Murine CXCL14 Is Dispensable for Dendritic Cell Function and Localization within Peripheral Tissues

REFERENCES

• Anjuere, F., P. Martin, I. Ferrero, M. L. Fraga, G. M. Del Hoyo, N. Wright, and C. Ardavin. 1999. Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse. Blood 93:590–598.
   PubMed Web of Science ®Google Scholar
• Banchereau, J., F. Briere, C. Caux, J. Davoust, S. Lebecque, Y. J. Liu, B. Pulendran, and K. Palucka. 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18:767–811.
   PubMed Web of Science ®Google Scholar
• Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392:245–252.
   PubMed Web of Science ®Google Scholar
• Cao, X., W. Zhang, T. Wan, L. He, T. Chen, Z. Yuan, S. Ma, Y. Yu, and G. Chen. 2000. Molecular cloning and characterization of a novel CXC chemokine macrophage inflammatory protein-2 gamma chemoattractant for human neutrophils and dendritic cells. J. Immunol. 165:2588–2595.
   PubMedGoogle Scholar
• Charbonnier, A. S., N. Kohrgruber, E. Kriehuber, G. Stingl, A. Rot, and D. Maurer. 1999. Macrophage inflammatory protein 3α is involved in the constitutive trafficking of epidermal Langerhans cells. J. Exp. Med. 190:1755–1767.
   PubMed Web of Science ®Google Scholar
• Clark, R. A. 1993. Biology of dermal wound repair. Dermatol. Clin. 11:647–666.
   PubMed Web of Science ®Google Scholar
• Cook, D. N., D. M. Prosser, R. Forster, J. Zhang, N. A. Kuklin, S. J. Abbondanzo, X. D. Niu, S. C. Chen, D. J. Manfra, M. T. Wiekowski, L. M. Sullivan, S. R. Smith, H. B. Greenberg, S. K. Narula, M. Lipp, and S. A. Lira. 2000. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 12:495–503.
   PubMed Web of Science ®Google Scholar
• Dieu-Nosjean, M. C., C. Massacrier, B. Homey, B. Vanbervliet, J. J. Pin, A. Vicari, S. Lebecque, C. Dezutter-Dambuyant, D. Schmitt, A. Zlotnik, and C. Caux. 2000. Macrophage inflammatory protein 3α is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J. Exp. Med. 192:705–718.
   PubMedGoogle Scholar
• Frederick, M. J., Y. Henderson, X. Xu, M. T. Deavers, A. A. Sahin, H. Wu, D. E. Lewis, A. K. El Naggar, and G. L. Clayman. 2000. In vivo expression of the novel CXC chemokine BRAK in normal and cancerous human tissue. Am. J. Pathol. 156:1937–1950.
   PubMed Web of Science ®Google Scholar
• Ginhoux, F., F. Tacke, V. Angeli, M. Bogunovic, M. Loubeau, X. M. Dai, E. R. Stanley, G. J. Randolph, and M. Merad. 2006. Langerhans cells arise from monocytes in vivo. Nat. Immunol. 7:265–273.
   PubMed Web of Science ®Google Scholar
• Gordon, S., and P. R. Taylor. 2005. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5:953–964.
   PubMed Web of Science ®Google Scholar
• Henri, S., D. Vremec, A. Kamath, J. Waithman, S. Williams, C. Benoist, K. Burnham, S. Saeland, E. Handman, and K. Shortman. 2001. The dendritic cell populations of mouse lymph nodes. J. Immunol. 167:741–748.
   PubMed Web of Science ®Google Scholar
• Homey, B., M. C. Dieu-Nosjean, A. Wiesenborn, C. Massacrier, J. J. Pin, E. Oldham, D. Catron, M. E. Buchanan, A. Muller, M. R. deWaal, G. Deng, R. Orozco, T. Ruzicka, P. Lehmann, S. Lebecque, C. Caux, and A. Zlotnik. 2000. Up-regulation of macrophage inflammatory protein-3α/CCL20 and CC chemokine receptor 6 in psoriasis. J. Immunol. 164:6621–6632.
   PubMed Web of Science ®Google Scholar
• Homey, B., A. Muller, and A. Zlotnik. 2002. Chemokines: agents for the immunotherapy of cancer? Nat. Rev. Immunol. 2:175–184.
   PubMed Web of Science ®Google Scholar
• Hromas, R., H. E. Broxmeyer, C. Kim, H. Nakshatri, K. Christopherson, I. I., M. Azam, and Y. H. Hou. 1999. Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells. Biochem. Biophys. Res. Commun. 255:703–706.
   PubMed Web of Science ®Google Scholar
• Jung, S., J. Aliberti, P. Graemmel, M. J. Sunshine, G. W. Kreutzberg, A. Sher, and D. R. Littman. 2000. Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20:4106–4114.
   PubMed Web of Science ®Google Scholar
• Kissenpfennig, A., S. Henri, B. Dubois, C. Laplace-Builhe, P. Perrin, N. Romani, C. H. Tripp, P. Douillard, L. Leserman, D. Kaiserlian, S. Saeland, J. Davoust, and B. Malissen. 2005. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22:643–654.
   PubMed Web of Science ®Google Scholar
• Kissenpfennig, A., and B. Malissen. 2006. Langerhans cells—revisiting the paradigm using genetically engineered mice. Trends Immunol. 27:132–139.
   PubMed Web of Science ®Google Scholar
• Kurth, I., K. Willimann, P. Schaerli, T. Hunziker, I. Clark-Lewis, and B. Moser. 2001. Monocyte selectivity and tissue localization suggests a role for breast and kidney-expressed chemokine (BRAK) in macrophage development. J. Exp. Med. 194:855–861.
   PubMed Web of Science ®Google Scholar
• Larregina, A. T., A. E. Morelli, L. A. Spencer, A. J. Logar, S. C. Watkins, A. W. Thomson, and L. D. Falo, Jr. 2001. Dermal-resident CD14+ cells differentiate into Langerhans cells. Nat. Immunol. 2:1151–1158.
   PubMed Web of Science ®Google Scholar
• Larsen, C. P., R. M. Steinman, M. Witmer-Pack, D. F. Hankins, P. J. Morris, and J. M. Austyn. 1990. Migration and maturation of Langerhans cells in skin transplants and explants. J. Exp. Med. 172:1483–1493.
   PubMed Web of Science ®Google Scholar
• Le, Y., Y. Zhou, P. Iribarren, and J. Wang. 2004. Chemokines and chemokine receptors: their manifold roles in homeostasis and disease. Cell Mol. Immunol. 1:95–104.
   PubMed Web of Science ®Google Scholar
• Mahnke, K., and A. H. Enk. 2005. Dendritic cells: key cells for the induction of regulatory T cells? Curr. Top. Microbiol. Immunol. 293:133–150.
   PubMedGoogle Scholar
• Merad, M., M. G. Manz, H. Karsunky, A. Wagers, W. Peters, I. Charo, I. L. Weissman, J. G. Cyster, and E. G. Engleman. 2002. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat. Immunol. 3:1135–1141.
   PubMed Web of Science ®Google Scholar
• Moser, B., and P. Loetscher. 2001. Lymphocyte traffic control by chemokines. Nat. Immunol. 2:123–128.
   PubMed Web of Science ®Google Scholar
• Moser, B., M. Wolf, A. Walz, and P. Loetscher. 2004. Chemokines: multiple levels of leukocyte migration control. Trends Immunol. 25:75–84.
   PubMed Web of Science ®Google Scholar
• Müller, G., U. E. Höpken, H. Stein, and M. Lipp. 2002. Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors. J. Leukoc. Biol. 72:1–8.
   PubMedGoogle Scholar
• Nakano, H., M. Yanagita, and M. D. Gunn. 2001. CD11c+B220+Gr-1+ cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 194:1171–1178.
   PubMed Web of Science ®Google Scholar
• Naldini, A., and F. Carraro. 2005. Role of inflammatory mediators in angiogenesis. Curr. Drug Targets Inflamm. Allergy 4:3–8.
   PubMedGoogle Scholar
• Niess, J. H., S. Brand, X. Gu, L. Landsman, S. Jung, B. A. McCormick, J. M. Vyas, M. Boes, H. L. Ploegh, J. G. Fox, D. R. Littman, and H. C. Reinecker. 2005. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307:254–258.
   PubMed Web of Science ®Google Scholar
• Ortner, U., K. Inaba, F. Koch, M. Heine, M. Miwa, G. Schuler, and N. Romani. 1996. An improved isolation method for murine migratory cutaneous dendritic cells. J. Immunol. Methods 193:71–79.
   PubMedGoogle Scholar
• Ozawa, S., Y. Kato, R. Komori, Y. Maehata, E. Kubota, and R. I. Hata. 2006. BRAK/CXCL14 expression suppresses tumor growth in vivo in human oral carcinoma cells. Biochem. Biophys. Res. Commun. 348:406–412.
   PubMed Web of Science ®Google Scholar
• Price, A. A., M. Cumberbatch, I. Kimber, and A. Ager. 1997. Alpha 6 integrins are required for Langerhans cell migration from the epidermis. J. Exp. Med. 186:1725–1735.
   PubMed Web of Science ®Google Scholar
• Proudfoot, A. E. 2002. Chemokine receptors: multifaceted therapeutic targets. Nat. Rev. Immunol. 2:106–115.
   PubMed Web of Science ®Google Scholar
• Roake, J. A., A. S. Rao, P. J. Morris, C. P. Larsen, D. F. Hankins, and J. M. Austyn. 1995. Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J. Exp. Med. 181:2237–2247.
   PubMed Web of Science ®Google Scholar
• Romani, N., S. Holzmann, C. H. Tripp, F. Koch, and P. Stoitzner. 2003. Langerhans cells—dendritic cells of the epidermis. APMIS 111:725–740.
   PubMed Web of Science ®Google Scholar
• Rosenkilde, M. M., and T. W. Schwartz. 2004. The chemokine system—a major regulator of angiogenesis in health and disease. APMIS 112:481–495.
   PubMed Web of Science ®Google Scholar
• Saeki, H., A. M. Moore, M. J. Brown, and S. T. Hwang. 1999. Secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J. Immunol. 162:2472–2475.
   PubMed Web of Science ®Google Scholar
• Sallusto, F., and A. Lanzavecchia. 2000. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunol. Rev. 177:134–140.
   PubMed Web of Science ®Google Scholar
• Sato, N., S. K. Ahuja, M. Quinones, V. Kostecki, R. L. Reddick, P. C. Melby, W. A. Kuziel, and S. S. Ahuja. 2000. CC chemokine receptor (CCR)2 is required for Langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, B cell outgrowth, and sustained neutrophilic inflammation. J. Exp. Med. 192:205–218.
   PubMedGoogle Scholar
• Schaerli, P., and B. Moser. 2005. Chemokines: control of primary and memory T-cell traffic. Immunol. Res. 31:57–74.
   PubMed Web of Science ®Google Scholar
• Schaerli, P., K. Willimann, L. M. Ebert, A. Walz, and B. Moser. 2005. Cutaneous CXCL14 targets blood precursors to epidermal niches for Langerhans cell differentiation. Immunity 23:331–342.
   PubMedGoogle Scholar
• Schwarze, S. R., J. Luo, W. B. Isaacs, and D. F. Jarrard. 2005. Modulation of CXCL14 (BRAK) expression in prostate cancer. Prostate 64:67–74.
   PubMed Web of Science ®Google Scholar
• Shellenberger, T. D., M. Wang, M. Gujrati, A. Jayakumar, R. M. Strieter, M. D. Burdick, C. G. Ioannides, C. L. Efferson, A. K. El Naggar, D. Roberts, G. L. Clayman, and M. J. Frederick. 2004. BRAK/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cells. Cancer Res. 64:8262–8270.
   PubMed Web of Science ®Google Scholar
• Shortman, K., and Y. J. Liu. 2002. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2:151–161.
   PubMed Web of Science ®Google Scholar
• Shurin, G. V., R. L. Ferris, I. L. Tourkova, L. Perez, A. Lokshin, L. Balkir, B. Collins, G. S. Chatta, and M. R. Shurin. 2005. Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo. J. Immunol. 174:5490–5498.
   PubMed Web of Science ®Google Scholar
• Sleeman, M. A., J. K. Fraser, J. G. Murison, S. L. Kelly, R. L. Prestidge, D. J. Palmer, J. D. Watson, and K. D. Kumble. 2000. B cell- and monocyte-activating chemokine (BMAC), a novel non-ELR alpha-chemokine. Int. Immunol. 12:677–689.
   PubMed Web of Science ®Google Scholar
• Steinman, R. M., D. Hawiger, and M. C. Nussenzweig. 2003. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21:685–711.
   PubMed Web of Science ®Google Scholar
• Stoitzner, P., M. Zanella, U. Ortner, M. Lukas, A. Tagwerker, K. Janke, M. B. Lutz, G. Schuler, B. Echtenacher, B. Ryffel, F. Koch, and N. Romani. 1999. Migration of Langerhans cells and dermal dendritic cells in skin organ cultures: augmentation by TNF-α and IL-1β. J. Leukoc. Biol. 66:462–470.
   PubMed Web of Science ®Google Scholar
• Streit, M., P. Velasco, L. Riccardi, L. Spencer, L. F. Brown, L. Janes, B. Lange-Asschenfeldt, K. Yano, T. Hawighorst, L. Iruela-Arispe, and M. Detmar. 2000. Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice. EMBO J. 19:3272–3282.
   PubMed Web of Science ®Google Scholar
• Sunderkotter, C., T. Nikolic, M. J. Dillon, N. Van Rooijen, M. Stehling, D. A. Drevets, and P. J. Leenen. 2004. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J. Immunol. 172:4410–4417.
   PubMed Web of Science ®Google Scholar
• Vanbervliet, B., B. Homey, I. Durand, C. Massacrier, S. Ait-Yahia, O. de Bouteiller, A. Vicari, and C. Caux. 2002. Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces. Eur. J. Immunol. 32:231–242.
   PubMedGoogle Scholar
• Varona, R., R. Villares, L. Carramolino, I. Goya, A. Zaballos, J. Gutierrez, M. Torres, A. Martinez, and G. Marquez. 2001. CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses. J. Clin. Investig. 107:R37–R45.
   PubMedGoogle Scholar
• Weinlich, G., M. Heine, H. Stossel, M. Zanella, P. Stoitzner, U. Ortner, J. Smolle, F. Koch, N. T. Sepp, G. Schuler, and N. Romani. 1998. Entry into afferent lymphatics and maturation in situ of migrating murine cutaneous dendritic cells. J. Invest Dermatol. 110:441–448.
   PubMed Web of Science ®Google Scholar