Brd4 Recruits P-TEFb to Chromosomes at Late Mitosis To Promote G₁ Gene Expression and Cell Cycle Progression

REFERENCES

• Bonifacino, J. S., J. B. Dasso, J. Harford, K. M. Lippincott-schwartz, Yamada, and K. S. Morgan (ed.). 1998. Current protocols in cell biology. John Wiley and Sons, New York, NY.
   Google Scholar
• Dey, A., F. Chitsaz, A. Abbasi, T. Misteli, and K. Ozato. 2003. The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. Proc. Natl. Acad. Sci. USA 100:8758–8763.
   PubMed Web of Science ®Google Scholar
• Dey, A., J. Ellenberg, A. Farina, A. E. Coleman, T. Maruyama, S. Sciortino, J. Lippincott-Schwartz, and K. Ozato. 2000. A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G2-to-M transition. Mol. Cell. Biol. 20:6537–6549.
   PubMed Web of Science ®Google Scholar
• Garriga, J., S. Bhattacharya, J. Calbo, R. M. Marshall, M. Truongcao, D. S. Haines, and X. Grana. 2003. CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2. Mol. Cell. Biol. 23:5165–5173.
   PubMed Web of Science ®Google Scholar
• Goldman, R. D., Y. Gruenbaum, R. D. Moir, D. K. Shumaker, and T. P. Spann. 2002. Nuclear lamins: building blocks of nuclear architecture. Genes Dev. 16:533–547.
   PubMed Web of Science ®Google Scholar
• Gottesfeld, J. M., and D. J. Forbes. 1997. Mitotic repression of the transcriptional machinery. Trends Biochem. Sci. 22:197–202.
   PubMed Web of Science ®Google Scholar
• Haraguchi, T., T. Koujin, T. Hayakawa, T. Kaneda, C. Tsutsumi, N. Imamoto, C. Akazawa, J. Sukegawa, Y. Yoneda, and Y. Hiraoka. 2000. Live fluorescence imaging reveals early recruitment of emerin, LBR, RanBP2, and Nup153 to reforming functional nuclear envelopes. J. Cell Sci. 113:779–794.
   PubMed Web of Science ®Google Scholar
• He, N., A. C. Pezda, and Q. Zhou. 2006. Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation. Mol. Cell. Biol. 26:7068–7076.
   PubMedGoogle Scholar
• Iyer, V. R., M. B. Eisen, D. T. Ross, G. Schuler, T. Moore, J. C. Lee, J. M. Trent, L. M. Staudt, J. Hudson, Jr., M. S. Boguski, D. Lashkari, D. Shalon, D. Botstein, and P. O. Brown. 1999. The transcriptional program in the response of human fibroblasts to serum. Science 283:83–87.
   PubMed Web of Science ®Google Scholar
• Jang, M. K., K. Mochizuki, M. Zhou, H. S. Jeong, J. N. Brady, and K. Ozato. 2005. The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol. Cell 19:523–534.
   PubMed Web of Science ®Google Scholar
• King, K. L., and J. A. Cidlowski. 1998. Cell cycle regulation and apoptosis. Annu. Rev. Physiol. 60:601–617.
   PubMed Web of Science ®Google Scholar
• Kruhlak, M. J., M. J. Hendzel, W. Fischle, N. R. Bertos, S. Hameed, X. J. Yang, E. Verdin, and D. P. Bazett-Jones. 2001. Regulation of global acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin. J. Biol. Chem. 276:38307–38319.
   PubMed Web of Science ®Google Scholar
• McPhillips, M. G., K. Ozato, and A. A. McBride. 2005. Interaction of bovine papillomavirus E2 protein with Brd4 stabilizes its association with chromatin. J. Virol. 79:8920–8932.
   PubMedGoogle Scholar
• Muchardt, C., J. C. Reyes, B. Bourachot, E. Leguoy, and M. Yaniv. 1996. The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis. EMBO J. 15:3394–3402.
   PubMedGoogle Scholar
• Nishiyama, A., A. Dey, J. Miyazaki, and K. Ozato. 2006. Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. Mol. Biol. Cell 17:814–823.
   PubMedGoogle Scholar
• Peterlin, B. M., and D. H. Price. 2006. Controlling the elongation phase of transcription with P-TEFb. Mol. Cell 23:297–305.
   PubMed Web of Science ®Google Scholar
• Prasanth, K. V., P. A. Sacco-Bubulya, S. G. Prasanth, and D. L. Spector. 2003. Sequential entry of components of the gene expression machinery into daughter nuclei. Mol. Biol. Cell 14:1043–1057.
   PubMed Web of Science ®Google Scholar
• Segil, N., M. Guermah, A. Hoffmann, R. G. Roeder, and N. Heintz. 1996. Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization. Genes Dev. 10:2389–2400.
   PubMed Web of Science ®Google Scholar
• Sims, R. J., III, R. Belotserkovskaya, and D. Reinberg. 2004. Elongation by RNA polymerase II: the short and long of it. Genes Dev. 18:2437–2468.
   PubMed Web of Science ®Google Scholar
• Ventura, A., A. Meissner, C. P. Dillon, M. McManus, P. A. Sharp, L. Van Parijs, R. Jaenisch, and T. Jacks. 2004. Cre-lox-regulated conditional RNA interference from transgenes. Proc. Natl. Acad. Sci. USA 101:10380–10385.
   PubMed Web of Science ®Google Scholar
• Wang, G., M. A. Balamotis, J. L. Stevens, Y. Yamaguchi, H. Handa, and A. J. Berk. 2005. Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol. Cell 17:683–694.
   PubMed Web of Science ®Google Scholar
• Whitfield, M. L., G. Sherlock, A. J. Saldanha, J. I. Murray, C. A. Ball, K. E. Alexander, J. C. Matese, C. M. Perou, M. M. Hurt, P. O. Brown, and D. Botstein. 2002. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol. Biol. Cell 13:1977–2000.
   PubMed Web of Science ®Google Scholar
• Wu, S. Y., A. Y. Lee, S. Y. Hou, J. K. Kemper, H. Erdjument-Bromage, P. Tempst, and C. M. Chiang. 2006. Brd4 links chromatin targeting to HPV transcriptional silencing. Genes Dev. 20:2383–2396.
   PubMedGoogle Scholar
• Yang, Z., J. H. Yik, R. Chen, N. He, M. K. Jang, K. Ozato, and Q. Zhou. 2005. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol. Cell 19:535–545.
   PubMed Web of Science ®Google Scholar
• You, J., J. L. Croyle, A. Nishimura, K. Ozato, and P. M. Howley. 2004. Interaction of the bovine papillomavirus E2 protein with Brd4 tethers the viral DNA to host mitotic chromosomes. Cell 117:349–360.
   PubMed Web of Science ®Google Scholar
• Zhou, Q., and J. H. Yik. 2006. The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation. Microbiol. Mol. Biol. Rev. 70:646–659.
   PubMed Web of Science ®Google Scholar