101
Views
122
CrossRef citations to date
0
Altmetric
Article

Semaphorin 3E Initiates Antiangiogenic Signaling through Plexin D1 by Regulating Arf6 and R-Ras

, , , , , , , , , , & show all
Pages 3086-3098 | Received 23 Dec 2009, Accepted 02 Apr 2010, Published online: 20 Mar 2023

REFERENCES

  • Avraamides, C. J., B. Garmy-Susini, and J. A. Varner. 2008. Integrins in angiogenesis and lymphangiogenesis. Nat. Rev. Cancer. 8:604–617.
  • Basile, J. R., K. Holmbeck, T. H. Bugge, and J. S. Gutkind. 2007. MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D. J. Biol. Chem. 282:6899–6905.
  • Belperio, J. A., M. P. Keane, D. A. Arenberg, C. L. Addison, J. E. Ehlert, M. D. Burdick, and R. M. Strieter. 2000. CXC chemokines in angiogenesis. J. Leukoc. Biol. 68:1–8.
  • Cao, R., E. Brakenhielm, R. Pawliuk, D. Wariaro, M. J. Post, E. Wahlberg, P. Leboulch, and Y. Cao. 2003. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat. Med. 9:604–613.
  • Carmeliet, P. 2005. Angiogenesis in life, disease and medicine. Nature 438:932–936.
  • Carmeliet, P., and M. Tessier-Lavigne. 2005. Common mechanisms of nerve and blood vessel wiring. Nature 436:193–200.
  • Casanova, J. E. 2007. Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors. Traffic 8:1476–1485.
  • Coultas, L., K. Chawengsaksophak, and J. Rossant. 2005. Endothelial cells and VEGF in vascular development. Nature 438:937–945.
  • Dawson, D. W., O. V. Volpert, P. Gillis, S. E. Crawford, H. Xu, W. Benedict, and N. P. Bouck. 1999. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 285:245–248.
  • Dunphy, J. L., R. Moravec, K. Ly, T. K. Lasell, P. Melancon, and J. E. Casanova. 2006. The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins. Curr. Biol. 16:315–320.
  • Folkman, J. 2007. Angiogenesis: an organizing principle for drug discovery? Nat. Rev. Drug Discov. 6:273–286.
  • Gerhardt, H., M. Golding, M. Fruttiger, C. Ruhrberg, A. Lundkvist, A. Abramsson, M. Jeltsch, C. Mitchell, K. Alitalo, D. Shima, and C. Betsholtz. 2003. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J. Cell Biol. 161:1163–1177.
  • Gitler, A. D., M. M. Lu, and J. A. Epstein. 2004. PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev. Cell 7:107–116.
  • Good, D. J., P. J. Polverini, F. Rastinejad, M. M. Le Beau, R. S. Lemons, W. A. Frazier, and N. P. Bouck. 1990. A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc. Natl. Acad. Sci. U. S. A. 87:6624–6628.
  • Gu, C., Y. Yoshida, J. Livet, D. V. Reimert, F. Mann, J. Merte, C. E. Henderson, T. M. Jessell, A. L. Kolodkin, and D. D. Ginty. 2005. Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science 307:265–268.
  • Hamadi, A., M. Bouali, M. Dontenwill, H. Stoeckel, K. Takeda, and P. Ronde. 2005. Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397. J. Cell Sci. 118:4415–4425.
  • Hla, T. 2003. Signaling and biological actions of sphingosine 1-phosphate. Pharmacol. Res. 47:401–407.
  • Maione, T. E., G. S. Gray, J. Petro, A. J. Hunt, A. L. Donner, S. I. Bauer, H. F. Carson, and R. J. Sharpe. 1990. Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. Science 247:77–79.
  • Neufeld, G., and O. Kessler. 2008. The semaphorins: versatile regulators of tumour progression and tumour angiogenesis. Nat. Rev. Cancer. 8:632–645.
  • Nyberg, P., L. Xie, and R. Kalluri. 2005. Endogenous inhibitors of angiogenesis. Cancer Res. 65:3967–3979.
  • Oinuma, I., Y. Ishikawa, H. Katoh, and M. Negishi. 2004. The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. Science 305:862–865.
  • Powelka, A. M., J. Sun, J. Li, M. Gao, L. M. Shaw, A. Sonnenberg, and V. W. Hsu. 2004. Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11. Traffic 5:20–36.
  • Raper, J. A. 2000. Semaphorins and their receptors in vertebrates and invertebrates. Curr. Opin. Neurobiol. 10:88–94.
  • Sakurai, A., S. Fukuhara, A. Yamagishi, K. Sako, Y. Kamioka, M. Masuda, Y. Nakaoka, and N. Mochizuki. 2006. MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion. Mol. Biol. Cell 17:966–976.
  • Serini, G., D. Valdembri, S. Zanivan, G. Morterra, C. Burkhardt, F. Caccavari, L. Zammataro, L. Primo, L. Tamagnone, M. Logan, M. Tessier-Lavigne, M. Taniguchi, A. W. Puschel, and F. Bussolino. 2003. Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function. Nature 424:391–397.
  • Takahashi, T., A. Fournier, F. Nakamura, L. H. Wang, Y. Murakami, R. G. Kalb, H. Fujisawa, and S. M. Strittmatter. 1999. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 99:59–69.
  • Tessier-Lavigne, M., and C. S. Goodman. 1996. The molecular biology of axon guidance. Science 274:1123–1133.
  • Toyofuku, T., J. Yoshida, T. Sugimoto, H. Zhang, A. Kumanogoh, M. Hori, and H. Kikutani. 2005. FARP2 triggers signals for Sema3A-mediated axonal repulsion. Nat. Neurosci. 8:1712–1719.
  • Uesugi, K., I. Oinuma, H. Katoh, and M. Negishi. 2009. Different requirement for Rnd GTPases of R-Ras GAP activity of plexin-C1 and plexin-D1. J. Biol. Chem. 284:6743–6751.
  • Yancopoulos, G. D., M. Klagsbrun, and J. Folkman. 1998. Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border. Cell 93:661–664.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.