Regulation of p53 Localization and Activity by Ubc13

REFERENCES

• Andersen, P. L., H. Zhou, L. Pastushok, T. Moraes, S. McKenna, B. Ziola, M. J. Ellison, V. M. Dixit, and W. Xiao. 2005. Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. J. Cell Biol. 170:745–755.
   PubMed Web of Science ®Google Scholar
• Ashcroft, M., and K. H. Vousden. 1999. Regulation of p53 stability. Oncogene 18:7637–7643.
   PubMed Web of Science ®Google Scholar
• Brooks, C. L., and W. Gu. 2003. Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr. Opin. Cell Biol. 15:164–171.
   PubMed Web of Science ®Google Scholar
• Brummelkamp, T. R., R. Bernards, and R. Agami. 2002. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2:243–247.
   PubMed Web of Science ®Google Scholar
• Brusky, J., Y. Zhu, and W. Xiao. 2000. UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae. Curr. Genet. 37:168–174.
   PubMedGoogle Scholar
• Chene, P. 2001. The role of tetramerization in p53 function. Oncogene 20:2611–2617.
   PubMedGoogle Scholar
• Davison, T. S., X. Nie, W. Ma, Y. Lin, C. Kay, S. Benchimol, and C. H. Arrowsmith. 2001. Structure and functionality of a designed p53 dimer. J. Mol. Biol. 307:605–617.
   PubMedGoogle Scholar
• Deng, L., C. Wang, E. Spencer, L. Yang, A. Braun, J. You, C. Slaughter, C. Pickart, and Z. J. Chen. 2000. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103:351–361.
   PubMed Web of Science ®Google Scholar
• Dornan, D., I. Wertz, H. Shimizu, D. Arnott, G. D. Frantz, P. Dowd, K. O'Rourke, H. Koeppen, and V. M. Dixit. 2004. The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature 429:86–92.
   PubMed Web of Science ®Google Scholar
• Ea, C. K., L. Sun, J. Inoue, and Z. J. Chen. 2004. TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. Proc. Natl. Acad. Sci. USA 101:15318–15323.
   PubMedGoogle Scholar
• Fontoura, B. M., C. A. Atienza, E. A. Sorokina, T. Morimoto, and R. B. Carroll. 1997. Cytoplasmic p53 polypeptide is associated with ribosomes. Mol. Cell. Biol. 17:3146–3154.
   PubMed Web of Science ®Google Scholar
• Habelhah, H., S. Takahashi, S. G. Cho, T. Kadoya, T. Watanabe, and Z. Ronai. 2004. Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB. EMBO J. 23:322–332.
   PubMed Web of Science ®Google Scholar
• Hainaut, P., T. Hernandez, A. Robinson, P. Rodriguez-Tome, T. Flores, M. Hollstein, C. C. Harris, and R. Montesano. 1998. IARC database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools. Nucleic Acids Res. 26:205–213.
   PubMed Web of Science ®Google Scholar
• Haupt, Y., R. Maya, A. Kazaz, and M. Oren. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387:296–299.
   PubMed Web of Science ®Google Scholar
• Hershko, A., and A. Ciechanover. 1998. The ubiquitin system. Annu. Rev. Biochem. 67:425–479.
   PubMed Web of Science ®Google Scholar
• Hershko, A., A. Ciechanover, and A. Varshavsky. 2000. Basic Medical Research Award. The ubiquitin system. Nat. Med. 6:1073–1081.
   PubMed Web of Science ®Google Scholar
• Hoege, C., B. Pfander, G. L. Moldovan, G. Pyrowolakis, and S. Jentsch. 2002. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419:135–141.
   PubMed Web of Science ®Google Scholar
• Hofmann, R. M., and C. M. Pickart. 1999. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 96:645–653.
   PubMed Web of Science ®Google Scholar
• Honda, R., H. Tanaka, and H. Yasuda. 1997. Oncoprotein MDM2 is an ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420:25–27.
   PubMed Web of Science ®Google Scholar
• Kawaguchi, Y., A. Ito, E. Appella, and T. Yao. 2006. Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. J. Biol. Chem. 281:1394–1400.
   PubMedGoogle Scholar
• Kubbutat, M. H., S. N. Jones, and K. H. Vousden. 1997. Regulation of p53 stability by Mdm2. Nature 387:299–303.
   PubMed Web of Science ®Google Scholar
• Leng, R. P., Y. Lin, W. Ma, H. Wu, B. Lemmers, S. Chung, J. M. Parant, G. Lozano, R. Hakem, and S. Benchimol. 2003. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell 112:779–791.
   PubMed Web of Science ®Google Scholar
• Li, M., C. L. Brooks, F. Wu-Baer, D. Chen, R. Baer, and W. Gu. 2003. Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 302:1972–1975.
   PubMed Web of Science ®Google Scholar
• Malkin, D., F. P. Li, L. C. Strong, J. F. Fraumeni, Jr., C. E. Nelson, D. H. Kim, J. Kassel, M. A. Gryka, F. Z. Bischoff, and M. A. Tainsky. 1990. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250:1233–1238.
   PubMed Web of Science ®Google Scholar
• Oren, M. 1999. Regulation of the p53 tumor suppressor protein. J. Biol. Chem. 274:36031–36034.
   PubMed Web of Science ®Google Scholar
• Saville, M. K., A. Sparks, D. P. Xirodimas, J. Wardrop, L. F. Stevenson, J. C. Bourdon, Y. L. Woods, and D. P. Lane. 2004. Regulation of p53 by the ubiquitination-conjugating enzymes UbcH5B/C in vivo. J. Biol. Chem. 279:42169–42181.
   PubMedGoogle Scholar
• Stommel, J. M., N. D. Marchenko, G. S. Jimenez, U. M. Moll, T. J. Hope, and G. M. Wahl. 1999. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J. 18:1660–1672.
   PubMed Web of Science ®Google Scholar
• Topisirovic, I., A. Kentsis, J. M. Perez, M. L. Guzman, C. T. Jordan, and K. L. Borden. 2005. Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels. Mol. Cell. Biol. 25:1100–1112.
   PubMed Web of Science ®Google Scholar
• Treier, M., L. M. Staszewski, and D. Bohmann. 1994. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 78:787–798.
   PubMed Web of Science ®Google Scholar
• Vogelstein, B., D. Lane, and A. J. Levine. 2000. Surfing the p53 network. Nature 408:307–310.
   PubMed Web of Science ®Google Scholar
• Vousden, K. H., and X. Lu. 2002. Live or let die: the cell's response to p53. Nat. Rev. Cancer 2:594–604.
   PubMed Web of Science ®Google Scholar
• Xirodimas, D. P., M. K. Saville, J. C. Bourdon, R. T. Hay, and D. P. Lane. 2004. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 118:83–97.
   PubMed Web of Science ®Google Scholar
• Yin, X., B. M. Fontoura, T. Morimoto, and R. B. Carroll. 2003. Cytoplasmic complex of p53 and eEF2. J. Cell. Physiol. 196:474–482.
   PubMedGoogle Scholar
• Zhou, H., I. Wertz, K. O'Rourke, M. Ultsch, S. Seshagiri, M. Eby, W. Xiao, and V. M. Dixit. 2004. Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature 427:167–171.
   PubMed Web of Science ®Google Scholar