Cooperative Transcriptional Activation by Klf4, Meis2, and Pbx1

REFERENCES

• Bartholin, L., et al. 2006. TGIF inhibits retinoid signaling. Mol. Cell. Biol. 26:990–1001.
   PubMed Web of Science ®Google Scholar
• Berkes, C. A., et al. 2004. Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential. Mol. Cell 14:465–477.
   PubMed Web of Science ®Google Scholar
• Berthelsen, J., V. Zappavigna, E. Ferretti, F. Mavilio, and F. Blasi. 1998. The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity. EMBO J. 17:1434–1445.
   PubMedGoogle Scholar
• Berthelsen, J., V. Zappavigna, F. Mavilio, and F. Blasi. 1998. Prep1, a novel functional partner of Pbx proteins. EMBO J. 17:1423–1433.
   PubMedGoogle Scholar
• Bertolino, E., B. Reimund, D. Wildt-Perinic, and R. Clerc. 1995. A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif. J. Biol. Chem. 270:31178–31188.
   PubMed Web of Science ®Google Scholar
• Briggs, M. R., J. T. Kadonaga, S. P. Bell, and R. Tjian. 1986. Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. Science 234:47–52.
   PubMed Web of Science ®Google Scholar
• Burglin, T. R. 1997. Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals. Nucleic Acids Res. 25:4173–4180.
   PubMed Web of Science ®Google Scholar
• Cai, C., et al. 2007. ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion. Mol. Endocrinol. 21:1835–1846.
   PubMedGoogle Scholar
• Chang, C. P., L. Brocchieri, W. F. Shen, C. Largman, and M. L. Cleary. 1996. Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus. Mol. Cell. Biol. 16:1734–1745.
   PubMedGoogle Scholar
• Chang, C. P., et al. 1995. Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins. Genes Dev. 9:663–674.
   PubMedGoogle Scholar
• Chang, C. P., et al. 2008. Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract. Development 135:3577–3586.
   PubMedGoogle Scholar
• Di Rosa, P., et al. 2007. The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem and progenitor cell activity. Dev. Biol. 311:324–334.
   PubMedGoogle Scholar
• Dynan, W. S., and R. Tjian. 1983. The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell 35:79–87.
   PubMed Web of Science ®Google Scholar
• Evans, P. M., and C. Liu. 2008. Roles of Krupel-like factor 4 in normal homeostasis, cancer and stem cells. Acta Biochim. Biophys. Sin. (Shanghai) 40:554–564.
   PubMed Web of Science ®Google Scholar
• Fognani, C., et al. 2002. Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors. Nucleic Acids Res. 30:2043–2051.
   PubMedGoogle Scholar
• Foster, K. W., et al. 2005. Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene 24:1491–1500.
   PubMedGoogle Scholar
• Gehring, W. J., M. Affolter, and T. Burglin. 1994. Homeodomain proteins. Annu. Rev. Biochem. 63:487–526.
   PubMed Web of Science ®Google Scholar
• Gehring, W. J., et al. 1994. Homeodomain-DNA recognition. Cell 78:211–223.
   PubMed Web of Science ®Google Scholar
• Geiman, D. E., H. Ton-That, J. M. Johnson, and V. W. Yang. 2000. Transactivation and growth suppression by the gut-enriched Kruppel-like factor (Kruppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction. Nucleic Acids Res. 28:1106–1113.
   PubMedGoogle Scholar
• Huang, H., et al. 2005. MEIS C termini harbor transcriptional activation domains that respond to cell signaling. J. Biol. Chem. 280:10119–10127.
   PubMedGoogle Scholar
• Hyman-Walsh, C., G. A. Bjerke, and D. Wotton. 2010. An autoinhibitory effect of the homothorax domain of Meis2. FEBS J. 277:2584–2597.
   PubMedGoogle Scholar
• Jacobs, Y., C. A. Schnabel, and M. L. Cleary. 1999. Trimeric association of hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol. Cell. Biol. 19:5134–5142.
   PubMed Web of Science ®Google Scholar
• Kaczynski, J., T. Cook, and R. Urrutia. 2003. Sp1- and Kruppel-like transcription factors. Genome Biol. 4:206.
   PubMed Web of Science ®Google Scholar
• Kadonaga, J. T., K. R. Carner, F. R. Masiarz, and R. Tjian. 1987. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 51:1079–1090.
   PubMed Web of Science ®Google Scholar
• Kamps, M. P., A. T. Look, and D. Baltimore. 1991. The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials. Genes Dev. 5:358–368.
   PubMed Web of Science ®Google Scholar
• Kamps, M. P., C. Murre, X. H. Sun, and D. Baltimore. 1990. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 60:547–555.
   PubMed Web of Science ®Google Scholar
• Kingsley, C., and A. Winoto. 1992. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol. Cell. Biol. 12:4251–4261.
   PubMedGoogle Scholar
• Knoepfler, P. S., et al. 1999. A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx- Meis1/Prep1. Nucleic Acids Res. 27:3752–3761.
   PubMedGoogle Scholar
• Knoepfler, P. S., K. R. Calvo, H. Chen, S. E. Antonarakis, and M. P. Kamps. 1997. Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc. Natl. Acad. Sci. U. S. A. 94:14553–14558.
   PubMed Web of Science ®Google Scholar
• Knoepfler, P. S., and M. P. Kamps. 1995. The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1. Mol. Cell. Biol. 15:5811–5819.
   PubMed Web of Science ®Google Scholar
• Laurent, A., R. Bihan, F. Omilli, S. Deschamps, and I. Pellerin. 2008. PBX proteins: much more than Hox cofactors. Int. J. Dev. Biol. 52:9–20.
   PubMedGoogle Scholar
• Li, J.-M., M. A. Nichols, S. Chandrasekharan, Y. Xiong, and X.-F. Wang. 1995. Transforming growth factor β activates the promoter of cyclin-dependent kinase inhibitor p15Ink4B through an Sp1 consensus site. J. Biol. Chem. 270:26750–26753.
   PubMed Web of Science ®Google Scholar
• Li, J. M., et al. 1998. Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites. Nucleic Acids Res. 26:2449–2456.
   PubMed Web of Science ®Google Scholar
• Liu, Y., R. J. MacDonald, and G. H. Swift. 2001. DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex. J. Biol. Chem. 276:17985–17993.
   PubMedGoogle Scholar
• Lu, Q., and M. P. Kamps. 1996. Selective repression of transcriptional activators by Pbx1 does not require the homeodomain. Proc. Natl. Acad. Sci. U. S. A. 93:470–474.
   PubMedGoogle Scholar
• Maherali, N., et al. 2007. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1:55–70.
   PubMed Web of Science ®Google Scholar
• Mann, R. S., and M. Affolter. 1998. Hox proteins meet more partners. Curr. Opin. Genet. Dev. 8:423–429.
   PubMed Web of Science ®Google Scholar
• McConnell, B. B., A. M. Ghaleb, M. O. Nandan, and V. W. Yang. 2007. The diverse functions of Kruppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays 29:549–557.
   PubMedGoogle Scholar
• McGinnis, W., R. L. Garber, J. Wirz, A. Kuroiwa, and W. J. Gehring. 1984. A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell 37:403–408.
   PubMed Web of Science ®Google Scholar
• McGinnis, W., M. S. Levine, E. Hafen, A. Kuroiwa, and W. J. Gehring. 1984. A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes. Nature 308:428–433.
   PubMedGoogle Scholar
• Melhuish, T. A., C. M. Gallo, and D. Wotton. 2001. TGIF2 interacts with histone deacetylase 1 and represses transcription. J. Biol. Chem. 276:32109–32114.
   PubMed Web of Science ®Google Scholar
• Moens, C. B., and L. Selleri. 2006. Hox cofactors in vertebrate development. Dev. Biol. 291:193–206.
   PubMed Web of Science ®Google Scholar
• Moskow, J. J., F. Bullrich, K. Huebner, I. O. Daar, and A. M. Buchberg. 1995. Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH- 2 mice. Mol. Cell. Biol. 15:5434–5443.
   PubMed Web of Science ®Google Scholar
• Mukherjee, K., and T. R. Burglin. 2007. Comprehensive analysis of animal TALE homeobox genes: new conserved motifs and cases of accelerated evolution. J. Mol. Evol. 65:137–153.
   PubMedGoogle Scholar
• Nakahara, Y., et al. 2010. Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. Neoplasia 12:20–27.
   PubMed Web of Science ®Google Scholar
• Nakamura, T., N. A. Jenkins, and N. G. Copeland. 1996. Identification of a new family of Pbx-related homeobox genes. Oncogene 13:2235–2242.
   PubMed Web of Science ®Google Scholar
• Okita, K., T. Ichisaka, and S. Yamanaka. 2007. Generation of germline-competent induced pluripotent stem cells. Nature 448:313–317.
   PubMed Web of Science ®Google Scholar
• Oulad-Abdelghani, M., et al. 1997. Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic acid during differentiation of P19 embryonal carcinoma cells. Dev. Dyn. 210:173–183.
   PubMed Web of Science ®Google Scholar
• Passner, J. M., H. D. Ryoo, L. Shen, R. S. Mann, and A. K. Aggarwal. 1999. Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex [see comments]. Nature 397:714–719.
   PubMedGoogle Scholar
• Penkov, D., et al. 2005. Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors. Mol. Cell. Biol. 25:10768–10781.
   PubMedGoogle Scholar
• Penkov, D., M. Palazzolo, A. Mondino, and F. Blasi. 2008. Cytosolic sequestration of Prep1 influences early stages of T cell development. PLoS One 3:e2424.
   PubMedGoogle Scholar
• Piper, D. E., A. H. Batchelor, C.-P. Chang, M. L. Cleary, and C. Wolberger. 1999. Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation. Cell 96:587–597.
   PubMed Web of Science ®Google Scholar
• Rieckhof, G. E., F. Casares, H. D. Ryoo, M. Abu-Shaar, and R. S. Mann. 1997. Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein. Cell 91:171–183.
   PubMedGoogle Scholar
• Ryoo, H. D., T. Marty, F. Casares, M. Affolter, and R. S. Mann. 1999. Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex. Development 126:5137–5148.
   PubMedGoogle Scholar
• Schnabel, C. A., Y. Jacobs, and M. L. Cleary. 2000. HoxA9-mediated immortalization of myeloid progenitors requires functional interactions with TALE cofactors Pbx and Meis. Oncogene 19:608–616.
   PubMed Web of Science ®Google Scholar
• Seoane, J., et al. 2001. TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat. Cell Biol. 3:400–408.
   PubMed Web of Science ®Google Scholar
• Shanmugam, K., N. C. Green, I. Rambaldi, H. U. Saragovi, and M. S. Featherstone. 1999. PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. Mol. Cell. Biol. 19:7577–7588.
   PubMed Web of Science ®Google Scholar
• Shields, J. M., and V. W. Yang. 1998. Identification of the DNA sequence that interacts with the gut-enriched Kruppel-like factor. Nucleic Acids Res. 26:796–802.
   PubMed Web of Science ®Google Scholar
• Silvestri, C., et al. 2008. Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Dev. Cell 14:411–423.
   PubMedGoogle Scholar
• Suske, G., E. Bruford, and S. Philipsen. 2005. Mammalian SP/KLF transcription factors: bring in the family. Genomics 85:551–556.
   PubMed Web of Science ®Google Scholar
• Thorsteinsdottir, U., E. Kroon, L. Jerome, F. Blasi, and G. Sauvageau. 2001. Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia. Mol. Cell. Biol. 21:224–234.
   PubMed Web of Science ®Google Scholar
• Wernig, M., et al. 2007. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448:318–324.
   PubMed Web of Science ®Google Scholar
• Wong, P., M. Iwasaki, T. C. Somervaille, C. W. So, and M. L. Cleary. 2007. Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev. 21:2762–2774.
   PubMed Web of Science ®Google Scholar
• Wotton, D., R. S. Lo, L. A. Swaby, and J. Massague. 1999. Multiple modes of repression by the smad transcriptional corepressor TGIF. J. Biol. Chem. 274:37105–37110.
   PubMedGoogle Scholar
• Yang, Y., et al. 2000. Tale homeodomain proteins Meis2 and TGIF differentially regulate transcription. J. Biol. Chem. 275:20734–20741.
   PubMed Web of Science ®Google Scholar
• Yet, S. F., et al. 1998. Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J. Biol. Chem. 273:1026–1031.
   PubMedGoogle Scholar
• Yori, J. L., E. Johnson, G. Zhou, M. K. Jain, and R. A. Keri. 2010. Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression. J. Biol. Chem. 285:16854–16863.
   PubMed Web of Science ®Google Scholar
• Zhao, W., et al. 2004. Identification of Kruppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. Oncogene 23:395–402.
   PubMed Web of Science ®Google Scholar