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Article

Genotoxic Stress-Induced Cyclin D1 Phosphorylation and Proteolysis Are Required for Genomic Stability

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Pages 7245-7258 | Received 10 Jul 2008, Accepted 14 Sep 2008, Published online: 27 Mar 2023

REFERENCES

  • Agami, R., and R. Bernards. 2000. Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage. Cell 102:55–66.
  • Aggarwal, P., M. D. Lessie, D. I. Lin, L. Pontano, A. B. Gladden, B. Nuskey, A. Goradia, M. A. Wasik, A. J. Klein-Szanto, A. K. Rustgi, C. H. Bassing, and J. A. Diehl. 2007. Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication. Genes Dev. 21:2908–2922.
  • Alt, J. R., J. L. Cleveland, M. Hannink, and J. A. Diehl. 2000. Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev. 14:3102–3114.
  • Barbash, O., P. Zamfirova, D. I. Lin, X. Chen, K. Yang, H. Nakagawa, F. Lu, A. K. Rustgi, and J. A. Diehl. 2008. Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. Cancer Cell 14:68–78.
  • Barnes, D. M., and C. E. Gillett. 1998. Cyclin D1 in breast cancer. Breast Cancer Res. Treat. 52:1–15.
  • Bartek, J., C. Lukas, and J. Lukas. 2004. Checking on DNA damage in S phase. Nat. Rev. Mol. Cell. Biol. 5:792–804.
  • Bartkova, J., J. Lukas, H. Muller, D. Lutzhoft, M. Strauss, and J. Bartek. 1994. Cyclin D1 protein expression and function in human breast cancer. Int. J. Cancer 57:353–361.
  • Bartkova, J., J. Lukas, H. Muller, M. Strauss, B. Gusterson, and J. Bartek. 1995. Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer. Cancer Res. 55:949–956.
  • Bartkova, J., J. Lukas, M. Strauss, and J. Bartek. 1994. The PRAD-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas. Int. J. Cancer 58:568–573.
  • Benzeno, S., and J. A. Diehl. 2004. C-terminal sequences direct cyclin D1-CRM1 binding. J. Biol. Chem. 279:56061–56066.
  • Benzeno, S., F. Lu, M. Guo, O. Barbash, F. Zhang, J. G. Herman, P. S. Klein, A. Rustgi, and J. A. Diehl. 2006. Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1. Oncogene 25:6291–6303.
  • Bianchi, V., E. Pontis, and P. Reichard. 1986. Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis. J. Biol. Chem. 261:16037–16042.
  • Brown, E. J., and D. Baltimore. 2003. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 17:615–628.
  • Calbo, J., M. Parreno, E. Sotillo, T. Yong, A. Mazo, J. Garriga, and X. Grana. 2002. G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression. J. Biol. Chem. 277:50263–50274.
  • Casanovas, O., F. Miro, J. M. Estanyol, E. Itarte, N. Agell, and O. Bachs. 2000. Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner. J. Biol. Chem. 275:35091–35097.
  • Costanzo, V., K. Robertson, C. Y. Ying, E. Kim, E. Avvedimento, M. Gottesman, D. Grieco, and J. Gautier. 2000. Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol. Cell 6:649–659.
  • Diehl, J. A., M. Cheng, M. F. Roussel, and C. J. Sherr. 1998. Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 12:3499–3511.
  • Diehl, J. A., F. Zindy, and C. J. Sherr. 1997. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev. 11:957–972.
  • Falck, J., J. H. Petrini, B. R. Williams, J. Lukas, and J. Bartek. 2002. The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat. Genet. 30:290–294.
  • Gladden, A. B., and J. A. Diehl. 2003. The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB. MCM7 binding. J. Biol. Chem. 278:9754–9760.
  • Gladden, A. B., R. Woolery, P. Aggarwal, M. A. Wasik, and J. A. Diehl. 2006. Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma Oncogene 25:998–1007.
  • Harbour, J. W., R. X. Luo, A. Dei Santi, A. A. Postigo, and D. C. Dean. 1999. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 98:859–869.
  • Hatakeyama, M., J. A. Brill, G. R. Fink, and R. A. Weinberg. 1994. Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. Genes Dev. 8:1759–1771.
  • Higa, L. A., I. S. Mihaylov, D. P. Banks, J. Zheng, and H. Zhang. 2003. Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. Nat. Cell Biol. 5:1008–1015.
  • Hu, J., C. M. McCall, T. Ohta, and Y. Xiong. 2004. Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat. Cell Biol. 6:1003–1009.
  • Ikeguchi, M., T. Sakatani, T. Ueta, and N. Kaibara. 2001. Cyclin D1 expression and retinoblastoma gene protein (pRB) expression in esophageal squamous cell carcinoma. J. Cancer Res. Clin. Oncol. 127:531–536.
  • Jazayeri, A., J. Falck, C. Lukas, J. Bartek, G. C. Smith, J. Lukas, and S. P. Jackson. 2006. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol. 8:37–45.
  • Jin, M., S. Inoue, T. Umemura, J. Moriya, M. Arakawa, K. Nagashima, and H. Kato. 2001. Cyclin D1, p16 and retinoblastoma gene product expression as a predictor for prognosis in non-small cell lung cancer at stages I and II. Lung Cancer 34:207–218.
  • Kasper, J. S., H. Kuwabara, T. Arai, S. H. Ali, and J. A. DeCaprio. 2005. Simian virus 40 large T antigen's association with the CUL7 SCF complex contributes to cellular transformation. J. Virol. 79:11685–11692.
  • Kastan, M. B., and J. Bartek. 2004. Cell-cycle checkpoints and cancer. Nature 432:316–323.
  • Khanna, K. K., and S. P. Jackson. 2001. DNA double-strand breaks: signaling, repair, and the cancer connection. Nat. Genet. 27:247–254.
  • Kida, A., K. Kakihana, S. Kotani, T. Kurosu, and O. Miura. 2007. Glycogen synthase kinase-3β and p38 phosphorylate cyclin D2 on Thr280 to trigger its ubiquitin/proteasome-dependent degradation in hematopoietic cells. Oncogene 26:6630–6640.
  • Kwak, Y. T., R. Li, C. R. Becerra, D. Tripathy, E. P. Frenkel, and U. N. Verma. 2005. IκB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylation. J. Biol. Chem. 280:33945–33952.
  • Lee, J. Y., S. J. Yu, Y. G. Park, J. Kim, and J. Sohn. 2007. Glycogen synthase kinase 3β phosphorylates p21WAF1/CIP1 for proteasomal degradation after UV irradiation. Mol. Cell. Biol. 27:3187–3198.
  • Leng, X., M. Noble, P. D. Adams, J. Qin, and J. W. Harper. 2002. Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. Mol. Cell. Biol. 22:2242–2254.
  • Lin, D. I., O. Barbash, K. G. Kumar, J. D. Weber, J. W. Harper, A. J. Klein-Szanto, A. Rustgi, S. Y. Fuchs, and J. A. Diehl. 2006. Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-αB crystallin) complex. Mol. Cell 24:355–366.
  • Lin, D. I., M. D. Lessie, A. B. Gladden, C. H. Bassing, K. U. Wagner, and J. A. Diehl. 2007. Disruption of cyclin D1 nuclear export and proteolysis accelerates mammary carcinogenesis. Oncogene 27:1231–1242.
  • Liu, J. S., S. R. Kuo, and T. Melendy. 2003. Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents. Mutat. Res. 532:215–226.
  • Lundin, C., K. Erixon, C. Arnaudeau, N. Schultz, D. Jenssen, M. Meuth, and T. Helleday. 2002. Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells. Mol. Cell. Biol. 22:5869–5878.
  • Matsushime, H., M. F. Roussel, R. A. Ashmun, and C. J. Sherr. 1991. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65:701–713.
  • Moreno-Bueno, G., S. Rodriguez-Perales, C. Sanchez-Estevez, D. Hardisson, D. Sarrio, J. Prat, J. C. Cigudosa, X. Matias-Guiu, and J. Palacios. 2003. Cyclin D1 gene (CCND1) mutations in endometrial cancer. Oncogene 22:6115–6118.
  • Nishitani, H., N. Sugimoto, V. Roukos, Y. Nakanishi, M. Saijo, C. Obuse, T. Tsurimoto, K. I. Nakayama, K. Nakayama, M. Fujita, Z. Lygerou, and T. Nishimoto. 2006. Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J. 25:1126–1136.
  • Okabe, H., S. H. Lee, J. Phuchareon, D. G. Albertson, F. McCormick, and O. Tetsu. 2006. A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS ONE 1:e128.
  • Raman, M., S. Earnest, K. Zhang, Y. Zhao, and M. H. Cobb. 2007. TAO kinases mediate activation of p38 in response to DNA damage. EMBO J. 26:2005–2014.
  • Sherr, C. J. 1996. Cancer cell cycles. Science 274:1672–1677.
  • Stambolic, V., L. Ruel, and J. R. Woodgett. 1996. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr. Biol. 6:1664–1668.
  • Stiff, T., S. A. Walker, K. Cerosaletti, A. A. Goodarzi, E. Petermann, P. Concannon, M. O'Driscoll, and P. A. Jeggo. 2006. ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J. 25:5775–5782.

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