Localization to the Cortical Cytoskeleton Is Necessary for Nf2/Merlin-Dependent Epidermal Growth Factor Receptor Silencing

REFERENCES

• Bates, I. R., B. Hebert, Y. Luo, J. Liao, A. I. Bachir, D. L. Kolin, P. W. Wiseman, and J. W. Hanrahan. 2006. Membrane lateral diffusion and capture of CFTR within transient confinement zones. Biophys. J. 91:1046–1058.
   PubMedGoogle Scholar
• Bonilha, V. L., M. E. Rayborn, I. Saotome, A. I. McClatchey, and J. G. Hollyfield. 2006. Microvilli defects in retinas of ezrin knockout mice. Exp. Eye Res. 82:720–729.
   PubMed Web of Science ®Google Scholar
• Brault, E., A. Gautreau, M. Lamarine, I. Callebaut, G. Thomas, and L. Goutebroze. 2001. Normal membrane localization and actin association of the NF2 tumor suppressor protein are dependent on folding of its N-terminal domain. J. Cell Sci. 114:1901–1912.
   PubMedGoogle Scholar
• Bretscher, A., K. Edwards, and R. G. Fehon. 2002. ERM proteins and merlin: integrators at the cell cortex. Nat. Rev. Mol. Cell Biol. 3:586–599.
   PubMed Web of Science ®Google Scholar
• Bubb, M. R., I. Spector, B. B. Beyer, and K. M. Fosen. 2000. Effects of jasplakinolide on the kinetics of actin polymerization. J. Biol. Chem. 275:5163–5170.
   PubMed Web of Science ®Google Scholar
• Charras, G. T., C. K. Hu, M. Coughlin, and T. J. Mitchison. 2006. Reassembly of contractile actin cortex in cell blebs. J. Cell Biol. 175:477–490.
   PubMed Web of Science ®Google Scholar
• Curto, M., B. K. Cole, D. Lallemand, C. Liu, and A. I. McClatchey. 2007. Contact-dependent inhibition of EGFR signaling by Nf2/merlin. J. Cell Biol. 177:893–903.
   PubMed Web of Science ®Google Scholar
• den Bakker, M. A., P. H. J. Riegman, R. A. C. P. Hekman, W. Boersma, P. J. A. Janssen, T. H. van der Kwast, and E. C. Zwarthoff. 1995. The product of the NF2 tumor suppressor gene localizes near the plasma membrane and is highly expressed in muscle cells. Oncogene 10:757–763.
   PubMedGoogle Scholar
• Evans, D. G., M. Sainio, and M. E. Baser. 2000. Neurofibromatosis type 2. J. Med. Genet. 37:897–904.
   PubMed Web of Science ®Google Scholar
• Fehon, R. G., T. Oren, D. R. LaJeunesse, T. E. Melby, and B. M. McCartney. 1997. Isolation of mutations in the Drosophila homologues of the human neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method. Genetics 146:245–252.
   PubMedGoogle Scholar
• Finnerty, C. M., D. Chambers, J. Ingraffea, H. R. Faber, P. A. Karplus, and A. Bretscher. 2004. The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain. J. Cell Sci. 117:1547–1552.
   PubMed Web of Science ®Google Scholar
• Giovannini, M., E. Robanus-Maandag, M. van der Valk, M. Niwa-Kawakita, V. Abramowski, L. Goutebroze, J. M. Woodruff, A. Berns, and G. Thomas. 2000. Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev. 14:1617–1630.
   PubMed Web of Science ®Google Scholar
• Göbel, V., P. L. Barrett, D. H. Hall, and J. T. Fleming. 2004. Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1. Dev. Cell 6:865–873.
   PubMedGoogle Scholar
• Gonzalez-Agosti, C., L. Xu, D. Pinney, R. Beauchamp, W. Hobbs, J. Gusella, and V. Ramesh. 1996. The merlin tumor suppressor localizes preferentially in membrane ruffles. Oncogene 13:1239–1247.
   PubMed Web of Science ®Google Scholar
• Haggie, P. M., J. K. Kim, G. L. Lukacs, and A. S. Verkman. 2006. Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions. Mol. Biol. Cell 17:4937–4945.
   PubMedGoogle Scholar
• Hitt, A. L., and E. J. Luna. 1994. Membrane interactions with the actin cytoskeleton. Curr. Opin. Cell Biol. 6:120–130.
   PubMedGoogle Scholar
• James, M. F., N. Manchanda, C. Gonzalez-Agosti, J. H. Hartwig, and V. Ramesh. 2001. The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association. Biochem. J. 356:377–386.
   PubMed Web of Science ®Google Scholar
• Johnson, K. C., J. L. Kissil, J. L. Fry, and T. Jacks. 2002. Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene. Oncogene 21:5990–5997.
   PubMed Web of Science ®Google Scholar
• Kalamarides, M., M. Niwa-Kawakita, H. Leblois, V. Abramowski, M. Perricaudet, A. Janin, G. Thomas, D. H. Gutmann, and M. Giovannini. 2002. NF2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse. Genes Dev. 16:1060–1065.
   PubMed Web of Science ®Google Scholar
• Kang, B. S., D. R. Cooper, Y. Devedjiev, U. Derewenda, and Z. S. Derewenda. 2002. The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product. Acta Crystallogr. D Biol. Crystallogr. 58:381–391.
   PubMedGoogle Scholar
• Karagiosis, S. A., and D. F. Ready. 2004. Moesin contributes an essential structural role in Drosophila photoreceptor morphogenesis. Development 131:725–732.
   PubMedGoogle Scholar
• Kissil, J. L., K. C. Johnson, M. S. Eckman, and T. Jacks. 2002. Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. J. Biol. Chem. 277:10394–10399.
   PubMed Web of Science ®Google Scholar
• Kusumi, A., and Y. Sako. 1996. Cell surface organization by the membrane skeleton. Curr. Opin. Cell Biol. 8:566–574.
   PubMedGoogle Scholar
• Kusumi, A., C. Nakada, K. Ritchie, K. Murase, K. Suzuki, H. Murakoshi, R. S. Kasai, J. Kondo, and T. Fujiwara. 2005. Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules. Annu. Rev. Biophys. Biomol. Struct. 34:351–378.
   PubMedGoogle Scholar
• Lallemand, D., M. Curto, I. Saotome, M. Giovannini, and A. I. McClatchey. 2003. NF2-deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev. 17:1090–1100.
   PubMed Web of Science ®Google Scholar
• Lazar, C. S., C. M. Cresson, D. A. Lauffenburger, and G. N. Gill. 2004. The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface. Mol. Biol. Cell 15:5470–5480.
   PubMedGoogle Scholar
• Lucero, H. A., and P. W. Robbins. 2004. Lipid rafts-protein association and the regulation of protein activity. Arch. Biochem. Biophys. 426:208–224.
   PubMed Web of Science ®Google Scholar
• Maeda, M., T. Matsui, M. Imamura, S. Tsukita, and S. Tsukita. 1999. Expression level, subcellular distribution and Rho-GDI binding affinity of merlin in comparison with ezrin/radixin/moesin proteins. Oncogene 18:4788–4797.
   PubMed Web of Science ®Google Scholar
• Maitra, S., R. M. Kulikauskas, H. Gavilan, and R. G. Fehon. 2006. The tumor suppressors merlin and expanded function cooperatively to modulate receptor endocytosis and signaling. Curr. Biol. 16:702–709.
   PubMed Web of Science ®Google Scholar
• McCartney, B. M., and R. G. Fehon. 1996. Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin. J. Cell Biol. 133:843–852.
   PubMedGoogle Scholar
• McClatchey, A. I., I. Saotome, V. Ramesh, J. F. Gusella, and T. Jacks. 1997. The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes Dev. 11:1253–1265.
   PubMed Web of Science ®Google Scholar
• McClatchey, A. I., I. Saotome, K. Mercer, D. Crowley, J. F. Gusella, R. T. Bronson, and T. Jacks. 1998. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev. 12:1121–1133.
   PubMed Web of Science ®Google Scholar
• McClatchey, A. I., and M. Giovannini. 2005. Membrane organization and tumorigenesis—the NF2 tumor suppressor, merlin. Genes Dev. 19:2265–2277.
   PubMed Web of Science ®Google Scholar
• Morone, N., T. Fujiwara, K. Murase, R. S. Kasai, H. Ike, S. Yuasa, J. Usukura, and A. Kusumi. 2006. Three-dimensional reconstruction of the membrane skeleton at the plasma membrane interface by electron tomography. J. Cell Biol. 174:851–862.
   PubMed Web of Science ®Google Scholar
• Morrison, H., L. S. Sherman, J. Legg, F. Banine, C. Isacke, C. A. Haipek, D. H. Gutmann, H. Ponta, and P. Herrlich. 2001. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes Dev. 15:968–980.
   PubMed Web of Science ®Google Scholar
• Murase, K., T. Fujiwara, Y. Umemura, K. Suzuki, R. Iino, H. Yamashita, M. Saito, H. Murakoshi, K. Ritchie, and A. Kusumi. 2004. Ultrafine membrane compartments for molecular diffusion as revealed by single molecule techniques. Biophys. J. 86:4075–4093.
   PubMed Web of Science ®Google Scholar
• Murthy, A., C. Gonzalez-Agosti, E. Cordero, D. Pinney, C. Candia, F. Solomon, J. Gusella, and V. Ramesh. 1998. NHE-RF, a regulatory cofactor for Na+-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins. J. Biol. Chem. 273:1273–1276.
   PubMedGoogle Scholar
• Ratner, N., J. P. Williams, J. J. Kordich, and H. A. Kim. 2005. Schwann cell preparation from single mouse embryos: analysis of neurofibromin function in Schwann cells. Methods Enzymol. 407:22–33.
   Google Scholar
• Resh, M. D. 1994. Myristylation and palmitylation of Src family members: the fats of the matter. Cell 76:411–413.
   PubMed Web of Science ®Google Scholar
• Rouleau, G. A., P. Merel, M. Lutchman, M. Sanson, J. Zucman, C. Marineau, K. Hoang-Xuan, S. Demczuk, C. Desmaze, B. Plougastel, S. M. Pulst, G. Lenoir, E. Bijlsmaparallel, R. Fashold, J. Dumanski, P. de Jong, D. Parry, R. Eldrige, A. Aurias, O. Delattre, and G. Thomas. 1993. Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2. Nature 363:515–521.
   PubMed Web of Science ®Google Scholar
• Sainio, M., F. Zhao, L. Heiska, O. Turunen, M. den Bakker, E. Zwarthoff, M. Luthman, G. A. Rouleau, J. Jääskeläinen, A. Vaheri, and O. Carpén. 1997. Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton. J. Cell Sci. 110:2249–2260.
   PubMedGoogle Scholar
• Saotome, I., M. Curto, and A. I. McClatchey. 2004. Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine. Dev. Cell 6:855–864.
   PubMedGoogle Scholar
• Shaw, R. J., A. I. McClatchey, and T. Jacks. 1998. Localization and functional domains of the neurofibromatosis type II tumor suppressor, merlin. Cell Growth Differ. 9:287–296.
   PubMedGoogle Scholar
• Shaw, R. J., A. I. McClatchey, and T. Jacks. 1998. Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli. J. Biol. Chem. 273:7757–7764.
   PubMedGoogle Scholar
• Shaw, R. J., J. G. Paez, M. Curto, A. Yaktine, W. M. Pruitt, I. Saotome, J. P. O'Bryan, V. Gupta, N. Ratner, C. J. Der, T. Jacks, and A. I. McClatchey. 2001. The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev. Cell 1:63–72.
   PubMed Web of Science ®Google Scholar
• Shimizu, T., A. Seto, N. Maita, K. Hamada, S. Tsukita, S. Tsukita, and T. Hakoshima. 2002. Structural basis for the neurofibromatosis type 2. J. Biol. Chem. 277:10332–10336.
   PubMed Web of Science ®Google Scholar
• Speck, O., S. C. Hughes, N. K. Noren, R. M. Kulikauskas, and R. G. Fehon. 2003. Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity. Nature 421:83–87.
   PubMedGoogle Scholar
• Stickney, J. T., W. C. Bacon, M. Rojas, N. Ratner, and W. Ip. 2004. Activation of the tumor suppressor merlin modulates its interaction with lipid rafts. Cancer Res. 64:2717–2724.
   PubMed Web of Science ®Google Scholar
• Terawaki, S., R. Maesaki, and T. Hakoshimam. 2006. Structural basis for NHERF recognition by ERM proteins. Structure 14:777–789.
   PubMedGoogle Scholar
• Trofatter, J. A., M. M. MacCollin, J. L. Rutter, J. R. Murrell, M. P. Duyao, D. M. Parry, R. Eldridge, N. Kley, A. G. Menon, K. Pulaski, V. H. Haase, C. M. Ambrose, D. Munroe, C. Bove, J. L. Haines, R. L. Martuza, M. E. MacDonald, B. R. Seizinger, M. P. Short, A. J. Buckler, and J. F. Gusella. 1993. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 72:791–800.
   PubMed Web of Science ®Google Scholar
• Xiao, G. H., R. Gallagher, J. Shetler, K. Skele, D. A. Altomare, R. G. Pestell, S. Jhanwar, and J. R. Testa. 2005. The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol. Cell. Biol. 25:2384–2394.
   PubMed Web of Science ®Google Scholar