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Article

An Autoregulatory Pathway Establishes the Definitive Chromatin Conformation at the Pit-1 Locus

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Pages 1523-1532 | Received 22 Oct 2014, Accepted 09 Feb 2015, Published online: 20 Mar 2023

REFERENCES

  • Misteli T. 2007. Beyond the sequence: cellular organization of genome function. Cell 128:787–800. http://dx.doi.org/10.1016/j.cell.2007.01.028.
  • Phillips-Cremins JE, Sauria ME, Sanyal A, Gerasimova TI, Lajoie BR, Bell JS, Ong CT, Hookway TA, Guo C, Sun Y, Bland MJ, Wagstaff W, Dalton S, McDevitt TC, Sen R, Dekker J, Taylor J, Corces VG. 2013. Architectural protein subclasses shape 3D organization of genomes during lineage commitment. Cell 153:1281–1295. http://dx.doi.org/10.1016/j.cell.2013.04.053.
  • Bulger M, Groudine M. 2011. Functional and mechanistic diversity of distal transcription enhancers. Cell 144:327–339. http://dx.doi.org/10.1016/j.cell.2011.01.024.
  • Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grontved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kovalchuk AL, Zou J, Joung JK, Sartorelli V, Wei CL, Ruan X, Hager GL, Ruan Y, Casellas R. 2013. Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation. Cell 155:1507–1520. http://dx.doi.org/10.1016/j.cell.2013.11.039.
  • Dean A. 2006. On a chromosome far, far away: LCRs and gene expression. Trends Genet 22:38–45. http://dx.doi.org/10.1016/j.tig.2005.11.001.
  • Palstra RJ, Grosveld F. 2012. Transcription factor binding at enhancers: shaping a genomic regulatory landscape in flux. Front Genet 3:195. http://dx.doi.org/10.3389/fgene.2012.00195.
  • Ho Y, Elefant F, Cooke N, Liebhaber S. 2002. A defined locus control region determinant links chromatin domain acetylation with long-range gene activation. Mol Cell 9:291–302. http://dx.doi.org/10.1016/S1097-2765(02)00447-1.
  • Ho Y, Tadevosyan A, Liebhaber SA, Cooke NE. 2008. The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression. EMBO Rep 9:891–898. http://dx.doi.org/10.1038/embor.2008.126.
  • Wang Q, Carroll JS, Brown M. 2005. Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Mol Cell 19:631–642. http://dx.doi.org/10.1016/j.molcel.2005.07.018.
  • de Wit E, de Laat W. 2012. A decade of 3C technologies: insights into nuclear organization. Genes Dev 26:11–24. http://dx.doi.org/10.1101/gad.179804.111.
  • Dekker J, Rippe K, Dekker M, Kleckner N. 2002. Capturing chromosome conformation. Science 295:1306–1311. http://dx.doi.org/10.1126/science.1067799.
  • Krivega I, Dean A. 2012. Enhancer and promoter interactions—long distance calls. Curr Opin Genet Dev 22:79–85. http://dx.doi.org/10.1016/j.gde.2011.11.001.
  • Visel A, Blow MJ, Li Z, Zhang T, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Wright C, Chen F, Afzal V, Ren B, Rubin EM, Pennacchio LA. 2009. ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature 457:854–858. http://dx.doi.org/10.1038/nature07730.
  • Zhu X, Gleiberman AS, Rosenfeld MG. 2007. Molecular physiology of pituitary development: signaling and transcriptional networks. Physiol Rev 87:933–963. http://dx.doi.org/10.1152/physrev.00006.2006.
  • Kelberman D, Rizzoti K, Lovell-Badge R, Robinson IC, Dattani MT. 2009. Genetic regulation of pituitary gland development in human and mouse. Endocr Rev 30:790–829. http://dx.doi.org/10.1210/er.2009-0008.
  • Hogan KA, Jefferson HS, Karschner VA, Shewchuk BM. 2009. Expression of Pit-1 in nonsomatotrope cell lines induces human growth hormone locus control region histone modification and hGH-N transcription. J Mol Biol 390:26–44. http://dx.doi.org/10.1016/j.jmb.2009.04.081.
  • Qi Y, Ranish JA, Zhu X, Krones A, Zhang J, Aebersold R, Rose DW, Rosenfeld MG, Carriere C. 2008. Atbf1 is required for the Pit1 gene early activation. Proc Natl Acad Sci U S A 105:2481–2486. http://dx.doi.org/10.1073/pnas.0712196105.
  • DiMattia GE, Rhodes SJ, Krones A, Carriere C, O'Connell S, Kalla K, Arias C, Sawchenko P, Rosenfeld MG. 1997. The Pit-1 gene is regulated by distinct early and late pituitary-specific enhancers. Dev Biol 182:180–190. http://dx.doi.org/10.1006/dbio.1996.8472.
  • Rhodes SJ, Chen R, DiMattia GE, Scully KM, Kalla KA, Lin SC, Yu VC, Rosenfeld MG. 1993. A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene. Genes Dev 7:913–932. http://dx.doi.org/10.1101/gad.7.6.913.
  • Chen RP, Ingraham HA, Treacy MN, Albert VR, Wilson L, Rosenfeld MG. 1990. Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements. Nature 346:583–586. http://dx.doi.org/10.1038/346583a0.
  • Lew D, Brady H, Klausing K, Yaginuma K, Theill LE, Stauber C, Karin M, Mellon PL. 1993. GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice. Genes Dev 7:683–693. http://dx.doi.org/10.1101/gad.7.4.683.
  • Sizova D, Ho Y, Cooke NE, Liebhaber SA. 2010. Research resource: T-antigen transformation of pituitary cells captures three novel cell lines in the Pit-1 lineage. Mol Endocrinol 24:2232–2240. http://dx.doi.org/10.1210/me.2010-0235.
  • Mayo KE, Hammer RE, Swanson LW, Brinster RL, Rosenfeld MG, Evans RM. 1988. Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene. Mol Endocrinol 2:606–612. http://dx.doi.org/10.1210/mend-2-7-606.
  • Ho Y, Shewchuk BM, Liebhaber SA, Cooke NE. 2013. Distinct chromatin configurations regulate the initiation and the maintenance of hGH gene expression. Mol Cell Biol 33:1723–1734. http://dx.doi.org/10.1128/MCB.01166-12.
  • Ho Y, Elefant F, Liebhaber SA, Cooke NE. 2006. Locus control region transcription plays an active role in long-range gene activation. Mol Cell 23:365–375. http://dx.doi.org/10.1016/j.molcel.2006.05.041.
  • Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden KL, Rauscher FJ, III. 2014. LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase. Cancer Res 74:1390–1403. http://dx.doi.org/10.1158/0008-5472.CAN-13-1275.
  • Dolle P, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M. 1990. Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity. Cell 60:809–820. http://dx.doi.org/10.1016/0092-8674(90)90095-V.
  • Palstra RJ, Tolhuis B, Splinter E, Nijmeijer R, Grosveld F, de Laat W. 2003. The beta-globin nuclear compartment in development and erythroid differentiation. Nat Genet 35:190–194. http://dx.doi.org/10.1038/ng1244.
  • Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, Hanna J, Lodato MA, Frampton GM, Sharp PA, Boyer LA, Young RA, Jaenisch R. 2010. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A 107:21931–21936. http://dx.doi.org/10.1073/pnas.1016071107.
  • Rada-Iglesias A, Bajpai R, Swigut T, Brugmann SA, Flynn RA, Wysocka J. 2011. A unique chromatin signature uncovers early developmental enhancers in humans. Nature 470:279–283. http://dx.doi.org/10.1038/nature09692.
  • Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge K. 2011. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J 30:249–262. http://dx.doi.org/10.1038/emboj.2010.318.
  • Komarnitsky P, Cho EJ, Buratowski S. 2000. Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription. Genes Dev 14:2452–2460. http://dx.doi.org/10.1101/gad.824700.
  • Li P, He X, Gerrero MR, Mok M, Aggarwal A, Rosenfeld MG. 1993. Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors. Genes Dev 7:2483–2496. http://dx.doi.org/10.1101/gad.7.12b.2483.
  • Rhodes SJ, Krones A, Nelson C, Rosenfeld MG. 1996. Function of the conserved Pit-1 gene distal enhancer in progenitor and differentiated pituitary cells. Mol Cell Endocrinol 124:163–172. http://dx.doi.org/10.1016/S0303-7207(96)03959-7.
  • Krapp A, Knofler M, Ledermann B, Burki K, Berney C, Zoerkler N, Hagenbuchle O, Wellauer PK. 1998. The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev 12:3752–3763. http://dx.doi.org/10.1101/gad.12.23.3752.
  • Pashos E, Park JT, Leach S, Fisher S. 2013. Distinct enhancers of ptf1a mediate specification and expansion of ventral pancreas in zebrafish. Dev Biol 381:471–481. http://dx.doi.org/10.1016/j.ydbio.2013.07.011.
  • Toyoda S, Yoshimura T, Mizuta J, Miyazaki J. 2014. Auto-regulation of the Sohlh1 gene by the SOHLH2/SOHLH1/SP1 complex: implications for early spermatogenesis and oogenesis. PLoS One 9:e101681. http://dx.doi.org/10.1371/journal.pone.0101681.
  • Cullen KE, Kladde MP, Seyfred MA. 1993. Interaction between transcription regulatory regions of prolactin chromatin. Science 261:203–206. http://dx.doi.org/10.1126/science.8327891.
  • Kadauke S, Blobel GA. 2009. Chromatin loops in gene regulation. Biochim Biophys Acta 1789:17–25. http://dx.doi.org/10.1016/j.bbagrm.2008.07.002.
  • Stadhouders R, Thongjuea S, Andrieu-Soler C, Palstra RJ, Bryne JC, van den Heuvel A, Stevens M, de Boer E, Kockx C, van der Sloot A, van den Hout M, van Ijcken W, Eick D, Lenhard B, Grosveld F, Soler E. 2012. Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development. EMBO J 31:986–999. http://dx.doi.org/10.1038/emboj.2011.450.
  • Jing H, Vakoc CR, Ying L, Mandat S, Wang H, Zheng X, Blobel GA. 2008. Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus. Mol Cell 29:232–242. http://dx.doi.org/10.1016/j.molcel.2007.11.020.
  • Krivega I, Dale RK, Dean A. 2014. Role of LDB1 in the transition from chromatin looping to transcription activation. Genes Dev 28:1278–1290. http://dx.doi.org/10.1101/gad.239749.114.
  • Song SH, Hou C, Dean A. 2007. A positive role for NLI/Ldb1 in long-range beta-globin locus control region function. Mol Cell 28:810–822. http://dx.doi.org/10.1016/j.molcel.2007.09.025.
  • Chubb JR, Boyle S, Perry P, Bickmore WA. 2002. Chromatin motion is constrained by association with nuclear compartments in human cells. Curr Biol 12:439–445. http://dx.doi.org/10.1016/S0960-9822(02)00695-4.
  • Chuang CH, Carpenter AE, Fuchsova B, Johnson T, de Lanerolle P, Belmont AS. 2006. Long-range directional movement of an interphase chromosome site. Curr Biol 16:825–831. http://dx.doi.org/10.1016/j.cub.2006.03.059.
  • Dorsett D. 2007. Roles of the sister chromatid cohesion apparatus in gene expression, development, and human syndromes. Chromosoma 116:1–13. http://dx.doi.org/10.1007/s00412-006-0072-6.
  • Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA. 2010. Mediator and cohesin connect gene expression and chromatin architecture. Nature 467:430–435. http://dx.doi.org/10.1038/nature09380.
  • Jacobson EM, Li P, Leon-del-Rio A, Rosenfeld MG, Aggarwal AK. 1997. Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility. Genes Dev 11:198–212. http://dx.doi.org/10.1101/gad.11.2.198.

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