AIRE Recruits P-TEFb for Transcriptional Elongation of Target Genes in Medullary Thymic Epithelial Cells

REFERENCES

• Aasland, R., T. J. Gibson, and A. F. Stewart. 1995. The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem. Sci. 20:56–59.
   PubMed Web of Science ®Google Scholar
• Adams, M., L. Sharmeen, J. Kimpton, J. Romeo, J. Garcia, B. Peterlin, M. Groudine, and M. Emerman. 1994. Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts. Proc. Natl. Acad. Sci. USA 91:3862–3866.
   PubMedGoogle Scholar
• Anderson, M. S., E. S. Venanzi, Z. Chen, S. P. Berzins, C. Benoist, and D. Mathis. 2005. The cellular mechanism of Aire control of T cell tolerance. Immunity 23:227–239.
   PubMed Web of Science ®Google Scholar
• Anderson, M. S., E. S. Venanzi, L. Klein, Z. Chen, S. P. Berzins, S. J. Turley, H. von Boehmer, R. Bronson, A. Dierich, C. Benoist, and D. Mathis. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science 298:1395–1401.
   PubMed Web of Science ®Google Scholar
• Bjorses, P., M. Pelto-Huikko, J. Kaukonen, J. Aaltonen, L. Peltonen, and I. Ulmanen. 1999. Localization of the APECED protein in distinct nuclear structures. Hum. Mol. Genet. 8:259–266.
   PubMed Web of Science ®Google Scholar
• Blau, J., H. Xiao, S. McCracken, P. O'Hare, J. Greenblatt, and D. Bentley. 1996. Three functional classes of transcriptional activation domain. Mol. Cell. Biol. 16:2044–2055.
   PubMed Web of Science ®Google Scholar
• Chao, S.-H., K. Fujinaga, J. E. Marion, R. Taube, E. A. Sausville, A. M. Senderowicz, B. M. Peterlin, and D. H. Price. 2000. Flavopiridol inhibits P-TEFb and blocks HIV-1 replication. J. Biol. Chem. 275:28345–28348.
   PubMed Web of Science ®Google Scholar
• Chin, R. K., J. C. Lo, O. Kim, S. E. Blink, P. A. Christiansen, P. Peterson, Y. Wang, C. Ware, and Y.-X. Fu. 2003. Lymphotoxin pathway directs thymic Aire expression. Nat. Immunol. 4:1121–1127.
   PubMedGoogle Scholar
• Derbinski, J., J. Gabler, B. Brors, S. Tierling, S. Jonnakuty, M. Hergenhahn, L. Peltonen, J. Walter, and B. Kyewski. 2005. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J. Exp. Med. 202:33–45.
   PubMed Web of Science ®Google Scholar
• Gibson, T. J., C. Ramu, C. Gemund, and R. Aasland. 1998. The APECED polyglandular autoimmune syndrome protein, AIRE-1, contains the SAND domain and is probably a transcription factor. Trends Biochem. Sci. 23:242–244.
   PubMed Web of Science ®Google Scholar
• Gillard, G. O., and A. G. Farr. 2006. Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression. J. Immunol. 176:5815–5824.
   PubMed Web of Science ®Google Scholar
• Gomez, J. A., P. Majumder, U. M. Nagarajan, and J. M. Boss. 2005. X box-like sequences in the MHC class II region maintain regulatory function. J. Immunol. 175:1030–1040.
   PubMedGoogle Scholar
• Greenblatt, J., J. R. Nodwell, and S. W. Mason. 1993. Transcriptional antitermination. Nature 364:401–406.
   PubMed Web of Science ®Google Scholar
• Halonen, M., H. Kangas, T. Ruppell, T. Ilmarinen, J. Ollila, M. Kolmer, M. Vihinen, J. Palvimo, J. Saarela, I. Ulmanen, and P. Eskelin. 2004. APECED-causing mutations in AIRE reveal the functional domains of the protein. Hum. Mutat. 23:245–257.
   PubMedGoogle Scholar
• Heery, D. M., E. Kalkhoven, S. Hoare, and M. G. Parker. 1997. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387:733–736.
   PubMed Web of Science ®Google Scholar
• Heino, M., P. Peterson, J. Kudoh, K. Nagamine, A. Lagerstedt, V. Ovod, A. Ranki, I. Rantala, M. Nieminen, J. Tuukkanen, H. S. Scott, S. E. Antonarakis, N. Shimizu, and K. Krohn. 1999. Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla. Biochem. Biophys. Res. Commun. 257:821–825.
   PubMed Web of Science ®Google Scholar
• Herrmann, C. H., and M. A. Mancini. 2001. The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions. J. Cell Sci. 114:1491–1503.
   PubMed Web of Science ®Google Scholar
• Jiang, W., M. S. Anderson, R. Bronson, D. Mathis, and C. Benoist. 2005. Modifier loci condition autoimmunity provoked by Aire deficiency. J. Exp. Med. 202:805–815.
   PubMed Web of Science ®Google Scholar
• Johnnidis, J. B., E. S. Venanzi, D. J. Taxman, J. P.-Y. Ting, C. O. Benoist, and D. J. Mathis. 2005. Chromosomal clustering of genes controlled by the aire transcription factor. Proc. Natl. Acad. Sci. USA 102:7233–7238.
   PubMed Web of Science ®Google Scholar
• Kanazawa, S., T. Okamoto, and B. M. Peterlin. 2000. Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection. Immunity 12:61–70.
   PubMedGoogle Scholar
• Kao, S.-Y., A. F. Calman, P. A. Luciw, and B. M. Peterlin. 1987. Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product. Nature 330:489–493.
   PubMed Web of Science ®Google Scholar
• Kasai, M., K. Hirokawa, K. Kajino, K. Ogasawara, M. Tatsumi, E. Hermel, J. J. Monaco, and T. Mizuochi. 1996. Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells. Eur. J. Immunol. 26:2101–2107.
   PubMedGoogle Scholar
• Kohoutek, J., D. Blazek, and B. M. Peterlin. 2006. Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters. Proc. Natl. Acad. Sci. USA 103:17349–17354.
   PubMedGoogle Scholar
• Kumar, P. G., M. Laloraya, C.-Y. Wang, Q.-G. Ruan, A. Davoodi-Semiromi, K.-J. Kao, and J.-X. She. 2001. The autoimmune regulator (AIRE) is a DNA-binding protein. J. Biol. Chem. 276:41357–41364.
   PubMedGoogle Scholar
• Lis, J. 1998. Promoter-associated pausing in promoter architecture and postinitiation transcriptional regulation. Cold Spring Harbor Symp. Quant. Biol. 63:347–356.
   PubMedGoogle Scholar
• Liston, A., S. Lesage, J. Wilson, L. Peltonen, and C. C. Goodnow. 2003. Aire regulates negative selection of organ-specific T cells. Nat. Immunol. 4:350–354.
   PubMed Web of Science ®Google Scholar
• Ma, J., and M. Ptashne. 1987. Deletion analysis of GAL4 defines two transcriptional activating segments. Cell 48:847–853.
   PubMed Web of Science ®Google Scholar
• Mathis, D., and C. Benoist. 2004. Back to central tolerance. Immunity 20:509–516.
   PubMedGoogle Scholar
• Michels, A. A., A. Fraldi, Q. Li, T. E. Adamson, F. Bonnet, V. T. Nguyen, S. C. Sedore, J. P. Price, D. H. Price, L. Lania, and O. Bensaude. 2004. Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor. EMBO J. 23:2608–2619.
   PubMed Web of Science ®Google Scholar
• Naar, A. M., B. D. Lemon, and R. Tjian. 2001. Transcriptional coactivator complexes. Annu. Rev. Biochem. 70:475–501.
   PubMed Web of Science ®Google Scholar
• Nagamine, K., P. Peterson, H. S. Scott, J. Kudoh, S. Minoshima, M. Heino, K. J. Krohn, M. D. Lalioti, P. E. Mullis, S. E. Antonarakis, K. Kawasaki, S. Asakawa, F. Ito, and N. Shimizu. 1997. Positional cloning of the APECED gene. Nat. Genet. 17:393–398.
   PubMed Web of Science ®Google Scholar
• Notarangelo, L. D., C. Mazza, C. Forino, E. Mazzolari, and F. Buzi. 2004. AIRE and immunological tolerance: insights from the study of autoimmune polyendocrinopathy candidiasis and ectodermal dystrophy. Curr. Opin. Allergy Clin. Immunol. 4:491–496.
   PubMedGoogle Scholar
• Ohneda, K., H. Ee, and M. German. 2000. Regulation of insulin gene transcription. Semin. Cell Dev. Biol. 11:227–233.
   PubMedGoogle Scholar
• Ouchida, R., M. Kusuhara, N. Shimizu, T. Hisada, Y. Makino, C. Morimoto, H. Handa, F. Ohsuzu, and H. Tanaka. 2003. Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells. Genes Cells 8:95–107.
   PubMedGoogle Scholar
• Peterlin, B. M., and D. H. Price. 2006. Controlling the elongation phase of transcription with P-TEFb. Mol. Cell 23:297–305.
   PubMed Web of Science ®Google Scholar
• Peterson, P., J. Pitkanen, N. Sillanpaa, and K. Krohn. 2004. Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunity. Clin. Exp. Immunol. 135:348–357.
   PubMed Web of Science ®Google Scholar
• Pitkanen, J., V. Doucas, T. Sternsdorf, T. Nakajima, S. Aratani, K. Jensen, H. Will, P. Vahamurto, J. Ollila, M. Vihinen, H. S. Scott, S. E. Antonarakis, J. Kudoh, N. Shimizu, K. Krohn, and P. Peterson. 2000. The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein. J. Biol. Chem. 275:16802–16809.
   PubMed Web of Science ®Google Scholar
• Pitkanen, J., A. Rebane, J. Rowell, A. Murumagi, P. Strobel, K. Moll, M. Saare, J. Heikkila, V. Doucas, A. Marx, and P. Peterson. 2005. Cooperative activation of transcription by autoimmune regulator AIRE and CBP. Biochem. Biophys. Res. Commun. 333:944–953.
   PubMedGoogle Scholar
• Purohit, S., P. G. Kumar, M. Laloraya, and J. X. She. 2005. Mapping DNA-binding domains of the autoimmune regulator protein. Biochem. Biophys. Res. Commun. 327:939–944.
   PubMedGoogle Scholar
• Ramsey, C., O. Winqvist, L. Puhakka, M. Halonen, A. Moro, O. Kampe, P. Eskelin, M. Pelto-Huikko, and L. Peltonen. 2002. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 11:397–409.
   PubMed Web of Science ®Google Scholar
• Reith, W., and B. Mach. 2001. The bare lymphocyte syndrome and the regulation of MHC expression. Annu. Rev. Immunol. 19:331–373.
   PubMed Web of Science ®Google Scholar
• Sawado, T., J. Halow, M. A. Bender, and M. Groudine. 2003. The beta-globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation. Genes Dev. 17:1009–1018.
   PubMed Web of Science ®Google Scholar
• Southgate, C. D., and M. R. Green. 1991. The HIV-1 Tat protein activates transcription from an upstream DNA-binding site: implications for Tat function. Genes Dev. 5:2496–2507.
   PubMedGoogle Scholar
• Tao, Y., R. Kupfer, B. J. Stewart, C. Williams-Skipp, C. K. Crowell, D. D. Patel, S. Sain, and R. I. Scheinman. 2006. AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix. Mol. Immunol. 43:335–345.
   PubMedGoogle Scholar
• Taube, R., K. Fujinaga, J. Wimmer, M. Barboric, and B. M. Peterlin. 1999. Tat transactivation: a model for the regulation of eukaryotic transcriptional elongation. Virology 264:245–253.
   PubMed Web of Science ®Google Scholar
• Taube, R., X. Lin, D. Irwin, K. Fujinaga, and B. M. Peterlin. 2002. Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes. Mol. Cell. Biol. 22:321–331.
   PubMed Web of Science ®Google Scholar
• Uchida, D., S. Hatakeyama, A. Matsushima, H. Han, S. Ishido, H. Hotta, J. Kudoh, N. Shimizu, V. Doucas, K. I. Nakayama, N. Kuroda, and M. Matsumoto. 2004. AIRE functions as an E3 ubiquitin ligase. J. Exp. Med. 199:167–172.
   PubMed Web of Science ®Google Scholar
• Villasenor, J., C. Benoist, and D. Mathis. 2005. AIRE and APECED: molecular insights into an autoimmune disease. Immunol. Rev. 204:156–164.
   PubMed Web of Science ®Google Scholar
• Vodicka, M. A., W. C. Goh, L. I. Wu, M. E. Rogel, S. R. Bartz, V. L. Schweickart, C. J. Raport, and M. Emerman. 1997. Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses. Virology 233:193–198.
   PubMed Web of Science ®Google Scholar
• Wurst, W., J. Rossant, V. Prideaux, M. Kownacka, A. Joyner, D. P. Hill, F. Guillemot, S. Gasca, D. Cado, A. Auerbach, et al. 1995. A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice. Genetics 139:889–899.
   PubMedGoogle Scholar
• Zhu, P., S. H. Baek, E. M. Bourk, K. A. Ohgi, I. Garcia-Bassets, H. Sanjo, S. Akira, P. F. Kotol, C. K. Glass, M. G. Rosenfeld, and D. W. Rose. 2006. Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell 124:615–629.
   PubMed Web of Science ®Google Scholar