Histone Acetyltransferase CBP Is Vital To Demarcate Conventional and Innate CD8⁺ T-Cell Development

REFERENCES

• Allis, C. D., S. L. Berger, J. Cote, S. Dent, T. Jenuwien, T. Kouzarides, L. Pillus, D. Reinberg, Y. Shi, R. Shiekhattar, A. Shilatifard, J. Workman, and Y. Zhang. 2007. New nomenclature for chromatin-modifying enzymes. Cell 131:633–636.
   PubMed Web of Science ®Google Scholar
• Atherly, L. O., J. A. Lucas, M. Felices, C. C. Yin, S. L. Reiner, and L. J. Berg. 2006. The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity 25:79–91.
   PubMedGoogle Scholar
• Bendelac, A., P. B. Savage, and L. Teyton. 2007. The biology of NKT cells. Annu. Rev. Immunol. 25:297–336.
   PubMed Web of Science ®Google Scholar
• Berg, L. J. 2007. Signalling through TEC kinases regulates conventional versus innate CD8+ T-cell development. Nat. Rev. Immunol. 7:479–485.
   PubMedGoogle Scholar
• Broussard, C., C. Fleischacker, R. Horai, M. Chetana, A. M. Venegas, L. L. Sharp, S. M. Hedrick, B. J. Fowlkes, and P. L. Schwartzberg. 2006. Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 25:93–104.
   PubMedGoogle Scholar
• Brunner, C., A. Sindrilaru, I. Girkontaite, K. D. Fischer, C. Sunderkotter, and T. Wirth. 2007. BOB. 1/OBF. 1 controls the balance of TH1 and TH2 immune responses. EMBO J. 26:3191–3202.
   PubMed Web of Science ®Google Scholar
• Chi, T. H., M. Wan, P. P. Lee, K. Akashi, D. Metzger, P. Chambon, C. B. Wilson, and G. R. Crabtree. 2003. Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte development. Immunity 19:169–182.
   PubMedGoogle Scholar
• Dubois, S., T. A. Waldmann, and J. R. Muller. 2006. ITK and IL-15 support two distinct subsets of CD8+ T cells. Proc. Natl. Acad. Sci. USA 103:12075–12080.
   PubMed Web of Science ®Google Scholar
• Gebuhr, T. C., G. I. Kovalev, S. Bultman, V. Godfrey, L. Su, and T. Magnuson. 2003. The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell development. J. Exp. Med. 198:1937–1949.
   PubMedGoogle Scholar
• Glimcher, L. H., M. J. Townsend, B. M. Sullivan, and G. M. Lord. 2004. Recent developments in the transcriptional regulation of cytolytic effector cells. Nat. Rev. Immunol. 4:900–911.
   PubMed Web of Science ®Google Scholar
• Goodman, R. H., and S. Smolik. 2000. CBP/p300 in cell growth, transformation, and development. Genes Dev. 14:1553–1577.
   PubMed Web of Science ®Google Scholar
• Hennet, T., F. K. Hagen, L. A. Tabak, and J. D. Marth. 1995. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc. Natl. Acad. Sci. USA 92:12070–12074.
   PubMedGoogle Scholar
• Intlekofer, A. M., A. Banerjee, N. Takemoto, S. M. Gordon, C. S. Dejong, H. Shin, C. A. Hunter, E. J. Wherry, T. Lindsten, and S. L. Reiner. 2008. Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science 321:408–411.
   PubMed Web of Science ®Google Scholar
• Intlekofer, A. M., N. Takemoto, E. J. Wherry, S. A. Longworth, J. T. Northrup, V. R. Palanivel, A. C. Mullen, C. R. Gasink, S. M. Kaech, J. D. Miller, L. Gapin, K. Ryan, A. P. Russ, T. Lindsten, J. S. Orange, A. W. Goldrath, R. Ahmed, and S. L. Reiner. 2005. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat. Immunol. 6:1236–1244.
   PubMed Web of Science ®Google Scholar
• Joshi, N. S., and S. M. Kaech. 2008. Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation. J. Immunol. 180:1309–1315.
   PubMedGoogle Scholar
• Kaech, S. M., S. Hemby, E. Kersh, and R. Ahmed. 2002. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111:837–851.
   PubMed Web of Science ®Google Scholar
• Kang-Decker, N., C. Tong, F. Boussouar, D. J. Baker, W. Xu, A. A. Leontovich, W. R. Taylor, P. K. Brindle, and J. M. Van Deursen. 2004. Loss of CBP causes T cell lymphomagenesis in synergy with p27(Kip1) insufficiency. Cancer Cell 5:177–189.
   PubMedGoogle Scholar
• Kappes, D. J., X. He, and X. He. 2005. CD4-CD8 lineage commitment: an inside view. Nat. Immunol. 6:761–766.
   PubMed Web of Science ®Google Scholar
• Kasper, L. H., F. Boussouar, P. A. Ney, C. W. Jackson, J. Rehg, J. M. van Deursen, and P. K. Brindle. 2002. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature 419:738–743.
   PubMed Web of Science ®Google Scholar
• Kasper, L. H., and P. K. Brindle. 2006. Mammalian gene expression program resiliency: the roles of multiple coactivator mechanisms in hypoxia-responsive transcription. Cell Cycle 5:142–146.
   PubMed Web of Science ®Google Scholar
• Kasper, L. H., T. Fukuyama, M. A. Biesen, F. Boussouar, C. Tong, A. de Pauw, P. J. Murray, J. M. van Deursen, and P. K. Brindle. 2006. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol. Cell. Biol. 26:789–809.
   PubMed Web of Science ®Google Scholar
• Kennedy, M. K., M. Glaccum, S. N. Brown, E. A. Butz, J. L. Viney, M. Embers, N. Matsuki, K. Charrier, L. Sedger, C. R. Willis, K. Brasel, P. J. Morrissey, K. Stocking, J. C. Schuh, S. Joyce, and J. J. Peschon. 2000. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 191:771–780.
   PubMed Web of Science ®Google Scholar
• Kim, J., J. Lee, N. Yadav, Q. Wu, C. Carter, S. Richard, E. Richie, and M. T. Bedford. 2004. Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development. J. Biol. Chem. 279:25339–25344.
   PubMed Web of Science ®Google Scholar
• Kioussis, D., and K. Georgopoulos. 2007. Epigenetic flexibility underlying lineage choices in the adaptive immune system. Science 317:620–622.
   PubMedGoogle Scholar
• Kuo, H. Y., C. C. Chang, J. C. Jeng, H. M. Hu, D. Y. Lin, G. G. Maul, R. P. Kwok, and H. M. Shih. 2005. SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx. Proc. Natl. Acad. Sci. USA 102:16973–16978.
   PubMedGoogle Scholar
• Lee, P. P., D. R. Fitzpatrick, C. Beard, H. K. Jessup, S. Lehar, K. W. Makar, M. Perez-Melgosa, M. T. Sweetser, M. S. Schlissel, S. Nguyen, S. R. Cherry, J. H. Tsai, S. M. Tucker, W. M. Weaver, A. Kelso, R. Jaenisch, and C. B. Wilson. 2001. A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15:763–774.
   PubMed Web of Science ®Google Scholar
• Ma, H., C. Nguyen, K. S. Lee, and M. Kahn. 2005. Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression. Oncogene 24:3619–3631.
   PubMed Web of Science ®Google Scholar
• McManus, K. J., and M. J. Hendzel. 2003. Quantitative analysis of CBP- and P300-induced histone acetylations in vivo using native chromatin. Mol. Cell. Biol. 23:7611–7627.
   PubMedGoogle Scholar
• Miller, A. T., and L. J. Berg. 2002. Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase. J. Immunol. 168:2163–2172.
   PubMedGoogle Scholar
• Oukka, M., M. N. Wein, and L. H. Glimcher. 2004. Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells. J. Exp. Med. 199:15–24.
   PubMedGoogle Scholar
• Pearce, E. L., A. C. Mullen, G. A. Martins, C. M. Krawczyk, A. S. Hutchins, V. P. Zediak, M. Banica, C. B. DiCioccio, D. A. Gross, C. A. Mao, H. Shen, N. Cereb, S. Y. Yang, T. Lindsten, J. Rossant, C. A. Hunter, and S. L. Reiner. 2003. Control of effector CD8+ T cell function by the transcription factor eomesodermin. Science 302:1041–1043.
   PubMed Web of Science ®Google Scholar
• Reiner, S. L. 2005. Epigenetic control in the immune response. Hum. Mol. Genet. 14(Spec. no. 1):R41–R46.
   PubMedGoogle Scholar
• Rothenberg, E. V. 2007. Cell lineage regulators in B and T cell development. Nature Immunol. 8:441–444.
   PubMedGoogle Scholar
• Schaeffer, E. M., J. Debnath, G. Yap, D. McVicar, X. C. Liao, D. R. Littman, A. Sher, H. E. Varmus, M. J. Lenardo, and P. L. Schwartzberg. 1999. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science 284:638–641.
   PubMed Web of Science ®Google Scholar
• Spiegelman, B. M., and R. Heinrich. 2004. Biological control through regulated transcriptional coactivators. Cell 119:157–167.
   PubMed Web of Science ®Google Scholar
• Srinivas, S., T. Watanabe, C. S. Lin, C. M. William, Y. Tanabe, T. M. Jessell, and F. Costantini. 2001. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1:4.
   PubMedGoogle Scholar
• Sullivan, B. M., A. Juedes, S. J. Szabo, M. von Herrath, and L. H. Glimcher. 2003. Antigen-driven effector CD8 T cell function regulated by T-bet. Proc. Natl. Acad. Sci. USA 100:15818–15823.
   PubMed Web of Science ®Google Scholar
• Szabo, S. J., B. M. Sullivan, C. Stemmann, A. R. Satoskar, B. P. Sleckman, and L. H. Glimcher. 2002. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295:338–342.
   PubMed Web of Science ®Google Scholar
• Tanaka, Y., I. Naruse, T. Hongo, M. Xu, T. Nakahata, T. Maekawa, and S. Ishii. 2000. Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding protein. Mech. Dev. 95:133–145.
   PubMed Web of Science ®Google Scholar
• Wang, J., R. A. Barke, and S. Roy. 2007. Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine. J. Biol. Chem. 282:7164–7171.
   PubMedGoogle Scholar
• Williams, C. J., T. Naito, P. G. Arco, J. R. Seavitt, S. M. Cashman, B. De Souza, X. Qi, P. Keables, U. H. Von Andrian, and K. Georgopoulos. 2004. The chromatin remodeler Mi-2β is required for CD4 expression and T cell development. Immunity 20:719–733.
   PubMedGoogle Scholar
• Wilson, A., L. M. Day, R. Scollay, and K. Shortman. 1988. Subpopulations of mature murine thymocytes: properties of CD4− CD8+ and CD4+ CD8− thymocytes lacking the heat-stable antigen. Cell Immunol. 117:312–326.
   PubMedGoogle Scholar
• Wilson, C. B., and M. Merkenschlager. 2006. Chromatin structure and gene regulation in T cell development and function. Curr. Opin. Immunol. 18:143–151.
   PubMedGoogle Scholar
• Xu, W., T. Fukuyama, P. A. Ney, D. Wang, J. Rehg, K. Boyd, J. M. van Deursen, and P. K. Brindle. 2006. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood 107:4407–4416.
   PubMed Web of Science ®Google Scholar
• Xu, W., L. H. Kasper, S. Lerach, T. Jeevan, and P. K. Brindle. 2007. Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms. EMBO J. 26:2890–2903.
   PubMed Web of Science ®Google Scholar
• Yao, T. P., S. P. Oh, M. Fuchs, N. D. Zhou, L. E. Ch'ng, D. Newsome, R. T. Bronson, E. Li, D. M. Livingston, and R. Eckner. 1998. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell 93:361–372.
   PubMed Web of Science ®Google Scholar
• Yu, C. T., M. H. Feng, H. M. Shih, and M. Z. Lai. 2002. Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection. Mol. Cell. Biol. 22:4556–4566.
   PubMedGoogle Scholar