• Eggan K, Akutsu H, Loring J, Jackson-Grusby L, Klemm M, Rideout WM, Yanagimachi R, Jaenisch R. 2001. Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc Natl Acad Sci U S A 98:6209–6214. http://dx.doi.org/10.1073/pnas.101118898.
   PubMed Web of Science ®Google Scholar
• Nagy A, Gertsenstein M, Vintersten K, Behringer R. 2003. Manipulating the mouse embryo, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
   Google Scholar
• Koulnis M, Pop R, Porpiglia E, Shearstone JR, Hidalgo D, Socolovsky M. 2011. Identification and analysis of mouse erythroid progenitors using the CD71/TER119 flow-cytometric assay. J Vis Exp 5:2809.
   Google Scholar
• Shearstone JR, Pop R, Bock C, Boyle P, Meissner A, Socolovsky M. 2011. Global DNA demethylation during mouse erythropoiesis in vivo. Science 334:799–802. http://dx.doi.org/10.1126/science.1207306.
   PubMedGoogle Scholar
• Camacho C, Coulouris G, Avagyan V, Ma N, Papadopoulos J, Bealer K, Madden TL. 2009. BLAST+: architecture and applications. BMC Bioinformatics 10:421. http://dx.doi.org/10.1186/1471-2105-10-421.
   PubMed Web of Science ®Google Scholar
• Trapnell C, Pachter L, Salzberg SL. 2009. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25:1105–1111. http://dx.doi.org/10.1093/bioinformatics/btp120.
   PubMed Web of Science ®Google Scholar
• Anders S, Pyl PT, Huber W. 2015. HTSeq—a Python framework to work with high-throughput sequencing data. Bioinformatics 31:166–169. http://dx.doi.org/10.1093/bioinformatics/btu638.
   PubMed Web of Science ®Google Scholar
• Martin M. 2011. Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet J 17:10–12. http://dx.doi.org/10.14806/ej.17.1.200.
   Google Scholar
• Love MI, Huber W, Anders S. 2014. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550. http://dx.doi.org/10.1186/s13059-014-0550-8.
   PubMed Web of Science ®Google Scholar
• D'Alton S, Altshuler M, Lewis J. 2015. Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesis. RNA 21:1419–1432. http://dx.doi.org/10.1261/rna.047647.114.
   PubMed Web of Science ®Google Scholar
• Hornstein E, Git A, Braunstein I, Avni D, Meyuhas O. 1999. The expression of poly(A)-binding protein gene is translationally regulated in a growth-dependent fashion through a 5′-terminal oligopyrimidine tract motif. J Biol Chem 274:1708–1714. http://dx.doi.org/10.1074/jbc.274.3.1708.
   PubMedGoogle Scholar
• Tesson L, Usal C, Ménoret S, Leung E, Niles BJ, Remy S, Santiago Y, Vincent AI, Meng X, Zhang L, Gregory PD, Anegon I, Cost GJ. 2011. Knockout rats generated by embryo microinjection of TALENs. Nat Biotechnol 29:695–696. http://dx.doi.org/10.1038/nbt.1940.
   PubMed Web of Science ®Google Scholar
• Sanjana NE, Cong L, Zhou Y, Cunniff MM, Feng G, Zhang F. 2012. A transcription activator-like effector toolbox for genome engineering. Nat Protoc 7:171–192. http://dx.doi.org/10.1038/nprot.2011.431.
   PubMed Web of Science ®Google Scholar
• Qian W, Zhang J. 2008. Gene dosage and gene duplicability. Genetics 179:2319–2324. http://dx.doi.org/10.1534/genetics.108.090936.
   PubMedGoogle Scholar
• Kong J, Sumaroka M, Eastmond DL, Liebhaber SA. 2006. Shared stabilization functions of pyrimidine-rich determinants in the erythroid 15-lipoxygenase and alpha-globin mRNAs. Mol Cell Biol 26:5603–5614. http://dx.doi.org/10.1128/MCB.01845-05.
   PubMedGoogle Scholar
• Palis J, Robertson S, Kennedy M, Wall C, Keller G. 1999. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development 126:5073–5084.
   PubMedGoogle Scholar
• Vannucchi AM, Paoletti F, Linari S, Cellai C, Caporale R, Ferrini PR, Sanchez M, Migliaccio G, Migliaccio AR. 2000. Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice. Blood 95:2559–2568.
   PubMed Web of Science ®Google Scholar
• Akashi K, Traver D, Miyamoto T, Weissman IL. 2000. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404:193–197. http://dx.doi.org/10.1038/35004599.
   PubMed Web of Science ®Google Scholar
• Huang DW, Sherman BT, Lempicki RA. 2009. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44–57. http://dx.doi.org/10.1038/nprot.2008.211.
   PubMed Web of Science ®Google Scholar
• Novershtern N, Subramanian A, Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N, Yosef N, Chang CY, Shay T, Frampton GM, Drake ACB, Leskov I, Nilsson B, Preffer F, Dombkowski D, Evans JW, Liefeld T, Smutko JS, Chen J, Friedman N, Young RA, Golub TR, Regev A, Ebert BL. 2011. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell 144:296–309. http://dx.doi.org/10.1016/j.cell.2011.01.004.
   PubMed Web of Science ®Google Scholar
• Pimkin M, Kossenkov AV, Mishra T, Morrissey CS, Wu W, Keller CA, Blobel GA, Lee D, Beer MA, Hardison RC, Weiss MJ. 2014. Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis. Genome Res 24:1932–1944. http://dx.doi.org/10.1101/gr.164178.113.
   PubMed Web of Science ®Google Scholar
• Ho JJD, Robb GB, Tai SC, Turgeon PJ, Mawji IA, Man HSJ, Marsden PA. 2013. Active stabilization of human endothelial nitric oxide synthase mRNA by hnRNP E1 protects against antisense RNA and microRNAs. Mol Cell Biol 33:2029–2046. http://dx.doi.org/10.1128/MCB.01257-12.
   PubMedGoogle Scholar
• Makeyev AV, Liebhaber SA. 2000. Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins. Genomics 67:301–316. http://dx.doi.org/10.1006/geno.2000.6244.
   PubMed Web of Science ®Google Scholar
• Valverde R, Edwards L, Regan L. 2008. Structure and function of KH domains. FEBS J 275:2712–2726. http://dx.doi.org/10.1111/j.1742-4658.2008.06411.x.
   PubMed Web of Science ®Google Scholar
• Lunde BM, Moore C, Varani G. 2007. RNA-binding proteins: modular design for efficient function. Nat Rev Mol Cell Biol 8:479–490. http://dx.doi.org/10.1038/nrm2178.
   PubMed Web of Science ®Google Scholar
• Feng Y, Absher D, Eberhart DE, Brown V, Malter HE, Warren ST. 1997. FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association. Mol Cell 1:109–118. http://dx.doi.org/10.1016/S1097-2765(00)80012-X.
   PubMed Web of Science ®Google Scholar
• Maquat LE, Li X. 2001. Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay. RNA 7:445–456. http://dx.doi.org/10.1017/S1355838201002229.
   PubMedGoogle Scholar
• Neu-Yilik G, Gehring NH, Thermann R, Frede U, Hentze MW, Kulozik AE. 2001. Splicing and 3′ end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs. EMBO J 20:532–540. http://dx.doi.org/10.1093/emboj/20.3.532.
   PubMedGoogle Scholar
• Reed DR, Lawler MP, Tordoff MG. 2008. Reduced body weight is a common effect of gene knockout in mice. BMC Genet 9:4. http://dx.doi.org/10.1186/1471-2156-9-4.
   PubMed Web of Science ®Google Scholar
• Deutschbauer AM, Jaramillo DF, Proctor M, Kumm J, Hillenmeyer ME, Davis RW, Nislow C, Giaever G. 2005. Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics 169:1915–1925. http://dx.doi.org/10.1534/genetics.104.036871.
   PubMed Web of Science ®Google Scholar
• Park T-J, Boyd K, Curran T. 2006. Cardiovascular and craniofacial defects in Crk-null mice. Mol Cell Biol 26:6272–6282. http://dx.doi.org/10.1128/MCB.00472-06.
   PubMedGoogle Scholar
• Arthur J, Elce JS, Hegadorn C, Williams K, Greer PA. 2000. Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division. Mol Cell Biol 20:4474–4481. http://dx.doi.org/10.1128/MCB.20.12.4474-4481.2000.
   PubMed Web of Science ®Google Scholar
• Hisa T, Spence SE, Rachel RA, Fujita M, Nakamura T, Ward JM, Devor-Henneman DE, Saiki Y, Kutsuna H, Tessarollo L, Jenkins NA, Copeland NG. 2004. Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. EMBO J 23:450–459. http://dx.doi.org/10.1038/sj.emboj.7600038.
   PubMedGoogle Scholar
• Ji X, Kong J, Liebhaber SA. 2003. In vivo association of the stability control protein αCP with actively translating mRNAs. Mol Cell Biol 23:899–907. http://dx.doi.org/10.1128/MCB.23.3.899-907.2003.
   PubMed Web of Science ®Google Scholar
• Kong J, Ji X, Liebhaber SA. 2003. The KH-domain protein αCP has a direct role in mRNA stabilization independent of its cognate binding site. Mol Cell Biol 23:1125–1134. http://dx.doi.org/10.1128/MCB.23.4.1125-1134.2003.
   PubMedGoogle Scholar
• Kong J, Liebhaber SA. 2007. A cell type-restricted mRNA surveillance pathway triggered by ribosome extension into the 3′ untranslated region. Nat Struct Mol Biol 14:670–676. http://dx.doi.org/10.1038/nsmb1256.
   PubMedGoogle Scholar
• Weiss IM, Liebhaber SA. 1994. Erythroid cell-specific determinants of alpha-globin mRNA stability. Mol Cell Biol 14:8123–8132. http://dx.doi.org/10.1128/MCB.14.12.8123.
   PubMed Web of Science ®Google Scholar
• Crispino JD, Weiss MJ. 2014. Erythro-megakaryocytic transcription factors associated with hereditary anemia. Blood 123:3080–3088. http://dx.doi.org/10.1182/blood-2014-01-453167.
   PubMed Web of Science ®Google Scholar
• Li X, Lu Y-C, Dai K, Torregroza I, Hla T, Evans T. 2014. Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. Blood 123:1384–1392. http://dx.doi.org/10.1182/blood-2013-09-526962.
   PubMedGoogle Scholar
• Zhang L, Sankaran VG, Lodish HF. 2012. MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment. Leukemia 26:2310–2316. http://dx.doi.org/10.1038/leu.2012.137.
   PubMed Web of Science ®Google Scholar
• Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH. 1995. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell 81:695–704. http://dx.doi.org/10.1016/0092-8674(95)90531-6.
   PubMed Web of Science ®Google Scholar
• Iwasaki H, Mizuno S, Arinobu Y, Ozawa H, Mori Y, Shigematsu H, Takatsu K, Tenen DG, Akashi K. 2006. The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev 20:3010–3021. http://dx.doi.org/10.1101/gad.1493506.
   PubMedGoogle Scholar
• Iwasaki H, Akashi K. 2007. Myeloid lineage commitment from the hematopoietic stem cell. Immunity 26:726–740. http://dx.doi.org/10.1016/j.immuni.2007.06.004.
   PubMed Web of Science ®Google Scholar