Protein Kinase A, Ca²⁺/Calmodulin-Dependent Kinase II, and Calcineurin Regulate the Intracellular Trafficking of Myopodin between the Z-Disc and the Nucleus of Cardiac Myocytes

REFERENCES

• Asanuma, K., K. Kim, J. Oh, L. Giardino, S. Chabanis, C. Faul, J. Reiser, and P. Mundel. 2005. Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner. J. Clin. Investig. 115:1188–1198.
   PubMed Web of Science ®Google Scholar
• Asanuma, K., E. Yanagida-Asanuma, C. Faul, Y. Tomino, K. Kim, and P. Mundel. 2006. Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat. Cell Biol. 8:485–491.
   PubMed Web of Science ®Google Scholar
• Beckerle, M. C. 1997. Zyxin: zinc fingers at sites of cell adhesion. Bioessays 19:949–957.
   PubMedGoogle Scholar
• Chow, C. W., and R. J. Davis. 2000. Integration of calcium and cyclic AMP signaling pathways by 14-3-3. Mol. Cell. Biol. 20:702–712.
   PubMed Web of Science ®Google Scholar
• Clark, K. A., A. S. McElhinny, M. C. Beckerle, and C. C. Gregorio. 2002. Striated muscle cytoarchitecture: an intricate web of form and function. Annu. Rev. Cell. Dev. Biol. 18:637–706.
   PubMed Web of Science ®Google Scholar
• Crabtree, G. R., and E. N. Olson. 2002. NFAT signaling: choreographing the social lives of cells. Cell 109(Suppl.):S67–S79.
   PubMed Web of Science ®Google Scholar
• Dodge, K. L., S. Khouangsathiene, M. S. Kapiloff, R. Mouton, E. V. Hill, M. D. Houslay, L. K. Langeberg, and J. D. Scott. 2001. mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. EMBO J. 20:1921–1930.
   PubMed Web of Science ®Google Scholar
• Dougherty, M. K., and D. K. Morrison. 2004. Unlocking the code of 14-3-3. J. Cell Sci. 117:1875–1884.
   PubMedGoogle Scholar
• Epstein, N. D., and J. S. Davis. 2003. Sensing stretch is fundamental. Cell 112:147–150.
   PubMedGoogle Scholar
• Ervasti, J. M. 2003. Costameres: the Achilles' heel of Herculean muscle. J. Biol. Chem. 278:13591–13594.
   PubMedGoogle Scholar
• Faul, C., S. Huttelmaier, J. Oh, V. Hachet, R. H. Singer, and P. Mundel. 2005. Promotion of importin α-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3. J. Cell Biol. 169:415–424.
   PubMedGoogle Scholar
• Fimia, G. M., D. De Cesare, and P. Sassone-Corsi. 2000. A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM. Mol. Cell. Biol. 20:8613–8622.
   PubMed Web of Science ®Google Scholar
• Frank, D., C. Kuhn, H. A. Katus, and N. Frey. 2006. The sarcomeric Z-disc: a nodal point in signalling and disease. J. Mol. Med. 84:446–468.
   PubMedGoogle Scholar
• Frey, N., J. A. Richardson, and E. N. Olson. 2000. Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. Proc. Natl. Acad. Sci. USA 97:14632–14637.
   PubMed Web of Science ®Google Scholar
• Garcia-Cozar, F. J., H. Okamura, J. F. Aramburu, K. T. Shaw, L. Pelletier, R. Showalter, E. Villafranca, and A. Rao. 1998. Two-site interaction of nuclear factor of activated T cells with activated calcineurin. J. Biol. Chem. 273:23877–23883.
   PubMed Web of Science ®Google Scholar
• Heineke, J., H. Ruetten, C. Willenbockel, S. C. Gross, M. Naguib, A. Schaefer, T. Kempf, D. Hilfiker-Kleiner, P. Caroni, T. Kraft, R. A. Kaiser, J. D. Molkentin, H. Drexler, and K. C. Wollert. 2005. Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc. Proc. Natl. Acad. Sci. USA 102:1655–1660.
   PubMedGoogle Scholar
• Houslay, M. D., and D. R. Adams. 2003. PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. Biochem. J. 370:1–18.
   PubMed Web of Science ®Google Scholar
• Kadrmas, J. L., and M. C. Beckerle. 2004. The LIM domain: from the cytoskeleton to the nucleus. Nat. Rev. Mol. Cell Biol. 5:920–931.
   PubMed Web of Science ®Google Scholar
• Kapiloff, M. S., R. V. Schillace, A. M. Westphal, and J. D. Scott. 1999. mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes. J. Cell Sci. 112:2725–2736.
   PubMed Web of Science ®Google Scholar
• Kato, T., J. Muraski, Y. Chen, Y. Tsujita, J. Wall, C. C. Glembotski, E. Schaefer, M. Beckerle, and M. A. Sussman. 2005. Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. J. Clin. Investig. 115:2716–2730.
   PubMed Web of Science ®Google Scholar
• Klee, C. B., H. Ren, and X. Wang. 1998. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J. Biol. Chem. 273:13367–13370.
   PubMed Web of Science ®Google Scholar
• Knoll, R., M. Hoshijima, H. M. Hoffman, V. Person, I. Lorenzen-Schmidt, M. L. Bang, T. Hayashi, N. Shiga, H. Yasukawa, W. Schaper, W. McKenna, M. Yokoyama, N. J. Schork, J. H. Omens, A. D. McCulloch, A. Kimura, C. C. Gregorio, W. Poller, J. Schaper, H. P. Schultheiss, and K. R. Chien. 2002. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell 111:943–955.
   PubMed Web of Science ®Google Scholar
• Kong, Y., M. J. Flick, A. J. Kudla, and S. F. Konieczny. 1997. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol. Cell. Biol. 17:4750–4760.
   PubMedGoogle Scholar
• Laflamme, M. A., and P. L. Becker. 1999. G(s) and adenylyl cyclase in transverse tubules of heart: implications for cAMP-dependent signaling. Am. J. Physiol. 277:H1841–H1848.
   PubMedGoogle Scholar
• Lange, S., E. Ehler, and M. Gautel. 2006. From A to Z and back? Multicompartment proteins in the sarcomere. Trends Cell Biol. 16:11–18.
   PubMedGoogle Scholar
• Lin, Z., M. H. Lu, T. Schultheiss, J. Choi, S. Holtzer, C. DiLullo, D. A. Fischman, and H. Holtzer. 1994. Sequential appearance of muscle-specific proteins in myoblasts as a function of time after cell division: evidence for a conserved myoblast differentiation program in skeletal muscle. Cell Motil. Cytoskel. 29:1–19.
   PubMedGoogle Scholar
• Liu, Y., Z. Cseresnyes, W. R. Randall, and M. F. Schneider. 2001. Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibers. J. Cell Biol. 155:27–40.
   PubMed Web of Science ®Google Scholar
• Macian, F. 2005. NFAT proteins: key regulators of T-cell development and function. Nat. Rev. Immunol. 5:472–484.
   PubMed Web of Science ®Google Scholar
• McConnachie, G., L. K. Langeberg, and J. D. Scott. 2006. AKAP signaling complexes: getting to the heart of the matter. Trends Mol. Med. 12:317–323.
   PubMed Web of Science ®Google Scholar
• Mongillo, M., T. McSorley, S. Evellin, A. Sood, V. Lissandron, A. Terrin, E. Huston, A. Hannawacker, M. J. Lohse, T. Pozzan, M. D. Houslay, and M. Zaccolo. 2004. Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ. Res. 95:67–75.
   PubMed Web of Science ®Google Scholar
• Morgan, M. J., and A. J. Madgwick. 1999. The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. Biochem. Biophys. Res. Commun. 255:245–250.
   PubMed Web of Science ®Google Scholar
• O'Keefe, S. J., J. Tamura, R. L. Kincaid, M. J. Tocci, and E. A. O'Neill. 1992. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357:692–694.
   PubMed Web of Science ®Google Scholar
• Orr, A. W., B. P. Helmke, B. R. Blackman, and M. A. Schwartz. 2006. Mechanisms of mechanotransduction. Dev. Cell 10:11–20.
   PubMed Web of Science ®Google Scholar
• Pare, G. C., A. L. Bauman, M. McHenry, J. J. Michel, K. L. Dodge-Kafka, and M. S. Kapiloff. 2005. The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. J. Cell Sci. 118:5637–5646.
   PubMed Web of Science ®Google Scholar
• Pawson, T., and J. D. Scott. 2005. Protein phosphorylation in signaling—50 years and counting. Trends Biochem. Sci. 30:286–290.
   PubMed Web of Science ®Google Scholar
• Pyle, W. G., and R. J. Solaro. 2004. At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function. Circ. Res. 94:296–305.
   PubMed Web of Science ®Google Scholar
• Pyo, R. T., J. Sui, A. Dhume, J. Palomeque, B. C. Blaxall, G. Diaz, J. Tunstead, D. E. Logothetis, R. J. Hajjar, and A. D. Schecter. 2006. CXCR4 modulates contractility in adult cardiac myocytes. J. Mol. Cell. Cardiol. 41:834–844.
   PubMed Web of Science ®Google Scholar
• Robson, R. M., D. E. Goll, N. Arakawa, and M. H. Stromer. 1970. Purification and properties of alpha-actinin from rabbit skeletal muscle. Biochim. Biophys. Acta 200:296–318.
   PubMedGoogle Scholar
• Scott, J. D. 2006. Compartmentalized cAMP signalling: a personal perspective. Biochem. Soc. Trans. 34:465–467.
   PubMed Web of Science ®Google Scholar
• Sheng, T., S. Chi, X. Zhang, and J. Xie. 2006. Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal. J. Biol. Chem. 281:9–12.
   PubMed Web of Science ®Google Scholar
• Smith, F. D., and J. D. Scott. 2002. Signaling complexes: junctions on the intracellular information super highway. Curr. Biol. 12:R32–R40.
   PubMed Web of Science ®Google Scholar
• Verde, I., G. Pahlke, M. Salanova, G. Zhang, S. Wang, D. Coletti, J. Onuffer, S. L. Jin, and M. Conti. 2001. Myomegalin is a novel protein of the Golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. J. Biol. Chem. 276:11189–11898.
   PubMed Web of Science ®Google Scholar
• Weins, A., K. Schwarz, C. Faul, L. Barisoni, W. A. Linke, and P. Mundel. 2001. Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. J. Cell Biol. 155:393–404.
   PubMedGoogle Scholar
• Zaccolo, M., T. Cesetti, G. Di Benedetto, M. Mongillo, V. Lissandron, A. Terrin, and I. Zamparo. 2005. Imaging the cAMP-dependent signal transduction pathway. Biochem. Soc. Trans. 33:1323–1326.
   PubMedGoogle Scholar