75
Views
35
CrossRef citations to date
0
Altmetric
Article

Control of Dendritic Cell Migration, T Cell-Dependent Immunity, and Autoimmunity by Protein Tyrosine Phosphatase PTPN12 Expressed in Dendritic Cells

, , , &
Pages 888-899 | Received 12 Oct 2013, Accepted 18 Dec 2013, Published online: 20 Mar 2023

REFERENCES

  • Murphy K, Travers P, Walport M, Janeway C. 2008. Immunobiology, 7th Ed. Garland Science, New York, NY.
  • Ganguly D, Haak S, Sisirak V, Reizis B. 2013. The role of dendritic cells in autoimmunity. Nat. Rev. Immunol. 13:566–577. http://dx.doi.org/10.1038/nri3477.
  • Veillette A, Rhee I, Souza CM, Davidson D. 2009. PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders. Immunol. Rev. 228:312–324. http://dx.doi.org/10.1111/j.1600-065X.2008.00747.x.
  • Yang Q, Co D, Sommercorn J, Tonks NK. 1993. Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase. J. Biol. Chem. 268:6622–6628. (Erratum, 268:17650.)
  • Rhee I, Veillette A. 2012. Protein tyrosine phosphatases in lymphocyte activation and autoimmunity. Nat. Immunol. 13:439–447. http://dx.doi.org/10.1038/ni.2246.
  • Angers-Loustau A, Cote JF, Charest A, Dowbenko D, Spencer S, Lasky LA, Tremblay ML. 1999. Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J. Cell Biol. 144:1019–1031. http://dx.doi.org/10.1083/jcb.144.5.1019.
  • Davidson D, Shi X, Zhong MC, Rhee I, Veillette A. 2010. The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein tyrosine kinase Pyk2. Immunity 33:167–180. http://dx.doi.org/10.1016/j.immuni.2010.08.001.
  • Garton AJ, Tonks NK. 1999. Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST. J. Biol. Chem. 274:3811–3818. http://dx.doi.org/10.1074/jbc.274.6.3811.
  • Sastry SK, Lyons PD, Schaller MD, Burridge K. 2002. PTP-PEST controls motility through regulation of Rac1. J. Cell Sci. 115:4305–4316. http://dx.doi.org/10.1242/jcs.00105.
  • Sirois J, Cote JF, Charest A, Uetani N, Bourdeau A, Duncan SA, Daniels E, Tremblay ML. 2006. Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. Mech. Dev. 123:869–880. http://dx.doi.org/10.1016/j.mod.2006.08.011.
  • Souza CM, Davidson D, Rhee I, Gratton JP, Davis EC, Veillette A. 2012. The phosphatase PTP-PEST/PTPN12 regulates endothelial cell migration and adhesion, but not permeability, and controls vascular development and embryonic viability. J. Biol. Chem. 287:43180–43190. http://dx.doi.org/10.1074/jbc.M112.387456.
  • Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF. 2011. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell 144:703–718. http://dx.doi.org/10.1016/j.cell.2011.02.003.
  • Rhee I, Davidson D, Souza CM, Vacher J, Veillette A. 2013. Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12. Mol. Cell. Biol. 33:2458–2469. http://dx.doi.org/10.1128/MCB.00197-13.
  • Caton ML, Smith-Raska MR, Reizis B. 2007. Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen. J. Exp. Med. 204:1653–1664. http://dx.doi.org/10.1084/jem.20062648.
  • Barnden MJ, Allison J, Heath WR, Carbone FR. 1998. Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 76:34–40. http://dx.doi.org/10.1046/j.1440-1711.1998.00709.x.
  • Cloutier JF, Veillette A. 1996. Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells. EMBO J. 15:4909–4918.
  • Davidson D, Cloutier JF, Gregorieff A, Veillette A. 1997. Inhibitory tyrosine protein kinase p50csk is associated with protein-tyrosine phosphatase PTP-PEST in hemopoietic and non-hemopoietic cells. J. Biol. Chem. 272:23455–23462. http://dx.doi.org/10.1074/jbc.272.37.23455.
  • Martin-Fontecha A, Sebastiani S, Hopken UE, Uguccioni M, Lipp M, Lanzavecchia A, Sallusto F. 2003. Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J. Exp. Med. 198:615–621. http://dx.doi.org/10.1084/jem.20030448.
  • Tse KW, Dang-Lawson M, Lee RL, Vong D, Bulic A, Buckbinder L, Gold MR. 2009. B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading. J. Biol. Chem. 284:22865–22877. http://dx.doi.org/10.1074/jbc.M109.013169.
  • Han S, Mistry A, Chang JS, Cunningham D, Griffor M, Bonnette PC, Wang H, Chrunyk BA, Aspnes GE, Walker DP, Brosius AD, Buckbinder L. 2009. Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J. Biol. Chem. 284:13193–13201. http://dx.doi.org/10.1074/jbc.M809038200.
  • Veillette A, Bookman MA, Horak EM, Bolen JB. 1988. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 55:301–308. http://dx.doi.org/10.1016/0092-8674(88)90053-0.
  • Villadangos JA, Schnorrer P. 2007. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nat. Rev. Immunol. 7:543–555. http://dx.doi.org/10.1038/nri2103.
  • Zhong MC, Kerlero de Rosbo N, Ben-Nun A. 2002. Multiantigen/multiepitope-directed immune-specific suppression of “complex autoimmune encephalomyelitis” by a novel protein product of a synthetic gene. J. Clin. Invest. 110:81–90. http://dx.doi.org/10.1172/JCI15692.
  • Avraham H, Park SY, Schinkmann K, Avraham S. 2000. RAFTK/Pyk2-mediated cellular signalling. Cell Signal. 12:123–133. http://dx.doi.org/10.1016/S0898-6568(99)00076-5.
  • Bonnette PC, Robinson BS, Silva JC, Stokes MP, Brosius AD, Baumann A, Buckbinder L. 2010. Phosphoproteomic characterization of PYK2 signaling pathways involved in osteogenesis. J. Proteomics 73:1306–1320. http://dx.doi.org/10.1016/j.jprot.2010.01.011.
  • Hagel M, George EL, Kim A, Tamimi R, Opitz SL, Turner CE, Imamoto A, Thomas SM. 2002. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol. Cell. Biol. 22:901–915. http://dx.doi.org/10.1128/MCB.22.3.901-915.2002.
  • Turner CE. 2000. Paxillin and focal adhesion signalling. Nat. Cell Biol. 2:E231–E236. http://dx.doi.org/10.1038/35046659.
  • Cote JF, Chung PL, Theberge JF, Halle M, Spencer S, Lasky LA, Tremblay ML. 2002. PSTPIP is a substrate of PTP-PEST and serves as a scaffold guiding PTP-PEST toward a specific dephosphorylation of WASP. J. Biol. Chem. 277:2973–2986. http://dx.doi.org/10.1074/jbc.M106428200.
  • Riol-Blanco L, Sanchez-Sanchez N, Torres A, Tejedor A, Narumiya S, Corbi AL, Sanchez-Mateos P, Rodriguez-Fernandez JL. 2005. The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed. J. Immunol. 174:4070–4080.
  • Benvenuti F, Hugues S, Walmsley M, Ruf S, Fetler L, Popoff M, Tybulewicz VL, Amigorena S. 2004. Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming. Science 305:1150–1153. http://dx.doi.org/10.1126/science.1099159.
  • Hauck CR, Klingbeil CK, Schlaepfer DD. 2000. Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration. Immunol. Res. 21:293–303. http://dx.doi.org/10.1385/IR:21:2-3:293.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.