Multidrug Transporter ABCG2/Breast Cancer Resistance Protein Secretes Riboflavin (Vitamin B₂) into Milk

REFERENCES

• Allen, J. D., A. van Loevezijn, J. M. Lakhai, M. A. van der Valk, O. van Tellingen, G. Reid, J. H. M. Schellens, G. J. Koomen, and A. H. Schinkel. 2002. Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Mol. Cancer Ther. 1:417–425.
   PubMed Web of Science ®Google Scholar
• Bardelmeijer, H. A., J. H. Beijnen, K. R. Brouwer, H. Rosing, W. J. Nooijen, J. H. M. Schellens, and O. van Tellingen. 2000. Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein. Clin. Cancer Res 6:4416–4421.
   PubMed Web of Science ®Google Scholar
• Bosch, T. M., L. M. Kjellberg, A. Bouwers, B. P. Koeleman, J. H. M. Schellens, J. H. Beijnen, P. H. Smits, and I. Meijerman. 2005. Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population. Am. J. Pharmacogenom. 5:123–131.
   PubMedGoogle Scholar
• Breedveld, P., N. Zelcer, D. Pluim, Ö. Sönmezer, M. M. Tibben, J. H. Beijnen, A. H. Schinkel, O. van Tellingen, P. Borst, and J. H. M. Schellens. 2004. Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions. Cancer Res 64:5804–5811.
   PubMed Web of Science ®Google Scholar
• Breedveld, P., J. H. Beijnen, and J. H. M. Schellens. 2006. Use of P-gp (ABCB1) and BCRP (ABCG2) inhibitors to improve oral bioavailability and brain penetration of anticancer drugs. Trends Pharmacol. Sci. 27:17–24.
   PubMed Web of Science ®Google Scholar
• Cohen-Zinder, M., E. Seroussi, D. M. Larkin, J. J. Loor, A. Everts-van der Wind, J. H. Lee, J. K. Drackley, M. R. Band, A. G. Hernandez, M. Shani, H. A Lewin, J. I. Weller, and M. Ron. 2005. Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle. Genome Res. 15:936–944.
   PubMed Web of Science ®Google Scholar
• Foraker, A. B., C. M. Khantwal, and P. W. Swaan. 2003. Current perspectives on the cellular uptake and trafficking of riboflavin. Adv. Drug Del. Rev. 55:1467–1483.
   PubMed Web of Science ®Google Scholar
• Hill, M. J. 1997. Intestinal flora and endogenous vitamin synthesis. Eur. J. Cancer Prev. 6:S43–S45.
   PubMed Web of Science ®Google Scholar
• Huang, S., and P. W. Swaan. 2000. Involvement of a receptor-mediated component in cellular translocation of riboflavin. J. Pharmacol. Exp. Ther. 294:117–125.
   PubMed Web of Science ®Google Scholar
• Ifergan, I., A. Shafran, G. Jansen, J. H. Hooijberg, G. L. Scheffer, and Y. G. Assaraf. 2004. Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis. J. Biol. Chem. 279:25527–25534.
   PubMed Web of Science ®Google Scholar
• Imai, Y., M. Nakane, K. Kage, S. Tsukahara, E. Ishikawa, T. Tsuruo, Y. Miki, and Y. Sugimoto. 2002. C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Mol. Cancer Ther. 1:611–616.
   PubMed Web of Science ®Google Scholar
• Jonker, J. W., M. Buitelaar, E. Wagenaar, M. A. van der Valk, G. L. Scheffer, R. J. Scheper, T. Plösch, F. Kuipers, R. P. J. Oude Elferink, H. Rosing, J. H. Beijnen, and A. H. Schinkel. 2002. The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc. Natl. Acad. Sci. USA 99:15649–15654.
   PubMed Web of Science ®Google Scholar
• Jonker, J. W., G. Merino, S. Musters, A. E. van Herwaarden, E. Bolscher, E. Wagenaar, E. Mesman, T. C. Dale, and A. H. Schinkel. 2005. The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nat. Med. 11:127–129.
   PubMed Web of Science ®Google Scholar
• Lichtenstein, N. S., and I. D. Goldman. 1970. Riboflavin-methotrexate interactions. Photochemical reaction and competition for transport in the L1210 mouse leukemia cell. Biochem. Pharmacol. 19:1229–1239.
   PubMedGoogle Scholar
• Lowy, R. J., and K. R. Spring. 1990. Identification of riboflavin transport by MDCK cells using quantitative fluorescence video microscopy. J. Membr. Biol. 117:91–99.
   PubMedGoogle Scholar
• Merino, G., A. E. van Herwaarden, E. Wagenaar, J. W. Jonker, and A. H. Schinkel. 2005. Sex-dependent expression and activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP/ABCG2) in liver. Mol. Pharmacol. 67:1765–1771.
   PubMed Web of Science ®Google Scholar
• Powers, H. J. 2003. Riboflavin (vitamin B-2) and health. Am. J. Clin. Nutr. 77:1352–1360.
   PubMed Web of Science ®Google Scholar
• van Herwaarden, A. E., J. W. Jonker, E. Wagenaar, R. F. Brinkhuis, J. H. M. Schellens, J. H. Beijnen, and A. H. Schinkel. 2003. The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Res 63:6447–6452.
   PubMed Web of Science ®Google Scholar
• van Herwaarden, A. E., and A. H. Schinkel. 2006. The function of breast cancer resistance protein (BCRP/ABCG2) in epithelial barriers, in stem cells and in milk secretion of drugs and xenotoxins. Trends Pharmacol. Sci. 27:10–16.
   PubMed Web of Science ®Google Scholar
• Yanagawa, N., R. N. G. Shih, O. D. Jo, and H. M. Said. 2000. Riboflavin transport by isolated perfused rabbit renal proximal tubules. Am. J. Physiol. Cell Physiol. 279:C1782–C1786.
   PubMedGoogle Scholar
• Zamber, C. P., J. K. Lamba, K. Yasuda, J. Farnum, K. Thummel, J. D. Schuetz, and E. G. Schuetz. 2003. Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine. Pharmacogenetics 13:19–28.
   PubMedGoogle Scholar
• Zempleni, J. 1995. Determination of riboflavin and flavocoenzymes in human blood plasma by high-performance liquid chromatography. Ann. Nutr. Metab. 39:224–226.
   PubMedGoogle Scholar