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Article

Signaling through Tyr985 of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance

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Pages 1650-1659 | Received 28 Sep 2009, Accepted 11 Jan 2010, Published online: 20 Mar 2023

REFERENCES

  • Banks, A. S., S. M. Davis, S. H. Bates, and M. G. Myers, Jr. 2000. Activation of downstream signals by the long form of the leptin receptor. J. Biol. Chem. 275:14563–14572.
  • Bates, S. H., W. H. Stearns, T. A. Dundon, M. Schubert, A. W. Tso, Y. Wang, A. S. Banks, H. J. Lavery, A. K. Haq, E. Maratos-Flier, B. G. Neel, M. W. Schwartz, and M. G. Myers, Jr. 2003. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421:856–859.
  • Bence, K. K., M. Delibegovic, B. Xue, C. Z. Gorgun, G. S. Hotamisligil, B. G. Neel, and B. B. Kahn. 2006. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat. Med. 12:917–924.
  • Bingham, N. C., K. K. Anderson, A. L. Reuter, N. R. Stallings, and K. L. Parker. 2008. Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology 149:2138–2148.
  • Bjorbaek, C., K. El-Haschimi, J. D. Frantz, and J. S. Flier. 1999. The role of SOCS-3 in leptin signaling and leptin resistance. J. Biol. Chem. 274:30059–30065.
  • Bjorbaek, C., J. K. Elmquist, J. D. Frantz, S. E. Shoelson, and J. S. Flier. 1998. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell 1:619–625.
  • Bjorbaek, C., and B. B. Kahn. 2004. Leptin signaling in the central nervous system and the periphery. Recent Prog. Horm. Res. 59:305–331.
  • Bjorbaek, C., H. J. Lavery, S. H. Bates, R. K. Olson, S. M. Davis, J. S. Flier, and M. G. Myers, Jr. 2000. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 275:40649–40657.
  • Bjorbaek, C., R. M. Buchholz, S. M. Davis, S. H. Bates, D. D. Pierroz, H. Gu, B. G. Neel, M. G. Myers, Jr., and J. S. Flier. 2001. Divergent roles of SHP-2 in ERK activation by leptin receptors. J. Biol. Chem. 276:4747–4755.
  • Bjornholm, M., H. Munzberg, R. L. Leshan, E. C. Villanueva, S. H. Bates, G. W. Louis, J. C. Jones, R. Ishida-Takahashi, C. Bjorbaek, and M. G. Myers, Jr. 2007. Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J. Clin. Invest. 117:1354–1360.
  • Campfield, L. A., F. J. Smith, Y. Guisez, R. Devos, and P. Burn. 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546–549.
  • Cone, R. D. 2005. Anatomy and regulation of the central melanocortin system. Nat. Neurosci. 8:571–578.
  • Cota, D., K. Proulx, K. A. Smith, S. C. Kozma, G. Thomas, S. C. Woods, and R. J. Seeley. 2006. Hypothalamic mTOR signaling regulates food intake. Science 312:927–930.
  • de Luca, C., T. J. Kowalski, Y. Zhang, J. K. Elmquist, C. Lee, M. W. Kilimann, T. Ludwig, S. M. Liu, and S. C. Chua, Jr. 2005. Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J. Clin. Invest. 115:3484–3493.
  • Dhillon, H., J. M. Zigman, C. Ye, C. E. Lee, R. A. McGovern, V. Tang, C. D. Kenny, L. M. Christiansen, R. D. White, E. A. Edelstein, R. Coppari, N. Balthasar, M. A. Cowley, S. Chua, Jr., J. K. Elmquist, and B. B. Lowell. 2006. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49:191–203.
  • Eckel, R. H., S. M. Grundy, and P. Z. Zimmet. 2005. The metabolic syndrome. Lancet 365:1415–1428.
  • El-Haschimi, K., D. D. Pierroz, S. M. Hileman, C. Bjorbak, and J. S. Flier. 2000. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J. Clin. Invest. 105:1827–1832.
  • Enriori, P. J., A. E. Evans, P. Sinnayah, E. E. Jobst, L. Tonelli-Lemos, S. K. Billes, M. M. Glavas, B. E. Grayson, M. Perello, E. A. Nillni, K. L. Grove, and M. A. Cowley. 2007. Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons. Cell Metab. 5:181–194.
  • Ernst, M. B., C. M. Wunderlich, S. Hess, M. Paehler, A. Mesaros, S. B. Koralov, A. Kleinridders, A. Husch, H. Munzberg, B. Hampel, J. Alber, P. Kloppenburg, J. C. Bruning, and F. T. Wunderlich. 2009. Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity. J. Neurosci. 29:11582–11593.
  • Friedman, J. M., and J. L. Halaas. 1998. Leptin and the regulation of body weight in mammals. Nature 395:763–770.
  • Gabriely, I., X. H. Ma, X. M. Yang, L. Rossetti, and N. Barzilai. 2002. Leptin resistance during aging is independent of fat mass. Diabetes 51:1016–1021.
  • Gong, Y., R. Ishida-Takahashi, E. C. Villanueva, D. C. Fingar, H. Munzberg, and M. G. Myers, Jr. 2007. The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J. Biol. Chem. 282:31019–31027.
  • Gough, D. J., A. Corlett, K. Schlessinger, J. Wegrzyn, A. C. Larner, and D. E. Levy. 2009. Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. Science 324:1713–1716.
  • Howard, J. K., B. J. Cave, L. J. Oksanen, I. Tzameli, C. Bjorbaek, and J. S. Flier. 2004. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat. Med. 10:734–738.
  • Hwa, J. J., A. B. Fawzi, M. P. Graziano, L. Ghibaudi, P. Williams, H. M. Van, H. Davis, M. Rudinski, E. Sybertz, and C. D. Strader. 1997. Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice. Am. J. Physiol. 272:R1204–R1209.
  • Jiang, L., J. You, X. Yu, L. Gonzalez, Y. Yu, Q. Wang, G. Yang, W. Li, C. Li, and Y. Liu. 2008. Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proc. Natl. Acad. Sci. U. S. A. 105:18619–18624.
  • Ke, Z. J., L. A. DeGiorgio, B. T. Volpe, and G. E. Gibson. 2003. Reversal of thiamine deficiency-induced neurodegeneration. J. Neuropathol. Exp. Neurol. 62:195–207.
  • Li, C., and J. M. Friedman. 1999. Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc. Natl. Acad. Sci. U. S. A. 96:9677–9682.
  • Mantzoros, C. S., and J. S. Flier. 2000. Leptin as a therapeutic agent—trials and tribulations. J. Clin. Endocrinol. Metab. 85:4000–4002.
  • Minokoshi, Y., T. Alquier, N. Furukawa, Y. B. Kim, A. Lee, B. Xue, J. Mu, F. Foufelle, P. Ferre, M. J. Birnbaum, B. J. Stuck, and B. B. Kahn. 2004. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428:569–574.
  • Mori, H., R. Hanada, T. Hanada, D. Aki, R. Mashima, H. Nishinakamura, T. Torisu, K. R. Chien, H. Yasukawa, and A. Yoshimura. 2004. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat. Med. 10:739–743.
  • Munzberg, H., J. S. Flier, and C. Bjorbaek. 2004. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145:4880–4889.
  • Munzberg, H., and M. G. Myers, Jr. 2005. Molecular and anatomical determinants of central leptin resistance. Nat. Neurosci. 8:566–570.
  • Myers, M. G., Jr., H. Munzberg, G. M. Leinninger, and R. L. Leshan. 2009. The geometry of leptin action in the brain: more complicated than a simple ARC. Cell Metab. 9:117–123.
  • Niswender, K. D., G. J. Morton, W. H. Stearns, C. J. Rhodes, M. G. Myers, Jr., and M. W. Schwartz. 2001. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 413:794–795.
  • Peralta, S., J. M. Carrascosa, N. Gallardo, M. Ros, and C. Arribas. 2002. Ageing increases SOCS-3 expression in rat hypothalamus: effects of food restriction. Biochem. Biophys. Res. Commun. 296:425–428.
  • Rahmouni, K., C. D. Sigmund, W. G. Haynes, and A. L. Mark. 2009. Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes 58:536–542.
  • Ren, D., M. Li, C. Duan, and L. Rui. 2005. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab. 2:95–104.
  • Scarpace, P. J., M. Matheny, and E. W. Shek. 2000. Impaired leptin signal transduction with age-related obesity. Neuropharmacology 39:1872–1879.
  • Wegrzyn, J., R. Potla, Y. J. Chwae, N. B. Sepuri, Q. Zhang, T. Koeck, M. Derecka, K. Szczepanek, M. Szelag, A. Gornicka, A. Moh, S. Moghaddas, Q. Chen, S. Bobbili, J. Cichy, J. Dulak, D. P. Baker, A. Wolfman, D. Stuehr, M. O. Hassan, X. Y. Fu, N. Avadhani, J. I. Drake, P. Fawcett, E. J. Lesnefsky, and A. C. Larner. 2009. Function of mitochondrial Stat3 in cellular respiration. Science 323:793–797.
  • Zhang, E. E., E. Chapeau, K. Hagihara, and G. S. Feng. 2004. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc. Natl. Acad. Sci. U. S. A. 101:16064–16069.
  • Zhang, X., G. Zhang, H. Zhang, M. Karin, H. Bai, and D. Cai. 2008. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135:61–73.
  • Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425–432.

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